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3. Formation and evolution of carbonaceous asteroid Ryugu: Direct evidence from returned samples

Author

Nakamura, T., primary, Matsumoto, M., additional, Amano, K., additional, Enokido, Y., additional, Zolensky, M. E., additional, Mikouchi, T., additional, Genda, H., additional, Tanaka, S., additional, Zolotov, M. Y., additional, Kurosawa, K., additional, Wakita, S., additional, Hyodo, R., additional, Nagano, H., additional, Nakashima, D., additional, Takahashi, Y., additional, Fujioka, Y., additional, Kikuiri, M., additional, Kagawa, E., additional, Matsuoka, M., additional, Brearley, A. J., additional, Tsuchiyama, A., additional, Uesugi, M., additional, Matsuno, J., additional, Kimura, Y., additional, Sato, M., additional, Milliken, R. E., additional, Tatsumi, E., additional, Sugita, S., additional, Hiroi, T., additional, Kitazato, K., additional, Brownlee, D., additional, Joswiak, D. J., additional, Takahashi, M., additional, Ninomiya, K., additional, Takahashi, T., additional, Osawa, T., additional, Terada, K., additional, Brenker, F. E., additional, Tkalcec, B. J., additional, Vincze, L., additional, Brunetto, R., additional, Aléon-Toppani, A., additional, Chan, Q. H. S., additional, Roskosz, M., additional, Viennet, J.-C., additional, Beck, P., additional, Alp, E. E., additional, Michikami, T., additional, Nagaashi, Y., additional, Tsuji, T., additional, Ino, Y., additional, Martinez, J., additional, Han, J., additional, Dolocan, A., additional, Bodnar, R. J., additional, Tanaka, M., additional, Yoshida, H., additional, Sugiyama, K., additional, King, A. J., additional, Fukushi, K., additional, Suga, H., additional, Yamashita, S., additional, Kawai, T., additional, Inoue, K., additional, Nakato, A., additional, Noguchi, T., additional, Vilas, F., additional, Hendrix, A. R., additional, Jaramillo-Correa, C., additional, Domingue, D. L., additional, Dominguez, G., additional, Gainsforth, Z., additional, Engrand, C., additional, Duprat, J., additional, Russell, S. S., additional, Bonato, E., additional, Ma, C., additional, Kawamoto, T., additional, Wada, T., additional, Watanabe, S., additional, Endo, R., additional, Enju, S., additional, Riu, L., additional, Rubino, S., additional, Tack, P., additional, Takeshita, S., additional, Takeichi, Y., additional, Takeuchi, A., additional, Takigawa, A., additional, Takir, D., additional, Tanigaki, T., additional, Taniguchi, A., additional, Tsukamoto, K., additional, Yagi, T., additional, Yamada, S., additional, Yamamoto, K., additional, Yamashita, Y., additional, Yasutake, M., additional, Uesugi, K., additional, Umegaki, I., additional, Chiu, I., additional, Ishizaki, T., additional, Okumura, S., additional, Palomba, E., additional, Pilorget, C., additional, Potin, S. M., additional, Alasli, A., additional, Anada, S., additional, Araki, Y., additional, Sakatani, N., additional, Schultz, C., additional, Sekizawa, O., additional, Sitzman, S. D., additional, Sugiura, K., additional, Sun, M., additional, Dartois, E., additional, De Pauw, E., additional, Dionnet, Z., additional, Djouadi, Z., additional, Falkenberg, G., additional, Fujita, R., additional, Fukuma, T., additional, Gearba, I. R., additional, Hagiya, K., additional, Hu, M. Y., additional, Kato, T., additional, Kawamura, T., additional, Kimura, M., additional, Kubo, M. K., additional, Langenhorst, F., additional, Lantz, C., additional, Lavina, B., additional, Lindner, M., additional, Zhao, J., additional, Vekemans, B., additional, Baklouti, D., additional, Bazi, B., additional, Borondics, F., additional, Nagasawa, S., additional, Nishiyama, G., additional, Nitta, K., additional, Mathurin, J., additional, Matsumoto, T., additional, Mitsukawa, I., additional, Miura, H., additional, Miyake, A., additional, Miyake, Y., additional, Yurimoto, H., additional, Okazaki, R., additional, Yabuta, H., additional, Naraoka, H., additional, Sakamoto, K., additional, Tachibana, S., additional, Connolly, H. C., additional, Lauretta, D. S., additional, Yoshitake, M., additional, Yoshikawa, M., additional, Yoshikawa, K., additional, Yoshihara, K., additional, Yokota, Y., additional, Yogata, K., additional, Yano, H., additional, Yamamoto, Y., additional, Yamamoto, D., additional, Yamada, M., additional, Yamada, T., additional, Yada, T., additional, Wada, K., additional, Usui, T., additional, Tsukizaki, R., additional, Terui, F., additional, Takeuchi, H., additional, Takei, Y., additional, Iwamae, A., additional, Soejima, H., additional, Shirai, K., additional, Shimaki, Y., additional, Senshu, H., additional, Sawada, H., additional, Saiki, T., additional, Ozaki, M., additional, Ono, G., additional, Okada, T., additional, Ogawa, N., additional, Ogawa, K., additional, Noguchi, R., additional, Noda, H., additional, Nishimura, M., additional, Namiki, N., additional, Nakazawa, S., additional, Morota, T., additional, Miyazaki, A., additional, Miura, A., additional, Mimasu, Y., additional, Matsumoto, K., additional, Kumagai, K., additional, Kouyama, T., additional, Kikuchi, S., additional, Kawahara, K., additional, Kameda, S., additional, Iwata, T., additional, Ishihara, Y., additional, Ishiguro, M., additional, Ikeda, H., additional, Hosoda, S., additional, Honda, R., additional, Honda, C., additional, Hitomi, Y., additional, Hirata, N., additional, Hayashi, T., additional, Hayakawa, M., additional, Hatakeda, K., additional, Furuya, S., additional, Fukai, R., additional, Fujii, A., additional, Cho, Y., additional, Arakawa, M., additional, Abe, M., additional, and Tsuda, Y., additional

