82 results on '"Tzu Ching Lin"'
Search Results
2. Long-term complications and outcomes of augmentation cystoplasty in children with neurogenic bladder
- Author
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Jei-Wen Chang, Fang-Cheng Kuo, Tzu-Ching Lin, Tai-Wai Chin, Ling-Yu Yang, Hsin-Hung Chen, Yu-Hua Fan, Hui-Hsin Yang, Chin-Su Liu, and Hsin-Lin Tsai
- Subjects
Augmentation cystoplasty ,Complication ,Neurogenic bladder ,Pediatric ,Medicine ,Science - Abstract
Abstract Augmentation cystoplasty (AC) is an effective surgical procedure for patients with neurogenic bladder whenever conservative treatments have failed. The present study aimed to determine the risks of metabolic complications, malignancy, long-term outcomes and histopathologic changes of native bladder and the augmented intestine after AC in children with neurogenic bladder. Pediatric patients 10 years, no cases of malignancy or metaplastic changes were identified in the native bladder or augmented bowel epithelium. AC is a safe and effective procedure with low surgical and metabolic complication rates. In addition, AC provides a satisfactory continence rate and long-term protection of renal function, increases functional capacity, and regresses reflux and hydronephrosis. Individualized surveillance is recommended for the early identification of urolithiasis and metabolic disturbances.
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- 2024
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3. Risk factors for fractures following liver transplantation: a population-based cohort study
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Jei-Wen Chang, Hui-Hsin Yang, Niang-Cheng Lin, Fang-Cheng Kuo, Tzu-Ching Lin, and Hsin-Lin Tsai
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Fracture ,glucocorticoid ,hepatitis B ,hepatitis C ,immunosuppressant ,liver transplantation ,Medicine - Abstract
AbstractBackground Liver transplant recipients have an increased risk of osteoporosis and fractures. The aim of this study was to identify risk factors for fractures after liver transplant in a Taiwanese population.Methods We identified newly diagnosed liver transplant recipients from the National Health Insurance Research Database in Taiwan between 2003 and 2015. Risk factors of post-transplant fractures were analyzed using a Cox proportional hazards model.Results A total of 4821 patients underwent liver transplantation, of whom 419 (8.7%) had post-transplant fractures. Independent predictors of post-transplant fractures were age ≥65 years at transplantation (hazard ratio (HR): 1.566; 95% confidence interval (CI) 1.122–2.186), female sex (HR: 1.648; 95% CI 1.319–2.057), fractures within 1 year prior to transplant (HR: 3.664; 95% CI 2.503–5.364), hepatitis C carriers (HR: 1.594; 95% CI 1.289–1.970), alcoholism (HR: 1.557; 95% CI 1.087–2.230) and daily prednisolone dose >1.61–3.78 mg/day (HR: 1.354; 95% CI 1.005–1.824), >3.78–9.18 mg (HR: 4.182; 95% CI 3.155–5.544) and >9.18 mg (HR: 13.334; 95% CI 9.506–18.703). Post-transplant fractures were inversely correlated with tacrolimus (HR: 0.617; 95% CI 0.417–0.913) and sirolimus/everolimus (HR: 0.504; 95% CI 0.391–0.650) treatment.Conclusions The liver transplant recipients, and especially those who were aged ≥65 years, female, hepatitis C carriers, had a history of fractures within 1 year prior to transplant, alcoholism, and higher daily prednisolone dose were associated with an increased risk of post-transplant fractures. Conversely, the use of tacrolimus and sirolimus/everolimus was associated with a decreased risk of fractures.
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- 2023
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4. Efficient Weighted and Balanced Resource Allocation for High-Performance Render Farms.
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Lung-Pin Chen, Fang-Yie Leu, Chia-Chen Kuo, Tzu-Ching Lin, and Ming-Jen Wang
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- 2022
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5. Deep Learning-based Diagnosis and Localization of Pneumothorax on Portable Supine Chest X-ray in Intensive and Emergency Medicine: A Retrospective Study.
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Chih-Hung Wang, Tzu-Ching Lin, Guanru Chen, Meng-Rui Lee, Joyce Tay, Cheng-Yi Wu, Meng-Che Wu, Holger R. Roth, Dong Yang 0005, Can Zhao 0001, Weichung Wang, and Chien-Hua Huang
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- 2024
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6. Application of Deep Learning Techniques for Detection of Pneumothorax in Chest Radiographs
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Lawrence Y. Deng, Xiang-Yann Lim, Tang-Yun Luo, Ming-Hsun Lee, and Tzu-Ching Lin
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artificial intelligence ,machine learning ,X-ray ,magnetic resonance imaging ,Detectron2 ,lung diseases classification ,Chemical technology ,TP1-1185 - Abstract
With the advent of Artificial Intelligence (AI) and even more so recently in the field of Machine Learning (ML), there has been rapid progress across the field. One of the prominent examples is image recognition in the medical category, such as X-ray imaging, Computed Tomography (CT), and Magnetic Resonance Imaging (MRI). It has the potential to alleviate a doctor’s heavy workload of sifting through large quantities of images. Due to the rising attention to lung-related diseases, such as pneumothorax and nodules, ML is being incorporated into the field in the hope of alleviating the already strained medical resources. In this study, we proposed a system that can detect pneumothorax diseases reliably. By comparing multiple models and hyperparameter configurations, we recommend a model for hospitals, as its focus on minimizing false positives aligns with the precision required by medical professionals. Through our cooperation with Poh-Ai Hospital, we acquired a total of over 8000 X-ray images, with more than 1000 of them from pneumothorax patients. We hope that by integrating AI systems into the automated process of scanning chest X-ray images with various diseases, more resources will be available in the already strained medical systems. Our proposed system showed that the best model that is used for transfer learning from our dataset performed with an AP of 51.57 and an AP75 of 61.40, with accuracy at 93.89%, a false positive of 1.12%, and a false negative of 4.99%. Based on the feedback from practicing doctors, they are more wary of false positives. For their use case, we recommend another model due to the lower false positive rate and higher accuracy compared with other models, which in our test shows a rate of only 0.88% and 95.68%, demonstrating the feasibility of the research. This promising result showed that it could be utilized in other types of diseases and expand to more hospitals and medical organizations, potentially benefitting more people.
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- 2023
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7. Myricetin Nanofibers Enhanced Water Solubility and Skin Penetration for Increasing Antioxidant and Photoprotective Activities
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Tzu-Ching Lin, Chun-Yin Yang, Tzu-Hui Wu, Chih-Hua Tseng, and Feng-Lin Yen
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myricetin ,water solubility ,skin penetration ,myricetin nanofiber ,antioxidant ,photoprotective ,Pharmacy and materia medica ,RS1-441 - Abstract
Excessive exposure to ultraviolet radiation (UV) can induce oxidative stress through the over-production of reactive oxygen species (ROS) on the skin. Myricetin (MYR), a natural flavonoid compound, significantly inhibited UV-induced keratinocyte damage; however, its bioavailability is limited by its poor water solubility and inefficient skin penetration ability, which subsequently influences its biological activity. The purpose of the study was to develop a myricetin nanofibers (MyNF) system of hydroxypropyl-β-cyclodextrin (HPBCD)/polyvinylpyrrolidone K120 (PVP)-loaded with MYR that would enhance the water solubility and skin penetration by changing the physicochemical characteristics of MYR, including reducing the particle size, increasing the specific surface area, and amorphous transformation. The results also revealed that the MyNF can reduce cytotoxicity in HaCaT keratinocytes when compared with MYR; additionally, MyNF had better antioxidant and photoprotective activity than raw MYR for the UVB-induced HaCaT keratinocytes damage model due to the MyNF increased water solubility and permeability. In conclusion, our results demonstrate that MyNF is a safe, photostable, and thermostable topical ingredient of antioxidant nanofibers to enhance the skin penetration of MYR and prevent UVB-induced skin damage.
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- 2023
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8. Lipid Metabolism and its Mechanism Triggered by Supercritical CO2 Extract of Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) Bran in High-Fat Diet Induced Hyperlipidemic Hamsters
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Chiao-Chih Huang, Tzu-Ching Lin, Chiung-Hui Liu, Hao-Chun Hu, Szu-Yin Yu, Shu-Jing Wu, Ming-Hong Yen, Yi-Hong Tsai, and Fang-Rong Chang
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adlay bran ,supercritical fluid extract ,hypolipidemic capacity ,unsaturated fatty acids (UFAs) ,ferulate phytostanol esters ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Adlay (Coix lacryma-jobi var. ma-yuen (Rom. Caill.) Stapf) seeds are edible crop classified as Traditional Chinese Medicine (TCM). Adlay bran (AB) is one of the wastes generated during adlay refining processes. In this work, supercritical fluid extract of AB (AB-SCF) was investigated to reveal its lipid regulating potential and decode its bifunctional ingredients. AB-SCF×0.5 (30.84 mg/kg/body weight), AB-SCF×1 (61.67 mg/kg/BW), AB-SCF×5 (308.35 mg/kg/BW) and AB-SCF×10 (616.70 mg/kg/BW) were administrated to high fat-diet (HFD) induced hyperglycemic hamsters for 8 weeks. The results indicates that AB-SCF displays a prevention of dramatic body weight gains, lower levels of serum TG, TC, LDL-C and higher in HDL-C, amelioration of cardiovascular risk, alleviation of hepatic TG, TC and lipid peroxidation, and enhancement on cholesterol metabolism with higher bile acid excretion. Investigations on energy metabolic mechanism demonstrates that the hyperlipidemia mitigating capacities of AB-SCF are up-regulated on lipoprotein lipase, AMPK, p-AMPK and down-regulated at fatty acid synthase. Major bio-functional lipid compositions are identified as linoleic acid (28.59%) and oleic acid (56.95%). Non-lipid chemical and active markers are confirmed as 3-O-(trans-4-feruloyl)-β-sitostanol (1463.42 ppm), 3-O-(cis-4-feruloyl)-β-sitostanol (162.60 ppm), and β-sitosterol (4117.72 ppm). These compositions might synergistically responsible for the mentioned activities and can be regarded as analytical targets in quality control. AB-SCF may be considered as a promising complementary supplement, and developed as a functional food or new botanical drug in the future.
