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The sedimentation rate in the northeastern South China Sea (SCS) is high and it therefore offers an opportunity for a high-resolution paleoceanographic study. This study is based on high-resolution AMS 14C dating on forams and oxygen isotope data of two planktonic foraminifera species (Globigerinoides ruber and Neogloboquadrina dutertrei) from the sediment core, MD18-3568, collected from the northeastern SCS, to reconstruct upper-ocean stratification since 35 ka.The marine sediment core MD18-3568 is located on the accretionary wedge off SW Taiwan at a water depth of 1,315 m, the whole core is dominated by hemipelagic sediments and is of 20.7 m in length. Samples for AMS 14C dating were selected at roughly 2 ka interval with a total of 16 samples. The ages show a continuously younging-upward trend with bottom of this core around 35,000 years BP. Samples for high-resolution oxygen isotope measurements were selected at a nominal 500-year age interval. The difference in δ18O between G. ruber (mixed layer dwelling species) and N. dutertrei (thermocline dwelling species) is used to reconstruct the upper ocean stratification with large difference indicating significant ocean stratification and vice versa. The results show moderate upper ocean stratification during 35-24 ka, and it became less stratified during the Last Glacial Maximum (LGM, 23-19 ka). During the deglacial stage, the stratification gradually became stronger until the early Holocene (12-9 ka), and it has kept strong upper-ocean stratification since 9 ka. Literature has documented less rainfall intensity during the LGM and heavy rainfall during the Holocene in southern Taiwan. We interpret the upper-ocean stratification in the NE South China Sea near Taiwan is linked to the amount of freshwater inputs from Taiwan. Less Taiwan freshwater input during the LGM led to a weak stratified upper ocean and a large amount of freshwater input from Taiwan led to a strong upper-ocean stratification during the Holocene.

We report a high-risk cachexia patient receiving special regional anesthesia in a colostomy operation. Because of multiple underlying diseases and severe malnutrition status, we combined epidural anesthesia (EA) with transversus abdominis plane (TAP) block. Low concentration EA (Lidocaine 1% as test dose and rescue dose; Bupivacaine 0.2% as loading and maintenance dose) aimed for visceral pain; subcostal TAP block (Bupivacaine 0.25%) focused on the skin incision. The colostomy was done completely without any complication. Our case showed that low concentration EA combined with TAP block provided stable and sufficient anesthesia and could be a sole anesthesia technique in a colostomy.

Invariant NKT (iNKT) cells bridge innate and adaptive immune responses, resulting in the expansion of Ag-specific B and T cell responses. α-Galactosylceramide (α-GalCer), the most studied glycolipid that activates iNKT cells, has been proposed to be an effective adjuvant against infections and tumors. We found that the activation of iNKT cells by intranasal injection of α-GalCer induced airway eosinophilia in naive mice. Eosinophils, which mediate tissue damage and dysfunction by secreting mediators, play important roles in the pathogenesis of allergic diseases. In this study, we investigated the mechanism of how eosinophils are recruited to the lung by α-GalCer. Our results demonstrated that α-GalCer–induced eosinophil inflammation was mediated through iNKT cells. These cells secreted IL-5 to recruit eosinophils directly to the lung and/or secreted IL-4 and IL-13 to recruit eosinophils indirectly by inducing lung epithelial cells, endothelial cells, and fibroblast to secrete the eosinophil chemoattractant eotaxin. In addition, in the OVA-alum murine model of allergic asthma, α-GalCer administration in OVA-immunized mice also increased airway eosinophilia after challenge. Given our findings, intranasal administration of α-GalCer induced airway eosinophilic inflammation in both naive and allergic mice. Hence, it remains to be determined whether the activation of iNKT cells would be applicable in therapeutics for human diseases.