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509 results on '"Ueda, Yusuke"'

1. Polarization superposition of room-temperature polariton condensation

Author

Moriyama, Yuta, Inukai, Takaya, Hirao, Tsukasa, Ueda, Yusuke, Takahashi, Shun, and Yamashita, Kenichi

Subjects
Condensed Matter - Materials Science, Physics - Optics
Abstract

A methodology for forming a qubit state is essential for quantum applications of room temperature polaritons. While polarization degree of freedom is expected as a possible means for this purpose, the coupling of linearly polarized polariton condensed states has been still a challenging issue. In this study, we show a polarization superposition of a polariton condensed states in an all-inorganic perovskite microcavity at room temperature. We realized the energy resonance of the two orthogonally polarized polariton modes with the same number of antinodes by exploiting the blue shift of the polariton condensed state. The polarization coupling between the condensed states results in a polarization switching in the polariton lasing emission. The orthorhombic crystal structure of the perovskite active layer and/or a slight off-axis orientation of the perovskite crystal axis from the normal direction of microcavity plane enable the interaction between the two orthogonally polarized states. These observations demonstrate a great promise of polariton as a room temperature qubit technology.

Published
2023

6. Elucidation of lasing mechanism in all-inorganic perovskite microcavity with exciton/free-carrier hybrid nature

Author

Enomoto, Shuki, Ueda, Yusuke, Tagami, Tomoya, Fujiwara, Kentaro, Takahashi, Shun, and Yamashita, Kenichi

Subjects
Physics - Applied Physics, Condensed Matter - Materials Science, Physics - Optics
Abstract

Lead-halide perovskites are highly promising for various optoelectronic applications including laser devices. However, fundamental photophysics describing the lasing behaviour in this material family have not been investigated systematically, and thus the detailed lasing mechanism remains veiled. Here, we demonstrate that an all-inorganic perovskite shows a lasing emission based on a novel principle. A series of photoluminescence experiment results reveals that the excited state of CsPbBr3 single crystal exhibits free carrier nature. In a form of microcavity, on the other hand, the CsPbBr3 single crystal shows emission from polaritonic excited state, demonstrating the coexistence of excitonic nature. Room temperature polariton lasing is also clearly observed. This unprecedent mechanism, i.e. polariton lasing based on free-carrier reservoir, is accomplished by the exciton/free-carrier hybrid nature of CsPbBr3.

Published
2020

16. Photoinduced Enantioselective Triplet Radical Reaction on Metal: Copper‐Catalyzed Conjugate Addition of Acylsilanes to α,β‐Unsaturated Ketones and Aldehydes.

Author

Masuda, Yusuke, Ueda, Yusuke, Sueki, Aiko, Shimosato, Junpei, Nishimura, Kousei, Gao, Min, Hasegawa, Jun‐ya, and Sawamura, Masaya

Abstract

A photoinduced copper‐catalyzed enantioselective conjugate addition of acylsilanes has been developed. The conjugate acylation of α,β‐unsaturated ketones and aldehydes was promoted by a copper(I)/chiral NHC catalyst under visible‐light irradiation for synthesizing various 2‐substituted 1,4‐dicarbonyl compounds in enantioenriched forms. Mechanistic studies combining experiments and quantum chemical calculations indicated a reaction mechanism involving copper‐to‐acyl charge transfer (i. e., metal‐to‐ligand charge transfer (MLCT)) excitation of an alkene‐bound acylcopper complex. The MLCT excitation is followed by an electronical and geometrical change to generate a triplet β‐radical‐C‐enolate‐Cu(II)‐acyl complex with an acyl radical character, which undergoes facile excited state C−C bond formation in the copper coordination sphere, affording the 1,4‐conjugate addition product. [ABSTRACT FROM AUTHOR]

Published
2024
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17. Fatal hemophagocytic lymphohistiocytosis with intravascular large B-cell lymphoma following coronavirus disease 2019 vaccination in a patient with systemic lupus erythematosus: an intertwined case.