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- 2021
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9. Acoustic Scene Classification Using Reduced MobileNet Architecture.
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Jun-Xiang Xu, Tzu-Ching Lin, Tsai-Ching Yu, Tzu-Chiang Tai, and Pao-Chi Chang
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- 2018
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10. Diagnosis of Arboleda-Tham syndrome by whole genome sequencing in an Asian boy with severe developmental delay
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Yung-Feng Lin, Tzu-Ching Lin, Ralph Kirby, Hui-Ying Weng, Yen-Ming Liu, Dau-Ming Niu, Shih-Feng Tsai, and Chia-Feng Yang
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Developmental disabilities ,Histone acetyltransferases ,Whole genome sequencing ,Medicine (General) ,R5-920 ,Biology (General) ,QH301-705.5 - Abstract
Diagnosis of a 9-month-old boy brought to our genetics clinic with chief complaints of developmental delay (DD), failure to thrive, microcephaly, trunk hypotonia and hypertonia of the extremities. Multiple congenital defects but no significant syndromes or diseases were impressed. The chromosomal analysis and array comparative genomic hybridization (aCGH) revealed no significant pathogenic changes. Whole Genome Sequencing (WGS) identified a p.Glu1139fs de novo mutation of the KAT6A gene. The patient's phenotype was consistent clinically with Arboleda-Tham syndrome (ARTHS). Reviewing the literature showed that this is the first patient in Taiwan detected by WGS and that it involves a novel mutation. Comparing the highly variable clinical presentations of this syndrome with our patient, this boy's features and severe developmental defects seem to be due to a late-truncating mutation at the carboxyl end of the KAT6A protein. Our study demonstrates the power of WGS to confirm a diagnosis within 4 weeks for this rare condition.
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- 2020
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11. Development and Efficacy of Lateral Flow Point-of-Care Testing Devices for Rapid and Mass COVID-19 Diagnosis by the Detections of SARS-CoV-2 Antigen and Anti-SARS-CoV-2 Antibodies
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Wen-Yeh Hsieh, Cheng-Han Lin, Tzu-Ching Lin, Chao-Hsu Lin, Hui-Fang Chang, Chin-Hung Tsai, Hsi-Tien Wu, and Chih-Sheng Lin
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lateral flow immunoassay ,lateral flow test ,COVID-19 ,SARS-CoV-2 ,antigen ,antibodies ,Medicine (General) ,R5-920 - Abstract
The COVID-19 pandemic is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2020–2021. COVID-19 is becoming one of the most fatal pandemics in history and brings a huge challenge to the global healthcare system. Opportune detection, confinement, and early treatment of infected cases present the first step in combating COVID-19. Diagnosis via viral nucleic acid amplification tests (NAATs) is frequently employed and considered the standard procedure. However, with an increasing urge for point-of-care tests, rapid and cheaper immunoassays are widely utilized, such as lateral flow immunoassay (LFIA), which can be used for rapid, early, and large-scale detection of SARS-CoV-2 infection. In this narrative review, the principle and technique of LFIA applied in COVID-19 antigen and antibody detection are introduced. The diagnostic sensitivity and specificity of the commercial LFIA tests are outlined and compared. Generally, LFIA antigen tests for SARS-CoV-2 are less sensitive than viral NAATs, the “gold standard” for clinical COVID-19 diagnosis. However, antigen tests can be used for rapid and mass testing in high-risk congregate housing to quickly identify people with COVID-19, implementing infection prevention and control measures, thus preventing transmission. LFIA anti-SARS-CoV-2 antibody tests, IgM and/or IgG, known as serology tests, are used for identification if a person has previously been exposed to the virus or vaccine immunization. Notably, advanced techniques, such as LFT-based CRISPR-Cas9 and surface-enhanced Raman spectroscopy (SERS), have added new dimensions to the COVID-19 diagnosis and are also discussed in this review.
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- 2021
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12. Property Tax Capitalization in Sweden--Evidence from the 2008 Reform
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Torbjörn E. M. Nordling, Tzu-Ching Lin, Yi-Yun Lee, Timotheos Mavropoulos, and Hsi-Wei Chou
- Abstract
The paper investigates the effect of the property taxation reform introduced in Sweden from 2006 to 2008 on the market price of the affected properties (one-family houses). We make an extensive empirical analysis of the tax capitalization effect, given that prior research has detected only partial capitalization and that there has been an extensive debate regarding the extent to which the tax gets capitalized into property market prices. In particular, the tax capitalization effect for single-family house prices was investigated by looking into various sub-groups of properties and doing extensive statistical inquiries into the property transaction data. Despite a relatively broad time period in which the reform took place, a jump in the market values of the affected properties is detectable in the fourth quarter of 2006. Our findings emphasise the importance of creating a representative data sample in analyzing and assessing the outcomes and impacts of policy interventions such as a taxation reform.
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- 2023
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13. Electrospun Resveratrol-Loaded Polyvinylpyrrolidone/Cyclodextrin Nanofibers and Their Biomedical Applications
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Ying-Cheng Lin, Stephen Chu-Sung Hu, Pao-Hsien Huang, Tzu-Ching Lin, and Feng-Lin Yen
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resveratrol ,cyclodextrin ,nanofiber ,electrospinning ,antioxidant activity ,Pharmacy and materia medica ,RS1-441 - Abstract
Resveratrol is a naturally occurring polyphenol compound which has been shown to possess antioxidant and anti-inflammatory properties. However, its pharmaceutical applications are limited by its poor water solubility. In this study, we used electrospinning technology to synthesize nanofibers of polyvinylpyrrolidone (PVP) and hydroxypropyl-β-cyclodextrin (HPBCD) loaded with resveratrol. We used X-ray diffractometry to analyze crystalline structure, Fourier transform infrared spectroscopy to determine intermolecular hydrogen bonding, antioxidant assays to measure antioxidant activity, and Franz diffusion cells to evaluate skin penetration. Our results showed that the aqueous solubility of resveratrol nanofibers was greatly improved (by more than 20,000-fold) compared to the pure compound. Analysis of physicochemical properties demonstrated that following nanofiber formation, resveratrol was converted from a crystalline to amorphous structure, and resveratrol formed new intermolecular bonds with PVP and HPBCD. Moreover, resveratrol nanofibers showed good antioxidant activity. In addition, the skin penetration ability of resveratrol in the nanofiber formulation was greater than that of pure resveratrol. Furthermore, resveratrol nanofibers suppressed particulate matter (PM)-induced expression of inflammatory proteins (COX-2 and MMP-9) in HaCaT keratinocytes. Therefore, resveratrol-loaded nanofibers can effectively improve the solubility and physicochemical properties of resveratrol, and may have potential applications as an antioxidant and anti-inflammatory formulation for topical skin application.
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- 2020
- Full Text
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14. A Reliable Dynamic User-Remote Password Authentication Scheme over Insecure Network.
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Zhen Yu Wu, Dai-Lun Chiang, Tzu-Ching Lin, Yu-Fang Chung, and Tzer-Shyong Chen
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- 2012
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15. Dynamic Packet Selection for H.264 Video Streaming over IEEE 802.11e WLANs.
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Wen-Tsuen Chen, Tzu-Ching Lin, Yu-Chu Chang, and Jyh-Cheng Chen
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- 2008
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16. Secure Dynamic Access Control Scheme of PHR in Cloud Computing.
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Tzer-Shyong Chen, Chia-Hui Liu, Tzer-Long Chen, Chin-Sheng Chen, Jian-Guo Bau, and Tzu-Ching Lin
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- 2012
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17. EOG-based Human-Computer Interface system development.
