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1. Hematopoietic Cell Transplantation with Reduced Intensity Conditioning Using Fludarabine/Busulfan or Fludarabine/Melphalan for Primary Immunodeficiency Diseases

Author

Nishimura, Akira, Aoki, Yuki, Ishiwata, Yasuyoshi, Ichimura, Takuya, Ueyama, Junichi, Kawahara, Yuta, Tomoda, Takahiro, Inoue, Maiko, Matsumoto, Kazuaki, Inoue, Kento, Hiroki, Haruka, Ono, Shintaro, Yamashita, Motoi, Okano, Tsubasa, Tanaka-Kubota, Mari, Ashiarai, Miho, Miyamoto, Satoshi, Miyawaki, Reiji, Yamagishi, Chika, Tezuka, Mari, Okawa, Teppei, Hoshino, Akihiro, Endo, Akifumi, Yasuhara, Masato, Kamiya, Takahiro, Mitsuiki, Noriko, Ono, Toshiaki, Isoda, Takeshi, Yanagimachi, Masakatsu, Tomizawa, Daisuke, Nagasawa, Masayuki, Mizutani, Shuki, Kajiwara, Michiko, Takagi, Masatoshi, Kanegane, Hirokazu, Imai, Kohsuke, and Morio, Tomohiro

Published
2021
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3. Continuous and high-dose cytarabine combined chemotherapy in children with down syndrome and acute myeloid leukemia: Report from the Japanese childrenʼs cancer and leukemia study group (JCCLSG) AML 9805 down study

Author

Taga, Takashi, Shimomura, Yasuto, Horikoshi, Yasuo, Ogawa, Atsushi, Itoh, Masaki, Okada, Masahiko, Ueyama, Junichi, Higa, Takeshi, Watanabe, Arata, Kanegane, Hirokazu, Iwai, Asayuki, Saiwakawa, Yutaka, Kogawa, Kazuhiro, Yamanaka, Junko, and Tsurusawa, Masahito

Published
2011
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4. Minimal residual disease-based augmented therapy in childhood acute lymphoblastic leukemia: A report from the Japanese Childhood Cancer and Leukemia Study Group

Author

Yamaji, Kazutaka, Okamoto, Tomomi, Yokota, Shohei, Watanabe, Arata, Horikoshi, Yasuo, Asami, Keiko, Kikuta, Atsushi, Hyakuna, Nobuyuki, Saikawa, Yutaka, Ueyama, Junichi, Watanabe, Tsutomu, Okada, Masahiko, Taga, Takashi, Kanegane, Hirokazu, Kogawa, Kazuhiro, Chin, Motoaki, Iwai, Asayuki, Matsushita, Takeshi, Shimomura, Yasuto, Hori, Toshinori, and Tsurusawa, Masahito

Published
2010
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7. The Effect of Interim FDG-PET-guided Response-Adapted Therapy in Pediatric Patients with Hodgkin's Lymphoma (HL-14) : Protocol for a Phase II Study

Author

Koga, Yuhki, Baba, Shingo, Fukano, Reiji, Nakamura, Katsumasa, Soejima, Toshinori, Maeda, Naoko, Sunami, Shosuke, Ueyama, Junichi, Mitsui, Tetsuo, Mori, Takeshi, Osumi, Tomoo, Sekimizu, Masahiro, Ohki, Kentaro, Tanaka, Fumiko, Kamei, Michi, Fujita, Naoto, Mori, Tetsuya, Saito, Akiko M., Kada, Akiko, and Kobayashi, Ryoji

Subjects
Male, pediatric, Clinical Trials, Phase II as Topic, Hodgkin’s lymphoma, Fluorodeoxyglucose F18, Positron-Emission Tomography, Humans, Multicenter Studies as Topic, Female, Child, Hodgkin Disease, fludeoxyglucose positron emission tomography, Retrospective Studies
Abstract

This trial enrolls patients with untreated Hodgkin’s lymphoma aged

Published
2018

10. Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway

Author

Li, Yuanyuan, primary, Ohira, Miki, additional, Zhou, Yong, additional, Xiong, Teng, additional, Luo, Wen, additional, Yang, Chao, additional, Li, Xiangchun, additional, Gao, Zhibo, additional, Zhou, Rui, additional, Nakamura, Yohko, additional, Kamijo, Takehiko, additional, Kaneko, Yasuhiko, additional, Taketani, Takeshi, additional, Ueyama, Junichi, additional, Tajiri, Tatsuro, additional, Zhang, Hongyan, additional, Wang, Jian, additional, Yang, Huanming, additional, Yin, Ye, additional, and Nakagawara, Akira, additional

