Abstract\nIMPLICATIONS FOR REHABILITATION DOCUMENT\nPRACTITIONER SUMMARYPurpose of the article: As technologies continue to advance, designing wearable exoskeletons that are comfortable, safe, reliable, and engaging for users is an arduous task. The integration of HCD principles in exoskeleton development significantly contributes to ensuring that the product meets the needs and preferences of users. This study systematically reviews the application of human-centred design (HCD) principles in the development of wearable exoskeletons.Methodology: It synthesizes existing literature, identifies key HCD concepts and assesses their impact on exoskeleton usability, comfort, and safety. The findings of the study revealed a moderate application of HCD in many of the studies; however, the concepts were found to play a crucial role in enhancing the usability, safety, and comfort of wearable exoskeleton technology implementation. Challenges revealed in the study include limited stakeholder involvement, a lack of standardized evaluation metrics, non-consideration of ethical, legal, and social issues, and a lack of studies on the potential adverse effects of exoskeleton use. Besides identifying the challenges faced in integrating HCD principles into exoskeleton development, the study also proposed pragmatic approaches to overcome them.Results: The study underscores the significance of incorporating human-centred design principles in the design and development of wearable exoskeletons. This has implications for industry, rehabilitation, health, and agriculture to churn out positive outcomes. The research contributes to the expanding literature on wearable exoskeletons and HCD, offering valuable insights into the advancement of this technology in various domains and suggesting areas for future studies to address identified gaps.Wearable exoskeleton use in rehabilitation can revolutionize the field by providing enhanced support and assistance to individuals with mobility impairments.Applying HCD to exoskeleton development for rehabilitation ensures their effectiveness and can significantly improve the user’s ability to walk, regain independence, and participate in daily activities.The HCD approach enables the customization of exoskeletons to meet the unique needs and abilities of users, which in turn promotes comfort, usability, and overall user satisfaction.Rehabilitation professionals can create soft exoskeleton devices that are cost-effective, accessible, and sustainable for users to improve overall outcomes.Enhanced marketability and profitability of wearable exoskeletons can result in heightened investment and innovation within the sector.Wearable exoskeleton use in rehabilitation can revolutionize the field by providing enhanced support and assistance to individuals with mobility impairments.Applying HCD to exoskeleton development for rehabilitation ensures their effectiveness and can significantly improve the user’s ability to walk, regain independence, and participate in daily activities.The HCD approach enables the customization of exoskeletons to meet the unique needs and abilities of users, which in turn promotes comfort, usability, and overall user satisfaction.Rehabilitation professionals can create soft exoskeleton devices that are cost-effective, accessible, and sustainable for users to improve overall outcomes.Enhanced marketability and profitability of wearable exoskeletons can result in heightened investment and innovation within the sector.Our systematic literature review focused on applying HCD principles to develop wearable exoskeletons. The findings emphasized the significance of prioritizing user needs and preferences. The study has practical implications, for guiding product development, enhancing user experience, innovation, healthcare/rehabilitation, and some livelihood practices, influencing policy and regulation, and advancing future research. [ABSTRACT FROM AUTHOR]