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Lawrence Y. Deng, Chun-Liang Hsu, Tzu-Ching Lin, Jui-Sen Tuan, and Shih-Ming Chang
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- 2010
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18. Development and Efficacy of Lateral Flow Point-of-Care Testing Devices for Rapid and Mass COVID-19 Diagnosis by the Detections of SARS-CoV-2 Antigen and Anti-SARS-CoV-2 Antibodies
- Author
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Tzu-Ching Lin, Chih-Sheng Lin, Cheng-Han Lin, Wen-Yeh Hsieh, Chin-Hung Tsai, Chao-Hsu Lin, Hui-Fang Chang, and Hsi-Tien Wu
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Medicine (General) ,biology ,business.industry ,SARS-CoV-2 ,Point-of-care testing ,Clinical Biochemistry ,lateral flow immunoassay ,COVID-19 ,Review ,Gold standard (test) ,Virology ,Serology ,lateral flow test ,Lateral flow test ,antigen ,R5-920 ,Antigen ,Pandemic ,biology.protein ,Medicine ,Infection control ,antibodies ,Antibody ,business - Abstract
The COVID-19 pandemic is an ongoing global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2020–2021. COVID-19 is becoming one of the most fatal pandemics in history and brings a huge challenge to the global healthcare system. Opportune detection, confinement, and early treatment of infected cases present the first step in combating COVID-19. Diagnosis via viral nucleic acid amplification tests (NAATs) is frequently employed and considered the standard procedure. However, with an increasing urge for point-of-care tests, rapid and cheaper immunoassays are widely utilized, such as lateral flow immunoassay (LFIA), which can be used for rapid, early, and large-scale detection of SARS-CoV-2 infection. In this narrative review, the principle and technique of LFIA applied in COVID-19 antigen and antibody detection are introduced. The diagnostic sensitivity and specificity of the commercial LFIA tests are outlined and compared. Generally, LFIA antigen tests for SARS-CoV-2 are less sensitive than viral NAATs, the “gold standard” for clinical COVID-19 diagnosis. However, antigen tests can be used for rapid and mass testing in high-risk congregate housing to quickly identify people with COVID-19, implementing infection prevention and control measures, thus preventing transmission. LFIA anti-SARS-CoV-2 antibody tests, IgM and/or IgG, known as serology tests, are used for identification if a person has previously been exposed to the virus or vaccine immunization. Notably, advanced techniques, such as LFT-based CRISPR-Cas9 and surface-enhanced Raman spectroscopy (SERS), have added new dimensions to the COVID-19 diagnosis and are also discussed in this review.
- Published
- 2021
19. A review of epidemic investigation on cold-chain food-mediated SARS-CoV-2 transmission and food safety consideration during COVID-19 pandemic
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Li‐Che Lu, Irwin Quintela, Cheng‐Han Lin, Tzu‐Ching Lin, Chao‐Hsu Lin, Vivian C. H. Wu, and Chih‐Sheng Lin
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Invited Review ,business.industry ,Download ,Risk of infection ,Food safety ,Microbiology ,Hazard ,law.invention ,Food packaging ,Transmission (mechanics) ,law ,Environmental health ,Pandemic ,Invited Reviews ,Parasitology ,Cold chain ,business ,Food Science - Abstract
COVID‐19 has brought speculations on potential transmission routes of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causal agent of the pandemic. It is reported that the main route of virus transmission to be person‐to‐person by respiratory droplets; however, people have raised concerns on the possible transmission of SARS‐CoV‐2 to humans via food and packaging and its potential effects on food safety. This review discusses food safety issues in the COVID‐19 pandemic and reveals its possible transmission in cold‐chain food. The first outbreak of COVID‐19 in late 2019 was associated with a seafood market in Wuhan, China, while the second outbreak of COVID‐19 in June 2020 was also related to a seafood market in Beijing, China. As of 2020, several frozen seafood products linked with SARS‐CoV‐2 have been reported in China. According to the current survey and scientific studies, the risk of infection by SARS‐CoV‐2 from cold‐chain food, food products, and food packaging is thought to be very low. However, studies on food cold chain contamination have shown that SARS‐CoV‐2 remained highly stable under refrigerated (4°C) and even in freezing conditions (−10 to −80°C). Since one mode of SARS‐CoV‐2 transmission appears to be touching contaminated surfaces, it is important to clean and sanitize food contact surfaces properly. Understanding food safety hazard risks is essential to avoid potential negative health effects and SARS‐CoV‐2 transmission in the food supply chain during the COVID‐19 pandemic., Probable route of transmission for SARS‐CoV‐2 through cold‐chain transportation in the frozen food industry.
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- 2021
20. Pterostilbene Nanoparticles Downregulate Hypoxia-Inducible Factors in Hepatoma Cells Under Hypoxic Conditions
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Wei-Lin Teng, Yow-Ling Shiue, Pao-Hsien Huang, Wen-Sheng Tzeng, Feng-Lin Yen, and Tzu-Ching Lin
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Pterostilbene ,Proton Magnetic Resonance Spectroscopy ,Pharmaceutical Science ,Apoptosis ,02 engineering and technology ,Pharmacology ,01 natural sciences ,chemistry.chemical_compound ,International Journal of Nanomedicine ,Drug Discovery ,Spectroscopy, Fourier Transform Infrared ,Stilbenes ,Cytotoxic T cell ,Original Research ,Liver Neoplasms ,General Medicine ,Hep G2 Cells ,hepatocellular carcinoma ,021001 nanoscience & nanotechnology ,Cell Hypoxia ,Hypoxia-inducible factors ,Hepatocellular carcinoma ,medicine.symptom ,0210 nano-technology ,Crystallization ,transcatheter arterial chemoembolization ,Carcinoma, Hepatocellular ,Cell Survival ,Biophysics ,Down-Regulation ,Bioengineering ,Antineoplastic Agents ,010402 general chemistry ,Biomaterials ,Downregulation and upregulation ,medicine ,Humans ,Neoplasm Invasiveness ,Viability assay ,Particle Size ,hypoxia ,Organic Chemistry ,Hydrogen Bonding ,Hypoxia (medical) ,medicine.disease ,Hypoxia-Inducible Factor 1, alpha Subunit ,0104 chemical sciences ,Drug Liberation ,chemistry ,Solubility ,Nanoparticles ,Tumor Hypoxia - Abstract
Wen-Sheng Tzeng,1,2 Wei-Lin Teng,3 Pao-Hsien Huang,4 Tzu-Ching Lin,3 Feng-Lin Yen,2,5– 7 Yow-Ling Shiue2 1Department of Radiology, Pingtung Christian Hospital, Pingtung, Taiwan; 2Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan; 3Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; 4School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; 5Department of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; 6Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung, Taiwan; 7Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanCorrespondence: Feng-Lin YenDepartment of Fragrance and Cosmetic Science, College of Pharmacy, Kaohsiung Medical University, No.100, Shin-Chuan 1st Road, Sanmin Dist., Kaohsiung City, 80708, TaiwanTel +886 7 3121101 ext 2028Email flyen@cc.kmu.edu.twYow-Ling ShiueInstitute of Biomedical Sciences, National Sun Yat-Sen University, No 70 Lien-Hai Road., Kaohsiung City, 80424, TaiwanTel +886 7 5252000 ext 5818Email shirley@imst.nsysu.edu.twPurpose: Transcatheter arterial chemoembolization (TACE) is a common clinical treatment for hepatocellular carcinoma (HCC). However, hypoxia induction after treatment might trigger tumor invasiveness and metastasis. Although pterostilbene (PTS) has antitumor effects, its chemoprevention in HepG2 cells under hypoxia has not been investigated yet. In addition, the poor water solubility of raw PTS limits its clinical application. Here, we prepared nanoparticles of PTS (PSN) and compared their antihepatoma activities with those of raw PTS in HepG2 under hypoxic conditions.Materials and Methods: The PTS nanoparticle formulation was prepared by nanoprecipitation, using Eudragit® e100 (EE) and polyvinyl alcohol (PVA) as carriers. We analyzed the physicochemical properties of raw PTS and PSN, including yield, encapsulation efficiency, water-solubility, particle size, morphology, crystalline-to-amorphous transformation, and molecular interaction between PTS and carriers. We also evaluated their antihepatoma activities under hypoxia treatment in HepG2 cells, including cell viability, hypoxia, and apoptosis.Results: The yield and encapsulation efficiency of PSN were 86.33% and > 99%, respectively. The water solubility and drug release of PTS were effectively improved after nanoprecipitation corresponding to the reduction in particle size, amorphous transformation, and formation of hydrogen bonding with carriers. PSN had a better cytotoxic effect than raw PTS in HepG2 under pre- and post-hypoxia conditions. In addition, hypoxia- and apoptosis-related proteins in HepG2 cells under two different hypoxic conditions were significantly inhibited by PSN compared with the control group with hypoxia only, except for HIF-1α in the post-hypoxia group. PSN was also significantly better in inhibiting these proteins, except for Bcl2, under pre-hypoxic conditions.Conclusion: Our results suggested that PSN could improve the water solubility and drug release of PTS and enhance the efficacy of HCC treatment under hypoxic conditions.Keywords: hepatocellular carcinoma, hypoxia, transcatheter arterial chemoembolization
- Published
- 2021
21. Electrospun Resveratrol-Loaded Polyvinylpyrrolidone/Cyclodextrin Nanofibers and Their Biomedical Applications
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Stephen Chu-Sung Hu, Lin Ying-Cheng, Feng-Lin Yen, Pao-Hsien Huang, and Tzu-Ching Lin
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endocrine system diseases ,Pharmaceutical Science ,lcsh:RS1-441 ,antioxidant activity ,02 engineering and technology ,Resveratrol ,resveratrol ,Article ,lcsh:Pharmacy and materia medica ,03 medical and health sciences ,chemistry.chemical_compound ,medicine ,Fourier transform infrared spectroscopy ,Solubility ,skin and connective tissue diseases ,nanofiber ,electrospinning ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,Aqueous solution ,Polyvinylpyrrolidone ,Cyclodextrin ,Chemistry ,organic chemicals ,technology, industry, and agriculture ,food and beverages ,021001 nanoscience & nanotechnology ,Electrospinning ,cyclodextrin ,Nanofiber ,0210 nano-technology ,hormones, hormone substitutes, and hormone antagonists ,medicine.drug ,Nuclear chemistry - Abstract
Resveratrol is a naturally occurring polyphenol compound which has been shown to possess antioxidant and anti-inflammatory properties. However, its pharmaceutical applications are limited by its poor water solubility. In this study, we used electrospinning technology to synthesize nanofibers of polyvinylpyrrolidone (PVP) and hydroxypropyl-&beta, cyclodextrin (HPBCD) loaded with resveratrol. We used X-ray diffractometry to analyze crystalline structure, Fourier transform infrared spectroscopy to determine intermolecular hydrogen bonding, antioxidant assays to measure antioxidant activity, and Franz diffusion cells to evaluate skin penetration. Our results showed that the aqueous solubility of resveratrol nanofibers was greatly improved (by more than 20,000-fold) compared to the pure compound. Analysis of physicochemical properties demonstrated that following nanofiber formation, resveratrol was converted from a crystalline to amorphous structure, and resveratrol formed new intermolecular bonds with PVP and HPBCD. Moreover, resveratrol nanofibers showed good antioxidant activity. In addition, the skin penetration ability of resveratrol in the nanofiber formulation was greater than that of pure resveratrol. Furthermore, resveratrol nanofibers suppressed particulate matter (PM)-induced expression of inflammatory proteins (COX-2 and MMP-9) in HaCaT keratinocytes. Therefore, resveratrol-loaded nanofibers can effectively improve the solubility and physicochemical properties of resveratrol, and may have potential applications as an antioxidant and anti-inflammatory formulation for topical skin application.