Author

Ueda, Yusuke, Sakai, Tomoyuki, Yamada, Kazunori, Arita, Kotaro, Ishige, Yoko, Hoshi, Daisuke, Yanagisawa, Hiroto, Iwao-Kawanami, Haruka, Kawanami, Takafumi, Mizuta, Shuichi, Fukushima, Toshihiro, Yamada, Sohsuke, Yachie, Akihiro, and Masaki, Yasufumi

Subjects
COVID-19, SYSTEMIC lupus erythematosus, SYMPTOMS, HEMOPHAGOCYTIC lymphohistiocytosis, COVID-19 vaccines
Abstract

Hemophagocytic lymphohistiocytosis (HLH) has been recognized as a rare adverse event following the coronavirus disease 2019 (COVID-19) vaccination. We report a case of neuropsychiatric symptoms and refractory HLH in a woman with systemic lupus erythematosus (SLE) after receiving her COVID-19 vaccine treated with belimumab, later found to have intravascular large B-cell lymphoma (IVLBCL) at autopsy. A 61-year-old woman with SLE was referred to our hospital because of impaired consciousness and fever. One month prior to consulting, she received her second COVID-19 vaccine dose. Afterward, her consciousness level decreased, and she developed a high fever. She tested negative for SARS-CoV-2. Neuropsychiatric SLE was suspected; therefore, glucocorticoid pulse therapy was initiated on day 1 and 8. She had thrombocytopenia, increased serum ferritin levels and hemophagocytosis. The patient was diagnosed with HLH and treated with etoposide, dexamethasone and cyclosporine. Despite treatment, the patient died on day 75; autopsy report findings suggested IVLBCL as the underlying cause of HLH. Differentiating comorbid conditions remains difficult; however, in the case of an atypical clinical presentation, other causes should be considered. Therefore, we speculate that the COVID-19 vaccination and her autoimmune condition may have expedited IVLBCL development. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Relationship between duration of atrial fibrillation and right heart structure remodeling as assessed by 3-dimensional transesophageal echocardiography

Author

Izumi, Kanako, primary, Utsunomiya, Hiroto, additional, Takeuchi, Makoto, additional, Hamada, Ayano, additional, Hyodo, Yohei, additional, Mogami, Atsuo, additional, Tsuchiya, Akane, additional, Takemoto, Hajime, additional, Takahari, Kosuke, additional, Ueda, Yusuke, additional, Itakura, Kiho, additional, and Nakano, Yukiko, additional

Published
2023
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33. Hyposecretion of cervical MUC5B is related to preterm birth in pregnant women after cervical excisional surgery.

Author

Ueda, Yusuke, Mogami, Haruta, Chigusa, Yoshitsugu, Kawamura, Yosuke, Inohaya, Asako, Takakura, Masahito, Yasuda, Eriko, Matsuzaka, Yu, Shimada, Miho, Ito, Shinji, Morita, Satoshi, Mandai, Masaki, and Kondoh, Eiji

Subjects
*PREMATURE labor, *CERVICAL cerclage, *PREGNANT women, *CERVICAL intraepithelial neoplasia, *SURGERY, *GESTATIONAL age
Abstract

