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302 results on '"UOTILA, JUKKA"'

13. Labor induction at 41+0 gestational weeks or expectant management for the nulliparous woman: The Finnish randomized controlled multicenter trial

Author

Place, Katariina, primary, Rahkonen, Leena, additional, Tekay, Aydin, additional, Väyrynen, Kirsi, additional, Orden, Maija‐Riitta, additional, Vääräsmäki, Marja, additional, Uotila, Jukka, additional, Tihtonen, Kati, additional, Rinne, Kirsi, additional, Mäkikallio, Kaarin, additional, Heinonen, Seppo, additional, and Kruit, Heidi, additional

Published
2023
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19. Labor induction at 41+0 gestational weeks or expectant management for the nulliparous woman: The Finnish randomized controlled multicenter trial.

Author

Place, Katariina, Rahkonen, Leena, Tekay, Aydin, Väyrynen, Kirsi, Orden, Maija‐Riitta, Vääräsmäki, Marja, Uotila, Jukka, Tihtonen, Kati, Rinne, Kirsi, Mäkikallio, Kaarin, Heinonen, Seppo, and Kruit, Heidi

Subjects
INDUCED labor (Obstetrics), DELIVERY (Obstetrics), ECLAMPSIA, RANDOMIZED controlled trials, WOMEN executives, OBSTETRICAL extraction, CESAREAN section
Abstract

Introduction: Neonatal and maternal risks increase in term pregnancy as gestational age advances and become increasingly evident post‐term. Management practices of late‐ and post‐term pregnancies vary, and the optimal time point for intervention by labor induction is yet to be determined. Material and methods: This randomized controlled trial of 381 nulliparous women with unripe cervices compared labor induction at 41+0 gestational weeks (early induction) with expectant management and labor induction at 41+5 to 42+1 gestational weeks (expectant management). This multicenter study included all five university hospitals and the largest central hospital in Finland. The study period was 2018–2022. Participants were randomized to either early induction (48.8%, n = 186) or expectant management (51.2%, n = 195) with equal randomization ratios of 1:1. This was a superiority trial, and the primary outcomes were rates of cesarean section (CS) and composite of adverse neonatal outcomes. The trial was registered at the ISRCTN registry (ISRCTN83219789, https://doi.org/10.1186/ISRCTN83219789). Results: The rates of CS (16.7% [n = 31] vs. 24.1% [n = 47], RR 0.7 [95% CI: 0.5–1.0], p = 0.07) and a composite of adverse neonatal outcomes (9.7% [n = 18] vs. 14.4% [n = 28], RR 0.7 [95% CI: 0.4–1.2] p = 0.16) did not significantly differ between the groups, but the operative delivery rate was lower in the early induction group than in the expectant management group (30.6% [n = 57] vs. 45.6% [n = 89], p = 0.003). The rates of hemorrhage ≥1000 mL and neonatal weight ≥4000 g were also lower in the early induction group, as was the vacuum extraction rate in women with vaginal delivery. Of the women with expectant management, 45.6% (n = 89) had spontaneous onset of labor. No perinatal deaths occurred, but one case of eclampsia appeared in the expectant management group. Conclusions: Offering labor induction to nulliparous women at 41+0 gestational weeks may decrease the probability of operative delivery, postpartum hemorrhage, and neonatal weight ≥4000 g. However, this study was underpowered to affirm the trends of rising rates of CS and adverse neonatal outcomes in the expectant management group. Thus, expectant management could remain an option for some, as one in two women with expectant management had a spontaneous onset of labor. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Tafoxiparin, a novel drug candidate for cervical ripening and labor augmentation: results from 2 randomized, placebo-controlled studies

Author

Ekman-Ordeberg, Gunvor, primary, Hellgren-Wångdahl, Margareta, additional, Jeppson, Annika, additional, Rahkonen, Leena, additional, Blomberg, Marie, additional, Pettersson, Karin, additional, Bejlum, Carina, additional, Engberg, Malin, additional, Ludvigsen, Mette, additional, Uotila, Jukka, additional, Tihtonen, Kati, additional, Hallberg, Gunilla, additional, and Jonsson, Maria, additional

Published
2023
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32. The latent phase of labour and its treatment

Author

Kukko, Sanna-Kaisa, Uotila, Jukka, Tampere University, Naistentautien ja synnytysten vastuualue, and Kliininen lääketiede

Subjects
3123 Naisten- ja lastentaudit
Abstract

The latent phase of labour is a stage when the labour has begun but cervical opening is still slow. The duration of the latent phase varies, as does the women’s coping. Although there is usually no need to intervene in the delivery process during the latent phase, it is still necessary to identify those at risk of complications. Using a coping scale can identify those whose resources are in danger of decreasing. Care in the latent phase of labour needs to be tailored individually to the women’s needs and coping. publishedVersion

Published
2021

37. Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease

Author

Johnson, Matthew P., Brennecke, Shaun P., East, Christine E., Dyer, Thomas D., Roten, Linda T., Proffitt, J. Michael, Melton, Phillip E., Fenstad, Mona H., Aalto-Viljakainen, Tia, Mäkikallio, Kaarin, Heinonen, Seppo, Kajantie, Eero, Kere, Juha, Laivuori, Hannele, Austgulen, Rigmor, Blangero, John, Moses, Eric K., Pouta, Anneli, Kivinen, Katja, Ekholm, Eeva, Hietala, Reija, Sainio, Susanna, Saisto, Terhi, Uotila, Jukka, Klemetti, Miira, Inkeri Lokki, Anna, Georgiadis, Leena, Huovari, Elina, Kortelainen, Eija, Leminen, Satu, Lähdesmäki, Aija, Mehtälä, Susanna, and Salmen, Christina

Published
2013
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38. Invasive group B streptococcal infections in Finland: a population-based study. (Research)

Author

Lyytikainen, Outi, Nuorti, J. Pekka, Halmesmaki, Erja, Carlson, Petteri, Uotila, Jukka, Vuento, Risto, Ranta, Tapio, Sarkkinen, Hannu, Ammala, Martti, Kostiala, Anja, and Jarvenpaa, Anna-Liisa

Subjects
Bacterial infections -- Statistics, Bacterial infections -- Demographic aspects, Streptococcal infections -- Statistics, Streptococcal infections -- Demographic aspects
Abstract

We analyzed surveillance data on group B streptococcus (GBS) infection in Finland from 1995 to 2000 and reviewed neonatal cases of early-onset GBS infection in selected hospitals in 1999 to [...]

Published
2003

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