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19 results on '"Tzonis, Panagiotis"'

2. Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study

Author

Pantos, Konstantinos, primary, Simopoulou, Mara, additional, Maziotis, Evangelos, additional, Rapani, Anna, additional, Grigoriadis, Sokratis, additional, Tsioulou, Petroula, additional, Giannelou, Polina, additional, Nitsos, Nikolaos, additional, Tzonis, Panagiotis, additional, Koutsilieris, Michael, additional, and Sfakianoudis, Konstantinos, additional

Published
2021
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4. Evaluating different strategies for poor ovarian response management: a retrospective cohort study and literature review

Author

Pantou, Agni, primary, Giannelou, Polina, additional, Grigoriadis, Sokratis, additional, Maziotis, Evangelos, additional, Tzonis, Panagiotis, additional, Koutsouni, Anastasia, additional, Pappa, Charikleia, additional, Philippou, Anastassios, additional, Koutsilieris, Michael, additional, Pantos, Konstantinos, additional, Simopoulou, Mara, additional, and Sfakianoudis, Konstantinos, additional

Published
2021
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5. Introducing intrauterine antibiotic infusion as a novel approach in effectively treating chronic endometritis and restoring reproductive dynamics: a randomized pilot study

Author

Pantos, Konstantinos Simopoulou, Mara Maziotis, Evangelos and Rapani, Anna Grigoriadis, Sokratis Tsioulou, Petroula and Giannelou, Polina Nitsos, Nikolaos Tzonis, Panagiotis and Koutsilieris, Michael Sfakianoudis, Konstantinos

Abstract

The chronic nature of Chronic Endometritis (CE) along with the challenging management and infertility entailed, call for cutting-edge therapeutic approaches. This study introduces the novel treatment of intrauterine antibiotic infusion (IAI) combined with oral antibiotic administration (OAA), and it assesses respective performance against the gold standard treatment of OAA. Data sourced herein reports on treatment efficiency and fertility restoration for both patients aiming to conceive naturally or via In Vitro fertilization. Eighty CE patients, 40 presenting with recurrent implantation failure, and 40 with recurrent pregnancy loss, were enrolled in the IVF and the natural conception arm respectively. Treatment was subjected to randomization. Effectively treated patients proceeded with either a single IVF cycle or were invited to conceive naturally over a 6-month period. Combination of IAI and OAA provided a statistically significant enhanced effectiveness treatment rate (RR 1.40; 95%CI 1.07-1.82; p=0.01). No statistically significant difference was observed regarding the side-effects rate (RR 1.33; 95%CI 0.80-2.22; p=0.52). No statistically significant difference was observed for either arm regarding live-birth rate. Following an intention-to-treat analysis, employment of IAI corresponds to improved clinical pregnancy rate-albeit not reaching statistical significance. In conclusion, complimentary implementation of IAI could provide a statistically significant enhanced clinical treatment outcome.

Published
2021

9. Additional file 1: Figure S1. of Unraveling the role of preexisting immunity in prostate cancer patients vaccinated with a HER-2/neu hybrid peptide

Author

Voutsas, Ioannis, Anastasopoulou, Eleftheria, Tzonis, Panagiotis, Papamichail, Michael, Perez, Sonia, and Baxevanis, Constantin

Abstract

Frequencies of CD8+ cells recognizing HER85 (A), HER435 (B), PSMA (C), SURV96 (D), TERT (E) in HLA-A2+ patients and SURV20 (F) in HLA-A24+ patients, at time points R0 and Rmax. Statistical significant increase was observed for HER85 and TERT, while a strong trend was observed for SURV96. (PPTX 249Â kb)

Published
2016
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10. Subgroup efficacy evaluation of the AE37 HER2 vaccine in breast cancer patients in the adjuvant setting.

