Search

Your search keyword '"U, Deuticke"' showing total 23 results
Start Over Author "U, Deuticke"
23 results on '"U, Deuticke"'

2. Diabetische neuropathische Kachexie

Author

U Deuticke, M Talaulicar, E Kunze, and B Willms

Subjects
medicine.medical_specialty, business.industry, Insulin, medicine.medical_treatment, Glomerulosclerosis, General Medicine, Diabetic retinopathy, medicine.disease, Gastroenterology, Cachexia, Peripheral neuropathy, Weight loss, Internal medicine, Diabetes mellitus, Medicine, medicine.symptom, business, Depression (differential diagnoses)
Abstract

Marked weight loss with cachexia together with severe depression and pain from symmetrical peripheral neuropathy were noted in a 66-year-old man, known to have had diabetes for six years, which required insulin on admission to hospital. The patient died of bronchopneumonia after one year. The severe neuropathy was proven both neurophysiologically and at necropsy. There was no diabetic retinopathy and no histological evidence of renal glomerulosclerosis. There was no evidence of a malignant tumour either clinically or at necropsy.

Published
1979
Full Text
View/download PDF

3. Über das Verhalten von freiem Acetat beim Miniaturschwein

Author

I. Böttger, E. Evertz-Prüsse, O. Wieland, U. Deuticke, and B. D. Ross

Subjects
Gynecology, medicine.medical_specialty, Chemistry, medicine, General Medicine
Abstract

1. Bei einer Gruppe von 16 Miniaturschweinen, die unter Standardbedingungen gehalten wurde, wurde der Acetatspiegel im Blutplasma uber einen Zeitraum von 8 Monaten verfolgt. 2. Der mittlere Plasmaacetatspiegel betrug 195 nMol/ml Plasma, d. i. etwa doppelt so hoch wie beim Menschen. Verfutterung einer fettreichen Diat hatte keinen Einflus auf den Plasmaacetatspiegel. Ebenso ergaben sich keine Unterschiede bei Tieren, die im Stall gehalten wurden, oder die freien Auslauf hatten. 3. Die Enzyme Acetat-Thiokinase und Acetyl-CoA-Deacylase wurden in allen der untersuchten Gewebe angetroffen. Ihre Aktivitat war derjenigen von Rattengeweben vergleichbar. 4. Partikelfreie Extrakte aus Miniaturschweineaorten vermogen Acetat mit etwa gleich groser Geschwindigkeit in langkettige Fettsauren einzubauen wie Extrakte aus Rattenaorten. Die Bedeutung dieser Befunde fur die Entwicklung degenerativer Gefaswandveranderungen wird diskutiert.