Published
2023
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10. Minerology and Crystallography of Some Itokawa Particles Returned by the Hayabusa Mission

Author

Mikouchi, T, Komatsu, M, Hagiya, K, Ohsumi, K, Zolensky, M, Hoffmann, V, Martinez, J, Hochleitner, R, Kaliwoda, M, Terada, Y, Yagi, N, Takata, M, Satake, W, Aoyagi, Y, Takenouchi, A, Yada, T, Karouji, Y, Uesugi, M, and Miyamoto, M

Subjects
Lunar And Planetary Science And Exploration
Abstract

JAXA Hayabusa mission success-fully returned particles of the asteroid Itokawa to the earth in 2010. The recovered particles were carefully studied by the preliminary examination (PE) team and the obtained results are providing significant and unique information about the formation and evolution of meteorite parent bodies [1-6]. These particles further revealed that their mineral compositions and oxygen isotopes are close to those of equilibrated LL chon-drites [1,2], which matches with the observation at the orbit [7]. After the PE, JAXA distributed the samples as international AO study and we received 4 new and 3 PE particles. The new samples may contain some exot-ic components that have not been found by the PE study, and are of special interest. We have performed a detailed mineralogical and crystallographic study on these particles and here report the results.

Published
2014

11. Studies of Itokawa's Surface Exposure by Measurements of Cosmic-ray Produced Nuclides

Author

Caffee, M. W, Nishiizumi, K, Tsuchiyama, A, Uesugi, M, and Zolensky, M. E

Subjects
Space Sciences (General)
Abstract

We plan to investigate the evolutionary history of surface materials from 25143 Itokawa, the Hayabusa samples. Our studies are based on the measurement of nuclides produced in asteroidal surface materials by cosmic rays. Cosmogenic radionuclides are used to determine the duration and nature of the exposure of materials to energetic particles. Our goals are to understand both the fundamental processes on the asteroidal surface and the evolutionary history of its surface materials. They are also key to understanding the history of Itokawa's surface and asteroid-meteoroid evolutionary dynamics. To achieve our key goals, in particular reconstructing the evolutionary histories of the asteroidal surface, we proposed: (1) characterizing Itokawa particles using SXCT, SXRD, and FE-SEM without modification of the sample; (2) embedding each particle in acrylic resin, then slicing a small corner with an ultra-microtome and examining it using super-STEM and SIMS for characterizing surface morphology, space weathering, and oxygen three-isotope analysis; and finally (3) measuring small amounts of cosmogenic radionuclides (104-105 atoms) in Hayabusa samples by AMS. However, we have to modify our plan due to unexpected situation.

