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8 results on '"Ubeda-Sansano I"'

1. MAMI: a birth cohort focused on maternal-infant microbiota during early life

Author

Garcia-Mantrana I, Alcantara C, Selma-Royo M, Boix-Amoros A, Dzidic M, Gimeno-Alcaniz J, Ubeda-Sansano I, Sorribes-Monrabal I, Escuriet R, Gil-Raga F, Parra-Llorca A, Martinez-Costa C, Collado M, Bauerl C, Villoldo E, Zafra C, Olivares L, Perez-Martinez G, Mira A, Ferrer M, Santamaria J, Ahicart A, Vento M, Gormaz M, Cernada M, Bertua-Rios B, Padilla B, Crehua-Gaudiza E, Pereto-Moll A, Garcia A, Rico M, Martinez N, Segarra I, Soriano J, Blesa-Baviera L, Vidal A, Hornos L, del Moral T, Cano P, Delgado C, Atero A, and MAMI Team

Subjects
Meconium, Breast milk, Antibiotics, Microbiota, Birth, Lactation, Neonates, Growth, Early nutrition, Cohort study, Diet
Abstract

BackgroundEarly microbial colonization is a relevant aspect in human health. Altered microbial colonization patterns have been linked to an increased risk of non-communicable diseases (NCDs). Advances in understanding host-microbe interactions highlight the pivotal role of maternal microbiota on infant health programming. This birth cohort is aimed to characterize the maternal microbes transferred to neonates during the first 1000days of life, as well as to identify the potential host and environmental factors, such as gestational age, mode of delivery, maternal/infant diet, and exposure to antibiotics, which affect early microbial colonization.MethodsMAMI is a prospective mother-infant birth cohort in the Spanish-Mediterranean area. Mothers were enrolled at the end of pregnancy and families were follow-up during the first years of life. Maternal-infant biological samples were collected at several time points from birth to 24months of life. Clinical and anthropometric characteristics and dietary information is available. Specific qPCR and 16S rRNA gene sequencing as well as short chain fatty acid (SCFAs) profile would be obtained. Multivariable models will be used to identy associations between microbiota and clinical and anthropometric data controlling for confounders.MAMI would contribute to a better understanding of the interaction between diet, microbiota and host response in early life health programming, enabling new applications in the field of personalized nutrition and medicine.Trial registrationThe study is registered on the ClinicalTrial.gov platform NCT03552939. (June 12, 2018).

