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8 results on '"Uchida, Atsuo"'

1. Dietary diosgenin attenuates subacute intestinal inflammation associated with indomethacin in rats

Author

Yamada, Tamaki, Hoshino, Makoto, Hayakawa, Tomihiro, Ohhara, Hirotaka, Yamada, Hisashi, Nakazawa, Takahiro, Inagaki, Takanori, Iida, Masayuki, Ogasawara, Tetsuya, Uchida, Atsuo, Hasegawa, Chihiro, Murasaki, Geni, Miyaji, Makoto, Hirata, Akiyasu, and Takeuchi, Toshihiko

Subjects
Indomethacin -- Research, Intestines -- Inflammation, Rats -- Research, Bile acids -- Research, Biological sciences
Abstract

Experiment was conducted to investigate the effects of dietary diosgenin (Dio), a plant-derived sapogenin, on indomethacin (Indo)-induced rats. Bile secretion, intestinal inflammation and blood chemistry were assessed in anesthetized rats three days after two subcutaneous injections of Indo given 24 h apart. dio (>80 mg.kg-1-day-1) pretreatment significantly inhibited weight and food intake decreases and intestinal inflammation. Dio significantly increased biliary cholesterol output and prevented the decreases in bile flow, bile acid output and biliary alpha-muricholic acid.

Published
1997

2. Taurochenodeoxycholic acid ameliorates and ursodeoxycholic acid exacerbates small intestinal inflammation

Author

Uchida, Atsuo, Yamada, Tamaki, Hayakawa, Tomihiro, and Hoshino, Makoto

Subjects
Bile acids -- Physiological aspects, Intestine, Small -- Physiological aspects, Intestines -- Inflammation, Indomethacin -- Physiological aspects, Biological sciences
Abstract

The therapeutic effects of dietary treatments with bile acids were analyzed in the small intestines of rats subjected to prolonged dietary bile acid pretreatments. Administration of ursodeoxycholic acid (UDCA) enhanced the inhibitory effects of indomethacin on food intake and body weight. The stimulatory effects of indomethacin on the biliary contents of secondary bile acids and gross inflammatory scores in rat small intestines was also enhanced by UDCA. On the other hand, tauroursodeoxycholic acid inhibited the effects of indomethacin on the biliary contents of secondary bile acids.

Published
1997

3. Bile secretion in rats with indomethacin-induced intestinal inflammation

Author

Yamada, Tamaki, Hoshino, Makoto, Hayakawa, Tomihiro, Kamiya, Yasutaka, Ohhara, Hirotaka, Mizuno, Kiyoshi, Yamada, Hisashi, Nakazawa, Takahiro, Inagaki, Takanori, Uchida, Atsuo, Miyaji, Makoto, and Takeuchi, Toshihiko

Subjects
Indomethacin -- Physiological aspects, Bile acid metabolism -- Physiological aspects, Gastrointestinal diseases -- Physiological aspects, Biological sciences
Abstract

Bile secretion in rats with intestinal inflammation induced by the anti-inflammatory drug, indomethacin, was investigated. Indomethacin-treated rats had decreased bile flow, bile acid and cholesterol secretion but had increased biliary phospholipid production. They also displayed a marked reduction in alpha- and beta-muricholic acids in bile, but biliary excretion of horseradish peroxidase was significantly increased. Thus, it was concluded that indomethacin decreased biliary function but had no effect on hepatocyte function.

Published
1996

5. Efficacy of Plastic Tube Stents Without Side Holes for Middle and Lower Biliary Strictures

Author

Nakamura, Soichi, primary, Ohara, Hirotaka, additional, Yamada, Tamaki, additional, Nakazawa, Takahiro, additional, Sano, Hitoshi, additional, Ando, Hakuji, additional, Kajino, Shinichi, additional, Hashimoto, Takashi, additional, Ando, Tomoaki, additional, Nomura, Tomoyuki, additional, Joh, Takashi, additional, Okayama, Yasutaka, additional, Uchida, Atsuo, additional, Iida, Masayuki, additional, and Itoh, Makoto, additional

Published
2002
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6. Interleukin-6 Is a Useful Marker for Early Prediction of the Severity of Acute Pancreatitis

Author

Inagaki, Takanori, primary, Hoshino, Makoto, additional, Hayakawa, Tomihiro, additional, Ohara, Hirotaka, additional, Yamada, Tamaki, additional, Yamada, Hisashi, additional, Iida, Masayuki, additional, Nakazawa, Takahiro, additional, Ogasawara, Tetsuya, additional, Uchida, Atsuo, additional, Hasegawa, Chihiro, additional, Miyaji, Makoto, additional, and Takeuchi, Toshihiko, additional

Published
1997
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7. Interleukin6 Is a Useful Marker for Early Prediction of the Severity of Acute Pancreatitis

Author

Inagaki, Takanori, Hoshino, Makoto, Hayakawa, Tomihiro, Ohara, Hirotaka, Yamada, Tamaki, Yamada, Hisashi, Iida, Masayuki, Nakazawa, Takahiro, Ogasawara, Tetsuya, Uchida, Atsuo, Hasegawa, Chihiro, Miyaji, Makoto, and Takeuchi, Toshihiko

Abstract

Twelve patients with acute pancreatitis admitted to our department between January 1993 and December 1994 were studied prospectively and classified into two groups (severe group, five patients; mild group, seven patients), according to the criteria for grading severity of acute pancreatitis proposed by the Research Committee for Intractable Diseases of the Pancreas, Japanese Ministry of Health and Welfare (1990). To evaluate markers for early estimation of the severity of acute pancreatitis, we measured serum changes in various parameters. In the severe group interleukin-6 (IL-6) levels were increased significantly 5, 24, 72, and 120 h after the onset (p< 0.01), compared with the mild group. C-reactive protein (CRP), thrombin antithrombin III, and α2-plasmin inhibitor plasmin complex levels were significantly increased only at the 72-h time point. Peak values of interleukin-8 (IL-8) and soluble human E selectin were observed at 5 and 72 h, respectively, after the onset. There was a significant correlation between IL-6 at 5 h and both pancreatic secretory trypsin inhibitor (r0.85) and CRP (r0.94) at 72 h. We therefore conclude that IL-6 is a useful marker for assessment of the severity of acute pancreatitis in its early stages.

Published
1997

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