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2. Prognostic significance of serum cholinesterase in patients with acute decompensated heart failure: a prospective comparative study with other nutritional indices

Author

Seo, Masahiro, Yamada, Takahisa, Tamaki, Shunsuke, Morita, Takashi, Furukawa, Yoshio, Iwasaki, Yusuke, Kawasaki, Masato, Kikuchi, Atsushi, Kawai, Tsutomu, Abe, Makoto, Nakamura, Jun, Yamamoto, Kyoko, Kayama, Kiyomi, Kawahira, Masatsugu, Tanabe, Kazuya, Kimura, Takanari, Ueda, Kunpei, Sakamoto, Daisuke, Sakata, Yasushi, and Fukunami, Masatake

Published
2019
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3. Abstract 14608: Prognostic Value of Diuretic Resistance in Patients Admitted for Acute Decompensated Heart Failure With Reduced, Mid-range, or Preserved Left Ventricular Ejection Fraction

Author

Kimura, Takanari, Yamada, Takahisa, Watanabe, Tetsuya, Morita, Takashi, Furukawa, Yoshio, Tamaki, Shunsuke, Kawasaki, Masato, Kikuchi, Atsushi, Kawai, Tsutomu, Seo, Masahiro, Nakamura, Jun, Kayama, Kiyomi, Kawahira, Masatsugu, Ueda, Kunpei, Sakamoto, Daisuke, Ito, Shota, Kougame, Takehiro, Chang, Yongchol, and Fukunami, Masatake

Published
2020
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4. Abstract 12941: Long-term Prognostic Value of Cardiac Metaiodobenzylguanidine Imaging and Non-sustained Ventricular Tachycardia in Patients With Implantable Cardioverter Defibrillator

Author

Kawasaki, Masato, Yamada, Takahisa, Watanabe, Tetsuya, Morita, Takashi, Furukawa, Yoshio, Tamaki, Shunsuke, Kikuchi, Atsushi, Kawai, Tsutomu, Seo, Masahiro, Nakamura, Jun, Kawahira, Masatsugu, Kayama, Kiyomi, Ueda, Kunpei, Kimura, Takanari, and Sakamoto, Daisuke

Published
2020
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5. Effect of the Japanese herbal drug rikkunshito for the treatment of malnutrition in patients with chronic heart failure

Author

Seo, Masahiro, primary, Watanabe, Tetsuya, additional, Yamada, Takahisa, additional, Morita, Takashi, additional, Kawasaki, Masato, additional, Kikuchi, Atsushi, additional, Kawai, Tsutomu, additional, Nakamura, Jun, additional, Kayama, Kiyomi, additional, Ueda, Kunpei, additional, Sakamoto, Daisuke, additional, Kogame, Takehiro, additional, Tamura, Yuto, additional, Fujita, Takeshi, additional, Nishigaki, Keisuke, additional, Kokubu, Yuki, additional, Fukuda, Yuto, additional, and Fukunami, Masatake, additional

Published
2022
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6. Abstract 9078: The Bad Bleeding Score: A Simple Score to Assess Bleeding Risk in Atrial Fibrillation Patients With Direct Oral Anticoagulants

Author

Kawasaki, Masato, primary, Yamada, Takahisa, additional, Watanabe, Tetsuya, additional, Morita, Takashi, additional, Kikuchi, Atsushi, additional, Seo, Masahiro, additional, Nakamura, Jun, additional, Kayama, Kiyomi, additional, Sakamoto, Daisuke, additional, Ueda, Kunpei, additional, Kougame, Takehiro, additional, Tamura, Yuto, additional, Fujita, Takeshi, additional, Nishigaki, Keisuke, additional, Kokubu, Yuki, additional, Fukuda, Yuto, additional, and Fukunami, Masatake, additional

Published
2021
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7. Abstract 9077: Long-Term Prognostic Value of Controlling Nutritional Status Score and Six-Minute Walk Distance in Patients With Implantable Cardioverter Defibrillator