Published
2017
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11. Genomic analysis-integrated whole-exome sequencing of neuroblastomas identifies genetic mutations in axon guidance pathway

Author

Li Yuanyuan, Ohira Miki, Zhou Yong, Xiong Teng, Luo Wen, Yang Chao, Li Xiangchun, Gao Zhibo, Zhou Rui, Nakamura Yohko, Kamijo Takehiko, Kaneko Yasuhiko, Taketani, Takeshi, Ueyama Junichi, Tajiri Tatsuro, Zhang Hongyan, Wang Jian, Yang Huanming, Yin Ye, Nakagawara Akira, Li Yuanyuan, Ohira Miki, Zhou Yong, Xiong Teng, Luo Wen, Yang Chao, Li Xiangchun, Gao Zhibo, Zhou Rui, Nakamura Yohko, Kamijo Takehiko, Kaneko Yasuhiko, Taketani, Takeshi, Ueyama Junichi, Tajiri Tatsuro, Zhang Hongyan, Wang Jian, Yang Huanming, Yin Ye, and Nakagawara Akira

Published
2017

15. Continuous and high-dose cytarabine combined chemotherapy in children with down syndrome and acute myeloid leukemia: Report from the Japanese children's cancer and leukemia study group (JCCLSG) AML 9805 down study

Author

Taga, Takashi, primary, Shimomura, Yasuto, additional, Horikoshi, Yasuo, additional, Ogawa, Atsushi, additional, Itoh, Masaki, additional, Okada, Masahiko, additional, Ueyama, Junichi, additional, Higa, Takeshi, additional, Watanabe, Arata, additional, Kanegane, Hirokazu, additional, Iwai, Asayuki, additional, Saiwakawa, Yutaka, additional, Kogawa, Kazuhiro, additional, Yamanaka, Junko, additional, and Tsurusawa, Masahito, additional

Published
2010
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16. Correlation of Clinical Features With the Mutational Status of GM-CSF Signaling Pathway-Related Genes in Juvenile Myelomonocytic Leukemia

Author

Yoshida, Nao, primary, Yagasaki, Hiroshi, additional, Xu, Yinyan, additional, Matsuda, Kazuyuki, additional, Yoshimi, Ayami, additional, Takahashi, Yoshiyuki, additional, Hama, Asahito, additional, Nishio, Nobuhiro, additional, Muramatsu, Hideki, additional, Watanabe, Nobuhiro, additional, Matsumoto, Kimikazu, additional, Kato, Koji, additional, Ueyama, Junichi, additional, Inada, Hiroko, additional, Goto, Hiroaki, additional, Yabe, Miharu, additional, Kudo, Kazuko, additional, Mimaya, Junichi, additional, Kikuchi, Akira, additional, Manabe, Atsushi, additional, Koike, Kenichi, additional, and Kojima, Seiji, additional

Published
2009
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17. Correlation of Clinical Features with the Mutational Status of GM-CSF Signaling Pathway-Related Genes in Children with Juvenile Myelomonocytic Leukemia

Author

Yoshida, Nao, primary, Yagasaki, Hiroshi, additional, Yoshimi, Ayami, additional, Takahashi, Yoshiyuki, additional, Xu, Yinyan, additional, Tanaka, Makito, additional, Watanabe, Nobuhiro, additional, Matsumoto, Kimikazu, additional, Kato, Koji, additional, Ueyama, Junichi, additional, Inada, Hiroko, additional, Goto, Hiroaki, additional, Yabe, Miharu, additional, Mimaya, Junichi, additional, Kikuchi, Akira, additional, Manabe, Atsushi, additional, and Kojima, Seiji, additional

Published
2007
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18. Reduced-Intensity Unrelated Cord-Blood Transplantation (RI-UCBT) for Patients with High-Risk Myeloid Malignancies.

Author

Yuji, Koichiro, primary, Miyakoshi, Shigesaburo, primary, Takagi, Shinsuke, primary, Kato, Daisuke, primary, Miura, Yuji, primary, Narimatsu, Hiroto, primary, Kusumi, Eiji, primary, Kishi, Yukiko, primary, Matsumura, Tomoko, primary, Kobayashi, Kazuhiro, primary, Hamaki, Tamae, primary, Uchida, Naoyuki, primary, Kami, Masahiro, primary, Masuoka, Kazuhiro, primary, Murashige, Naoko, primary, Wake, Atsushi, primary, Ueyama, Junichi, primary, Yoneyama, Akiko, primary, Matsuzaki, Michio, primary, Morinaga, Shinichi, primary, Muto, Yoshitomo, primary, Takaue, Yoichi, primary, and Taniguchi, Shuichi, primary

Published
2005
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19. Late Effects and Quality of Life of Survivors of Childhood Hematologic Malignancies Treated Mainly during 80’s in Japanese Group Study.