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- 2020
- Full Text
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22. Going Green in Mega-Sporting Events
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Eric Chen F. Hsieh, Chen Peng, Tzu Ching Lin, Hsin Yi Huang, and Min-yuan Ma
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Process management ,Product design ,Sustainable products ,Computer science ,Product innovation ,Event (computing) ,User journey ,Sustainable design ,Product (category theory) ,Set (psychology) - Abstract
The emerging literature suggests that mega-sporting events have the potential to negatively impact local ecosystems by causing pollution and waste accumulation. This has raised the issue of “green sports,” which is a critical one. This study attempts to contribute a model to the design process to identify factors that attract spectators to sports, provide insights into the dynamics of mega-sporting events, and present a set of sustainable products that could interest sports-goers. A baseball game was selected as an example of a mega-sporting event. The study employed a combined model of the design process for product innovation, which included two in-depth qualitative interview methods: the evaluation grid method and a user journey map. A set of products designated as the “HOMERUN” set were designed based on the findings of the combined model. The result illustrated the possibility of transforming product features to meet users’ needs at different stages of the mega-sporting experience. The model applied in this study has implications for transforming product design thinking from a focus on specific points in problem solving to a linear pattern that focuses on a broader picture.
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- 2020
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23. A review of epidemic investigation on cold-chain foodmediated SARS-CoV-2 transmission and food safety consideration during COVID-19 pandemic.
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Li-Che Lu, Quintela, Irwin, Cheng-Han Lin, Tzu-Ching Lin, Chao-Hsu Lin, Wu, Vivian C. H., and Chih-Sheng Lin
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COVID-19 pandemic ,SARS-CoV-2 ,FOOD safety ,SEAFOOD markets ,EPIDEMICS - Abstract
COVID-19 has brought speculations on potential transmission routes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of the pandemic. It is reported that the main route of virus transmission to be person-to-person by respiratory droplets; however, people have raised concerns on the possible transmission of SARS-CoV-2 to humans via food and packaging and its potential effects on food safety. This review discusses food safety issues in the COVID-19 pandemic and reveals its possible transmission in cold-chain food. The first outbreak of COVID-19 in late 2019 was associated with a seafood market in Wuhan, China, while the second outbreak of COVID-19 in June 2020 was also related to a seafood market in Beijing, China. As of 2020, several frozen seafood products linked with SARS-CoV-2 have been reported in China. According to the current survey and scientific studies, the risk of infection by SARS-CoV-2 from cold-chain food, food products, and food packaging is thought to be very low. However, studies on food cold chain contamination have shown that SARS-CoV-2 remained highly stable under refrigerated (4°C) and even in freezing conditions (-10 to -80°C). Since one mode of SARS-CoV-2 transmission appears to be touching contaminated surfaces, it is important to clean and sanitize food contact surfaces properly. Understanding food safety hazard risks is essential to avoid potential negative health effects and SARS-CoV-2 transmission in the food supply chain during the COVID-19 pandemic. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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24. Fabrication of silicon nanowire/poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate)-graphene oxide hybrid solar cells.
- Author
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Uma, Kasimayan, Subramani, Thiyagu, Hong-Jhang Syu, Tzu-Ching Lin, and Ching-Fuh Lin
- Subjects
SILICON nanowires ,GRAPHENE oxide ,HYBRID solar cells ,ENERGY conversion ,SEMICONDUCTORS - Abstract
Silicon nanowire (SiNW)/Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) Schottky junctions have shown great promise as high efficiency, cost effective solar cells. Here, hybrid SiNWs/PEDOT:PSS blended graphene oxide (GO) solar cells are prepared and investigated. The SiNWs/PEDOT:PSS blended GO cells show enhanced light trapping and a large junction area when compared to pure PEDOT:PSS structures. SiNWs combined with GO solar cells show energy conversion efficiencies of up to 9.57% under the AM 1.5G condition, opening the possibility of using semiconductor/graphene oxide in photovoltaic applications. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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- View/download PDF
25. WO3/TiO2 core–shell nanostructure for high performance energy-saving smart windows
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Ying-Ming Liu, Tzu-Ching Lin, and Bohr-Ran Huang
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Nanostructure ,Materials science ,Renewable Energy, Sustainability and the Environment ,Nanowire ,Nanotechnology ,Electrochemistry ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Switching time ,Chemical engineering ,Electrochromism ,Photocatalysis ,Photodegradation ,Layer (electronics) - Abstract
The electrochromic, photodegradation, and photoinduced hydrophilicity properties of the WO3/TiO2 core–shell nanostructure as a smart building material for energy-saving are investigated. The core–shell nanostructure exhibits a highly reduced ion intercalation capacity with good reversible electrochemical cycling of intercalation–deintercalation, and shows a higher coloration efficiency (110.8 cm2 C−1), faster switching speed (0.7 s and 2.9 s) and better cycling performance than as-deposited WO3 nanowires (NWs). The TiO2 shell layer greatly enhanced the photocatalytic oxidation activity of WO3 NWs, increasing the photoinduced hydrophilic conversion. The enhanced photocatalytic reaction by the core–shell structure was attributed to the multi-electron reduction in the interlayer, caused by the electrons injected from the conduction band of the WO3 NWs. These results suggest that the WO3/TiO2 core–shell nanostructure enhances the electrochromic, photodegradation, and photoinduced hydrophilicity properties due to the increased density of charge separated electron–hole pairs aided by the TiO2 and WO3 interlayer. The WO3/TiO2 core–shell structure was found to possess superior properties giving it good potential for use in energy-saving smart windows.
- Published
- 2015
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26. Optical trapping enhancement from high density silicon nanohole and nanowire arrays for efficient hybrid organic–inorganic solar cells
- Author
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Ching-Fuh Lin, Tzu-Ching Lin, Hong-Jhang Syu, Chen-Chih Hsueh, Chien-Ting Liu, and Subramani Thiyagu
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Materials science ,Silicon ,business.industry ,General Chemical Engineering ,Energy conversion efficiency ,Nanowire ,chemistry.chemical_element ,Nanotechnology ,Heterojunction ,General Chemistry ,Hybrid solar cell ,Isotropic etching ,chemistry ,Photovoltaics ,Etching (microfabrication) ,business - Abstract
In this paper, we employ a series of metal-assisted chemical etching processes to fabricate low-cost silicon nanohole (SiNH) and silicon nanowire (SiNW) arrays for hybrid solar cells. The SiNH arrays and SiNW arrays are obtained by a two-step etching and one-step etching technique, respectively. Length and depth of SiNWs and SiNHs can be controlled by etching time. The SiNH arrays demonstrate higher optical trapping effect than SiNW arrays, resulting in leading performance power conversion efficiency of 11.25% in the hybrid organic–inorganic solar cells. SiNH arrays have a high surface area, compared to SiNW arrays, so they can give rise to more junction area in the organic–inorganic heterojunction structures. In addition, these SiNH arrays possess additional advantages of robust structures and higher density with low air-filling fraction as compared to SiNW arrays. Furthermore, the SiNH arrays show superior efficiency to SiNW arrays experimentally. In particular, the fabricated SiNH arrays with high density can suppress the optical reflection well below 5% over a broad wavelength range from 300 to 1100 nm in a short nanohole depth. The very low reflectance and excellent light trapping property are attributed to the sub-wavelength dimension of the SiNH structure. These SiNH arrays not only facilitate the optical trapping, but also provide efficient broadband and omnidirectional photon harvests for cost-effective future nanostructured photovoltaics.