Author

Kawasaki, Masato, primary, Yamada, Takahisa, additional, Watanabe, Tetsuya, additional, Morita, Takashi, additional, Kikuchi, Atsushi, additional, Kawai, Tsutomu, additional, Seo, Masahiro, additional, Nakamura, Jun, additional, Kayama, Kiyomi, additional, Ueda, Kunpei, additional, Sakamoto, Daisuke, additional, Kougame, Takehiro, additional, Tamura, Yuto, additional, Fujita, Takeshi, additional, Nishigaki, Keisuke, additional, Kokubu, Yuki, additional, Fukuda, Yuto, additional, and Fukunami, Masatake, additional

Published
2021
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8. Abstract 9075: Long-Term Prognostic Value of Cardiac MIBG Imaging and 6-Minute Walk Distance for Ventricular Tachyarrhythmias in Patients With Implantable Cardioverter Defibrillator

Author

Kawasaki, Masato, primary, Yamada, Takahisa, additional, Watanabe, Tetsuya, additional, Morita, Takashi, additional, Kikuchi, Atsushi, additional, Kawai, Tsutomu, additional, Seo, Masahiro, additional, Nakamura, Jun, additional, Kayama, Kiyomi, additional, Ueda, Kunpei, additional, Sakamoto, Daisuke, additional, Kogame, Takehiro, additional, Tamura, Yuto, additional, Fujita, Takeshi, additional, Nishigaki, Keisuke, additional, Kokubu, Yuki, additional, Fukuda, Yuto, additional, and Fukunami, Masatake, additional

Published
2021
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9. Prognostic value of impaired hepato‐renal function and liver fibrosis in patients admitted for acute heart failure

Author

Kawahira, Masatsugu, primary, Tamaki, Shunsuke, additional, Yamada, Takahisa, additional, Watanabe, Tetsuya, additional, Morita, Takashi, additional, Furukawa, Yoshio, additional, Kawasaki, Masato, additional, Kikuchi, Atsushi, additional, Kawai, Tsutomu, additional, Seo, Masahiro, additional, Nakamura, Jun, additional, Kayama, Kiyomi, additional, Kimura, Takanari, additional, Ueda, Kunpei, additional, Sakamoto, Daisuke, additional, Kogame, Takehiro, additional, Ito, Shota, additional, Chang, Yongchol, additional, and Fukunami, Masatake, additional

Published
2021
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10. Impact of adjunctive tolvaptan on sympathetic activity in acute heart failure with preserved ejection fraction

Author

Tamaki, Shunsuke, primary, Yamada, Takahisa, additional, Morita, Takashi, additional, Furukawa, Yoshio, additional, Kawasaki, Masato, additional, Kikuchi, Atsushi, additional, Kawai, Tsutomu, additional, Seo, Masahiro, additional, Abe, Makoto, additional, Nakamura, Jun, additional, Yamamoto, Kyoko, additional, Kayama, Kiyomi, additional, Kawahira, Masatsugu, additional, Tanabe, Kazuya, additional, Ueda, Kunpei, additional, Kimura, Takanari, additional, Sakamoto, Daisuke, additional, Tamura, Yuto, additional, Fujita, Takeshi, additional, and Fukunami, Masatake, additional

Published
2020
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11. Prognostic significance of cardiac I-123-metaiodobenzylguanidine imaging in patients with reduced, mid-range, and preserved left ventricular ejection fraction admitted for acute decompensated heart failure: a prospective study in Osaka Prefectural Acute Heart Failure Registry (OPAR)

Author

Seo, Masahiro, primary, Yamada, Takahisa, additional, Tamaki, Shunsuke, additional, Watanabe, Tetsuya, additional, Morita, Takashi, additional, Furukawa, Yoshio, additional, Kawasaki, Masato, additional, Kikuchi, Atsushi, additional, Kawai, Tsutomu, additional, Abe, Makoto, additional, Nakamura, Jun, additional, Yamamoto, Kyoko, additional, Kayama, Kiyomi, additional, Kawahira, Masatsugu, additional, Tanabe, Kazuya, additional, Kimura, Takanari, additional, Ueda, Kunpei, additional, Sakamoto, Daisuke, additional, Sakata, Yasushi, additional, and Fukunami, Masatake, additional