Published
2019

2. Epidemiological and clinical characteristics and the approach to infant chickenpox in primary care

Author

Rodriguez-Santana Y, Sanchez-Almeida E, Garcia-Vera C, Garcia-Ventura M, Martinez-Espligares L, Abad-Balaguer B, Acitores-Suz E, Aguilera-Lopez L, Aizpurua-Galdeano M, Albaladejo-Beltran S, Alcaraz-Quinonero M, Alonso-Bernardo L, Alvarez-Bueno E, de Laviada-Mulero T, Aparicio-Rodrigo M, Canedo-Arguelles C, Arnal-Alonso J, Arranz-Sanjuan R, Arroyo-Ubeda R, Asensi-Monzo M, Astiz-Blanco M, Ayechu-Diaz A, Balaguer-Martinez J, Barea-Garcia J, Barral-Mena E, Barrios-Gonzalez E, Batalla-Fado L, Bayona-Ferrer I, Bejarano-Lopez M, Belda-Garcia M, Benitez-Rubio M, Bercedo-Sanz A, Bernabe-Moyano M, Bernad-Usoz J, Biosca-Pamies M, Blanco-Gonzalez J, Blesa-Baviera L, Bombin-Granado J, Bonet-Garrosa A, del Arco I, Botella-Serrano B, Boullosa M, Bravo-Acuna J, Breton-Pena A, Burgaleta-Sagaseta A, Caballero-Morales M, Cairo-Corominas S, Calavia-Moreno C, Callejas-Pozo J, Calvo-Lorenzo M, Canadell-Villaret D, Cantarero-Vallejo M, Capell-Redondo G, Carballal-Marino M, Carmona-Cedres N, Caro-Gomez A, Carrera-Polanco M, Carretero L, Casado-Sanchez M, Casares-Alonso I, Cascon-Criado E, de-Asprer A, Casquet-Barcelo A, Caubet-Busquet I, Cayuela-Guerrero C, del-Olmo Y, Chinarro-Martinez P, Coello-Torres Z, Coto-Fuente M, Gallego E, Garcia M, Romero D, Diaz-Varela C, Aguas G, Calero C, Diaz-Cirujano A, Diaz-Sanchez A, Diaz-Zaera O, Dominguez-Aurrecoechea B, Duelo-Marcos M, Elorza-Beitia C, Escanciano-Garcia Y, Escribano-Romero M, Esparza-Olcina M, Espin-Quirante C, Espinazo-Ramos O, Esquivel-Ojeda J, Fabregat-Ferrer E, Fernandez-Leon A, Fernandez-Pastor F, Fernandez-Cuesta-Valcarce M, Ferrandiz-Cerda B, Flores-Erro U, Fontalva-Ballesteros M, Galan-Rico J, Galardi-Andonegui M, Gallego-Iborra A, Garach-Gomez A, Garces-Sanchez M, Garcia-Merida M, Garcia-Perez R, Garcia-Rebollar C, Garcia-Rodriguez A, Garcia-Santiago M, Garcia-Onieva-Artazcoz M, Garcia E, Garrido-Redondo M, Gil-Alexandres I, Gil-Camarero E, San Andres M, Giribet-Folch M, Gomez-Maraver M, Gomez-Sorrigueta P, Gonzalez-Cortes M, Gonzalez-Herrero M, Gonzalez-Rodriguez M, Gonzalez-Valdes S, Gracia-Alfonso M, Grau-Garcia A, Gros-Esteban D, Guillot-Rosello B, Gutierrez-Abad C, Gutierrez-Blasco J, Gutierrez-Sigler M, Heras-Galindo J, Hernandez-Encinas M, Hernandez-Guillen R, Hernandez-Ortiz M, Hernando-Helguero P, Hernando-Zarate Z, De Arce A, Iribarren-Udobro I, Iturrioz-Mata A, Jaldo-Jimenez M, Jaramillo-Hidalgo D, Jimenez-Ales R, Jimenez-Hereza J, Jove-Naval J, de Toledo B, Julia-Benito J, Labordena-Barcelo C, Laso-Murillo P, Ledesma-Albarran J, Lobelle-Gonzalez C, Lobera-Navaz P, Lopez-Alonso R, Lorente-Garcia S, Lorente-Garcia-Maurino A, Losa-Frias V, Lupiani-Castellanos P, Marco-Puche A, Marfil-Olink S, Marquez-Moreno M, Martin-Carballo G, Martin-Delgado M, Martin L, Martin-Rial S, Martinez-Moral N, Martinez-Rubio M, Martinez-Rubio A, Martos-Lozano C, Mendez-Gallego S, Menendez-Bada T, Menendez-Gonzalez N, Mengual-Gil J, Minguez-Verdejo R, Miranda-Berrioategortua I, Moneo-Hernandez I, Montanes-Sanchez A, Montes-Pena M, Munoz-Hiraldo M, Murcia-Garcia J, Mustieles-Moreno C, Navarro-Cabanas G, Navarro-Quesada F, Navas-Heredia C, Novo-Rodriguez A, Nuno-Martin F, Ordonez-Alonso A, Ortells-Ramon I, Padilla-Esteban M, Padilla-Sanchez M, Palomares-Gimeno M, Palomino-Urda N, Panizo-Santos M, Parejo-Carranza R, Pavo-Garcia M, Peix-Sambola M, Pena-Nieto M, Penarroja-Peirats S, Perez-Candas J, Taramona M, Perez-Garcia I, Perez-Gavilan J, Perez-Serrano M, Perez-Tomas R, Perez-Vidal M, Pinilla-Fuentes J, Polo-Mellado M, Prado-Munoz S, Pulido-Bosch M, Pumarola-Batlle M, Quintanilla-Sanchez M, Ramirez-Gavira R, Ramos-Zugasti M, del Castillo C, Ribera-Sirvent C, Rico-Mari E, Ripoll-Lozano A, Rivas-Abraldes N, Riveros-Huckstadt M, Robles-Garcia J, Rodriguez-Delgado J, Rodriguez-Fernandez M, Rodriguez-Fernandez-Oliva C, Rodriguez-Lombardia C, Rodriguez-Mur P, Rodriguez-Varela A, Rodriguez-Lopez-Marquez G, Rodriguez-Moldes-Vazquez B, Rodriguez-Salinas-Perez E, Romero-Reyes C, Ruiz-Chercoles E, Ruiz-Sanchez J, Ruiz-Canela-Caceres J, Ruiz-Cuevas-Garcias P, de Urturi-Sanchez A, De Lafuente-Arriazu A, Salva-Siquier A, Sanantonio-Valdearcos F, Sanchez-Andrada R, Sanchez-Calderon M, Sanchez-Cordero N, Sanchez-Diaz M, Sanchez-Echenique M, Sanchez-Fuentes V, Monge M, Sanchez-Gonzalez B, Sanchez-Jimenez M, Sanchez-Pina C, Sanchez-Precioso S, Sancho-Madrid B, Satrustegui-Gamboa F, Segovia-Ferrera C, Seijas-Vazquez L, Serna-Saugar M, Serrano-Gomez M, Servera-Ginard C, Somoza-Martin M, Soriano-Faura J, Suarez-Vicent E, Surribas-Murillo C, de Arcaya M, Ubeda-Sansano I, Valdivia-Jimenez C, Valls-Duran T, Vaquerizo-Pollino M, Vega-Perez M, Velasco-Guijarro O, Vera-Dominguez M, Viar-Urieta M, Vigueras-Abellan J, Vila-Alonso M, Vila-Buch G, Vilchez-Perez J, Villafruela-Alvarez C, Villaizan-Perez C, Villar-Fernandez M, de Velasco A, Viver-Gomez S, and PAPenRED

