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Dialogic reading (DR), first described in Whitehurst et al. (1988), is a specific reading technique that encourages parents to involve the child actively in verbal and nonverbal interactions during shared book reading. The well-known acronyms for DR techniques include CROWD (completion, recall, open-ended questions, wh-questions and distancing) and PEER (prompt, evaluate, expand and repeat). As DR was originally designed for children aged 2 to 5 years, it is less known about what the DR practices of parents would look like during shared book reading with 12 month-old infants. The current study analyzed observational data from 29 parent-infant dyads to address this issue during shared book reading. The results indicated that parents interacted with their 12 month-old infants by spontaneously applying most DR strategies during shared book reading, with some strategies used more frequently and commonly than others. The usage frequency of each DR strategy did not change as a function of infants' background characteristics. Parents with infants who had better abilities in communicative gestures tended to use information from the book cover to prompt the children to talk about the story more frequently during shared book reading. These results make a unique contribution in providing both quantitative and qualitative data to illustrate what the DR practices of parents look like while reading with preverbal infants.

Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT pathway was the most frequently mutated pathway, with frequent mutations in STAT5B as well as JAK1, JAK3, STAT3, and SOCS1 We also identified mutations in KRAS, TP53, and TERT Type I EATL and type II EATL (monomorphic epitheliotropic intestinal T cell lymphoma) had highly overlapping genetic alterations indicating shared mechanisms underlying their pathogenesis. We modeled the effects of SETD2 loss in vivo by developing a T cell-specific knockout mouse. These mice manifested an expansion of γδ T cells, indicating novel roles for SETD2 in T cell development and lymphomagenesis. Our data render the most comprehensive genetic portrait yet of this uncommon but lethal disease and may inform future classification schemes.

Using the Chinese writing system, which is unique with respect to the composition of each character in terms of its graphic shape, as an example, this chapter addresses the neurobiological underpinnings of reading and writing and how these brain circuits are used in different languages.

The present study examined the use of statistical cues for word boundaries during Chinese reading. Participants were instructed to read sentences for comprehension with their eye movements being recorded. A two-character target word was embedded in each sentence. The contrast between the probabilities of the ending character (C2) of the target word (C12) being used as word beginning and ending in all words containing it was manipulated. In addition, by using the boundary paradigm, parafoveal overlapping ambiguity in the string C123 was manipulated with three types of preview of the character C3, which was a single-character word in the identical condition. During preview, the combination of C23' was a legal word in the ambiguous condition and was not a word in the control condition. Significant probability and preview effects were observed. In the low-probability condition, inconsistency in the frequent within-word position (word beginning) and the present position (word ending) lengthened gaze durations and increased refixation rate on the target word. Although benefits from the identical previews were apparent, effects of overlapping ambiguity were negligible. The results suggest that the probability of within-word positions had an influence during character-to-word assignment, which was mainly verified during foveal processing. Thus, the overlapping ambiguity between parafoveal words did not interfere with reading. Further investigation is necessary to examine whether current computational models of eye movement control should incorporate statistical cues for word boundaries together with other linguistic factors in their word processing system to account for Chinese reading.

This study was aimed at investigating the semantic integration ability of people with WS in building up a coherent and gist theme from the context of presented sentences. Previous studies have indicated rich lexical semantic knowledge and typical semantic priming in this clinical group, but atypical brainwave patterns have been reported in studies of semantic comprehension. An integration difficulty hypothesis of merging meanings into sentences was proposed to explain the discrepancy (Tyler et al., 1997). In this study, this hypothesis was examined by means of proposition integration. Participants were presented sentences embedded with different numbers of propositions under various scenarios. Successful integration of semantically related propositions under same scenario was demonstrated by high false alarm recognition to sentences with more propositions (a maximum of four in this study). The results revealed that healthy adults showed integration ability when the number of propositions in a sentence were more than three, with increased false alarm rates and confidence ratings, whereas people with WS showed no differences in sentences with increased proposition numbers. Typically developing children controls confined recognition phenomenon to sentences carrying more than two propositions. Hence, it was concluded that contextual effects in terms of proposition integration was a gradual development from childhood into adulthood and a deviant development in people with WS. (Contains 2 figures and 2 tables.)

The spatial component of numerical and ordinal information has been explored in previous research. However, how such mapping emerges and how it is affected by the learning experience are issues still under debate. In the current study, we examined the orientation of the mental number line for different numerical notations in Chinese readers. Our data demonstrated that Arabic numbers are mentally aligned horizontally with a left-to-right directionality, while Chinese number words are aligned vertically with a top-to-bottom directionality. These findings indicate that different notations of the same concept have flexible mappings within space, which is plausibly shaped by the dominant context in which the numerical notations appear.

The role of phonological coding for character identification was examined with the benefit of processing parafoveal characters in eye fixations while reading Chinese sentences. In Experiment 1, the orthogonal manipulation of phonological and orthographic similarity can separate two types of phonological benefits for homophonic previews, according to whether these previews share the same phonetic radical with the targets or not. The significant phonological benefits indicate that phonological coding is activated early when the character is in the parafovea. Experiment 2 manipulated the character's consistency value and found that the phonological preview benefits are reliable only when the targets are high consistency characters. The results of two experiments suggest that phonological computation is rapid and early at both character and radical levels for Chinese character identification.

Describes four spaces of network learning models which are designed to integrate the Internet into education. Topics include learning technology; network learning environments; project-based learning; community-based learning; learner location; including distance learning; teacher-centered versus student-centered; interaction, including collaboration, peer tutoring, and competition; media types; knowledge structure; and knowledge acquisition. (Author/LRW)

Analyzes a report by D.D. Steinberg and J. Yamada that investigated which of the different types of scripts used in Japanese writing was the easiest to learn to read. (MKM)

Indicates that the way different languages reduce speech to script affects how visual information is processed in the brain, suggesting that the relation between script and speech underlying all types of writing systems plays an important part in reading behavior. Compares memory performance of native English/Chinese speakers. (JN)