Published
1968
Full Text
View/download PDF

4. Eighth annual meeting of the European Association for the Study of Diabetes

Author

K. G. M. M. Alberti, J. Darley, Pauline M. Emerson, T. D. R. Hockaday, M. Amherdt, A. A. Like, B. Blondel, B. Marliss, C. Wollheim, L. Orci, O. Ortved Andersen, Arne Andersson, F. M. Antonini, C. Fumagalli, E. Petruzzi, G. Bertini, S. Mori, P. Tinti, S. J. H. Ashcroft, L. C. C. Weerasinghe, P. J. Randle, R. Assan, N. Slusher, B. Guy-Grand, F. Girard, E. Soufflet, J. R. Attali, G. Ballerio, J. Boillot, T. Atkins, A. J. Matty, C. J. Bailey, A. Aynsley-Green, S. R. Bloom, R. A. Bacchus, L. G. Meade, D. R. London, L. Balant, G. Zahnd, B. Petitpierre, J. Fabre, E. O. Balasse, M. A. Neef, L. Barta, G. Brooser, Maria Molnar, D. P. Bataille, P. Freychet, P. Kitabgi, G. E. Rosselin, Christian Berne, J. Beyer, U. Cordes, G. Sell, C. Rosak, K. Schöffling, B. Birkner, J. Henner, P. Wagner, F. Erhardt, P. Dieterle, N. J. A. Vaughan, A. V. Edwards, L. Boquist, I. Brand, H. D. Söling, D. Brandenburg, J. Gliemann, H. A. Ooms, W. Puls, A. Wollmer, R. A. Camerini-Davalos, J. M. B. Bloodworth, B. Limburg, W. Oppermann, A. K. Campbell, K. Siddle, J. M. Cañadell, J. Barraquer, A. Muiños, C. D. Heredia, J. Castillo-Olivares, J. Guijo, L. F. Pallardo, E. Cerasi, S. Efendić, R. Luft, J. Wahren, P. Felig, Niels Juel Christensen, A. H. Christiansen, A. Vølund, J. J. Connon, E. Trimble, G. Copinschi, R. Leclercq, O. D. Bruno, E. Haupt, C. Creutzfeldt, N. S. Track, G. S. Cuendet, C. B. Wollheim, D. P. Cameron, W. Stauffacher, E. B. Marliss, A. Czyzyk, B. Lao, W. Bartosiewicz, Z. Szczepanik, E. De Nobel, A. Van't Laar, R. A. P. Koene, Th. J. Benraad, G. Dietze, K. D. Hepp, M. Wickmayr, H. Mehnert, K. Dixon, P. D. Exon, H. R. Hughes, D. W. Jones, R. S. Elkeles, M. G. FitzGerald, J. M. Malins, A. Falorni, F. Massi-Benedetti, G. Gallo, S. Maffei, D. Fedele, A. Tiengo, M. Muggeo, P. Fabris, G. Crepaldi, K. Federlin, K. Helmke, M. Slijepčević, E. F. Pfeiffer, J. P. Felber, J. Oulès, Ch. Schindler, V. Chabot, A. Fernandez-Cruz, E. Catalán, M. Luque Otero, O. Garcia Hermida, J. P. Flatt, G. Blackburn, G. Randers, H. Förster, I Hoos, D. Lerche, I. Hoos, M. Matthäus, J. R. M. Franckson, H. Frerichs, H. Daweke, F. Gries, D. Grüneklee, J. Hessing, K. Jahnke, U. Keup, H. Miss, H. Otto, D. Schmidt, C. Zumfelde, H. v. Funcke, G. Löffler, O. Wieland, D. J. Galton, R. Guttman, G. C. Gazzola, R. Franchi, P. Ronchi, V. Saibene, G. G. Guidotti, V. Gligore, N. Hîncu, Rodica