Published
2020
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12. Prognostic Value of Calculated Plasma Volume Status in Patients Admitted for Acute Decompensated Heart Failure ― A Prospective Comparative Study With Other Indices of Plasma Volume ―

Author

Tamaki, Shunsuke, primary, Yamada, Takahisa, additional, Morita, Takashi, additional, Furukawa, Yoshio, additional, Iwasaki, Yusuke, additional, Kawasaki, Masato, additional, Kikuchi, Atsushi, additional, Kawai, Tsutomu, additional, Seo, Masahiro, additional, Abe, Makoto, additional, Nakamura, Jun, additional, Yamamoto, Kyoko, additional, Kayama, Kiyomi, additional, Kawahira, Masatsugu, additional, Tanabe, Kazuya, additional, Ueda, Kunpei, additional, Kimura, Takanari, additional, Sakamoto, Daisuke, additional, and Fukunami, Masatake, additional

Published
2019
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13. Prognostic significance of cardiac I-123-metaiodobenzylguanidine imaging in patients with reduced, mid-range, and preserved left ventricular ejection fraction admitted for acute decompensated heart failure: a prospective study in Osaka Prefectural Acute Heart Failure Registry (OPAR)

Author

Seo, Masahiro, Yamada, Takahisa, Tamaki, Shunsuke, Watanabe, Tetsuya, Morita, Takashi, Furukawa, Yoshio, Kawasaki, Masato, Kikuchi, Atsushi, Kawai, Tsutomu, Abe, Makoto, Nakamura, Jun, Yamamoto, Kyoko, Kayama, Kiyomi, Kawahira, Masatsugu, Tanabe, Kazuya, Kimura, Takanari, Ueda, Kunpei, Sakamoto, Daisuke, Sakata, Yasushi, and Fukunami, Masatake

Subjects
HEART ventricle diseases, ANTHROPOMETRY, BLOOD collection, ECHOCARDIOGRAPHY, HEART, LEFT heart ventricle, HEART failure, HOSPITAL care, LONGITUDINAL method, MEDIASTINUM, MULTIVARIATE analysis, RADIONUCLIDE imaging, RISK assessment, SYMPATHETIC nervous system, PROPORTIONAL hazards models, ACUTE diseases, BENZENE derivatives, DESCRIPTIVE statistics, KAPLAN-Meier estimator, VENTRICULAR ejection fraction
Abstract

Aims Cardiac 123I-metaiodobenzylguanidine (123I-MIBG) imaging provides prognostic information in patients with chronic heart failure (HF). However, there is little information available on the prognostic role of cardiac 123I-MIBG imaging in patients admitted for acute decompensated heart failure (ADHF), especially relating to reduced ejection fraction [HFrEF; left ventricular ejection fraction (LVEF) < 40%], mid-range ejection fraction (HFmrEF; 40% ≤ LVEF < 50%) and preserved ejection fraction (HFpEF; LVEF ≥ 50%). Methods and results We studied 349 patients admitted for ADHF and discharged with survival. Cardiac 123I-MIBG imaging, echocardiography, and venous blood sampling were performed just before discharge. The cardiac 123I-MIBG heart-to-mediastinum ratio (late H/M) was measured on the chest anterior view images obtained at 200 min after the isotope injection. The endpoint was cardiac events defined as unplanned HF hospitalization and cardiac death. During a follow-up period of 2.1 ± 1.4 years, 128 patients had cardiac events (45/127 in HFrEF, 28/78 in HFmrEF, and 55/144 in HFpEF). On multivariable Cox analysis, late H/M was significantly associated with cardiac events in overall cohort (P = 0.0038), and in subgroup analysis of each LVEF subgroup (P = 0.0235 in HFrEF, P = 0.0119 in HFmEF and P = 0.0311 in HFpEF). Kaplan–Meier analysis showed that patients with low late H/M (defined by median) had significantly greater risk of cardiac events in overall cohort (49% vs. 25% P < 0.0001) and in each LVEF subgroup (HFrEF: 48% vs. 23% P = 0.0061, HFmrEF: 51% vs. 21% P = 0.0068 and HFpEF: 50% vs. 26% P = 0.0026). Conclusion Cardiac sympathetic nerve dysfunction was associated with poor outcome in ADHF patients irrespective of HFrEF, HFmrEF, or HFpEF. [ABSTRACT FROM AUTHOR]