Published
2014

12. Changing occupational structures and residential segregation in New York, London and Tokyo

Author

van Ham, M. (author), Uesugi, M. (author), Tammaru, T. (author), Manley, D.J. (author), Janssen, H.J. (author), van Ham, M. (author), Uesugi, M. (author), Tammaru, T. (author), Manley, D.J. (author), and Janssen, H.J. (author)

Abstract

Based on data from the 1980s, Sassen’s influential book ‘The Global City’ interrogated how changes in the occupational structure affect socio-economic residential segregation in global cities. Here, using data for New York City, London and Tokyo, we reframe and answer this question for recent decades. Our analysis shows an increase in the share of high-income occupations, accompanied by a fall in low-income occupations in all three cities, providing strong evidence for a consistent trend of professionalization of the workforce. Segregation was highest in New York and lowest in Tokyo. In New York and London, individuals in high-income occupations are concentrating in the city centre, while low-income occupations are pushed to urban peripheries. Professionalization of the workforce is accompanied by reduced levels of segregation by income, and two ongoing megatrends in urban change: gentrification of inner-city neighbourhoods and suburbanization of poverty, with larger changes in the social geography than in levels of segregation., Accepted Author Manuscript, Urbanism, Urban Studies

Published
2020
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13. Energy metabolism and mitochondrial defects in X-linked Charcot-Marie-Tooth (CMTX6) iPSC-derived motor neurons with the p.R158H PDK3 mutation

Author

Perez-Siles, G, Cutrupi, A, Ellis, M, Screnci, R, Mao, D, Uesugi, M, Yiu, EM, Ryan, MM, Choi, BO, Nicholson, G, Kennerson, ML, Perez-Siles, G, Cutrupi, A, Ellis, M, Screnci, R, Mao, D, Uesugi, M, Yiu, EM, Ryan, MM, Choi, BO, Nicholson, G, and Kennerson, ML

Abstract

Charcot-Marie-Tooth (CMT) is a group of inherited diseases clinically and genetically heterogenous, characterised by length dependent degeneration of axons of the peripheral nervous system. A missense mutation (p.R158H) in the pyruvate dehydrogenase kinase 3 gene (PDK3) has been identified as the genetic cause for an X-linked form of CMT (CMTX6) in two unrelated families. PDK3 is one of four PDK isoenzymes that regulate the activity of the pyruvate dehydrogenase complex (PDC). The balance between kinases (PDKs) and phosphatases (PDPs) determines the extend of oxidative decarboxylation of pyruvate to generate acetyl CoA, critically linking glycolysis and the energy producing Krebs cycle. We had shown the p.R158H mutation causes hyperactivity of PDK3 and CMTX6 fibroblasts show hyperphosphorylation of PDC, leading to reduced PDC activity and ATP production. In this manuscript we have generated induced pluripotent stem cells (iPSCs) by re-programming CMTX6 fibroblasts (iPSCCMTX6). We also have engineered an isogenic control (iPSCisogenic) and demonstrated that genetic correction of the p.R158H mutation reverses the CMTX6 phenotype. Patient-derived motor neurons (MNCMTX6) show increased phosphorylation of the PDC, energy metabolism defects and mitochondrial abnormalities, including reduced velocity of trafficking mitochondria in the affected axons. Treatment of the MNCMTX6 with a PDK inhibitor reverses PDC hyperphosphorylation and the associated functional deficits founds in the patient motor neurons, demonstrating that the MNCMTX6 and MNisogenic motor neurons provide an excellent neuronal system for compound screening approaches to identify drugs for the treatment of CMTX6.

