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40 results on '"Uede, Koji"'

10. Renal cell carcinoma in the Birt-Hogg-Dube syndrome: report of a case

Author

TAKAHASHI, Akira, HAYASHI, Tadashi, YOSHIDA, Osamu, UEDE, Koji, FURUKAWA, Fukumi, and SHUIN, Taro

Subjects
Hereditary, Birt-Hogg-Dube syndrome, 494.9, Renal cell carcinoma
Abstract

53歳女.20歳代前半より顔面, 頸部, 右腰部にドーム型の丘疹が出現し, 44歳時に皮膚科による生検の結果Birt-Hogg-Dube(BHD)症候群と診断された.近医で撮影した胸部レントゲン写真で異常陰影を指摘され, 呼吸器外科では腹部CTによる右腎腫瘍の指摘と共に異常陰影が肋骨転移と診断され受診した.腹部造影CTで右腎の腫瘍と, 骨シンチで多発性骨転移を認め, インターフェロン療法の効果を期待し右腎摘出術を施行した.術後, 骨転移に対し放射線治療及びインターフェロンを開始したが, 肺転移による呼吸不全の為術後約5ヵ月目に死亡した, Birt-Hogg-Dube (BHD) syndrome is a rare dermatological condition appearing with an autosomal dominant mode of inheritance. It was first reported in 1977 by Birt et al. and 28 cases have been reported since then. BHD syndrome is characterized by asymptomatic dome-shaped, skin-colored papules on the face and upper trunk. Recently, various neoplasms have been reported to associate with BHD syndrome, including three familial and one sporadic cases of renal tumors. We report another sporadic case with renal tumor. A 53-year-old woman complained of gross hematuria and visited our institute on November 1996. She visited the Department of Dermatology, Wakayama Medical College because of skin lesions on the face and upper trunk at her age of 44. These skin lesions were present since her mid twenties. Her daughter also had similar skin lesions and visited the same Department. There was no family history of renal tumor. The patient was diagnosed to have a right renal tumor, and radical nephrectomy was performed. Pathological diagnosis was renal cell carcinoma, papillary type. She underwent interferon injection therapy postoperatively, but died because of lung metastases on April 1997. This is the first reported case of renal tumor occurring in BHD syndrome in Japan.

Published
2001

37. Skin Cancer

Author

UEDE, Koji, primary, NAKATA, Masakatsu, additional, WADA, Mari, additional, and MATSUNAKA, Masahiro, additional

Published
1988
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38. Undershirts coated with borage oil alleviate the symptoms of atopic dermatitis in children.

Author

Kanehara S, Ohtani T, Uede K, and Furukawa F

Subjects
Child, Child, Preschool, Clothing, Dermatitis, Atopic complications, Dermatitis, Atopic pathology, Female, Humans, Male, Pruritus etiology, Skin pathology, Statistics, Nonparametric, Dermatitis, Atopic drug therapy, Dermatologic Agents administration & dosage, Plant Oils administration & dosage, Pruritus drug therapy, gamma-Linolenic Acid administration & dosage
Published
2007
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39. Changes of epidermal Langerhans cells in skin treated with trichloroacetic acid.

Author

Sakai A, Yamamoto Y, Uede K, and Furukawa F

Subjects
Adult, Antibodies, Monoclonal, Humans, Immunohistochemistry, Langerhans Cells immunology, Skin cytology, Keratolytic Agents pharmacology, Langerhans Cells drug effects, Nitrogen pharmacology, Skin drug effects, Trichloroacetic Acid pharmacology
Abstract

The changes in Langerhans cells (LCs) from normal human skin peeled with 40 and 60% trichloroacetic acid (TCA) or liquid nitrogen , which is known in cryosurgery as a control, were examined using monoclonal antibodies against the CD1a, HLA-DR and Lag in order to examine the immune surveillance system. In the 40% TCA group, the number of CD1a-positive cells decreased gradually until day 7, whereas both HLA-DR- and Lag-positive cells decreased for 12 hours, increased until day 2 and decreased thereafter. In the 60% TCA group, the number of CD1a-, HLA-DR- and Lag-positive cells decreased gradually until day1, increased temporarily until day 2, and decreased again until day 7. There were no significant differences in the decrease of the LCs between the 40% and 60% TCA groups. In both cases the number of LCs on day 7 was statistically lower than before treatment. In the liquid nitrogen group, which served as a control, the LCs decreased gradually and slightly until day 2, and then increased. Taken together, the number of epidermal LCs from TCA-treated skin was reduced more significantly than LCs from liquid nitrogen-treated skin, suggesting a temporary impairment of the skin defense system. Therefore, long-term and frequent TCA peeling will require special attention for potential carcinogenesis.

Published
2005

40. Digital gangrene associated with idiopathic hypereosinophilia: treatment with allogeneic cultured dermal substitute (CDS).

Author

Ohtani T, Okamoto K, Kaminaka C, Kishi T, Sakurane M, Yamamoto Y, Uede K, Kubo K, Kuroyanagi Y, and Furukawa F

Subjects
Aged, Amputation, Surgical, Diagnosis, Differential, Fingers surgery, Gangrene complications, Gangrene pathology, Gangrene therapy, Humans, Hypereosinophilic Syndrome complications, Hypereosinophilic Syndrome pathology, Hypereosinophilic Syndrome therapy, Male, Skin, Artificial, Toes surgery, Fingers pathology, Gangrene diagnosis, Hypereosinophilic Syndrome diagnosis, Toes pathology
Abstract

In the present case study, the patient was a 65-year-old man who suddenly developed purpuric and necrotic lesions with severe pain in his fingers and toes. Laboratory investigations revealed marked eosinophilia (77.9%), but there was no evidence to support a diagnosis of parasitic infections, allergic disease, neoplasm or connective tissue disorder. The histopathological findings did not show any distinct vasculitis, but there were obliterative changes of the arterioles. The digital gangrene gradually progressed and was unresponsive to corticosteroid therapy. The patient eventually underwent amputation of the distal phalanges. We applied allogeneic cultured dermal substitute (CDS) to the skin defect. The allogeneic CDS was prepared by culturing fibroblasts on a two-layered sponge of hyaluronic acid and atelo-collagen. This CDS is able to release a number of cytokines including VEGF. The present case had a good clinical result.

Published
2004

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