Author

Matsushita, Takeji, primary, Watanabe, Arata, additional, Satou, Noriko, additional, Kikuta, Atsushi, additional, Iizuka, Susumu, additional, Uehara, Takahiro, additional, Asami, Keiko, additional, Mugishima, Hideo, additional, Kaneko, Yasuhiko, additional, Hori, Toshinori, additional, Ohta, Shigeru, additional, Kuno, Tomoko, additional, Watanabe, Chikara, additional, Hyakuna, Nobuyuki, additional, Ueyama, Junichi, additional, Nomura, Keiko, additional, Kokawa, Kazuhiro, additional, Iwai, Tsuyako, additional, Mimaya, Jun-ichi, additional, Koizumi, Shouichi, additional, and Tsurusawa, Masahito, additional

Published
2005
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20. Reduced-intensity unrelated cord blood transplantation for patients with advanced malignant lymphoma

Author

Yuji, Koichiro, primary, Miyakoshi, Shigesaburo, additional, Kato, Daisuke, additional, Miura, Yuji, additional, Myojo, Tomohiro, additional, Murashige, Naoko, additional, Kishi, Yukiko, additional, Kobayashi, Kazuhiro, additional, Kusumi, Eiji, additional, Narimatsu, Hiroto, additional, Hamaki, Tamae, additional, Matsumura, Tomoko, additional, Kami, Masahiro, additional, Fukuda, Takahiro, additional, Masuo, Shigeru, additional, Masuoka, Kazuhiro, additional, Wake, Atsushi, additional, Ueyama, Junichi, additional, Yoneyama, Akiko, additional, Miyamoto, Ko, additional, Nagoshi, Haruhisa, additional, Matsuzaki, Michio, additional, Morinaga, Shinichi, additional, Muto, Yoshitomo, additional, Takeue, Yoichi, additional, and Taniguchi, Shuichi, additional

Published
2005
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21. Improvement of Concurrent Autoimmune Diseases Following Reduced-Intensity Stem Cell Transplantation (RIST) for Hematological Disorders: Graft-Versus Autoimmunity (GVA) Effect.

Author

Yuji, Koichiro, primary, Kami, Masahiro, primary, Kato, Daisuke, primary, Miura, Yuji, primary, Myojo, Tomohiro, primary, Kusumi, Eiji, primary, Narimatsu, Hiroto, primary, Kishi, Yukiko, primary, Hamaki, Tamae, primary, Matsumura, Tomoko, primary, Miyakoshi, Shigesaburo, primary, Ueyama, Junichi, primary, Morinaga, Shinichi, primary, Takaue, Yoichi, primary, and Taniguchi, Shuichi, primary

Published
2004
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22. Economic Analysis of Reduced-Intensity Cord Blood Transplantation.

Author

Yuji, Koichiro, primary, Miyakoshi, Shigesaburo, primary, Myojo, Tomohiro, primary, Miura, Yuji, primary, Kato, Daisuke, primary, Imataki, Osamu, primary, Narimatsu, Hiroto, primary, Kusumi, Eiji, primary, Matsumura, Tomoko, primary, Kami, Masahiro, primary, Masuoka, Kazuhiro, primary, Ueyama, Junichi, primary, Wake, Atsushi, primary, Morinaga, Shinichi, primary, and Taniguchi, Shuichi, primary

Published
2004
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23. Blood Stream Infection after Reduced- Intensity Unrelated Cord Blood Transplantation for Adults with Hematologic Diseases.

Author

Narimatsu, Hiroto, primary, Kami, Masahiro, additional, Matsumura, Tomoko, additional, Myojo, Tomohiro, additional, Masuoka, Kazuhiro, additional, Inokuchi, Chiho, additional, Yuji, Koichiro, additional, Miura, Yuji, additional, Kusumi, Eiji, additional, Ueyama, Junichi, additional, Wake, Atsushi, additional, Miyakoshi, Shigesaburo, additional, Yoneyama, Akiko, additional, Matsuzaki, Michio, additional, Morinaga, Shinichi, additional, Muto, Yoshitomo, additional, and Taniguchi, Shuichi, additional

Published
2004
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24. Reduced Intensity Umbilical Cord Blood Transplantation(RI-UCBT) in Adult Patients with Graft Failure or Relapse after First Allogeneic Transplantation.