- Published
- 2015
- Full Text
- View/download PDF
27. Hydrogen-sensing response of grass-like carbon nanotube/nickel nanostructure by microwave treatment
- Author
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Tzu-Ching Lin and Bohr-Ran Huang
- Subjects
Materials science ,Nanostructure ,Hydrogen ,chemistry.chemical_element ,Nanotechnology ,General Chemistry ,Carbon nanotube ,law.invention ,Nickel ,Chemical engineering ,chemistry ,law ,General Materials Science ,Microwave - Abstract
A grass-like carbon nanotube/nickel (CNT/Ni) sensor treated by microwave (MW) technique to enhance hydrogen (H 2 ) gas-sensing response was used. A leaf-like CNT/Ni nanostructure was changed into a grass-like CNT/Ni nanostructure through the MW treatment technique in order to enhance the H 2 sensor response. The H 2 gas sensing characteristics of grass-like CNT/Ni were found to have a much higher sensor response of ∼11% at 1000 ppm H 2 gas, approximately 33 times greater than that of leaf-like CNT/Ni (∼0.33%) without MW treatment. The MW technique is simple, energy-efficient at low temperature (58 °C), and effectively enhances the sensing response of CNT/Ni sensors.
- Published
- 2014
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28. Aggregated TiO2 nanotubes with high field emission properties
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Jun-Cheng Lin, Yu-Jyun Chen, Tzu-Ching Lin, and Bohr-Ran Huang
- Subjects
Thermal oxidation ,Materials science ,Analytical chemistry ,General Physics and Astronomy ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Cathode ,Surfaces, Coatings and Films ,law.invention ,Crystallinity ,Field electron emission ,symbols.namesake ,law ,Electric field ,symbols ,Chemical binding ,Raman spectroscopy ,Current density - Abstract
A facile approach is developed to easily fabricate field emission (FE) cathodes based on TiO 2 nanotubes with different geometrical structures at low temperature. Planar TiO 2 nanotubes (P-TNTs) are first synthesized using the electrochemical anodization process with applied voltages of 20–50 V for 1 h at room temperature followed by thermal oxidation at 280 °C for 2 h under atmosphere ambient. P-TNTs can be transformed into aggregated TiO 2 nanotubes (A-TNTs) after H 2 O 2 post-treatment for 1 h at room temperature. FESEM, XRD, and Raman spectroscopy were used to analyze the surface morphology, crystallinity, and chemical binding, respectively. The A-TNTs fabricated with the applied voltages of 30–50 V cathodes possess higher levels of FE properties (lower turn-on electric field and higher current density) than the other cathodes due to their greater number of emission sites and decrement of the screening effect. The A-TNT with an applied voltage of 40 V cathode exhibits the lowest turn-on electric field (4.87 V/μm, 1 μA/cm 2 ) and the highest enhancement factor β (1486). These superior properties indicate that the A-TNTs are promising field cathodes for future FE applications.
- Published
- 2014
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29. Synthesis of Tungsten Oxide Nanowires onto ITO Glass Using T-CVD
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Tzu-Ching Lin, Tomy Abuzairi, and Bohr-Ran Huang
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Materials science ,Thermal chemical vapor deposition ,business.industry ,Nanowire ,chemistry.chemical_element ,Tungsten oxide ,Tungsten ,Catalysis ,Tungsten film ,symbols.namesake ,Semiconductor ,Chemical engineering ,chemistry ,lcsh:TA1-2040 ,symbols ,ito glass, thermal chemical vapor deposition, tungsten oxide nanowires ,Raman spectroscopy ,business ,lcsh:Engineering (General). Civil engineering (General) - Abstract
Tungsten oxide is an n-type semiconductor with interesting physical and chemical properties that make it suitable for various technological applications. Tungsten oxide nanowires were synthesized not only at low temperature but also without the use of any catalysts. The tungsten oxide nanowires were synthesized at 550 °C with tungsten layers onto the ITO glass using thermal chemical vapor deposition (T-CVD). The SEM image shows that the tungsten oxide nanowires are effectively grown with the 200 nm tungsten film. The Raman spectra shoulder at ~690 cm-1 proves the synthesized of tungsten oxide nanowires.
- Published
- 2014
30. Hybrid structure of graphene sheets/ZnO nanorods for enhancing electron field emission properties
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Jun-Cheng Lin, Bohr-Ran Huang, and Tzu-Ching Lin
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Materials science ,Graphene ,General Physics and Astronomy ,Nanotechnology ,Surfaces and Interfaces ,General Chemistry ,Condensed Matter Physics ,Cathode ,Surfaces, Coatings and Films ,law.invention ,Field electron emission ,Crystallinity ,symbols.namesake ,Chemical engineering ,law ,Sputtering ,symbols ,Nanorod ,Raman spectroscopy ,Current density - Abstract
A hybrid structure of graphene sheets (GSs)/ZnO nanorods (ZNRs) is developed on glass substrates for applications in field emission (FE) cathodes. ZNRs are grown on glass substrates by a combination of sputtering and hydrothermal processes. Graphene films are synthesized on the Cu foils by the thermal chemical vapor deposition technique, and are transferred onto the ZNRs with various cycles (one, two, and three times) to form GS/ZNR hybrids with different morphology. FESEM, XRD, and Raman spectroscopy are used to analyze the surface morphology, crystallinity, and chemical composition, respectively. It is found that the FE properties of all GS/ZNR cathodes possess a lower turn-on electric field and higher current density than pristine ZNR cathode owing to the presence of the GS. The GSs/ZNRs with two transferred cycle exhibit the lowest turn-on electric field (3.7 V/μm, 1 μA/cm 2 ) and highest enhancement factor β (8723). These superior properties indicate that the GS/ZNR hybrids are promising field cathodes in FE applications.
- Published
- 2014
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31. Field emission properties of zinc oxide/zinc tungstate (ZnO/ZnWO 4 ) composite nanorods
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Ying-Kan Yang, Kuo-Ting Chu, Jun-Cheng Lin, Tzu-Ching Lin, and Bohr-Ran Huang
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Thermal oxidation ,Nanostructure ,Materials science ,Composite number ,chemistry.chemical_element ,Surfaces and Interfaces ,General Chemistry ,Zinc ,Tungsten ,Condensed Matter Physics ,Surfaces, Coatings and Films ,chemistry.chemical_compound ,Field electron emission ,Tungstate ,chemistry ,Chemical engineering ,Materials Chemistry ,Nanorod - Abstract
Zinc oxide/zinc tungstate (ZnO/ZnWO 4 ) nanorods were synthesized as composite nanostructure on the tungsten/glass substrates by thermal oxidation technique for field emission cathodes. The ZnWO 4 wolframite structure in the ZnO film formed the ZnO/ZnWO 4 composite nanostructure, as indicated by the XRD patterns and Raman spectrum. An ohmic contact was transformed to a Schottky contact between a silver electrode and the ZnO/ZnWO 4 composite nanorods from I–V measurement given that the work function of the ZnO/ZnWO 4 composite nanorods was lower than that of ZnO nanorods. The field emission properties of the ZnO/ZnWO 4 composite nanorods includes a turn-on electric field (E on ) of 2.1 V/μm and a threshold electric field (E th ) of 2.9 V/μm, both much lower than that found in ZnO nanorods without ZnWO 4 nanostructures. The novel ZnO/ZnWO 4 composite nanorod shows excellent potential for application in field emission cathodes and related devices.
- Published
- 2013
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32. Temperature effect on hydrogen response for cracked carbon nanotube/nickel (CNT/Ni) composite film with horizontally aligned carbon nanotubes
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Bohr-Ran Huang and Tzu-Ching Lin
- Subjects
Materials science ,Hydrogen ,Metals and Alloys ,chemistry.chemical_element ,Response time ,Composite film ,Carbon nanotube ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,law.invention ,Nickel ,chemistry ,law ,Desorption ,Materials Chemistry ,Electrical and Electronic Engineering ,Hydrogen absorption ,Composite material ,Instrumentation ,Lithography - Abstract
We have developed a free lithography technique for hydrogen sensors using a cracked carbon nanotube/nickel (CNT/Ni) film with horizontally aligned CNT (HA-CNT). Cracks were induced on CNT/Ni film by simple hydrogen absorption and desorption processes to enhance sensor response using heat treatment. Gas sensing measurements taken with various concentrations (200–16,000 ppm) of hydrogen at room temperature revealed that the sensors based on cracks in CNT/Ni film exhibit promising results for response, response time, and recovery time. Compared to CNT/Ni sensors fabricated without heat treatment, the hydrogen sensors fabricated at 350 °C on cracked CNT/Ni film with HA-CNT exhibited a much more response (14.1% vs. 0.6%) and a faster response time (422 s vs. 1095 s) at 200 ppm H2 gas. The heat treatment method used to form cracks in the HA-CNT is relatively simple and effectively improved the response of CNT/Ni hydrogen sensors.