Author

Peace, Kaitlin M., primary, Mittendorf, Elizabeth Ann, additional, Perez, Sonia A., additional, Tzonis, Panagiotis, additional, Pistamaltzian, Nikolaos Fragkiskos, additional, Anastasopoulou, Eleftheria A, additional, Vreeland, Timothy J., additional, Hale, Diane F, additional, Clifton, Guy T, additional, Litton, Jennifer Keating, additional, von Hofe, Eric, additional, Ardavanis, Alexandros, additional, Papamichail, Michael, additional, and Peoples, George Earl, additional

Published
2017
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12. Leukemia Inhibitory Factor, Tissue Factor, Thrombomodulin, P-Selectine, D-Dimer, Thrombin Generation and Procoagulant Phospholipid Dependent Clotting Time Are Predictive for in Vitro Fertilization Outcome. the Prospective Roadmap-IVF Study

Author

Lefkou, Eleftheria, Tzonis, Panagiotis, Sfakianoudis, Kostas, Rousseau, Aurelie, Elalamy, Ismail, Grusse, Matthieu, Mbemba, Elisabeth, Van Dreden, Patrick, and Gerotziafas, Grigoris

Abstract

BackgroundThe link between blood hypercoagulability, endothelial cell activation and infertility or in vitro fertilization (IVF) failure is a puzzling issue. Activation of platelets, endothelial cells and blood coagulation, proinflammatory and angiogenetic potential play important role in implantation and early embryonic development. Biomarkers of cellular hypercoagulability are associated with high risk of IVF failure. Soluble Leukemia Inhibitory Factor (LIF), an interleukin 6 class cytokine expressed in the trophectoderm of the developing embryo is an important regulator in the establishment of pregnancy. Endoglin (Eng), a co-receptor for TGF-β1 and TGF-β3 is implicated in vascular complications of pregnancy and particularly in preeclampsia.

Published
2023
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13. DRB1*11 allele expression and HER2 pre-existing immunity may predict benefit in breast cancer patients vaccinated with the HER2 modified AE37 peptide vaccine

Author

Anastasopoulou, Eleftheria A, primary, Tzonis, Panagiotis, additional, Fortis, Sotirios P, additional, Mahaira, Louisa, additional, Vaxevanis, Christoforos, additional, Ardavanis, Alexandros, additional, Mittendorf, Elizabeth A, additional, Peoples, George E, additional, Baxevanis, Constantin N, additional, Papamichail, Michael, additional, and Perez, Sonia A, additional

Published
2015
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15. Booster inoculations of the AE37 peptide vaccine enhance immunological responses in a phase II study.

Author

Anastasopoulou, Eleftheria A, primary, Pappou, Efi, additional, Tzonis, Panagiotis, additional, Ardavanis, Alexandros, additional, Ponniah, Sathibalan, additional, Baxevanis, Constantin N., additional, Murray, James L., additional, Papamichail, Michael, additional, Perez, Sonia A., additional, Peoples, George Earl, additional, and Mittendorf, Elizabeth Ann, additional

Published
2013
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17. Are Educators at High Risk of Sub-fertility? A Multicenter Study

Author

Perros, Gerasimos, primary, Tzonis, Panagiotis, additional, Tsilivakos, Vasilis, additional, Gerofotis, Antonios, additional, Dalavitsou, Vasiliki, additional, Vassilaki, Athina, additional, Keramitsoglou, Theodora, additional, Papaioannou, Dimitris, additional, Moschandreou, Dimitra, additional, Kontopoulou-Antonopoulou, Virginia, additional, Daniilidis, Michail, additional, and Varla-Leftherioti, Marighoula, additional

Published
2010
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18. Results from a Phase I Clinical Study of the Novel Ii-Key/HER-2/neu(776–790) Hybrid Peptide Vaccine in Patients with Prostate Cancer

Author

Perez, Sonia A., primary, Kallinteris, Nikoletta L., additional, Bisias, Stratos, additional, Tzonis, Panagiotis K., additional, Georgakopoulou, Katerina, additional, Varla-Leftherioti, Marighoula, additional, Papamichail, Michael, additional, Thanos, Anastasios, additional, von Hofe, Eric, additional, and Baxevanis, Constantin N., additional

Published
2010
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