Author

Masuoka, Kazuhiro, primary, Yuji, Koichiro, primary, Miura, Yuji, primary, Myojo, Tomohiro, primary, Kato, Daisuke, primary, Narimatsu, Hiroto, primary, Kusumi, Eiji, primary, Matsumura, Tomoko, primary, Wake, Atsushi, primary, Miyamoto, Ko, primary, Miyakoshi, Shigesaburo, primary, Yoneyama, Akiko, primary, Matsuzaki, Michio, primary, Ueyama, Junichi, primary, Morinaga, Shinichi, primary, and Taniguchi, Shuichi, primary

Published
2004
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25. Cytomegalovirus Infection after Unrelated Cord Blood Transplantation (CBT) for Adults with Hematological Diseases.

Author

Myojo, Tomohiro, primary, Matsumura, Tomoko, primary, Narimatsu, Hiroto, primary, Masuoka, Kazuhiro, primary, Inokuchi, Chiho, primary, Kami, Masahiro, primary, Miura, Yuji, primary, Kato, Daisuke, primary, Kusumi, Eiji, primary, Yuji, Koichiro, primary, Wake, Atsushi, primary, Ueyama, Junichi, primary, Miyakoshi, Shigesaburo, primary, Yoneyama, Akiko, primary, Matsuzaki, Michio, primary, Morinaga, Shinichi, primary, and Taniguchi, Shuichi, primary

Published
2004
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26. Vesicles as Initial Skin Manifestation of Disseminated Fusariosis after Non-myeloablative Stem Cell Transplantation

Author

Hamaki, Tamae, primary, Kami, Masahiro, additional, Kishi, Akiko, additional, Kusumi, Eiji, additional, Kishi, Yukiko, additional, Iwata, Hiroshi, additional, Miyakoshi, Shigesaburo, additional, Ueyama, Junichi, additional, Morinaga, Shinichi, additional, Taniguchi, Shuichi, additional, Ohara, Kuniaki, additional, and Muto, Yoshitomo, additional

Published
2004
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27. Clinical Efficacy of Fosfomycin in Combination with Sulbactam/Cefoperazone in the Treatment of Severe Infections Complicated to Blood Dyscrasia

Author

KITAMURA, Kiyoshi, primary, HIRAI, Hisamaru, additional, HOSOYA, Noriko, additional, SUGAI, Masao, additional, KARASAWA, Masamitu, additional, NARUSE, Takuji, additional, MIURA, Yasusada, additional, OHMINE, Ken, additional, TAKAGI, Syojiro, additional, HIRASHIMA, Kunitake, additional, BESSHO, Masami, additional, FUKUDA, Masataka, additional, KAWAI, Nobutaka, additional, DAN, Kazuo, additional, AN, Emi, additional, HOSHINO, Tetsuo, additional, OSHIMI, Kazuo, additional, NOGUCHI, Masaaki, additional, EGASHIRA, Motoki, additional, IKEDA, Yasuo, additional, KIZAKI, Masahiro, additional, TOYAMA, Keisuke, additional, MIYAZAWA, Keisuke, additional, NAGASU, Masaya, additional, INATOMI, Yuka, additional, KURIYAMA, Yuzuru, additional, IWASE, Osamu, additional, MIZOGUCHI, Hideaki, additional, KOBAYASHI, Shoko, additional, TSURUOKA, Nobuyoshi, additional, TOMOYASU, Shigeru, additional, NAKAMAKI, Tsuyoshi, additional, AKIMOTO, Yoshihisa, additional, KAKIMOTO, Tsunayuki, additional, MUTO, Yoshitomo, additional, UEYAMA, Junichi, additional, TOGAWA, Atsushi, additional, MIWA, Akiyoshi, additional, NAGAI, Mari, additional, URABE, Akio, additional, ENDO, Mitsue, additional, MORI, Mayumi, additional, KURAMOTO, Ken, additional, KIKUKAWA, Masayuki, additional, NAKAMURA, Noriko, additional, SUZUKI, Kenshi, additional, INOUE, Yasuyuki, additional, SAWANOBORI, Masakazu, additional, NAKAGAWA, Yasuaki, additional, ISHIKAWA, Kyozo, additional, KAWANO, Koichi, additional, HOMORI, Masashi, additional, MURAI, Yoshiro, additional, MIZUTANI, Ryoko, additional, NAKAMURA, Kyoko, additional, OMINE, Mitsuhiro, additional, FUJIWARA, Hikaru, additional, CHIBA, Shyozo, additional, and HIRASAWA, Akira, additional