- Published
- 2013
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33. Bilayer Structure of ZnO Nanorod/Nanodiamond Film Based Ultraviolet Photodetectors
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Tzu-Ching Lin, Bohr-Ran Huang, and Jun-Cheng Lin
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Materials science ,Renewable Energy, Sustainability and the Environment ,business.industry ,Bilayer ,Photodetector ,Condensed Matter Physics ,medicine.disease_cause ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Materials Chemistry ,Electrochemistry ,medicine ,Optoelectronics ,Nanorod ,business ,Nanodiamond ,Ultraviolet - Published
- 2013
- Full Text
- View/download PDF
34. Long-term stability of a horizontally-aligned carbon nanotube field emission cathode coated with a metallic glass thin film
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Jinn P. Chu, Yen-Chen Chen, Bohr-Ran Huang, and Tzu-Ching Lin
- Subjects
Materials science ,Composite number ,General Chemistry ,Carbon nanotube ,Cathode ,law.invention ,Field electron emission ,law ,Electric field ,Plating ,General Materials Science ,Thin film ,Composite material ,Current density - Abstract
A horizontally-aligned carbon nanotube (HACNT) field emission cathode was coated with a metallic glass thin film (MGTF) to improve the stability of the field emission properties. HACNT field emission cathodes have previously been fabricated on glass substrates using composite plating and crack-formation techniques. A carbon nanotubes/nickel (CNTs/Ni) composite film is deposited onto a glass substrate at 80 °C by the composite plating technique alone. Cracks are then formed in the CNT/Ni composite film during 30 min heating at 300 °C, and HACNTs are exposed in the cracks. The field emission properties of the HACNT field emission cathode show a low turn-on electric field Eon of about 2.3 V/μm, a low threshold electric field Eth of about 4.7 V/μm at an emission current density of 1 mA/cm2, and a stability time of 78 h. The degradation of the HACNT field emission cathode is prevented by using a MGTF-coating technique and superior long-term stability (i.e. >125 h, with 5 nm MGTF; >270 h, with 10 nm MGTF) for the MGTF/HACNT field emission cathode is achieved.
- Published
- 2012
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35. A simple and low-cost technique for silicon nanowire arrays based solar cells
- Author
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Wen-Luh Yang, Ying-Kan Yang, Bohr-Ran Huang, and Tzu-Ching Lin
- Subjects
Materials science ,Equivalent series resistance ,Renewable Energy, Sustainability and the Environment ,business.industry ,Doping ,Energy conversion efficiency ,Analytical chemistry ,Quantum dot solar cell ,Polymer solar cell ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,law.invention ,law ,Solar cell ,Optoelectronics ,Quantum efficiency ,business ,Common emitter - Abstract
A new PSG doping process was developed using a sol-gel method with phosphorus pentoxide (P2O5) powder combined with a screen-printing technique for the fabrication of electrodes. This process was applied in silicon nanowire (SiNW) arrays based solar cells. The PSG-doped SiNW arrays were used as both the anti-reflectance layer and the n+ emitter for the solar cells. The morphology and photoelectric characteristics of the SiNW array solar cells were measured by a scanning electron microscope (SEM), a UV/VIS/NIR spectrophotometer, a quantum efficiency measurement system and a solar cell simulator. It was found that the reflectivity (Rλ), internal quantum efficiency (IQE), series resistance (Rs) and power conversion efficiency (PCE) were influenced by the aspect ratio and the density of the PSG-doped SiNW arrays. Results indicate that there is a competition phenomenon between the aspect ratio and the density. It was observed that certain aspect ratio (∼5.15) with appropriate density (∼34.5%) of PSG-doped straight-aligned SiNW arrays possessed better solar cell (∼10.15%) performance. The SiNW array solar cells showed potential for low cost and mass-production in commercial solar cells applications.
- Published
- 2012
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36. Palladium nanoparticles modified carbon nanotube/nickel composite rods (Pd/CNT/Ni) for hydrogen sensing
- Author
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Bohr-Ran Huang and Tzu-Ching Lin
- Subjects
Nanotube ,Nanocomposite ,Materials science ,Hydrogen ,Composite number ,Metals and Alloys ,chemistry.chemical_element ,Carbon nanotube ,Condensed Matter Physics ,Rod ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,law.invention ,Nickel ,Chemical engineering ,chemistry ,law ,Plating ,Materials Chemistry ,Electrical and Electronic Engineering ,Instrumentation - Abstract
A leaf-like carbon nanotube/nickel (CNT/Ni) composite film modified with palladium nanoparticles (Pd NPs) was developed for hydrogen (H 2 ) gas sensing applications. A leaf-like CNT/Ni composite film was fabricated on glass by nanocomposite plating. A Pd/CNT/Ni film, which was treated by the sensitization and activation process, was then formed to improve the hydrogen sensing properties. The H 2 gas sensing properties of the Pd/CNT/Ni were found to have a much higher response (7.3%) and faster response time (312 s) at 200 ppm H 2 gas than those prepared without Pd NPs modified (0.7%, 1092 s). The modified Pd/CNT/Ni composite film sensor possessed good sensing properties and has potential for mass production in flexible sensing devices.
- Published
- 2012
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- View/download PDF
37. A novel technique to fabricate horizontally aligned CNT nanostructure film for hydrogen gas sensing
- Author
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Bohr-Ran Huang and Tzu-Ching Lin
- Subjects
Nanocomposite ,Nanostructure ,Materials science ,Hydrogen ,Renewable Energy, Sustainability and the Environment ,business.industry ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Response time ,Nanotechnology ,Carbon nanotube ,Condensed Matter Physics ,Oxygen ,law.invention ,symbols.namesake ,Fuel Technology ,chemistry ,law ,Plating ,symbols ,Optoelectronics ,Raman spectroscopy ,business - Abstract
A simple method using a combination of nanocomposite plating and firing techniques for the production of horizontally aligned carbon nanotube (HACNT)-based hydrogen gas sensors is presented. This low temperature (100 °C) firing process generates cracks in which HACNTs are formed. Hydrogen sensing characteristics are measured in various gas concentrations from 200 ppm to 16,000 ppm at room temperature. The HACNT-based hydrogen gas sensor performs with low noise, short response time, and fast recovery time. It is found that the HACNT-based sensors have a much better sensitivity response (approximately 5 times) than the original CNT/Ni film sensors which use a nanocomposite plating technique only. The Raman spectra of the HACNT-based sensors show that more defects and oxidation were generated on the HACNTs after the firing process. The firing process decreases the oxygen vacancies of CNTs to enhance the sensitivity response of HACNT-based sensors. In addition HACNT-based sensors are relatively simple, cost-effective and mass-producible.
- Published
- 2011
- Full Text
- View/download PDF
38. Gas Ionization Sensors with Carbon Nanotube/Nickel Field Emitters
- Author
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Bohr-Ran Huang, Tzu-Ching Lin, Ying-Kan Yang, and Shien-Der Tzeng
- Subjects
Materials science ,Biomedical Engineering ,Analytical chemistry ,Bioengineering ,General Chemistry ,Carbon nanotube ,Condensed Matter Physics ,law.invention ,Carbon nanotube quantum dot ,Field electron emission ,symbols.namesake ,law ,Torr ,Ionization ,Electric field ,symbols ,General Materials Science ,Raman spectroscopy ,Joule heating - Abstract
Gas ionization sensors based on the field emission properties of the carbon nanotube/nickel (CNT/Ni) field emitters were first developed in this work. It is found that the breakdown electric field (E(b)) slightly decreases from 2.2 V/microm to 1.9 V/microm as the pressure of H2 gas increases from 0.5 Torr to 100 Torr. On the contrary, E(b) obviously increases from 2.9 V/microm to 6.5 V/microm as O2 gas pressure increases from 0.5 Torr to 100 Torr. This may be explained by the depression of the electron emission that caused by the adsorption of the O2 gas on the CNT emitters. The Raman spectra of the CNT/Ni emitters also show that more defects were generated on the CNTs after O2 gas sensing. The Joule heating effect under high current density as performing H2 sensing was also observed. These effects may contribute the pressure dependence on the breakdown electric field of the CNT/Ni gas ionization sensors.