Published
2021
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14. Abstract 12132: Admission, Discharge, or In-Hospital Change of Get With the Guidelines-Heart Failure Risk Score and All-Cause Mortality in Patients Admitted for Acute Decompensated Heart Failure: A Prospective Study in Osaka Prefectural Acute Heart Failure Registry (OPAR)

Author

Tamaki, Shunsuke, Yamada, Takahisa, Morita, Takashi, Furukawa, Yoshio, Iwasaki, Yusuke, Kawasaki, Masato, Kikuchi, Atsushi, Kawai, Tsutomu, Seo, Masahiro, Abe, Makoto, Nakamura, Jun, Yamamoto, Kyoko, Kayama, Kiyomi, Kawahira, Masatsugu, Tanabe, Kazuya, Ueda, Kunpei, Kimura, Takanari, Sakamoto, Daisuke, and Fukunami, Masatake

Published
2018

15. Abstract 12126: Incremental Prognostic Value of Plasma Volume Status and Controlling Nutritional Status Score in Patients Admitted for Acute Decompensated Heart Failure: A Prospective Study in Osaka Prefectural Acute Heart Failure Registry (OPAR).

Author

Tamaki, Shunsuke, Yamada, Takahisa, Morita, Takashi, Furukawa, Yoshio, Iwasaki, Yusuke, Kawasaki, Masato, Kikuchi, Atsushi, Kawai, Tsutomu, Seo, Masahiro, Abe, Makoto, Nakamura, Jun, Yamamoto, Kyoko, Kayama, Kiyomi, Kawahira, Masatsugu, Tanabe, Kazuya, Ueda, Kunpei, Kimura, Takanari, Sakamoto, Daisuke, and Fukunami, Masatake

Published
2018

16. Abstract 12811: Prognostic Value of Cardiac Iodine-123 Metaiodobenzylguanidine Imaging is Influenced by Presence or Absence of Diabetes Mellitus in Patients Admitted for Acute Decompensated Heart Failure

Author

Tamaki, Shunsuke, Yamada, Takahisa, Morita, Takashi, Furukawa, Yoshio, Kawasaki, Masato, Kikuchi, Atsushi, Kawai, Tsutomu, Seo, Masahiro, Abe, Makoto, Nakamura, Jun, Yamamoto, Kyoko, Kayama, Kiyomi, Kawahira, Masatsugu, Tanabe, Kazuya, Ueda, Kunpei, Kimura, Takanari, Sakamoto, Daisuke, Tamura, Yuto, Fujita, Takeshi, and Fukunami, Masatake

