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29 results on '"Tyurin, Anton P."'

3. Molecular Decoration and Unconventional Double Bond Migration in Irumamycin Biosynthesis.

Author

Alferova, Vera A., Baranova, Anna A., Belozerova, Olga A., Gulyak, Evgeny L., Mikhaylov, Andrey A., Solovev, Yaroslav V., Zhitlov, Mikhail Y., Sinichich, Arseniy A., Tyurin, Anton P., Trusova, Ekaterina A., Beletsky, Alexey V., Mardanov, Andrey V., Ravin, Nikolai V., Lapchinskaya, Olda A., Korshun, Vladimir A., Gabibov, Alexander G., and Terekhov, Stanislav S.

Subjects
BIOENGINEERING, DOUBLE bonds, SYNTHETIC biology, ACTIVATION energy, RING formation (Chemistry)
Abstract

Irumamycin (Iru) is a complex polyketide with pronounced antifungal activity produced by a type I polyketide (PKS) synthase. Iru features a unique hemiketal ring and an epoxide group, making its biosynthesis and the structural diversity of related compounds particularly intriguing. In this study, we performed a detailed analysis of the iru biosynthetic gene cluster (BGC) to uncover the mechanisms underlying Iru formation. We examined the iru PKS, including the domain architecture of individual modules and the overall spatial structure of the PKS, and uncovered discrepancies in substrate specificity and iterative chain elongation. Two potential pathways for the formation of the hemiketal ring, involving either an olefin shift or electrocyclization, were proposed and assessed using 18O-labeling experiments and reaction activation energy calculations. Based on our findings, the hemiketal ring is likely formed by PKS-assisted double bond migration and TE domain-mediated cyclization. Furthermore, putative tailoring enzymes mediating epoxide formation specific to Iru were identified. The revealed Iru biosynthetic machinery provides insight into the complex enzymatic processes involved in Iru production, including macrocycle sculpting and decoration. These mechanistic details open new avenues for a targeted architecture of novel macrolide analogs through synthetic biology and biosynthetic engineering. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Gausemycin Antibiotic Family Acts via Ca2+-Dependent Membrane Targeting

Author

Kravchenko, Tatyana V., primary, Paramonov, Alexander S., additional, Kudzhaev, Arsen M., additional, Efimova, Svetlana S., additional, Khorev, Alexey S., additional, Kudryakova, Gulnara Kh., additional, Ivanov, Igor A., additional, Chistov, Alexey A., additional, Baranova, Anna A., additional, Krasilnikov, Maxim S., additional, Lapchinskaya, Olda A., additional, Tyurin, Anton P., additional, Ostroumova, Olga S., additional, Smirnov, Ivan V., additional, Terekhov, Stanislav S., additional, Dontsova, Olga A., additional, Shenkarev, Zakhar O., additional, Alferova, Vera A., additional, and Korshun, Vladimir A., additional

Published
2024
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7. Facile Condensation of 2‐Aminobenzaldehydes into Azolo[4,5‐b]Quinolones.

Author

Opryshko, Victoria E., Zaitseva, Elvira R., Ivanov, Dmitrii S., Eshtukov‐Shcheglov, Artur V., Tyurin, Anton P., Mikhaylov, Andrey A., Smirnov, Alexander Yu., and Baranov, Mikhail S.

Subjects
QUINOLONE antibacterial agents, CONDENSATION, QUINOLINE, RING formation (Chemistry), AMINATION
Abstract

An operationally simple approach to azolo[4,5‐b]quinolines based on the condensation of 2‐aminobenzaldehydes with various azolones is developed. A series of 22 compounds was synthesized typically in good yields (40–92 %). [ABSTRACT FROM AUTHOR]

Published
2024
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8. Astolides A and B, antifungal and cytotoxic naphthoquinone-derived polyol macrolactones from Streptomyces hygroscopicus

Author

Alferova, Vera A., Novikov, Roman A., Bychkova, Olga P., Rogozhin, Eugene A., Shuvalov, Maxim V., Prokhorenko, Igor A., Sadykova, Vera S., Kulko, Alexander B., Dezhenkova, Lyubov G., Stepashkina, Elena A., Efremov, Mikhail A., Sineva, Olga N., Kudryakova, Gulnara Kh., Peregudov, Aleksander S., Solyev, Pavel N., Tkachev, Yaroslav V., Fedorova, Galina B., Terekhova, Larisa P., Tyurin, Anton P., Trenin, Aleksey S., and Korshun, Vladimir A.

