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476 results on '"Uemura, Takuya"'

2. Fast Algorithm for Embedded Order Dependency Validation (Extended Version)

Author

Ramos, Alejandro, Uemura, Takuya, Amagata, Daichi, Shirai, Ryo, and Hara, Takahiro

Subjects
Computer Science - Databases
Abstract

Order Dependencies (ODs) have many applications, such as query optimization, data integration, and data cleaning. Although many works addressed the problem of discovering OD (and its variants), they do not consider datasets with missing values, a standard observation in real-world datasets. This paper introduces the novel notion of Embedded ODs (eODs) to deal with missing values. The intuition of eODs is to confirm ODs only on tuples with no missing values on a given embedding (a set of attributes). In this paper, we address the problem of validating a given eOD. If the eOD holds, we return true. Otherwise, we search for an updated embedding such that the updated eOD holds. If such embedding does not exist, we return false. A trivial requirement is to consider an embedding such that the number of ignored tuples is minimized. We show that it is NP-complete to compute such embedding. We therefore propose an efficient heuristic algorithm for validating embedded ODs. We conduct experiments on real-world datasets, and the results confirm the efficiency of our algorithm.

Published
2023

13. The powerful potential of amino acid menthyl esters for anti‐inflammatory and anti‐obesity therapies.

Author

Takasawa, Seidai, Kimura, Kosuke, Miyanaga, Masato, Uemura, Takuya, Hachisu, Masakazu, Miyagawa, Shinichi, Ramadan, Abdelaziz, Sukegawa, Satoru, Kobayashi, Masaki, Kimura, Seisuke, Matsui, Kenji, Shiroishi, Mitsunori, Terashita, Kaori, Nishiyama, Chiharu, Yashiro, Takuya, Nagata, Kazuki, Higami, Yoshikazu, and Arimura, Gen‐ichiro

Subjects
DEXTRAN sulfate, SODIUM sulfate, LIPID metabolism, AMINO acids, ESTERS
Abstract

Our newly developed menthyl esters of valine and isoleucine exhibit anti‐inflammatory properties beyond those of the well‐known menthol in macrophages stimulated by lipopolysaccharide (LPS) and in a mouse model of colitis induced by sodium dextran sulfate. Unlike menthol, which acts primarily through the cold‐sensitive TRPM8 channel, these menthyl esters displayed unique mechanisms that operate independently of this receptor. They readily penetrated target cells and efficiently suppressed LPS‐stimulated tumour necrosis factor‐alpha (Tnf) expression mediated by liver X receptor (LXR), a key nuclear receptor that regulates intracellular cholesterol and lipid balance. The menthyl esters showed affinity for LXR and enhanced the transcriptional activity through their non‐competitive and potentially synergistic agonistic effect. This effect can be attributed to the crucial involvement of SCD1, an enzyme regulated by LXR, which is central to lipid metabolism and plays a key role in the anti‐inflammatory response. In addition, we discovered that the menthyl esters showed remarkable efficacy in suppressing adipogenesis in 3T3‐L1 adipocytes at the mitotic clonal expansion stage in an LXR‐independent manner as well as in mice subjected to diet‐induced obesity. These multiple capabilities of our compounds establish them as formidable allies in the fight against inflammation and obesity, paving the way for a range of potential therapeutic applications. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Corrigendum

Author

Iida, Junya, primary, Desaki, Yoshitake, additional, Hata, Kumiko, additional, Uemura, Takuya, additional, Yasuno, Ayano, additional, Islam, Monirul, additional, Maffei, Massimo E., additional, Ozawa, Rika, additional, Nakajima, Tadaaki, additional, Galis, Ivan, additional, and Arimura, Gen‐ichiro, additional

Published
2023
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33. Silicone Implant Arthroplasty for Severe Bony Ankylosis of the Proximal Interphalangeal Joints in Rheumatoid Arthritis

Author

Uemura, Takuya, Egi, Takeshi, Okada, Mitsuhiro, Okano, Tadashi, Konishi, Sadahiko, Nakamura, Hiroaki, Uemura, Takuya, Egi, Takeshi, Okada, Mitsuhiro, Okano, Tadashi, Konishi, Sadahiko, and Nakamura, Hiroaki

Abstract

Arthrodesis and prosthetic arthroplasty have been used to treat severe proximal interphalangeal (PIP) joint arthritis. Silicone implant arthroplasty is an established treatment for rheumatoid arthritis (RA) of the fingers. However, ……