Published
2020

18. Three Dimensional Structures of Particles Recovered from the Asteroid Itokawa by the Hayabusa Mission and a Role of X-Ray Microtomography in the Preliminary Examination

Author

Tsuchiyama, A, Uesugi, M, Uesugi, K, Nakano, T, Nakamura, T, Noguchi, T, Noguchi, R, Matsumoto, T, Matsuno, J, Nagano, T, Takeuchi, A, Suzuki, Y, Ebihara, M, Ireland, T. R, Kiajima, F, Nagao, K, Naraoka, H, Okazaki, R, Sandford, S. A, Yurimoto, H, Zolensky, M. E, Fujimura, A, Abe, M, Yada, T, and Mukai, T

Subjects
Lunar And Planetary Science And Exploration
Abstract

Particles of regolith on S-type Asteroid 25143 Itokawa were successfully recovered by the Hayabusa mission of JAXA (Japan Aerospace Exploration Agency). Near-infrared spectral study of Itokawa s surface indicates that these particles are materials similar to LL5 or LL6 chondrites. High-resolution images of Itokawa's surface suggest that they may be breccias and some impact products. At least more than 1500 particles were identified as Itokawa origin at curation facility of JAXA. Preliminary analysis with SEM/EDX at the curation facility shows that they are roughly similar to LL chondrites. Although most of them are less than 10 micron in size, some larger particles of about 100 micron or larger were also identified. A part of the sample (probably several tens particles) will be selected by Hayabusa sample curation team, and sequential examination will start from January 2011 by Hayabusa Asteroidal Sample Preliminary Examination Team (HASPET). In mainstream of the analytical flow, each particle will be examined by microtomography, XRD and XRF first as nondestructive analyses, and then the particle will be cut by an ultra-microtome and examined by TEM, SEM, EPMA, SIMS, PEEM/XANES, and TOF-SIMS sequentially. Three-dimensional structures of Itokawa particles will be obtained by microtomography sub-team of HASPET. The results together with XRD and XRF will be used for design of later destructive analyses, such as determination of cutting direction and depth, to obtain as much information as possible from small particles. Scientific results and a role of the microtomography in the preliminary examination will be presented.

Published
2011

19. Preliminary Examination of Particles Recovered from the Surface of the Asteroid Itokawa by the Hayabusa Mission

Author

Tsuchiyama, A, Ebihara, M, Kimura, M, Kitajima, F, Kotsugi, M, Ito, S, Nagao, K, Nakamura, T, Naraoka, H, Noguchi, T, Okazaki, R, Uesugi, K, Uesugi, M, Yurimoto, H, Ireland, T. R, Sandford, S, Zolensky, M, Fujimura, A, Abe, M, Yada, T, Mukai, T, Okada, T, Ishibashi, Y, Shirai, K, and Ueno, M

Subjects
Lunar And Planetary Science And Exploration
Abstract

The Hayabusa spacecraft arrived at S-type Asteroid 25143 Itokawa in November 2006, and reveal astounding features of the small asteroid (535 x 294 x 209 m). Near-infrared spectral shape indicates that the surface of this body has an olivinerich mineral assemblage potentially similar to that of LL5 or LL6 chondrites with different degrees of space weathering. Based on the surface morphological features observed in high-resolution images of Itokawa s surface, two major types of boulders were distinguished: rounded and angular boulders. Rounded boulders seem to be breccias, while angular boulders seem to have severe impact origin. Although the sample collection did not be made by normal operations, it was considered that some amount of samples, probably small particles of regolith, was collected from MUSES-C regio on the Itokawa s surface. The sample capsule was successfully recovered on the earth on June 13, 2010, and was opened at curation facility of JAXA (Japan Aerospace Exploration Agency), Sagamihara, Japan. A large number of small particles were found in the sample container. Preliminary analysis with SEM/EDX at the curation facility showed that at least more than 1500 grains were identified as rocky particles, and most of them were judged to be of extraterrestrial origin, and definitely from Asteroid Itokawa. Minerals (olivine, low-Ca pyroxene, high-Ca pyroxene, plagioclase, Fe sulfide, Fe-Ni metal, chromite, Ca phosphate), roughly estimated mode the minerals and rough measurement of the chemical compositions of the silicates show that these particles are roughly similar to LL chondrites. Although their size are mostly less than 10 m, some larger particles of about 100 m or larger were also identified. A part of the sample (probably several tens particles) will be selected by Hayabusa sample curation team and examined preliminary in Japan within one year after the sample recovery in prior to detailed analysis phase. Hayabusa Asteroidal Sample Preliminary Examination Team (HASPET) has been preparing for the preliminary examination with close cooperation with the curation team.

