Search

Your search keyword '"Tzvi, Elinor"' showing total 33 results
Start Over Author "Tzvi, Elinor"
33 results on '"Tzvi, Elinor"'

13. Visuomotor Adaptation Deficits in Patients with Essential Tremor

Author

Bindel, Laura, primary, Mühlberg, Christoph, additional, Pfeiffer, Victoria, additional, Nitschke, Matthias, additional, Müller, Annekatrin, additional, Wegscheider, Mirko, additional, Rumpf, Jost-Julian, additional, Zeuner, Kirsten E., additional, Becktepe, Jos S., additional, Welzel, Julius, additional, Güthe, Miriam, additional, Classen, Joseph, additional, and Tzvi, Elinor, additional

Published
2022
Full Text
View/download PDF

18. Motor Sequence Learning Deficits in Idiopathic Parkinson’s Disease Are Associated With Increased Substantia Nigra Activity

Author

Tzvi, Elinor, Bey, Richard, Nitschke, Matthias, Brüggemann, Norbert, Classen, Joseph, Münte, Thomas F., Krämer, Ulrike M., and Rumpf, Jost-Julian

Subjects
Parkinson’s disease, motor sequence learning, fMRI, dynamic causal modeling, substantia nigra, hippocampus, ddc:610
Abstract

Previous studies have shown that persons with Parkinson’s disease (pwPD) share specific deficits in learning new sequential movements, but the neural substrates of this impairment remain unclear. In addition, the degree to which striatal dopaminergic denervation in PD affects the cortico-striato-thalamo-cerebellar motor learning network remains unknown. We aimed to answer these questions using fMRI in 16 pwPD and 16 healthy age-matched control subjects while they performed an implicit motor sequence learning task. While learning was absent in both pwPD and controls assessed with reaction time differences between sequential and random trials, larger error-rates during the latter suggest that at least some of the complex sequence was encoded. Moreover, we found that while healthy controls could improve general task performance indexed by decreased reaction times across both sequence and random blocks, pwPD could not, suggesting disease-specific deficits in learning of stimulus-response associations. Using fMRI, we found that this effect in pwPD was correlated with decreased activity in the hippocampus over time. Importantly, activity in the substantia nigra (SN) and adjacent bilateral midbrain was specifically increased during sequence learning in pwPD compared to healthy controls, and significantly correlated with sequence-specific learning deficits. As increased SN activity was also associated (on trend) with higher doses of dopaminergic medication as well as disease duration, the results suggest that learning deficits in PD are associated with disease progression, indexing an increased drive to recruit dopaminergic neurons in the SN, however, unsuccessfully. Finally, there were no differences between pwPD and controls in task modulation of the cortico-striato-thalamo-cerebellar network. However, a restricted nigral-striatal model showed that negative modulation of SN to putamen connection was larger in pwPD compared to controls during random trials, while no differences between the groups were found during sequence learning. We speculate that learning-specific SN recruitment leads to a relative increase in SN- > putamen connectivity, which returns to a pathological reduced state when no learning takes place

Published
2021

33. Cerebellar degeneration affects cortico-cortical connectivity in motor learning networks.

Author

Tzvi E, Zimmermann C, Bey R, Münte TF, Nitschke M, and Krämer UM

Subjects
Adult, Aged, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Status Schedule, Middle Aged, Models, Neurological, Nerve Net diagnostic imaging, Neural Pathways diagnostic imaging, Reaction Time, Brain Mapping, Cerebellar Ataxia pathology, Cerebellar Ataxia physiopathology, Cerebral Cortex pathology, Learning physiology, Motor Activity physiology, Nerve Net physiopathology
Abstract

The cerebellum plays an important role in motor learning as part of a cortico-striato-cerebellar network. Patients with cerebellar degeneration typically show impairments in different aspects of motor learning, including implicit motor sequence learning. How cerebellar dysfunction affects interactions in this cortico-striato-cerebellar network is poorly understood. The present study investigated the effect of cerebellar degeneration on activity in causal interactions between cortical and subcortical regions involved in motor learning. We found that cerebellar patients showed learning-related increase in activity in two regions known to be involved in learning and memory, namely parahippocampal cortex and cerebellar Crus I. The cerebellar activity increase was observed in non-learners of the patient group whereas learners showed an activity decrease. Dynamic causal modeling analysis revealed that modulation of M1 to cerebellum and putamen to cerebellum connections were significantly more negative for sequence compared to random blocks in controls, replicating our previous results, and did not differ in patients. In addition, a separate analysis revealed a similar effect in connections from SMA and PMC to M1 bilaterally. Again, neural network changes were associated with learning performance in patients. Specifically, learners showed a negative modulation from right SMA to right M1 that was similar to controls, whereas this effect was close to zero in non-learners. These results highlight the role of cerebellum in motor learning and demonstrate the functional role cerebellum plays as part of the cortico-striato-cerebellar network.

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results