Published
2022

35. Immune gene activation by NPR and TGA transcriptional regulators in the model monocot Brachypodium distachyon

Author

Shimizu, Kohei, primary, Suzuki, Hitomi, additional, Uemura, Takuya, additional, Nozawa, Akira, additional, Desaki, Yoshitake, additional, Hoshino, Ryosuke, additional, Yoshida, Ayako, additional, Abe, Hiroshi, additional, Nishiyama, Makoto, additional, Nishiyama, Chiharu, additional, Sawasaki, Tatsuya, additional, and Arimura, Gen‐ichiro, additional

Published
2022
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45. Bioabsorbable nerve conduits coated with induced pluripotent stem cell-derived neurospheres enhance axonal regeneration in sciatic nerve defects in aged mice

Author

Yokoi, Takuya, Uemura, Takuya, Takamatsu, Kiyohito, Shintani, Kosuke, Onode, Ema, Okada, Mitsuhiro, Hidaka, Noriaki, and Nakamura, Hiroaki

Subjects
人工多能性幹細胞, induced pluripotent stem cells, aging, iPS細胞, Nerve conduits, aged mouse, peripheral nerve regeneration
Abstract

Aging influences peripheral nerve regeneration. Nevertheless, most basic research of bioabsorbable nerve conduits including commercial products have been performed in very young animals. Results from these studies may not provide information about axonal regeneration in aged tissue, because young nerve tissue holds sufficient endogenous potential for axonal regeneration....

Published
2018

47. Nerve Grafting for Isolated Injury to the Intrinsic Motor Branch of the Ulnar Nerve due to a Stab Injury: A Case Report

Author

Yokoi, Takuya, Uemura, Takuya, Okada, Mitsuhiro, Saito, Kosuke, Onode, Ema, and Nakamura, Hiroaki

Abstract

Isolated injury to the deep motor branch of the ulnar nerve caused by stabbing is sporadic, with only one reported case in the English-language literature. We report one such case treated successfully using nerve grafting. A 33-year-old patient had sustained a stab wound to the right hypothenar eminence and showed a claw hand deformity. Needle electromyography study revealed denervation potentials with no voluntary motor unit action potentials (MUAPs) in the first dorsal interosseous (FDI) muscles. Nerve exploration revealed a neuroma-in-continuity in the intrinsic motor branch of the ulnar nerve. Intraoperative nerve stimulation confirmed the absence of compound muscle action potentials in the FDI. The damaged scarred nerve was resected, and the 15-mm defects were reconstructed with cable autografting. Two years and 5 months after the surgery, voluntary MUAPs were observed in the FDI. The pinch strengths recovered. Laceration of the deep branch of the ulnar nerve caused by stabbing can sometimes remain hidden as the hand sensation remains intact. Pre- and intraoperative electrophysiological examination is essential to assess the severity of the injured nerve and determine an appropriate surgical option. Even nerve grafting can facilitate satisfactory results as target intrinsic muscles are quite close to the repair site.

Published
2023
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48. Pain and numbness one month after carpal tunnel release predict patient-reported outcome measures at sixth months.

Author

Hama, Shunpei, Okada, Mitsuhiro, Yokoi, Takuya, Uemura, Takuya, and Nakamura, Hiroaki

Subjects
PATIENT reported outcome measures, CARPAL tunnel syndrome, NUMBNESS, VISUAL analog scale, PROGNOSIS
Abstract

A number of outcome predictors for carpal tunnel release (CTR) for carpal tunnel syndrome (CTS) have been reported. However, some predictors are controversial, and few studies have referred to the early postoperative outcome prognostic factors after CTR. The aim of this study was to investigate whether pain and numbness at 1 month post-CTR were early postoperative predictors of clinical outcomes 6 months after surgery. Pain and numbness were evaluated using the visual analog scale (VAS) preoperatively and at 1 month post-surgery. Patient-reported outcome measures (PROMs), including the Quick Disabilities of the Arm, Shoulder and Hand (QDASH) measure, the Hand20 questionnaire and the Boston Carpal Tunnel Questionnaire (BCTQ), were recorded for each patient 6 months after surgery. The BCTQ consisted of the Symptom Severity Scale (SSS) and Functional Status Scale (FSS). Multivariable linear regression analysis was performed to investigate the association between the VAS scores and PROMs. We retrospectively identified 93 patients who underwent open carpal tunnel release (OCTR) or endoscopic carpal tunnel release. The mean age of the patients was 67.5 years, and 67 patients (72.0%) were female. Sixty patients were treated by OCTR (65.0%). With multivariable linear regression analysis, we found that pain and numbness, evaluated with VAS 1 month post-surgery had significant correlations with QDASH, Hand20, SSS and FSS 6 months after surgery. In conclusion, pain and numbness 1 month after CTR predict PROMs at 6 months. [ABSTRACT FROM AUTHOR]

Published
2022
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