- Published
- 2011
- Full Text
- View/download PDF
39. Field emission property of arrayed nanocrystalline diamond
- Author
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Shyankay Jou, Ying-Kan Yang, Yao-Ming Wu, Chia-Hui Chou, Tzu-Ching Lin, and Bohr-Ran Huang
- Subjects
Materials science ,Plasma etching ,Synthetic diamond ,business.industry ,Mechanical Engineering ,Nanotechnology ,Nanocrystalline diamond ,General Chemistry ,Electrostatics ,Electronic, Optical and Magnetic Materials ,law.invention ,Field electron emission ,law ,Electric field ,Materials Chemistry ,Optoelectronics ,Electrical and Electronic Engineering ,Thin film ,business ,Electronic properties - Abstract
Arrays of nanocrystalline diamond (NCD) stripes were fabricated by plasma etching of a NCD film. Electron field emission (EFE) of NCD arrays with 100-μm-wide stripes separated by different spacings was analyzed. The NCD arrays had higher EFE efficacy than the non-patterned blanket NCD film. The turn-on electric field ( E on ) decreased from 5.4 V/μm -1 for the blanket NCD film to 4.2, 4.4 and 4.7 V/μm − 1 for the NCD arrays with 100, 500 and 1000 μm of spacing, respectively. Both the effective emitting area and the field enhancement factor for the NCD emitters were increased by patterning. The enhanced EFE from arrayed NCD stripes was possibly attributed to the edge effect and reduction of electrostatic screening.
- Published
- 2011
- Full Text
- View/download PDF
40. Fabrication of Carbon Nanotubes Field Emission Cathode by Composite Plating
- Author
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Fang-Hsing Wang, Shien-Der Tzeng, and Tzu-Ching Lin
- Subjects
Materials science ,Fabrication ,Scanning electron microscope ,Composite number ,Biomedical Engineering ,Bioengineering ,Nanotechnology ,General Chemistry ,Carbon nanotube ,Condensed Matter Physics ,law.invention ,Field electron emission ,symbols.namesake ,law ,Electric field ,Plating ,symbols ,General Materials Science ,Composite material ,Raman spectroscopy - Abstract
Carbon nanotubes (CNTs) have high aspect ratio and have great potential to be applied as the field emission cathode because of its large field enhancement factor. In this work, a high performance carbon nanotube field emission cathode (CNTFC) was fabricated by using a composite plating method. The CNTs were purified by acid solutions and then dispersed in electrobath with nickel ions at temperatures of 60, 70, or 80 degrees C for the electroless plating process on glass substrate. The resulting CNT-Ni composite film has strong adhesion on the glass substrate. The degree of graphitization and the microstructure of the CNTFCs were studied by Raman spectroscopy and scanning electron microscopy. The field emission properties of the CNTFCs show a low turn-on electric field E(on) of about 1.2 V/microm, and a low threshold electric field E(th) of about 1.9 V/microm. Such a composite plating method could be applied to the fabrication of large area CNT field-emission displays.
- Published
- 2010
- Full Text
- View/download PDF
41. A smoothing Newton method based on the generalized Fischer–Burmeister function for MCPs
- Author
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Tzu Ching Lin, Jein Shan Chen, and Shaohua Pan
- Subjects
Applied Mathematics ,Mathematical analysis ,Solution set ,symbols.namesake ,Rate of convergence ,Complementarity theory ,Norm (mathematics) ,Jacobian matrix and determinant ,symbols ,Applied mathematics ,Mixed complementarity problem ,Newton's method ,Analysis ,Smoothing ,Mathematics - Abstract
We present a smooth approximation for the generalized Fischer–Burmeister function where the 2-norm in the FB function is relaxed to a general p -norm ( p > 1 ), and establish some favorable properties for it — for example, the Jacobian consistency. With the smoothing function, we transform the mixed complementarity problem (MCP) into solving a sequence of smooth system of equations, and then trace a smooth path generated by the smoothing algorithm proposed by Chen (2000) [28] to the solution set. In particular, we investigate the influence of p on the numerical performance of the algorithm by solving all MCPLIP test problems, and conclude that the smoothing algorithm with p ∈ ( 1 , 2 ] has better numerical performance than the one with p > 2 .
- Published
- 2010
- Full Text
- View/download PDF
42. EOG-based Human–Computer Interface system development
- Author
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Jui-Sen Tuan, Lawrence Y. Deng, Shih-Ming Chang, Chun-Liang Hsu, and Tzu-Ching Lin
- Subjects
System development ,genetic structures ,business.industry ,Computer science ,Interface (computing) ,General Engineering ,Eye movement ,Tracking system ,Signal ,eye diseases ,Computer Science Applications ,Analog signal ,Artificial Intelligence ,Human–computer interaction ,Digital signal ,sense organs ,User interface ,business - Abstract
Several Human-Machine/Computer Interfaces (HMI/HCI) had been developed in recent years. Some designs were specifically made for people with disabilities such as injured-vertebra, apoplexy or poliomyelitis, Amyotrophic Lateral Sclerosis (ALS), and Motor Neuron Disease, (MND). In this paper, we proposed an eye-movement tracking system. Based on Electro-Oculography (EOG) technology we detected the signal with different directions in eye-movements and then analyzed to understand what they represented about (e.g. horizontal direction or vertical direction). We converted the analog signal to digital signal and then used as the control signals for Human-Computer Interface (HCI). In order to make the system ''robust'', several applications with EOG-based HCI had been designed. Our preliminary results revealed more than 90% accuracy rate for examining the eye-movement that may become a new useful human-machine user interface in the near future.
- Published
- 2010
- Full Text
- View/download PDF
43. The stability of the CNT/Ni field emission cathode fabricated by the composite plating method
- Author
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Bohr-Ran Huang, Ying-Kan Yang, Shien-Der Tzeng, and Tzu-Ching Lin
- Subjects
Materials science ,Scanning electron microscope ,Mechanical Engineering ,Ultra-high vacuum ,Analytical chemistry ,General Chemistry ,Microstructure ,Electronic, Optical and Magnetic Materials ,Field electron emission ,Electric field ,Materials Chemistry ,Electrical and Electronic Engineering ,Joule heating ,Current density ,Common emitter - Abstract
A novel composite plating method has been developed for the fabrication of carbon nanotube/Ni (CNT/Ni) field emission cathode. The field emission properties of the initial CNT/Ni field emitter show a low turn-on electric field E on of about 1.1 V/μm with an emission current density of 1 μA/cm 2 , and a low threshold electric field E th of about 1.7 V/μm with an emission current density of 1 mA/cm 2 . After performing a stability test with a high emission current density in high vacuum, the corresponding microstructure and the degree of graphitization of the CNT/Ni field emitter were measured by using scanning electron microscopy and Raman spectroscopy. We found that the degree of graphitization slowly decreases with the duration time t FE of the stability test, the size of small rod-like CNT/Ni composite structures in the film increases with t FE , and obvious cracks appear in the film as t FE is larger than 60 h. The degradation of the field emission properties may be explained by the Joule heating effect on the CNT/Ni field emitter under high emission current density.
- Published
- 2010
- Full Text
- View/download PDF
44. Work stress, occupational burnout and depression levels: a clinical study of paediatric intensive care unit nurses in Taiwan
- Author
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Mei-Chen Ou-Yang, Su-Fen Cheng, Li-Min Wu, Tzu-Ching Lin, and Huey-Shyan Lin
- Subjects
Adult ,medicine.medical_specialty ,health care facilities, manpower, and services ,education ,Psychological intervention ,Taiwan ,Context (language use) ,Nursing Staff, Hospital ,Critical Care Nursing ,Intensive Care Units, Pediatric ,Occupational burnout ,03 medical and health sciences ,Paediatric intensive care unit ,Young Adult ,0302 clinical medicine ,Surveys and Questionnaires ,medicine ,Humans ,030212 general & internal medicine ,Psychiatry ,Burnout, Professional ,General Nursing ,Depression (differential diagnoses) ,Aged ,Government ,030504 nursing ,business.industry ,Depression ,General Medicine ,Middle Aged ,Checklist ,Pediatric Nursing ,Cross-Sectional Studies ,Work stress ,Socioeconomic Factors ,Family medicine ,Female ,0305 other medical science ,business ,psychological phenomena and processes - Abstract
Aims and objectives This study aimed to examine the relationship between work stress and depression; and investigate the mediating effect of occupational burnout among nurses in paediatric intensive care units. Background The relationships among work stress, occupational burnout and depression level have been explored, neither regarding occupational burnout as the mediating role that causes work stress to induce depression nor considering the paediatric intensive care unit context. Design A cross-sectional correlational design was conducted. Methods One hundred and forty-four female paediatric intensive care unit nurses from seven teaching hospitals in southern Taiwan were recruited as the participants. Data were collected by structured questionnaires including individual demographics, the Nurse Stress Checklist, the Occupational Burnout Inventory and the Taiwan Depression Questionnaire. Results The results indicated that after controlling for individual demographic variables, the correlations of work stress with occupational burnout, as well as work stress and occupational burnout with depression level were all positive. Furthermore, occupational burnout may exert a partial mediating effect on the relationship between work stress and depression level. Conclusion This study provides information about work stress, occupational burnout and depression level, and their correlations, as well as the mediating role of occupational burnout among paediatric intensive care unit nurses. Relevance to clinical practice It suggests government departments and hospital administrators when formulating interventions to prevent work stress and occupational burnout. These interventions can subsequently prevent episodes of depression in paediatric intensive care unit nurses, thereby providing patients with a safe and high-quality nursing environment.