Published
2018
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13. Amicoumacins and Related Compounds: Chemistry and Biology

Author

Tyurin, Anton P., primary, Efimenko, Tatyana A., additional, Prokhorenko, Igor A., additional, Rogozhin, Eugene A., additional, Malanicheva, Irina A., additional, Zenkova, Valentina A., additional, Efremenkova, Olga V., additional, and Korshun, Vladimir A., additional

Published
2018
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17. Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction

Author

Slesarchuk, Nikita A., Khvatov, Evgeny V., Chistov, Alexey A., Proskurin, Gleb V., Nikitin, Timofei D., Lazarevich, Anastasiya I., Ulanovskaya, Angelina A., Ulashchik, Egor A., Orlov, Alexey A., Jegorov, Artjom V., Ustinov, Alexey V., Tyurin, Anton P., Shmanai, Vadim V., Ishmukhametov, Aydar A., Korshun, Vladimir A., Osolodkin, Dmitry I., Kozlovskaya, Liubov I., and Aralov, Andrey V.

Published
2020
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18. Photosensitizing Antivirals

Author

Mariewskaya, Kseniya A., primary, Tyurin, Anton P., additional, Chistov, Alexey A., additional, Korshun, Vladimir A., additional, Alferova, Vera A., additional, and Ustinov, Alexey V., additional

Published
2021
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19. Gausemycins A,B: Cyclic Lipoglycopeptides from Streptomyces sp.**

Author

Tyurin, Anton P., primary, Alferova, Vera A., additional, Paramonov, Alexander S., additional, Shuvalov, Maxim V., additional, Kudryakova, Gulnara K., additional, Rogozhin, Eugene A., additional, Zherebker, Alexander Y., additional, Brylev, Vladimir A., additional, Chistov, Alexey A., additional, Baranova, Anna A., additional, Biryukov, Mikhail V., additional, Ivanov, Igor A., additional, Prokhorenko, Igor A., additional, Grammatikova, Natalia E., additional, Kravchenko, Tatyana V., additional, Isakova, Elena B., additional, Mirchink, Elena P., additional, Gladkikh, Elena G., additional, Svirshchevskaya, Elena V., additional, Mardanov, Andrey V., additional, Beletsky, Aleksey V., additional, Kocharovskaya, Milita V., additional, Kulyaeva, Valeriya V., additional, Shashkov, Alexander S., additional, Tsvetkov, Dmitry E., additional, Nifantiev, Nikolay E., additional, Apt, Alexander S., additional, Majorov, Konstantin B., additional, Efimova, Svetlana S., additional, Ravin, Nikolai V., additional, Nikolaev, Evgeny N., additional, Ostroumova, Olga S., additional, Katrukha, Genrikh S., additional, Lapchinskaya, Olda A., additional, Dontsova, Olga A., additional, Terekhov, Stanislav S., additional, Osterman, Ilya A., additional, Shenkarev, Zakhar O., additional, and Korshun, Vladimir A., additional

Published
2021
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20. Innentitelbild: Gausemycins A,B: Cyclic Lipoglycopeptides from Streptomyces sp. (Angew. Chem. 34/2021)