Tecuceanu, R. Goberna, F. Garcia-Albertos, J. Tamarit-Rodriguez, E. del Rio, R. Roca, José Gomez-Acebo, A. V. Creco, G. Fedeli, G. Ghirlanda, R. Fenici, M. Lucente, A. Gutman, G. Agam, N. Nahas, P. Cazalis, E. Gylfe, B. Hellman, D. R. Hadden, J. H. Connolly, D. A. D. Montgomery, J. A. Weaver, Claes Hellerström, Simon Howell, John Edwards, J. Sehlin, I. -B. Täljedal, W. Heptner, H. B. Neubauer, A. Herchuelz, D. G. Pipeleers, W. J. Malaisse, E. Herrera, Eladio Montoya, H. Hommel, IT. Fischer, B. Schmid, H. Fiedler, H. Bibergeil, J. Iversen, P. B. Iynedjian, G. Peters, C. Jacquemin, B. Lambert, B. Ch. J. Sutter, A. Jakob, J. Zapf, E. R. Froesch, F. K. Jansen, G. Freytag, L. Herberg, R. J. Jarrett, I. A. Baker, C. Jarrousse, F. Rancon, D. Job, G. Tchobroutsky, E. Eschwege, C. Guyot-Argenton, J. P. Aubry, M. Déret, H. Karman, P. Mialhe, A. Kissebah, B. Tulloch, Russell Fraser, N. Vydelingum, J. Kissing, S. Raptis, H. Dollinger, J. Faulhaber, G. Rothenbuchner, J. Kleineke, H. Sauer, J. Kloeze, Eva M. Kohner, Barbara A. Sutcliffe, M. Tudball, C. T. Dollery, W. Korp, J. Neubert, H. Bruneder, A. Lenhardt, R. E. Levett, T. Koschinsky, F. A. Gries, M. M. C. Landgraf-Leurs, R. Landgraf, R. Hörl, D. R. Langslow, H. Laube, R. Fussgänger, R. Mayer, H. Klör, E. Lázaro, V. Leclercq-Meyer, J. J. Marchand, W. Malaisse, Thomas Ledet, P. J. Lefébvre, A. S. Luyckx, Y. Le Marchand, F. Assimacopoulos, A. Singh, Ch. Rouiller, B. Jeanrenaud, G. Lenti, R. Frezzotti, G. Angotzi, A. M. Bardelli, G. Pagano, A. Basetti-Sani, M. Galli, Å. Lernmark, G. Fex, D. G. Lindsay, O. Loge, C. Lopez-Quijada, L. Chiva, M. Rodriguez-Lopez, E. G. Loten, A. L. Loubatières, M. M. Loubatières-Mariani, G. Ribes, J. Chapal, J. Lubetzki, J. Duprey, Cl. Sambourg, P. J. Lefebvre, V. Maier, M. Hinz, H. Schatz, C. Nierle, F. Malaisse-Lagae, M. Ravazzola, A. E. Renold, P. Manzano, E. Rojas-Hidalgo, J. Marco, D. Diaz-Fierros, C. Calle, D. Roman, M. L. Villanueva, I. Valverde, A. Like, A. L. Luycks, F. Fracassini, R. Menzel, D. Michaelis, I. Neumann, B. Schulz, W. Wilke, P. Wulfert, K. Krämer, G. Menzinger, F. Fallucca, F. Tamburrano, R. Carratu', D. Andreani, P. Metzger, P. Franken, R. Michael, W. Hildmann, E. Jutzi, J. Michl, S. Fankhauser, J. Schlichtkrull, J. Mirouze, A. Orsetti, Y. Vierne, N. Arnoux, L. Mølsted-Pederson, Inge