Published
2011

20. Oxygen and Magnesium Isotopic Compositions of Asteroidal Materials Returned from Itokawa by the Hayabusa Mission

Author

Yurimoto, H, Abe, M, Ebihara, M, Fujimura, A, Hashizume, K, Ireland, T. R, Itoh, S, Kawaguchi, K, Kitajima, F, Mukai, T, Nagao, K, Nakamura, T, Naraoka, H, Noguchi, T, Okazaki, R, Sakamoto, N, Seto, Y, Tsuchiyama, A, Uesugi, M, Yada, T, Yoshikawa, M, and Zolensky, M

Subjects
Space Sciences (General)
Abstract

The Hayabusa spacecraft made two touchdowns on the surface of Asteroid 25143 Itokawa on November 20th and 26th, 2005. The Asteroid 25143 Itokawa is classified as an S-type asteroid and inferred to consist of materials similar to ordinary chondrites or primitive achondrites [1]. Near-infrared spectroscopy by the Hayabusa spacecraft proposed that the surface of this body has an olivine-rich mineral assemblage potentially similar to that of LL5 or LL6 chondrites with different degrees of space weathering [2]. The spacecraft made the reentry into the Earth s atmosphere on June 12th, 2010 and the sample capsule was successfully recovered in Australia on June 13th, 2010. Although the sample collection processes on the Itokawa surface had not been made by the designed operations, more than 1,500 grains were identified as rocky particles in the sample curation facility of JAXA, and most of them were judged to be of extraterrestrial origin, and definitely from Asteroid Itokawa on November 17th, 2010 [3]. Although their sizes are mostly less than 10 microns, some larger grains of about 100 microns or larger were also included. The mineral assembly is olivine, pyroxene, plagioclase, iron sulfide and iron metal. The mean mineral compositions are consistent with the results of near-infrared spectroscopy from Hayabusa spacecraft [2], but the variations suggest that the petrologic type may be smaller than the spectroscopic results. Several tens of grains of relatively large sizes among the 1,500 grains will be selected by the Hayabusa sample curation team for preliminary examination [4]. Each grain will be subjected to one set of preliminary examinations, i.e., micro-tomography, XRD, XRF, TEM, SEM, EPMA and SIMS in this sequence. The preliminary examination will start from the last week of January 2011. Therefore, samples for isotope analyses in this study will start from the last week of February 2011. By the time of the LPSC meeting we will have measured the oxygen and magnesium isotopic composition of several grains. We will present the first results from the isotope analyses that will have been performed.

Published
2011

21. Neutron Activation Analysis of Single Grains Recovered by the Hayabusa Spacecraft

Author

Ebihara, M, Sekimoto, S, Hamajima, Y, Yamamoto, M, Kumagai, K, Oura, Y, Shirai, N, Ireland. T. R, Kitajima, F, Nagao, K, Nakamura, T, Naraoka, H, Noguchi, T, Okazaki, R, Tsuchiyama, A, Uesugi, M, Yurimoto, H, Zolensky, M. E, Abe, M, Fujimura, A, Mukai, T, and Yada, T

Subjects
Geophysics
Abstract

The Hayabusa spacecraft was launched on May 9, 2003 and reached an asteroid Itokawa (25143 Itokawa) in September 2005. After accomplishing several scientific observations, the spacecraft tried to collect the surface material of Itokawa by touching down to the asteroid in November. The spacecraft was then navigated for the earth. In encountering several difficulties, Hayabusa finally returned to the earth on June 12, 2010 and the entry capsule was successfully recovered. Initially, a g-scale of solid material was aimed to be captured into the entry capsule. Although the sample collection was not perfectly performed, it was hoped that some extraterrestrial material was stored into the capsule. After careful and extensive examination, more than 1500 particles were recognized visibly by microscopes, most of which were eventually judged to be extraterrestrial, highly probably originated from Itokawa [1]. Several years before the launching of the Hayabusa spacecraft, the initial analysis team was officially formed under the selection panel at ISAS. As a member of this team, we have been preparing for the initial inspection of the returned material from many scientific viewpoints [2]. Once the recovered material had been confirmed to be much less than 1 g, a scheme for the initial analysis was updated accordingly [3]. In this study, we aim to analyze tiny single grains by instrumental neutron activation analysis (INAA). As the initial analysis is to be started in mid-January, 2011, some progress for the initial analysis using INAA is described here. Analytical procedure

Published
2011

23. Current status of consortium study of silica-containing Hayabusa-returned particle

Author

Hashiguchi, M., Miyake, A., Tsuchiyama, A., Nakamura, T., Uesugi, M., Matsuno, J., Nakato, A., Yada, T., Yoshitake, M., Okada, T., Abe, M., and Yurimoto, H.