Published
1998
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28. Three Cases of Hereditary Nonspherocytic Hemolytic Anemia Associated With Red Blood Cell Glutathione Deficiency

Author

Hirono, Akira, lyori, Hideaki, Sekine, Isao, Ueyama, Junichi, Chiba, Hirotane, Kanno, Hitoshi, Fujii, Hisaichi, and Miwa, Shiro

Abstract

Three unrelated Japanese patients with chronic nonspherocytic hemolytic anemia were found to have marked deficiency of red blood cell (RBC) reduced glutathione (GSH) (4.4%, 13.1%, and 6.9% of normal, respectively). A panel of RBC enzyme assays showed that one patient had decreased glutathione synthetase activity and the other two were moderately deficient in γ-glutamylcysteine synthetase. Some family members of each patient showed mild deficiency of the respective enzymes. RBCs of these patients also showed a decreased level of glutathione-S-transferase as in previously described GSH-deficient cases. Hemolytic anemia was their only manifestation, and neither 5-oxoproli-nemia nor 5-oxoprolinuria, which are usually associated with the generalized type of glutathione synthetase deficiency, was noted in our patients.

Published
1996
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29. A Multicenter, Open-label, Clinical Trial to Assess the Effectiveness and Safety of Allogeneic Hematopoietic Stem Cell Transplantation Using Reduced-intensity Conditioning in Relapsed/refractory Anaplastic Large-cell Lymphoma in Children.

Author

Kada A, Fukano R, Mori T, Kamei M, Tanaka F, Ueyama J, Sekimizu M, Osumi T, Mori T, Koga Y, Ohki K, Fujita N, Mitsui T, Saito AM, Hashimoto H, and Kobayashi R

Subjects
Adolescent, Antineoplastic Agents therapeutic use, Antineoplastic Combined Chemotherapy Protocols, Child, Clinical Trials as Topic, Humans, Melphalan therapeutic use, Vidarabine analogs & derivatives, Vidarabine therapeutic use, Hematopoietic Stem Cell Transplantation methods, Lymphoma, Large-Cell, Anaplastic therapy, Transplantation Conditioning methods
Abstract

No standard treatment for relapsed or refractory anaplastic large-cell lymphoma (ALCL) has been established. This study is a multicenter, open-label trial to examine the effectiveness and safety of transplantation with reduced-intensity conditioning (RIC) for patients under 20 years old with relapsed or refractory ALCL. We defined RIC as the administration of fludarabine (30 mg/m2/day) for five days plus melphalan (70 mg/m2/day) for two days and total body irradiation at 4 Gy, followed by allogeneic hematopoietic stem cell transplantation., Competing Interests: No potential conflict of interest relevant to this article was reported.

Published
2020
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30. Fatal airway obstruction caused by invasive aspergillosis of the thyroid gland.

Author

Kishi Y, Negishi M, Kami M, Hamaki T, Miyakoshi S, Ueyama J, Morinaga S, and Mutou Y

Subjects
Adult, Airway Obstruction etiology, Aspergillosis pathology, Aspergillus fumigatus, Fatal Outcome, Humans, Male, Thyroid Diseases complications, Thyroid Diseases pathology, Airway Obstruction microbiology, Aspergillosis complications, Thyroid Diseases microbiology
Abstract

Invasive aspergillosis is a common form of fungal infection in patients with hematological malignancies. Because Aspergillus species have angioinvasive properties, they frequently disseminate from the lung to a variety of organs via hematogenous spread. Extra-pulmonary involvement occurs at an advanced stage of invasive aspergillosis, and represents an ominous sign. However, few reports have been published on extra-pulmonary involvement in cases of aspergillosis. Its clinical features have not been fully clarified. We experienced a patient who developed thyrotoxicosis and fatal airway obstruction caused by invasive aspergillosis of the thyroid. A 26-year-old man was admitted to our hospital for the treatment of non-Hodgkin's lymphoma. During myelosuppression following the chemotherapy, he developed cervical swelling and hyperthyroidism. We suspected lymphoma infiltration to the thyroid, and irradiated it with a total of 26 Gy. However, the cervical lesion enlarged rapidly, and he complained of wheezing and dyspnea. We underwent immediate tracheostomy to secure the airway, but he died. Autopsy findings were striking. Extensive necrosis with diffuse infiltration of Aspergillus hyphae was observed in the thyroid gland. Necrotic tissues of the thyroid protruded into the tracheal lumen, causing airway obstruction. This case demonstrated that invasive aspergillosis of the thyroid can lead to medical emergency.

Published
2002
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