Problem: Excisional surgery for cervical intraepithelial neoplasia is a risk factor for preterm birth in subsequent pregnancies. However, the underlying mechanisms of this association remain unclear. We previously showed that cervical MUC5B, a mucin protein, may be a barrier to ascending pathogens during pregnancy. We thus hypothesized that hyposecretion of cervical MUC5B is associated with preterm birth after cervical excisional surgery. Method of study: This prospective nested case‐control study (Study 1) included pregnant women who had previously undergone cervical excisional surgery across 11 hospitals. We used proteomics to compare cervicovaginal fluid at 18–22 weeks of gestation between the preterm and term birth groups. In another case‒control analysis (Study 2), we compared MUC5B expression in nonpregnant uterine tissues between 15 women with a history of cervical excisional surgery and 26 women without a history of cervical surgery. Results: The abundance of MUC5B in cervicovaginal fluid was significantly decreased in the preterm birth group (fold change = 0.41, p =.035). Among the 480 quantified proteins, MUC5B had the second highest positive correlation with gestational age at delivery in the combined preterm and term groups. The cervicovaginal microbiome composition was not significantly different between the two groups. Cervical length was not correlated with gestational age at delivery (r = 0.18, p =.079). Histologically, the MUC5B‐positive area in the nonpregnant cervix was significantly decreased in women with a history of cervical excisional surgery (0.85‐fold, p =.048). The distribution of MUC5B‐positive areas in the cervical tissues of 26 women without a history of cervical excisional surgery differed across individuals. Conclusions: This study suggests that the primary mechanism by which cervical excisional surgery causes preterm birth is the hyposecretion of MUC5B due to loss of the cervical glands. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Suggestion of Operation Method of the Interest Shift Model of the Twitter User

Author

Ueda, Yusuke, Asahi, Yumi, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Kobsa, Alfred, editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Weikum, Gerhard, editor, and Yamamoto, Sakae, editor

Published
2014
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45. Shear stress in the intervillous space promotes syncytial formation of iPS cells-derived trophoblasts†

Author

Inohaya, Asako, Chigusa, Yoshitsugu, Takakura, Masahito, Io, Shingo, Kim, Min-A, Matsuzaka, Yu, Yasuda, Eriko, Ueda, Yusuke, Kawamura, Yosuke, Takamatsu, Shiro, Mogami, Haruta, Takashima, Yasuhiro, Mandai, Masaki, and Kondoh, Eiji

Abstract

The intervillous space of human placenta is filled with maternal blood, and villous trophoblasts are constantly exposed to the shear stress generated by maternal blood pressure and flow throughout the entire gestation period. However, the effects of shear stress on villous trophoblasts and their biological significance remain unknown. Here, using our recently established naïve human pluripotent stem cells-derived cytotrophoblast stem cells (nCTs) and a device that can apply arbitrary shear stress to cells, we investigated the impact of shear stress on early-stage trophoblasts. After 72 h of exposure to 10 dyn/cm2shear stress, nCTs became fused and multinuclear, and mRNA expression of the syncytiotrophoblast (ST) markers, such as glial cell missing 1, endogenous retrovirus group W member 1 envelope, chorionic gonadotropin subunit beta 3, syndecan 1, pregnancy specific beta-1-glycoprotein 3, placental growth factor, and solute carrier family 2 member 1 were significantly upregulated compared to static conditions. Immunohistochemistry showed that shear stress increased fusion index, human chorionic gonadotropin secretion, and human placental lactogen secretion. Increased microvilli formation on the surface of nCTs under flow conditions was detected using scanning electron microscopy. Intracellular cyclic adenosine monophosphate significantly increased under flow conditions. Moreover, transcriptome analysis of nCTs subjected to shear stress revealed that shear stress upregulated ST-specific genes and downregulated CT-specific genes. Collectively, these findings indicate that shear stress promotes the differentiation of nCTs into ST.Fluid shear stress acts on naïve human pluripotent stem cell-derived cytotrophoblasts, causing cell fusion, increased hormone secretion and microvilli formation, and upregulated syncytiotrophoblast specific genes, thereby promoting syncytialization.Graphical Abstract

Published
2024
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47. TAFRO Syndrome: A Disease Requiring Immediate Medical Attention

Author

Masaki, Yasufumi, primary, Ueda, Yusuke, additional, Yanagisawa, Hiroto, additional, Arita, Kotaro, additional, Sakai, Tomoyuki, additional, Yamada, Kazunori, additional, Mizuta, Shuichi, additional, Fukushima, Toshihiro, additional, Takai, Kazue, additional, Aoki, Sadao, additional, and Kawabata, Hiroshi, additional

Published
2023
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49. Prediction of the Concern of People Using CGM

Author

Ueda, Yusuke, Asahi, Yumi, Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, and Yamamoto, Sakae, editor

Published
2013
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