Abstract

第8回極域科学シンポジウム/個別セッション：[OA] 南極隕石 / はやぶさ12月5日（火）国立極地研究所 1階交流アトリウムThe Eighth Symposium on Polar Science/Ordinary sessions: [OA] Antarctic meteorites / HayabusaTue. 5 Dec./Entrance Hall (1st floor), National Institute of Polar Research

Published
2017

27. Current status of the consortium study for Hayabusa-returned sample: RB-QD04-0040 containning Fe-S-Ni phase

Author

Nakato, A., Tsuchiyama, A., Nakamura, T., Uesugi, M., Uesugi, K., Takeuchi, A., Nakano, T., Yada, T., Yoshitake, M., Kumagai, K., Nishimura, M., Matsumoto, T., Sakamoto, K., Kawasaki, N., Nakano, Y., Matsui, S., Okada, T., Abe, M., and Yurimoto, H.

Abstract

第7回極域科学シンポジウム:[OA] 南極隕石/はやぶさ11月29日（火）国立極地研究所 1階交流アトリウム

Published
2016

29. Current status of consortium study for silica-containing Hayabusa-returned particle

Author

Hashiguchi, M., Nakamura, T., Tsuchiyama, A., Tomioka, N., Uesugi, M., Han, J., Nakato, A., Yada, T., Yoshitake, M., Kumagai, K., Nishimura, M., Matsumoto, T., Sakamoto, K., Kawasaki, N., Nakano, Y., Matsui, S., Okada, T., Abe, M., and Yurimoto, H.

Abstract

第7回極域科学シンポジウム:[OA] 南極隕石/はやぶさ11月29日（火）国立極地研究所 1階交流アトリウム

Published
2016

34. Chemical and mineralogical compositions of two grains recovered from asteroid Itokawa

Author

Ebihara, M., primary, Shirai, N., additional, Sekimoto, S., additional, Nakamura, T., additional, Tsuchiyama, A., additional, Matsuno, J., additional, Matsumoto, T., additional, Tanaka, M., additional, Abe, M., additional, Fujimura, A., additional, Ishibashi, Y., additional, Karouji, Y., additional, Mukai, T., additional, Okada, T., additional, Uesugi, M., additional, and Yada, T., additional

Published
2015
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35. Assessing the bilateral geometrical differences of the tibia - Are they the same?

Author

Mohd Radzi, Shairah Binte, Uesugi, M., Baird, A., Mishra, Sanjay, Schuetz, Michael, Schmutz, Beat, Mohd Radzi, Shairah Binte, Uesugi, M., Baird, A., Mishra, Sanjay, Schuetz, Michael, and Schmutz, Beat

Abstract

Contralateral bones are often used in many medical applications but it is assumed that their bilateral differences are insignificant. Previous studies used a limited number of distance measurements in quantifying the corresponding differences; therefore, little is known about their bilateral 3D surface asymmetries. The aim of the study is to develop a comprehensive method to quantify geometrical asymmetries between the left and right tibia in order to provide first results on whether the contralateral tibia can be used as an equivalent reference. In this study, 3D bone models were reconstructed from CT scans of seven tibiae pairs, and 34 variables consisting of 2D and 3D measurements were measured from various anatomical regions. All 2D measurements, and lateral plateau and distal subchondral bone surface measurements showed insignificant differences (p > 0.05), but the rest of the surfaces showed significant differences (p < 0.05). Our results suggest that the contralateral tibia can be used as a reference especially in surgical applications such as articular reconstructions since the bilateral differences in the subchondral bone surfaces were less than 0.3 mm. The method can also be potentially transferable to other relevant studies that require the accurate quantification of bone bilateral asymmetries.