Author

Tyurin, Anton P., primary, Alferova, Vera A., additional, Paramonov, Alexander S., additional, Shuvalov, Maxim V., additional, Kudryakova, Gulnara K., additional, Rogozhin, Eugene A., additional, Zherebker, Alexander Y., additional, Brylev, Vladimir A., additional, Chistov, Alexey A., additional, Baranova, Anna A., additional, Biryukov, Mikhail V., additional, Ivanov, Igor A., additional, Prokhorenko, Igor A., additional, Grammatikova, Natalia E., additional, Kravchenko, Tatyana V., additional, Isakova, Elena B., additional, Mirchink, Elena P., additional, Gladkikh, Elena G., additional, Svirshchevskaya, Elena V., additional, Mardanov, Andrey V., additional, Beletsky, Aleksey V., additional, Kocharovskaya, Milita V., additional, Kulyaeva, Valeriya V., additional, Shashkov, Alexander S., additional, Tsvetkov, Dmitry E., additional, Nifantiev, Nikolay E., additional, Apt, Alexander S., additional, Majorov, Konstantin B., additional, Efimova, Svetlana S., additional, Ravin, Nikolai V., additional, Nikolaev, Evgeny N., additional, Ostroumova, Olga S., additional, Katrukha, Genrikh S., additional, Lapchinskaya, Olda A., additional, Dontsova, Olga A., additional, Terekhov, Stanislav S., additional, Osterman, Ilya A., additional, Shenkarev, Zakhar O., additional, and Korshun, Vladimir A., additional

Published
2021
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21. Inside Cover: Gausemycins A,B: Cyclic Lipoglycopeptides from Streptomyces sp. (Angew. Chem. Int. Ed. 34/2021)

Author

Tyurin, Anton P., primary, Alferova, Vera A., additional, Paramonov, Alexander S., additional, Shuvalov, Maxim V., additional, Kudryakova, Gulnara K., additional, Rogozhin, Eugene A., additional, Zherebker, Alexander Y., additional, Brylev, Vladimir A., additional, Chistov, Alexey A., additional, Baranova, Anna A., additional, Biryukov, Mikhail V., additional, Ivanov, Igor A., additional, Prokhorenko, Igor A., additional, Grammatikova, Natalia E., additional, Kravchenko, Tatyana V., additional, Isakova, Elena B., additional, Mirchink, Elena P., additional, Gladkikh, Elena G., additional, Svirshchevskaya, Elena V., additional, Mardanov, Andrey V., additional, Beletsky, Aleksey V., additional, Kocharovskaya, Milita V., additional, Kulyaeva, Valeriya V., additional, Shashkov, Alexander S., additional, Tsvetkov, Dmitry E., additional, Nifantiev, Nikolay E., additional, Apt, Alexander S., additional, Majorov, Konstantin B., additional, Efimova, Svetlana S., additional, Ravin, Nikolai V., additional, Nikolaev, Evgeny N., additional, Ostroumova, Olga S., additional, Katrukha, Genrikh S., additional, Lapchinskaya, Olda A., additional, Dontsova, Olga A., additional, Terekhov, Stanislav S., additional, Osterman, Ilya A., additional, Shenkarev, Zakhar O., additional, and Korshun, Vladimir A., additional

Published
2021
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25. Diversity, Novelty, and Antimicrobial Activity of Endophytic Actinobacteria From Mangrove Plants in Beilun Estuary National Nature Reserve of Guangxi, China

Author

Jiang, Zhong-ke, primary, Tuo, Li, additional, Huang, Da-lin, additional, Osterman, Ilya A., additional, Tyurin, Anton P., additional, Liu, Shao-wei, additional, Lukyanov, Dmitry A., additional, Sergiev, Petr V., additional, Dontsova, Olga A., additional, Korshun, Vladimir A., additional, Li, Fei-na, additional, and Sun, Cheng-hang, additional

Published
2018
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26. Crystallomycin revisited after 60 years: aspartocins B and C

Author

Tyurin, Anton P., primary, Alferova, Vera A., additional, Paramonov, Alexander S., additional, Shuvalov, Maxim V., additional, Malanicheva, Irina A., additional, Grammatikova, Natalia E., additional, Solyev, Pavel N., additional, Liu, Shaowei, additional, Sun, Chenghang, additional, Prokhorenko, Igor A., additional, Efimenko, Tatyana A., additional, Terekhova, Larisa P., additional, Efremenkova, Olga V., additional, Shenkarev, Zakhar O., additional, and Korshun, Vladimir A., additional

Published
2018
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27. Imaging‐based profiling for elucidation of antibacterial mechanisms of action.

