462 results on '"Tyrrell, D. Lorne"'
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2. Recombinant H77C gpE1/gpE2 heterodimer elicits superior HCV cross-neutralisation than H77C gpE2 alone
3. Interferon-λ treatment accelerates SARS-CoV-2 clearance despite age-related delays in the induction of T cell immunity
4. Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies
5. SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1
6. The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism
7. Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor
8. Characterization of Monoclonal Antibodies to Measure Cell Surface Protein Levels of Human Interferon-Lambda Receptor 1
9. 177 Single Cell Rna Sequencing Characterization of an in Vitro Model for Studies of Hepatitis B Virus
10. Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
11. Interferon regulatory factor 3 mediates effective antiviral responses to human coronavirus 229E and OC43 infection
12. Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
13. Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication
14. Efficient Pyrophosphorolysis by a Hepatitis B Virus Polymerase may be a Primer-Unblocking Mechanism
15. Multiplex Assays Enable Simultaneous Detection and Identification of SARS-CoV-2 Variants of Concern in Clinical and Wastewater Samples
16. Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model
17. Comprehensive in vitro characterization of PD-L1 small molecule inhibitors
18. Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry
19. Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on Erythropoiesis
20. Validation of TaqMan® SNP genotyping specificity for rs12979860 of IL-28B: Modeling primer specificity in vitro
21. Immunomodulatory Function of Interleukin 28B During Primary Infection With Cytomegalovirus
22. Bovine Serum Albumin-Protected Gold Nanoclusters for Sensing of SARS-CoV‑2 Antibodies and Virus.
23. Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum
24. Modulation of Fatty Acid Synthase Enzyme Activity and Expression during Hepatitis C Virus Replication
25. Highly bioavailable silibinin nanoparticles inhibit HCV infection
26. Pegylated-interferon-λ treatment-induced peripheral interferon stimulated genes are associated with SARS-CoV-2 viral load decline despite delayed T cell response in older individuals
27. On-Site Viral Inactivation and RNA Preservation of Gargle and Saliva Samples Combined with Direct Analysis of SARS-CoV-2 RNA on Magnetic Beads
28. Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses
29. Utilization of a Glucometer Test Strip and Enzymatic Reactions to Quantify Anti-SARS-CoV-2 Spike RBD IgG Antibody and SARS-CoV-2 Virus in Saliva and Serum
30. Synthesis and in vitro antiviral activities of 3′-fluoro (or chloro) and 2′,3′-difluoro 2′,3′-dideoxynucleoside analogs against hepatitis B and C viruses
31. Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19
32. Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for the One-Tube Assay of RNA
33. Structural studies towards the development of an oral main protease (Mpro) inhibitor to treat SARS-CoV-2 infection
34. To be ready for the next pandemic, Canada's biotech industry needs to be stronger; OPINION
35. CRISPR Technique Incorporated with Single-Cell RNA Sequencing for Studying Hepatitis B Infection
36. Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability
37. N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer
38. Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2
39. Additional file 1 of Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19
40. Topical Undecylenic Acid for Herpes Simplex Labialis: A Multicenter, Placebo-Controlled Trial
41. Lipoprotein profiles in SCID/uPA mice transplanted with human hepatocytes become human-like and correlate with HCV infection success
42. CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice
43. N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 Mpro
44. In Vitro Infection with Hepatitis B Virus Using Differentiated Human Serum Culture of Huh7.5-NTCP Cells without Requiring Dimethyl Sulfoxide
45. Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors
46. CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules
47. Antibodies to neutralising epitopes synergistically block the interaction of the receptor‐binding domain of SARS‐CoV‐2 to ACE 2
48. Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase
49. Isothermal Amplification and Ambient Visualization in a Single Tube for the Detection of SARS-CoV-2 Using Loop-Mediated Amplification and CRISPR Technology
50. Peginterferon-lambda for the treatment of COVID-19 in outpatients
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