Tygstrup, Åge L. Villumsen, Jørgen Pedersen, W. Montague, S. L. Howell, A. J. Moody, G. S. Agerbak, F. Sundby, A. Baritussio, Peter Naeser, R. Navalesi, A. Pilo, S. Lenzi, P. Cecchetti, G. Corsini, L. Donato, J. Nerup, G. Bendixen, J. Egeberg, J. E. Poulsen, J. Høiriis Nielsen, F. Mølgaard Hansen, A. Niki, H. Niki, T. Koide, B. J. Lin, R. E. Nikkels, J. Terpstra, A. Gay, R. H. Oakman, Norman R. Lazarus, C. Rouiller, J. Ostman, L. Backman, D. Hallberg, K. Ostrowski, U. Panten, J. Christians, H. -H. Parving, S. Munkgaard Rasmussen, M. Marichal, H. Platilovà, M. Dufek, E. Konopàsek, V. Pozuelo, J. Tamarit, A. Suner, C. Castell, E. D. R. Pruett, S. Maehlum, B. Grebe, M. Chrissiku, R. Müller, H. J. Hinze, H. Reinauer, E. R. Müller-Ruchholtz, X. Rietzler, P. Passa, J. Canivet, J. Otto, G. Behrens, T. Bücher, U. Schlumpf, B. Morell, A. Zingg, J. Schönborn, P. Westphal, G. D. Bloom, L. -A. Idahl, A. Lernmark, M. Söderberg, M. Serrano Rios, F. G. Hawkins, F. Escobar, J. M. Mato, L. Larrodera, M. de Oya, J. L. Rodriguez-Miñon, E. Shafrir, G. Sitbon, Z. Skrabalo, N. Panajatović, Z. Papić, J. Posinovec, A. Stavljenić, V. Lipovac, I. Aganović, N. G. Soler, M. A. Bennett, H. Peters, G. Janson, P. H. Sönksen, M. C. Srivastava, C. V. Tompkins, J. D. N. Nabarro, N. Schwartz Sørensen, K. Ladefoged, K. E. Wildenhoff, F. Sorge, H. -J. Diehl, H. Hoffmann, W. Schwartzkopff, E. Standl, H. Kolb, A. Standl, H. W. Sutherland, J. M. Stowers, J. C. G. Whetham, B. C. J. Sutter, B. Billaudel, M. T. Sutter-Dub, R. Jacquot, I. B. Täljedal, R. Gobema, Gy. Tamás, Éva Baranyi, A. Baranyi, A. Radvanyi, J. Tatoń, A. Hinek, A. Wiśniewska, R. B. Tattersall, D. A. Pyke, J. Bruins Slot, P. L. M. v. d. Sande, J. K. Radder, K. J. J. Waldeok, R. C. P. A. v. Muijden, W. Creutzfeldt, D. S. Turner, R. W. Baker, W. G. L. Gent, A. Shabaan, V. Marks, D. A. B. Young, Ph. Vague, H. Heim, C. Martin Laval, M. Vegezzi, C.Di Campo, G. Rahamandridona, D. Garron, B. Heyraud, J. Vague, I. Lozano, M. Diaz-Fierros, F. A. Van Assche, W. Gepts, E. Van Obberghen, G. Somers, G. Devis, G. D. Vaughan, J. Veleminsky, E. Spirova, W. Waldhäusl, H. Frisch, H. Haydl, L. Weiss, B. Willms, U. Deuticke, M. Zrůstová, and J. Roštlapil