Abstract

Introduction:Cardiac iodine-123 metaiodobenzylguanidine (MIBG) imaging has been shown to provide prognostic information in patients with chronic heart failure. Patients with diabetes mellitus (DM) often have impaired cardiac sympathetic innervation. However, little is known about the influence of DM on the prognostic value of cardiac MIBG imaging in patients who are admitted for acute decompensated heart failure (ADHF).Hypothesis:We assessed the hypothesis that the prognostic value of cardiac MIBG imaging is different between the ADHF patients with and without DM.Methods:We prospectively studied 374 consecutive patients who were admitted for ADHF and survived to discharge. Cardiac MIBG imaging was performed just before discharge. The cardiac MIBG heart-to-mediastinum ratio (HMR) and washout rate (WR) were calculated from the chest anterior view images obtained at 20 and 200 min after isotope injection. The endpoint was a composite of all-cause mortality and unplanned hospitalization for worsening heart failure.Results:There were 166 patients with DM and 208 patients without DM. During a median follow-up period of 2.2 years, 165 patients reached the endpoint. In the multivariate Cox analysis, HMR on delayed image (late HMR) was significantly independently associated with the endpoint (p=0.0001) in patients with DM but not in those without DM, although late HMR showed a significant association with the endpoint in patients without DM in the univariate analysis. Kaplan-Meier analysis showed that the difference in the risk of the endpoint was more pronounced in DM patients compared to patients without DM when patients were stratified into 2 groups based on the median value of late HMR (Figure).Conclusions:Cardiac sympathetic nerve dysfunction had higher prognostic impact in ADHF patients with DM than in those without DM.

Published
2019
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17. Prognostic significance of cardiac I-123-metaiodobenzylguanidine imaging in patients with reduced, mid-range, and preserved left ventricular ejection fraction admitted for acute decompensated heart failure: a prospective study in Osaka Prefectural Acute Heart Failure Registry (OPAR).

Author

Seo M, Yamada T, Tamaki S, Watanabe T, Morita T, Furukawa Y, Kawasaki M, Kikuchi A, Kawai T, Abe M, Nakamura J, Yamamoto K, Kayama K, Kawahira M, Tanabe K, Kimura T, Ueda K, Sakamoto D, Sakata Y, and Fukunami M

Subjects
3-Iodobenzylguanidine, Hospitalization, Humans, Iodine Radioisotopes, Prognosis, Prospective Studies, Registries, Stroke Volume, Ventricular Function, Left, Heart Failure diagnostic imaging
Abstract

Aims: Cardiac 123I-metaiodobenzylguanidine (123I-MIBG) imaging provides prognostic information in patients with chronic heart failure (HF). However, there is little information available on the prognostic role of cardiac 123I-MIBG imaging in patients admitted for acute decompensated heart failure (ADHF), especially relating to reduced ejection fraction [HFrEF; left ventricular ejection fraction (LVEF) < 40%], mid-range ejection fraction (HFmrEF; 40% ≤ LVEF < 50%) and preserved ejection fraction (HFpEF; LVEF ≥ 50%)., Methods and Results: We studied 349 patients admitted for ADHF and discharged with survival. Cardiac 123I-MIBG imaging, echocardiography, and venous blood sampling were performed just before discharge. The cardiac 123I-MIBG heart-to-mediastinum ratio (late H/M) was measured on the chest anterior view images obtained at 200 min after the isotope injection. The endpoint was cardiac events defined as unplanned HF hospitalization and cardiac death. During a follow-up period of 2.1 ± 1.4 years, 128 patients had cardiac events (45/127 in HFrEF, 28/78 in HFmrEF, and 55/144 in HFpEF). On multivariable Cox analysis, late H/M was significantly associated with cardiac events in overall cohort (P = 0.0038), and in subgroup analysis of each LVEF subgroup (P = 0.0235 in HFrEF, P = 0.0119 in HFmEF and P = 0.0311 in HFpEF). Kaplan-Meier analysis showed that patients with low late H/M (defined by median) had significantly greater risk of cardiac events in overall cohort (49% vs. 25% P < 0.0001) and in each LVEF subgroup (HFrEF: 48% vs. 23% P = 0.0061, HFmrEF: 51% vs. 21% P = 0.0068 and HFpEF: 50% vs. 26% P = 0.0026)., Conclusion: Cardiac sympathetic nerve dysfunction was associated with poor outcome in ADHF patients irrespective of HFrEF, HFmrEF, or HFpEF., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.)

Published
2021
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