- Published
- 2015
45. Hybrid organic-inorganic heterojunction solar cells with 12% efficiency by utilizing flexible film-silicon with a hierarchical surface
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Chen-Chih Hsueh, Subramani Thiyagu, Tzu-Ching Lin, Ching-Fuh Lin, Chien-Ting Liu, and Hong-Jhang Syu
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Range (particle radiation) ,Materials science ,Silicon ,business.industry ,Energy conversion efficiency ,chemistry.chemical_element ,Heterojunction ,Hybrid solar cell ,Polymer solar cell ,chemistry ,PEDOT:PSS ,Angle of incidence (optics) ,Optoelectronics ,General Materials Science ,business - Abstract
This paper reports an organic–inorganic hybrid solar cell with a hierarchical surface composed of high density silicon nanoholes and micro-desert textures. High-efficiency organic–inorganic hybrid solar cell Si/PEDOT–PSS with a hierarchical surface, showing a power conversion efficiency of 12%. The structure provides excellent light absorption over 97% for the spectral range of 300 to 1100 nm with a thickness of 60 μm due to internal multiple reflections caused by subwavelength features of high density silicon nanoholes and micro-desert textures. In addition, from the angle of incidence (AOI) observed, even at the large angle of 75°, the reflectance value still exhibits less than 1%. With the advantage of very thin silicon material and inexpensive processing, hybrid silicon/polymer solar cells are promising for various applications and thus could be an economically feasible alternative energy solution in the future.
- Published
- 2014
46. Fabrication of large-scaled synergetic silicon nanowire arrays using metal-assisted chemical etching for solar cell applications
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Ching-Fuh Lin, Tzu-Ching Lin, Chen-Chih Hsueh, Subramani Thiyagu, and Chien-Ting Liu
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Materials science ,Fabrication ,Silicon ,business.industry ,Nanowire ,chemistry.chemical_element ,Isotropic etching ,law.invention ,Nanolithography ,chemistry ,Etching (microfabrication) ,law ,Solar cell ,Optoelectronics ,Wafer ,business - Abstract
We fabricate Silicon nanowire (SiNW) arrays for solar-cell applications on 6-inch wafers employing metal-assisted chemical etching (MacEtch). It can reduce cost and energy consumption. However it is difficult to make uniform SiNW arrays on large size wafer. Here we demonstrate a simple method to achieve a uniform SiNW on 6 inch wafers. Moreover, optical properties and surface morphologies of 6 inch N-type pyramid/SiNW arrays and 6 inch P-type as-cut/SiNW arrays are investigated. Reflectance indicates the extensive light-trapping effect by the SiNW arrays. Thus, the improved MacEtch method is promising for future commercial mass production on large size wafers.
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- 2013
- Full Text
- View/download PDF
47. Morphology dependence of silicon nanostructure/organic polymer solar cell
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Ching-Fuh Lin, Thiyagu Subramani, Hong-Jhang Syu, Kasimayan Uma, Chien-Ting Liu, Chen-Chih Hsueh, and Tzu-Ching Lin
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Materials science ,Silicon ,business.industry ,Energy conversion efficiency ,Nanowire ,chemistry.chemical_element ,Polymer solar cell ,law.invention ,Organic semiconductor ,chemistry ,PEDOT:PSS ,law ,Solar cell ,Optoelectronics ,Quantum efficiency ,business - Abstract
Si nanohole and nanowire/organic polymer solar cell is fabricated by low temperature and simple spin-coating method. The results show that the nanohole device performance is better than that of nanowire device. The Si nanohole device has higher external quantum efficiency in all wavelengths. The reason for the enhancement is analyzed from optical reflectance and the observation between Si nanohole and PEDOT:PSS interface. With nanohole structure, the short-circuit current density is increased from 22.1 to 26.9 mA/cm2 (22% increase), and the power conversion efficiency is enhanced from 7.4% to 8.0%. Nanohole structure is promising for high-efficiency Si/organic polymer solar cell.
- Published
- 2013
- Full Text
- View/download PDF
48. Secure Dynamic access control scheme of PHR in cloud computing
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Tzu-Ching Lin, Chin-Sheng Chen, Chia-Hui Liu, Tzer-Long Chen, Jian-Guo Bau, and Tzer-Shyong Chen
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Computer science ,Information access ,Medicine (miscellaneous) ,Information Storage and Retrieval ,Health Informatics ,Cloud computing ,Access control ,Encryption ,Computer security ,computer.software_genre ,Access to Information ,Health Information Management ,Electronic Health Records ,Key management ,Information exchange ,Computer Security ,Internet ,business.industry ,Information technology ,Health Records, Personal ,The Internet ,business ,computer ,Algorithms ,Confidentiality ,Information Systems - Abstract
With the development of information technology and medical technology, medical information has been developed from traditional paper records into electronic medical records, which have now been widely applied. The new-style medical information exchange system "personal health records (PHR)" is gradually developed. PHR is a kind of health records maintained and recorded by individuals. An ideal personal health record could integrate personal medical information from different sources and provide complete and correct personal health and medical summary through the Internet or portable media under the requirements of security and privacy. A lot of personal health records are being utilized. The patient-centered PHR information exchange system allows the public autonomously maintain and manage personal health records. Such management is convenient for storing, accessing, and sharing personal medical records. With the emergence of Cloud computing, PHR service has been transferred to storing data into Cloud servers that the resources could be flexibly utilized and the operation cost can be reduced. Nevertheless, patients would face privacy problem when storing PHR data into Cloud. Besides, it requires a secure protection scheme to encrypt the medical records of each patient for storing PHR into Cloud server. In the encryption process, it would be a challenge to achieve accurately accessing to medical records and corresponding to flexibility and efficiency. A new PHR access control scheme under Cloud computing environments is proposed in this study. With Lagrange interpolation polynomial to establish a secure and effective PHR information access scheme, it allows to accurately access to PHR with security and is suitable for enormous multi-users. Moreover, this scheme also dynamically supports multi-users in Cloud computing environments with personal privacy and offers legal authorities to access to PHR. From security and effectiveness analyses, the proposed PHR access scheme in Cloud computing environments is proven flexible and secure and could effectively correspond to real-time appending and deleting user access authorization and appending and revising PHR records.
- Published
- 2012
49. Layer transfer of crystalline Si thin film by metal-assisted chemical etching concerning different H2O2/HF ratios
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Keng-Lam Pun, Tzu-Ching Lin, Shu-Chia Shiu, Ching-Fuh Lin, and Hong-Jhang Syu
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Materials science ,Silicon ,business.industry ,Photovoltaic system ,chemistry.chemical_element ,Isotropic etching ,Hafnium ,Nanolithography ,Optics ,chemistry ,Chemical engineering ,Etching (microfabrication) ,Thin film ,business ,Layer (electronics) - Abstract
Thin-film crystalline photovoltaic (PV) cell is a trend for future PV with its potential to achieve low cost and high efficiency. Concerning material utilization efficiency, we propose a method with a fast manufacturing method of thin crystalline Si by chemical solution. To obtain the highest efficiency of material utilization, experiments with different H 2 O 2 /HF ratio are conducted, where related mechanisms are discussed. Moreover, large-area (87.7 mm2) thin film transferred to glass is demonstrated, and with embedded nanohole structure, lowest optical reflectance of 0.26% is measured. These characteristics show that the fabricated thin film has potential for large-area crystalline thin film PV.
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- 2012
- Full Text
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50. A Reliable Dynamic User-Remote Password Authentication Scheme over Insecure Network
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Dai-Lun Chiang, Tzu-Ching Lin, Yu-Fang Chung, Zhen-Yu Wu, and Tzer-Shyong Chen
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Zero-knowledge password proof ,Otway–Rees protocol ,Computer science ,computer.internet_protocol ,Salt (cryptography) ,Data_MISCELLANEOUS ,Computer security ,computer.software_genre ,One-time password ,S/KEY ,Password strength ,Key stretching ,Syskey ,Password authentication protocol ,Key derivation function ,Password psychology ,Replay attack ,Password ,Authentication ,Password policy ,User authentication ,Cognitive password ,business.industry ,Password cracking ,Cryptographic protocol ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,Rainbow table ,HMAC-based One-time Password Algorithm ,Smart card ,Challenge–response authentication ,business ,computer - Abstract
Protocols of user authentication are able to ensure the security of data transmission and usersi¦ communication over insecure networks. Among various authenticated mechanisms run currently, the password-based user authentication, because of its efficiency, is the most widely employed in different areas, such as computer networks, wireless networks, remote login, operation systems, and database management systems. Even as password is endowed with the property of simple and human memorable, for which causes such an attack of brute force, for example, the previous works often suffer off-line password guessing attack. Therefore, an ameliorative password-based authentication scheme is proposed in this paper, achieving to resist off-line password guessing attacks, replay attacks, on-line password guessing attacks, and ID-theft attacks. In light of security, the proposed scheme is provided with good practicability, even over insecure network.
- Published
- 2012
- Full Text
- View/download PDF
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