Subjects
0303 health sciences, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Association (object-oriented programming), 030209 endocrinology & metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, medicine, business, 030304 developmental biology
Published
1973
Full Text
View/download PDF

5. Seventh Annual Meeting of the European Association for the Study Of Diabetes Southampton, England, September 15–17, 1971 Abstacts, Part 1

Author

H. Bibergeil, W. J. H. Butterfield, F. Fallucca, H. Brunengraber, M. J. Munday, Eveline Eschwège, M. Hinz, J. Rogers, O. Richter, J. Hanoune, B. Jeanrenaud, Kjell Asplund, H. Laube, G. Stirati, G. Ghirlanda, C. Dumitrescu, Aa. Hein Christiansen, I. Pencev, L. Nye, S. Ditzov, Claes Hellerström, L. Bodic, V. Gligore, G. Brooser, I. Mastrogiacomo, K. W. Taylor, R. Franchi, R. Fussgänger, L. Stoichescu, Y. Vierne, B. Charbonnel, L. Sjöström, J. Girard, E. Jéquier, U. Fischer, George E, O. Alpi, G. C. Gazzola, M. Austoni, G. Ballerio, F. K. Jansen, G. Chiumello, G. G. Guidotti, J. G. Mills, L. Baldet, Elizabeth Mayne, S. Munkgaard Rasmussen, G. Tamburrano, P. Zöfel, A. Luyckx, M. Carnelutti, U. Cordes, H. Hommel, J. P. Felber, R. Luft, Aa. Vø und, F. Mira, V. Chabot, I. Calusera, S. Frezzato, J. Guillon, J. Terpstra, R. Michael, Brigitte Ziegler, L. Anghelescu, Ernst-Friedrich Pfeiffer, Aa. Vølund, S. Nistrup Madsen, M. Miclutia, S. E. Brolin, G. Freytag, J. Linde, W. D. Gassel, A. Fernandez-CruzJr., M. Ionesou, W. Creutzfeldt, A. Hegedüs, U. Deuticke, J. B. Attali, J. F. Biebuyck, L. Kerp, Gh. Bacanu, J. J. Connon, H. Fiedler, K. E. Schröder, G. Fedeli, N. Katsilambros, S. K. Varma, K. G. M. M. Alberti, Günter Klöppel, E. Napoli, Margaret J. Whichelow, G. A. Cinotti, B. Bierens de Haan, M. J. del Guercio, B. Bruni, G. Tchobroutsky, G. Perry, N. Mosora, L. Papoz, M. Bolea-Feldman, K. D. Hepp, N. Sicolo, F. A. Gries, G. Cavazzini, A. Fernandes-CruzJr., D. Bal, A. C. Asmal, M. Ziegler, Beyer J, J. Lawecki, D. Grüneklee, H. Daweke, Barbara Rudas, J. J. Turner, B. Schröder, K. D. Buchanan, G. Sell, K. Mylarch, T. Holan, E. Capra, S. Fankhauser, E. O. Baiasse, E. Bruck, C. Creutzfeldt, F. Belfiore, J. M. Warnet, S. Campeami, G. Menzinger, L. Olteanu, K. Bojanowicz, J. A. Weaver, T. Fekete, L. Herberg, O. Wieland, M. Varma, V. Turcanu, John Edwards, F. Gomez, M. Rathery, Y. Abdel Rahman, S. J. H. Ashcroft, C. J. Vardey, T. Deckert, P. Lefebvre, D. Andreani, M. Zaccaria, N. Sieolo, Raimundo Goberna, D. P. M. Howells, D. Andreev, B. Karamanos, F. Nistor, S. W. Cushman, Hung Cheng, J. J. Heindel, G. Piemonte, Jean Franckson, R. R. de Mowbray, W. Guder, B. D. Cox, Etienne Brachet, L. Boquist, W. Stauffacher, T. Beraru, M. Luque Otero, N. Krall, J. Hahn, Ch. Rouiller, L. Sirskov, V. Maier, L. Orci, C. Lopiz-Quijada, C. Coscelli, W. G. Whyte, W. Rippel, V. Büber, J. Fövenyi, A. Gnudi, V. Palmari, R. K. Blach, P. W. Adams, J. Iversen, A. J. Valleron, P. Ronchi, H. Rogala, E. Goth, Niels Juel Christensen, J. G. Devlin, U. Keller, H. Keen, R. Leclercq, D. P. Cameron, C. Geldermans, J. Kuti, F. Assimacopoulos, R. A. Jackson, Åke Lernmark, E. Jutzi, N. W. Oakley, H. Schatz, J. P. Aboulker, J. L. Richard, L. Campeanu, R. A. Bacchus, R. Assan, A. Serban, S. J. Heaney, I. De Leeuw, R. Fenici, R. S. Walker, M. Amherdt, A. Z. Middelheim, D. Casara, L. Lo Vecchio, H. M. J. Krans, J. M. Bassett, L. B. Martin, N. S. Track, J. Sehlin, J. Mirouze, E. Cerasi, George Gross, T. Clausen, R. M. Buckle, A. Aynsley-Green, B. Hellman, U. Advani, D. Pometta, L. Barta, V. V. Pipilian, U. Heink, E. Rattenhuber, R. Arnold, S. Efendic, H. Kaffarnik, Christian Berne, A. Kaeding, S. R. Bloom, S. D. Garner, V. Wynn, C. A. Geser, A. V. Greco, S. Triggs, G. C. Reffo, C. Jafflol, W. J. H. Butterfieid, D. R. Hadden, H. J. Hahn, R. Vanroux, C. De Palo, G. Federspil, L. G. Meade, Henri Ooms, D. Ancreev, Mária Judit Molnár, U. Birk Lauridsen, I. B. Täljedal, P. Björntorp, J. Michl, B. Petersson, A. Czyzyk, R. J. Jarrett, S. Steinhilber, D. R. London, J. R. Scherrer, O. Förster, G. Gambassi, Schöffling K, H. Frerichs, D. A. D. Montgomery, E. Saibene, M. Javicoli, J. Hessing, M. Szadkowski, W. H. Davies, N. Tarkolev, P. J. Randle, C. Scandellari, and E. R. Froesch

Subjects
0303 health sciences, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Family medicine, Diabetes mellitus, Internal Medicine, medicine, Optometry, business, 030304 developmental biology
Published
1971
Full Text
View/download PDF

