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Your search keyword '"Ucakhan, Omur O."' showing total 10 results
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10 results on '"Ucakhan, Omur O."'

1. TFOS Lifestyle: Impact of contact lenses on the ocular surface

Author

Jones, Lyndon, Efron, Nathan, Bandamwar, Kalika, Barnett, Melissa, Jacobs, Deborah S., Jalbert, Isabelle, Pult, Heiko, Rhee, Michelle K., Sheardown, Heather, Shovlin, Joseph P., Stahl, Ulli, Stanila, Adriana, Tan, Jacqueline, Tavazzi, Silvia, Ucakhan, Omur O., Willcox, Mark D.P., and Downie, Laura E.

Published
2023
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2. Comparative Evaluation of Anterior Segment Optical Coherence Tomography Findings Following Accelerated Corneal Crosslinking Protocols Using Different Riboflavin Formulations and Soaking Durations.

Author

Celik-Buyuktepe, Tuna and Ucakhan, Omur O.

Subjects
*CORNEAL cross-linking, *OPTICAL coherence tomography, *VITAMIN B2, *METHYLCELLULOSE, *ENDOTHELIAL cells
Abstract

Purpose: To comparatively evaluate the influence of different riboflavin formulations and soaking durations on the anterior segment optical coherence tomography (AS-OCT) findings following accelerated corneal crosslinking (ACXL) at 9 mW/cm2 for in progressive keratoconus. Methods: In this prospective study, consecutive patients with progressive keratoconus were randomized into 4 groups. Group 1: hydroxypropyl methylcellulose (HPMC)-based riboflavin for 10 min; Group 2: HPMC-based riboflavin for 20 min; Group 3: dextran-based riboflavin (0.1%) for 30 min. Riboflavin soaking was followed by ultraviolet-A irradiation at 9 mW/cm2 for 10 min in all three groups. Group 4 underwent conventional CXL (CCXL) using Dresden protocol. The AS-OCT features of the crosslinked cornea were evaluated at postoperative month 1 and correlated to the clinical outcomes at postoperative month 12. Results: The study enrolled 26 eyes of 26 patients in each group. In groups 1 and 2, the AS-OCT findings were similar (p >.05) and the demarcation lines depth (DLD) were deep as obtained following CCXL. The DLD was significantly shallower in group 3 compared to the other groups (p <.01). There were no between-group differences in regards to the visual, refractive, keratometric, and tomographic outcomes at postoperative month 12. No significant endothelial cell loss or any other clinically significant adverse event was encountered in any patient's eye at 12 months follow-up. Conclusion: Although structural variations were noted in the crosslinked cornea, DLDs observed following ACXL (9 mW/cm2) using HPMC-based solution for 10 or 20 min were similar to those observed following CCXL. Whereas, ACXL (9 mW/cm2) using dextran-based solution for 30 min resulted in the shallowest DLD. Despite these remodeling differences, the visual, refractive and tomographic outcomes of all groups were comparable at postoperative 1-year follow-up. Studies with a greater number of patients and longer follow-ups are required to establish any relation between AS-OCT characteristics of crosslinked cornea and ACXL efficacy. [ABSTRACT FROM AUTHOR]

Published
2025
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7. TFOS DEWS II Tear Film Report

Author

Willcox, Mark D. P., Argueso, Pablo, Georgiev, Georgi A., Holopainen, Juha M., Laurie, Gordon W., Millar, Tom J., Papas, Eric B., Rolland, Jannick P., Schmidt, Tannin A., Stahl, Ulrike, Suarez, Tatiana, Subbaraman, Lakshman N., Ucakhan, Omur O., Jones, Lyndon, Clinicum, Department of Ophthalmology and Otorhinolaryngology, Silmäklinikka, University of Helsinki, and HUS Head and Neck Center

Subjects
OPTICAL COHERENCE TOMOGRAPHY, HUMAN LACRIMAL GLAND, Proteome, BREAK-UP TIME, HORMONE REPLACEMENT THERAPY, Evaporation, MEIBOMIAN-GLAND DYSFUNCTION, LIPID LAYER THICKNESS, Tear film stability, Lipidome, eye diseases, Osmolarity, Tear film, Tears, Mucin, CONTACT-LENS WEARERS, VERSUS-HOST-DISEASE, HUMAN OCULAR SURFACE, sense organs, Dry eye disease, 3125 Otorhinolaryngology, ophthalmology, DRY-EYE DISEASE
Abstract

The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research. Tear film osmolarity increases in DED. Changes to other components such as proteins and mucins can be used as biomarkers for DED. The Subcommittee recommended areas for future research to advance our understanding of the tear film and how this changes with DED. The final report was written after review by all Subcommittee members and the entire TFOS DEWS II membership. (C) 2017 Elsevier Inc. All rights reserved.

Published
2017

8. Outcome of Two Corneal Collagen Crosslinking Methods in Bullous Keratopathy due to Fuchs’ Endothelial Dystrophy

Author

Ucakhan, Omur O. and Saglik, Ayhan

Subjects
genetic structures, Article Subject, sense organs, eye diseases
Abstract

Four eyes of 2 patients with corneal edema due to Fuchs’ endothelial dystrophy were treated with CXL using the standard protocol. Since no improvement in visual acuity, corneal clarity, thickness, or pain sensation was evident in any eye at month 12, 2 eyes of the 2 patients were retreated, this time, following intraoperative corneal dehydration with glycerol 70% drops. This retreatment also failed to produce any significant effect on vision, corneal clarity, thickness, or pain in either eye. Collagen crosslinking with the current protocols may not be effective in the management of eyes with corneal edema due to Fuchs’ endothelial dystrophy. Further studies are required to establish the efficacy of CXL and optimize the technique and/or dehydration method utilized in these cases.

Published
2014
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