Search

Your search keyword '"Tzeng,Nian-Sheng"' showing total 929 results
Start Over Author "Tzeng,Nian-Sheng"
929 results on '"Tzeng,Nian-Sheng"'

6. Effects of online high‐definition transcranial direct current stimulation over left dorsolateral prefrontal cortex on predominant negative symptoms and EEG functional connectivity in patients with schizophrenia: a randomized, double‐blind, controlled trial

Author

Yeh, Ta‐Chuan, Lin, Yen‐Yue, Tzeng, Nian‐Sheng, Kao, Yu‐Chen, Chung, Yong‐An, Chang, Chuan‐Chia, Fang, Hsu‐Wei, and Chang, Hsin‐An

Subjects
DEFAULT mode network, MAGNETIC induction tomography, PREFRONTAL cortex, TRANSCRANIAL direct current stimulation, FUNCTIONAL connectivity, PATHOLOGICAL psychology
Abstract

Aims: Schizophrenia, a debilitating mental disorder, is characterized by persistent negative symptoms such as avolition and anhedonia. Currently, there are no effective treatments available for these symptoms. Thus, our study aims to assess the efficacy of online high‐definition transcranial direct current stimulation (online HD‐tDCS) in addressing the negative symptoms of schizophrenia, utilizing a double‐blind, randomized, sham‐controlled trial design. Methods: Fifty‐nine patients with schizophrenia were randomized to receive either active HD‐tDCS or sham stimulation, targeting the left dorsolateral prefrontal cortex. Outcomes were measured by changes in the Positive and Negative Syndrome Scale Factor Score for Negative Symptom (PANSS‐FSNS). Exact low‐resolution electromagnetic tomography was used to assess the functional connectivity. Results: All 59 participants, including 50.84% females with an average age of 43.36 years, completed the trial. In the intention‐to‐treat analysis, patients receiving active HD‐tDCS showed greater improvement in PANSS‐FSNS scores compared to those receiving the sham procedure. The differences were 2.34 (95% confidence interval [CI], 1.28–3.40), 4.28 (95% CI, 2.93–5.62), and 4.91 (95% CI, 3.29–6.52) after the intervention, as well as at 1‐week and 1‐month follow‐ups, respectively. A tingling sensation on the scalp was more common in the active group (63.3%) compared to the sham group (10.3%). Additionally, HD‐tDCS was associated with a decrease in delta‐band connectivity within the default mode network. Conclusions: High‐definition transcranial direct current stimulation was effective and safe in ameliorating negative symptoms in patients with schizophrenia when combined with online functional targeting. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

24. Sex-specific pathways among tri-allelic serotonin transporter polymorphism, trait neuroticism and generalized anxiety disorder

Author

Chang, Hsin-An, Fang, Wen-Hui, Liu, Yia-Ping, Tzeng, Nian-Sheng, Shyu, Jia-Fwu, Wan, Fang-Jung, Huang, San-Yuan, Chang, Tieh-Ching, and Chang, Chuan-Chia

Subjects
Generalized anxiety disorder -- Genetic aspects -- Demographic aspects, Sex differences (Psychology) -- Health aspects -- Genetic aspects, Transport proteins -- Physiological aspects -- Genetic aspects, Neuroticism -- Demographic aspects -- Genetic aspects, Genetic polymorphisms -- Psychological aspects -- Health aspects, Serotonin -- Physiological aspects -- Genetic aspects, Health, Psychology and mental health
Abstract