6. Biochemical and morphological investigations of 30 human insulinomas

Author

U. Deuticke, N. S. Track, Rudolf Arnold, C. Creutzfeldt, H. Frerichs, and Werner Creutzfeldt

Subjects
endocrine system, medicine.medical_specialty, Pathology, Adenoma, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, medicine, Diazoxide, Insulinoma, 030304 developmental biology, Proinsulin, 0303 health sciences, geography, geography.geographical_feature_category, business.industry, Insulin, medicine.disease, Islet, 3. Good health, Endocrinology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Ultrastructure, Pancreas, business, medicine.drug
Abstract

Thirty human insulinomas have been investigated histologically and their immunoreactive insulin (IRI) content estimated. In most cases immunohistological and ultrastructural studies were also performed and the percentage of proinsulin-like components (PLC) in the tumour determined. Except for 1 case the IRI concentration in the tumours was lower (0.01–89.0 U/g) than in the islet tissue. Histologically, immunohistologically and ultrastructurally a variable number of tumour cells contained few and often no beta-granules, indicating a decreased storage capacity for insulin. This defective storage capacity seems to be the major functional abnormality of insulinoma cells. Ultrastructurally four types of insulinoma can be distinguished. The ultra-structural diagnosis of an insulinoma can only be made in type I (typical beta-granules, 13 cases) and type II (typical and atypical granules, 7 cases) but not in type III (atypical granules only, 4 cases) and type IV (virtually agranular, 4 cases). The type IV tumours had the lowest IRI concentration and did not respond to diazoxide treatment. The IRI concentration of the uninvolved pancreas of 19 patients was 2.0±0.2 U/g and in the range of non-diabetic adults. — The percentage PLC in 19 insulinomas was higher (5.3–22%) than in the pancreas of human adults with and without insulinoma (1.7–4.8%). The percentage of PLC in the serum of patients with insulinoma was always higher than in their tumours (33–61%). It is suggested that the higher PLC levels found in the tumour and serum of insulinoma patients are the consequence of the reduced storage capacity of the tumour cells resulting in a rapid passage through the granular route or even a non-granular release of newly synthesized insulin.

Published
1973
Full Text
View/download PDF

7. Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides

Author

B. Willms, W. Reimold, D. Emrich, U. Deuticke, I. Zavada, and W. F. Caspary

Subjects
Vitamin, Male, medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Glycocholic acid, Biguanides, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Phenformin, 03 medical and health sciences, chemistry.chemical_compound, Feces, 0302 clinical medicine, Schilling test, Internal medicine, Internal Medicine, medicine, Diabetes Mellitus, Humans, Vitamin B12, Buformin, Bile acid, medicine.diagnostic_test, Chemistry, Bile acid malabsorption, Cholic Acids, Carbon Dioxide, Middle Aged, medicine.disease, Metformin, 3. Good health, Vitamin B 12, Endocrinology, Doxycycline, Female, Glycocholic Acid, medicine.drug
Abstract

Since vitamin B12malabsorption has been described in diabetics on biguanides and inhibition of bile acid absorption found in rat ileum the effect of treatment with different biguanides (phenformin, buformin, metformin) on bile acid metabolism and vitamin B12 absorption was assessed in maturity onset diabetics. Biguanides did not alter faecal weight or faecal fat excretion, but they decreased faecal bile acid excretion. All biguanides tested increased deconjugation of glycocholic acid, as determined by a simple breath test technique. Vitamin B12 malabsorption was most prominent in patients on metformin. Discontinuation of biguanide treatment, or administration of antibiotics, normalized or improved the increased deconjugation of bile acids and the Schilling test. Decreased faecal bile acid excretion, positive 14C-glycocholate breath tests, pathological Schilling tests and the reversal of pathological tests by antibiotic treatment suggest that small intestinal bacterial overgrowth, leading to binding of the intrinsic-factor-vitamin B12-complex to bacteria, is responsible for the previously observed pathological Schilling tests in diabetics on biguanides. Bile acid malabsorption, possibly responsible for the cholesterol-lowering effect of biguanides, does not occur in diabetics on biguanides. Whether qualitative changes in small intestinal bile acid composition might affect cholesterol metabolism remains to be determined.