Author

Baranova, Anna A., Alferova, Vera A., Korshun, Vladimir A., and Tyurin, Anton P.

Subjects
*ANTIBACTERIAL agents, *ANTIBIOTICS, *PHENOTYPES, *MICROSCOPY, *MORPHOLOGY
Abstract

In this review, we aim to summarize experimental data and approaches to identifying cellular targets or mechanisms of action of antibacterials based on imaging techniques. Imaging‐based profiling methods, such as bacterial cytological profiling, dynamic bacterial morphology imaging, and others, have become a useful research tool for mechanistic studies of new antibiotics as well as combinations with conventional ones and other therapeutic options. The main methodological and experimental details and obtained results are summarized and discussed. The review covers the literature up to February 2024. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Chemical Elicitors of Antibiotic Biosynthesis in Actinomycetes.

Author

Tyurin, Anton P., Alferova, Vera A., and Korshun, Vladimir A.

Subjects
ELICITORS (Botany), BIOSYNTHESIS, ANTIBIOTICS manufacturing, MICROBIOLOGICAL chemistry, ACTINOMYCETALES
Abstract

Whole genome sequencing of actinomycetes has uncovered a new immense realm of microbial chemistry and biology. Most biosynthetic gene clusters present in genomes were found to remain “silent” under standard cultivation conditions. Some small molecules—chemical elicitors—can be used to induce the biosynthesis of antibiotics in actinobacteria and to expand the chemical diversity of secondary metabolites. Here, we outline a brief account of the basic principles of the search for regulators of this type and their application. [ABSTRACT FROM AUTHOR]

Published
2018
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29. Gausemycin Antibiotic Family Acts via Ca 2+ -Dependent Membrane Targeting.

Author

Kravchenko TV, Paramonov AS, Kudzhaev AM, Efimova SS, Khorev AS, Kudryakova GK, Ivanov IA, Chistov AA, Baranova AA, Krasilnikov MS, Lapchinskaya OA, Tyurin AP, Ostroumova OS, Smirnov IV, Terekhov SS, Dontsova OA, Shenkarev ZO, Alferova VA, and Korshun VA

Subjects
Molecular Structure, Cell Membrane drug effects, Daptomycin pharmacology, Daptomycin chemistry, Lipid Bilayers chemistry, Micelles, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents chemistry, Calcium metabolism, Microbial Sensitivity Tests, Gram-Positive Bacteria drug effects
Abstract

We report the molecular mechanism of action of gausemycins and the isolation of new members of the family, gausemycins C ( 1c ), D ( 1d ), E ( 1e ), and F ( 1f ), the minor components of the mixture. To elucidate the mechanism of action of gausemycins, we investigated the antimicrobial activity of the most active compounds, gausemycins A and B, in the presence of Ca 2+ , other metal ions, and phosphate. Gausemycins require a significantly higher Ca 2+ concentration for maximum activity than daptomycin but lower than that required for malacidine and cadasides. Species-specific antimicrobial activity was found upon testing against a wide panel of Gram-positive bacteria. Membranoactivity of gausemycins was demonstrated upon their interactions with model lipid bilayers and micelles. The pore-forming ability was found to be dramatically dependent on the Ca 2+ concentration and the membrane lipid composition. An NMR study of gausemycin B in zwitterionic and anionic micelles suggested the putative structure of the gausemycin/membrane complex and revealed the binding of Ca 2+ by the macrocyclic domain of the antibiotic.

Published
2024
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