Background: Neuroticism personality trait is recognized as an important endophenotypic predictor of generalized anxiety disorder (GAD). Furthermore, endophenotype-based pathway approaches have recently been shown to have greater advantages for gene-finding strategies than traditional case-control studies. In the present study, in addition to conventional case-control methods, we used pathway analyses to test whether the tri-allelic serotonin transporter promoter polymorphism (combining 5-HTTLPR and rs25531) is associated with risk of GAD through its effects on trait neuroticism. Methods: We included 2236 Han Chinese adults in this study, including 736 patients with GAD and 1500 healthy participants. We genotyped the 5-HTTLPR and rs25531 polymorphisms using the polymerase chain reaction restriction fragment length polymorphism method. We used the Neuroticism scale of the Maudsley Personality Inventory (MPI) short version (MPI-Neuroticism) to measure participants' tendency toward neuroticism. Results: Using endophenotype-based path analyses, we found significant indirect effects of the tri-allelic genotype on risk of GAD, mediated by MPI-Neuroticism in both men and women. Compared to women carrying the S'S' genotype, women carrying the L' allele had higher levels of MPI-Neuroticism, which in turn were associated with higher risk of GAD. Men, however, showed the opposite pattern. Using traditional case-control comparisons, we observed that the effect of tri-allelic genotype on GAD was significant, but only in women. Limitations: Participants were restricted to Han Chinese, and we used only 1 questionnaire to assess neuroticism. Conclusion: These findings are the first to show that the triallelic 5-HTTLPR polymorphism is associated with elevated risk of GAD, and that this effect is mediated via increased trait neuroticism, a sex-dependent risk pathway., Introduction Generalized anxiety disorder (GAD) is characterized by persistent worry associated with a variety of symptoms, including concentration problems, difficulty sleeping, fatigue, irritability, muscle tension and restlessness. It is a [...]

Published
2020
Full Text
View/download PDF

34. Effects of Subchronic Buspirone Treatment on Depressive Profile in Socially Isolated Rats: Implication of Early Life Experience on 5-HT1A Receptor-Related Depression.

Author

Tzeng, Nian-Sheng, Chung, Jing-Yi, Lin, Chen-Cheng, Cheng, Pao-Yun, and Liu, Yia-Ping

Subjects
*BUSPIRONE, *HIPPOCAMPUS (Brain), *RATS, *MENTAL depression, *PREFRONTAL cortex
Abstract

The heterogeneity of etiology may serve as a crucial factor in the challenges of treatment, including the low response rate and the delay in establishing therapeutic effect. In the present study, we examined whether social experience since early life is one of the etiologies, with the involvement of the 5-HT1A receptors, and explored the potentially therapeutic action of the subchronic administration of buspirone, a partial 5-HT1A agonist. Rats were isolation reared (IR) since their weaning, and the depressive profile indexed by the forced-swim test (FST) was examined in adulthood. Nonspecific locomotor activity was used for the IR validation. Buspirone administration (1 mg/kg/day) was introduced for 14 days (week 9–11). The immobility score of the FST was examined before and after the buspirone administration. Tissue levels of serotonin (5-HT) and its metabolite 5-HIAA were measured in the hippocampus, the amygdala, and the prefrontal cortex. Efflux levels of 5-HT, dopamine (DA), and norepinephrine (NE) were detected in the hippocampus by brain dialysis. Finally, the full 5-HT1A agonist 8-OH-DPAT (0.5 mg/kg) was acutely administered in both behavioral testing and the dialysis experiment. Our results showed (i) increased immobility time in the FST for the IR rats as compared to the social controls, which could not be reversed by the buspirone administration; (ii) IR-induced FST immobility in rats receiving buspirone was corrected by the 8-OH-DPAT; and (iii) IR-induced reduction in hippocampal 5-HT levels can be reversed by the buspirone administration. Our data indicated the 5-HT1A receptor-linked early life social experience as one of the mechanisms of later life depressive mood. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

47. Headaches and Risk of Dementia

Author

Tzeng, Nian-Sheng, Chung, Chi-Hsiang, Lin, Fu-Huang, Yeh, Chin-Bin, Huang, San-Yuan, Lu, Ru-Band, Chang, Hsin-An, Kao, Yu-Chen, Chiang, Wei-Shan, Chou, Yu-Ching, Tsao, Chang-Huei, Wu, Yung-Fu, and Chien, Wu-Chien

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results