Published
1977

8. [Diabetic neuropathic cachexia (author's transl)]

Author

B, Willms, M, Talaulicar, U, Deuticke, and E, Kunze

Subjects
Diabetes Complications, Male, Cachexia, Diabetic Neuropathies, Depression, Humans, Pain, Autopsy, Aged
Abstract

Marked weight loss with cachexia together with severe depression and pain from symmetrical peripheral neuropathy were noted in a 66-year-old man, known to have had diabetes for six years, which required insulin on admission to hospital. The patient died of bronchopneumonia after one year. The severe neuropathy was proven both neurophysiologically and at necropsy. There was no diabetic retinopathy and no histological evidence of renal glomerulosclerosis. There was no evidence of a malignant tumour either clinically or at necropsy.

Published
1979

9. Biochemical and morphological investigations of 30 human insulinomas. Correlation between the tumour content of insulin and proinsulin-like components and the histological and ultrastructural appearance

Author

W, Creutzfeldt, R, Arnold, C, Creutzfeldt, U, Deuticke, H, Frerichs, and N S, Track

Subjects
Adult, Immunoassay, Male, Histocytochemistry, Diazoxide, Middle Aged, Adenoma, Islet Cell, Cytoplasmic Granules, Pancreatic Neoplasms, Microscopy, Electron, Insulin Secretion, Chromatography, Gel, Humans, Insulin, Female, Pancreas, Aged, Proinsulin
Published
1973

10. Immunohistologic investigations of human insulinomas

Author

Werner Creutzfeldt, U. Deuticke, H. Frerichs, and Rudolf Arnold

Subjects
medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Biology, Stain, Glucagon, Antibodies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, Carcinoma, medicine, Humans, Insulin, Insulinoma, Pancreas, 030304 developmental biology, Antiserum, Immunoassay, 0303 health sciences, geography, geography.geographical_feature_category, Histocytochemistry, medicine.disease, Islet, Adenoma, Islet Cell, 3. Good health, Pancreatic Neoplasms, Endocrinology, medicine.anatomical_structure, Peroxidases, 030220 oncology & carcinogenesis, Peptides
Abstract

14 insulinomas were examined immunohistologically using the peroxidase labelled antibody method. 8 tumours were investigated immediately after extirpation. 7 of these reacted with insulin and porcine-C-peptide antisera but not with glucagon antiserum. Only a B-cell carcinoma with an unusually low insulin concentration was negative. One year after embedding in paraffin the immunohistologic reaction with insulin antiserum had markedly decreased in the tumours; however, not in the islet of the adjacent pancreas. From 6 patients 1 to 4 years old paraffin-embedded material of the tumour and the normal pancreas was available. In this group 4 tumours with an elevated insulin concentration reacted immunohistologically only weakly with an insulin antiserum and two tumours (one with high and one with low insulin concentration were immunohistologically negative, while the islets of the adjacent panceas of all six cases showed a strong reaction. Thus the immunohistilogic reaction of insulin in B-cell tumours but not in normal islets depends on the time elapsed between the paraffin embedding and the examination. Only tumours fixed in Bouin's fluid but not in Karnovsky's solution gave a positive immunohistologie reaction, while the islets of the adjacent pancreas reacted positively also after fixation in Karnovsky's solution. These findings suggest differences between the normal and the tumour insulin. A correlation between aldehyde-thionin stain and immunohistology indicates the superiority of immunohistology in identifying insulin producing tumour cells.