Published
2019

5. ANTIBODY PERSISTENCE 12 MONTHS AFTER A BOOSTER DOSE OF MENINGOCOCCAL-C CONJUGATED VACCINE IN THE SECOND YEAR OF LIFE

Author

Diez-Domingo J, Planelles-Cantarino MV, Baldo-Torrenti JM, Ubeda-Sansano I, Jubert-Rosich A, Puig-Barbera J, and Gutierrez-Gimeno MV

Subjects
serotype C, Neisseria meningitidis, immunization, secondary, meningococcal vaccines, complex mixtures
Abstract

We report on the results of the 12-month follow-up of children aged 14 to 18 months who received primary and booster vaccinations with either a meningococcal-C vaccine conjugated to tetanus toxoid or CRM(197). Seroprotection (92.8%) and geometric mean titers/serum bactericidal activity (410.5; 95% CI: 273.4-616.3) were higher in children receiving the meningococcal serogroup C tetanus toxoid conjugate, compared with 61.5% and serum bactericidal antibody geometric mean titer of 45.1 (95% CI: 28.5-71.3) when MenC-CRM(197) conjugate was used.

Published
2010

7. [Incidence and cost of hospitalizations for bronchiolitis and respiratory syncytial virus infections in the autonomous community of Valencia in Spain (2001 and 2002)].

Author

Díez Domingo J, Ridao López M, Ubeda Sansano I, and Ballester Sanz A

Subjects
Bronchiolitis economics, Costs and Cost Analysis, Female, Hospitalization economics, Hospitalization statistics & numerical data, Humans, Incidence, Infant, Infant, Newborn, Male, Respiratory Syncytial Virus Infections economics, Spain epidemiology, Bronchiolitis epidemiology, Respiratory Syncytial Virus Infections epidemiology
Abstract

Objective: To assess the incidence and costs of hospitalizations for bronchiolitis and respiratory syncytial virus (RSV) infections the Autonomous Community of Valencia, Spain., Methods: The minimum data set (MDS) of the Autonomous Community of Valencia was analyzed. Hospital discharges with the codes for bronchiolitis (with or without etiologic determination) and RSV infections occurring in 2001 and 2002 in children less than 2 years old were included. Second cases of bronchiolitis and RSV infections of possible nosocomial origin occurring during prolonged hospitalization were excluded. The average cost of hospitalization in a pediatric ward was estimated at euro 310.30 per day. To calculate the incidence, we assumed that 95 % of the hospitals reported to the MDS; the population used was that of the National Census, 2001., Results: A total of 3,705 hospitalizations were obtained, of which 3,507 were coded as bronchiolitis and 42.2 % of these were RSV-positive. Virological assessment varied greatly among hospitals. Hospitalizations were most frequent between October and April, with no differences between the two years. The incidence of bronchiolitis hospitalization was 40.2 cases/1000 children < 1 year/year, with an average annual cost of 3,618 thousand Euros., Conclusions: The cost of bronchiolitis hospitalizations is high. Microbiological investigation is low in some hospitals, leading the economic impact of RSV on society to be underestimated.

Published
2006
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8. [Survey of the judicious use of antibiotics in primary care].

Author

Casaní Martínez C, Calvo Rigual F, Peris Vidal A, Alvarez de Lavida Mulero T, Díez Domingo J, Graullera Millas M, and Ubeda Sansano I

Subjects
Child, Drug Utilization standards, Humans, Primary Health Care, Anti-Bacterial Agents therapeutic use, Otitis Media drug therapy, Pharyngitis drug therapy, Practice Patterns, Physicians' statistics & numerical data, Surveys and Questionnaires, Tonsillitis drug therapy
Abstract

Objective: To identify pediatricians' antibiotic prescribing habits in acute otitis media and tonsillopharyngitis and to determine the interaction between parents and pediatricians concerning antibiotic use in the Autonomous Community of Valencia (Spain)., Method: Four hundred members of the Valencian Society of Pediatrics were randomly selected. A semi-structured questionnaire with non-excluding answers was sent by mail and, when responses were not obtained, a second one was sent. The confidentiality of the information was guaranteed., Results: Of 400 questionnaires sent, 143 (35.8 %) were completed; 88.1 % were completed by pediatricians and 51.1 % by primary care workers. A total of 48.3 % of pediatricians used antibiotics in all cases of acute otitis media and 94.5 % prescribed them when fever and otalgia persisted for more than 48 hours. Amoxicillin-clavulanate was the most frequently prescribed antibiotic (63.6 %). Less than 10 % of pediatricians prescribed antibiotics as empirical treatment in tonsillopharyngitis; amoxicillin was the most frequently prescribed antibiotic (54.6 %). Indications for antibiotic treatment were fever, odynophagia and adenomegaly (69.5 %) and tonsillar exudate (62.5 %). Inappropriate antibiotic use was mainly due to excess workload. Providing health education to parents could be the best way of reducing inappropriate use., Conclusions: Antibiotic use is frequent in the treatment of acute otitis media. Amoxicillin-clavulanate and amoxicillin were the most frequently prescribed antibiotics in tonsillopharyngitis. Providing health education to parents and reducing pediatricians' workload would decrease inappropriate antibiotic use.

Published
2003
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