Published
2014

38. Sylvite and halite on particles recovered from 25143 Itokawa: A preliminary report

Author

Noguchi, T., primary, Kimura, M., additional, Hashimoto, T., additional, Konno, M., additional, Nakamura, T., additional, Zolensky, M. E., additional, Tsuchiyama, A., additional, Matsumoto, T., additional, Matsuno, J., additional, Okazaki, R., additional, Uesugi, M., additional, Karouji, Y., additional, Yada, T., additional, Ishibashi, Y., additional, Shirai, K., additional, Abe, M., additional, and Okada, T., additional

Published
2014
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40. Assessment of Four Methodologies (Microparticle Enzyme Immunoassay, Chemiluminescent Enzyme Immunoassay, Affinity Column-Mediated Immunoassay, and Flow Injection Assay-Tandem Mass Spectrometry) for Measuring Tacrolimus Blood Concentration in Japanese Liver Transplant Recipients

Author

Hashi, S., primary, Masuda, S., additional, Kikuchi, M., additional, Uesugi, M., additional, Yano, I., additional, Omura, T., additional, Yonezawa, A., additional, Fujimoto, Y., additional, Ogawa, K., additional, Kaido, T., additional, Uemoto, S., additional, and Matsubara, K., additional

Published
2014
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41. Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial–mesenchymal transition (EMT) to mesenchymal–epithelial transition (MET) states

Author

Yoshida, T, primary, Ozawa, Y, additional, Kimura, T, additional, Sato, Y, additional, Kuznetsov, G, additional, Xu, S, additional, Uesugi, M, additional, Agoulnik, S, additional, Taylor, N, additional, Funahashi, Y, additional, and Matsui, J, additional

Published
2014
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42. Development of a medical-text parsing algorithm based on character adjacent probability distribution for Japanese radiology reports.

Author

Nishimoto N, Terae S, Uesugi M, Ogasawara K, Sakurai T, Nishimoto, N, Terae, S, Uesugi, M, Ogasawara, K, and Sakurai, T

Abstract

Objectives: The objectives of this study were to investigate the transitional probability distribution of medical term boundaries between characters and to develop a parsing algorithm specifically for medical texts.Methods: Medical terms in Japanese computed tomography (CT) reports were identified using the ChaSen morphological analysis system. MeSH-based medical terms (51,385 entries), obtained from the metathesaurus in the Unified Medical Language System (UMLS, 2005AA), were added as a medical dictionary for ChaSen. A radiographer corrected the set of results containing 300 parsed CT reports. In addition, two radiologists checked the medical term parsing of 200 CT sentences.Results: We obtained modified inter-annotator agreement scores for the text corrected by the radiologists. We retrieved the transitional probability as the conditional probability of a uni-gram, bi-gram, and tri-gram. The highest transitional probability P(Ci | Ci- 2(*)Ci- 1) was 1.00. For an example of anatomical location, the term "pulmonary hilum" was parsed as a tri-gram.Conclusions: Retrieval of transitional probability will improve the accuracy of parsing compound medical terms. [ABSTRACT FROM AUTHOR]

Published
2008

44. Analytical dual-energy microtomography: A new method for obtaining three-dimensional mineral phase images and its application to Hayabusa samples

Author

Tsuchiyama, A., primary, Nakano, T., additional, Uesugi, K., additional, Uesugi, M., additional, Takeuchi, A., additional, Suzuki, Y., additional, Noguchi, R., additional, Matsumoto, T., additional, Matsuno, J., additional, Nagano, T., additional, Imai, Y., additional, Nakamura, T., additional, Ogami, T., additional, Noguchi, T., additional, Abe, M., additional, Yada, T., additional, and Fujimura, A., additional

Published
2013
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46. Myocardial scarring in the left ventricular basal posterolateral region may negatively impact on response to cardiac resynchronization therapy: analysis with quantitative myocardial perfusion SPECT

Author

Morishima, I., primary, Sone, T., additional, Tsuboi, H., additional, Uesugi, M., additional, Matsushita, E., additional, Morita, Y., additional, Furuta, T., additional, Kanzaki, Y., additional, Ogasawara, S., additional, and Tomomatsu, T., additional

Published
2013
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