Published
1972

14. [Adverse effect of oral antidiabetics: hypoglycemia]

Author

H, Frerichs, U, Deuticke, and W, Creutzfeldt

Subjects
Blood Glucose, Male, Time Factors, Liver Diseases, Age Factors, Middle Aged, Hypoglycemia, Acute Disease, Glyburide, Humans, Hypoglycemic Agents, Drug Interactions, Female, Kidney Diseases, Aged, Half-Life
Published
1973

16. Alteration of bile acid metabolism and vitamin-B12-absorption in diabetics on biguanides.

Author

Caspary WF, Zavada I, Reimold W, Deuticke U, Emrich D, and Willms B

Subjects
Buformin therapeutic use, Carbon Dioxide metabolism, Doxycycline therapeutic use, Feces analysis, Female, Humans, Male, Metformin therapeutic use, Middle Aged, Phenformin therapeutic use, Biguanides therapeutic use, Cholic Acids metabolism, Diabetes Mellitus drug therapy, Glycocholic Acid metabolism, Vitamin B 12 metabolism
Abstract

Since vitamin B12malabsorption has been described in diabetics on biguanides and inhibition of bile acid absorption found in rat ileum the effect of treatment with different biguanides (phenformin, buformin, metformin) on bile acid metabolism and vitamin B12 absorption was assessed in maturity onset diabetics. Biguanides did not alter faecal weight or faecal fat excretion, but they decreased faecal bile acid excretion. All biguanides tested increased deconjugation of glycocholic acid, as determined by a simple breath test technique. Vitamin B12 malabsorption was most prominent in patients on metformin. Discontinuation of biguanide treatment, or administration of antibiotics, normalized or improved the increased deconjugation of bile acids and the Schilling test. Decreased faecal bile acid excretion, positive 14C-glycocholate breath tests, pathological Schilling tests and the reversal of pathological tests by antibiotic treatment suggest that small intestinal bacterial overgrowth, leading to binding of the intrinsic-factor-vitamin B12-complex to bacteria, is responsible for the previously observed pathological Schilling tests in diabetics on biguanides. Bile acid malabsorption, possibly responsible for the cholesterol-lowering effect of biguanides, does not occur in diabetics on biguanides. Whether qualitative changes in small intestinal bile acid composition might affect cholesterol metabolism remains to be determined.

Published
1977
Full Text
View/download PDF

18. Biochemical and morphological investigations of 30 human insulinomas. Correlation between the tumour content of insulin and proinsulin-like components and the histological and ultrastructural appearance.

Author

Creutzfeldt W, Arnold R, Creutzfeldt C, Deuticke U, Frerichs H, and Track NS

Subjects
Adenoma, Islet Cell pathology, Adult, Aged, Chromatography, Gel, Cytoplasmic Granules, Diazoxide pharmacology, Female, Histocytochemistry, Humans, Immunoassay, Insulin blood, Insulin metabolism, Insulin Secretion, Male, Microscopy, Electron, Middle Aged, Pancreas analysis, Proinsulin analysis, Proinsulin blood, Adenoma, Islet Cell metabolism, Insulin analysis, Pancreatic Neoplasms metabolism
Published
1973
Full Text
View/download PDF

20. [Adverse effect of oral antidiabetics: hypoglycemia].

Author

Frerichs H, Deuticke U, and Creutzfeldt W

Subjects
Acute Disease, Age Factors, Aged, Blood Glucose analysis, Drug Interactions, Female, Glyburide adverse effects, Half-Life, Humans, Hypoglycemic Agents metabolism, Kidney Diseases complications, Liver Diseases complications, Male, Middle Aged, Time Factors, Hypoglycemia chemically induced, Hypoglycemic Agents adverse effects
Published
1973

23. Immunohistologic investigations of human insulinomas.

Author

Arnold R, Deuticke U, Frerichs H, and Creutzfeldt W

Subjects
Adenoma, Islet Cell pathology, Antibodies, Glucagon analysis, Histocytochemistry, Humans, Immunoassay, Pancreas analysis, Pancreatic Neoplasms pathology, Peptides analysis, Peroxidases, Adenoma, Islet Cell metabolism, Insulin analysis, Pancreatic Neoplasms metabolism
Published
1972
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results