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4. Is Parental Longevity Associated With the Cardiovascular Risk and the Successful Aging of Their Offspring? Results From the Multinational MEDIS Study

Author

Tyrovolas, Stefanos, Polychronopoulos, Evangelos, Mariolis, Anargiros, Piscopo, Suzanne, Valacchi, Giuseppe, Makri, Kornilia, Zeimbekis, Akis, Tyrovola, Dimitra, Bountziouka, Vassiliki, Gotsis, Efthimios, Metallinos, George, Tur, Josep-Antoni, Matalas, Antonia, Lionis, Christos, Haro, Josep Maria, and Panagiotakos, Demosthenes B.

Published
2017
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5. His bundle pacing: A promising alternative strategy for anti-bradycardic pacing – report of a single-center experience

Author

Archontakis, Stefanos, primary, Sideris, Konstantinos, additional, Laina, Ageliki, additional, Arsenos, Petros, additional, Paraskevopoulou, Dimitra, additional, Tyrovola, Dimitra, additional, Gatzoulis, Konstantinos, additional, Tousoulis, Dimitrios, additional, Tsioufis, Konstantinos, additional, and Sideris, Skevos, additional

Published
2022
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6. Overview of Chios Mastic Gum (Pistacia lentiscus) Effects on Human Health

Author

Soulaidopoulos, Stergios, primary, Tsiogka, Aikaterini, additional, Chrysohoou, Christina, additional, Lazarou, Emilia, additional, Aznaouridis, Konstantinos, additional, Doundoulakis, Ioannis, additional, Tyrovola, Dimitra, additional, Tousoulis, Dimitris, additional, Tsioufis, Konstantinos, additional, Vlachopoulos, Charalambos, additional, and Lazaros, George, additional

Published
2022
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8. Global, regional, and national burden of aortic aneurysm, 1990–2017: a systematic analysis of the Global Burden of Disease Study 2017

Author

Tyrovolas, Stefanos, primary, Tyrovola, Dimitra, additional, Giné-Vázquez, Iago, additional, Koyanagi, Ai, additional, Bernabe-Ortiz, Antonio, additional, Rodriguez-Artalejo, Fernando, additional, Haro, Josep Maria, additional, Pan, William K, additional, Miranda, J Jaime, additional, and Panagiotakos, Demosthenes, additional

Published
2021
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9. The association between sleeping time and metabolic syndrome features among older adults living in Mediterranean region. The MEDIS study

Author

Georgousopoulou, Ekavi, D'Cunha, Nathan, Mellor, Duane, Tyrovolas, Stefanos, Naumovski, Nenad, Foscolou, Alexandra, Bountzioka, Vassoliki, Gotsis, Efthimios, Metallinos, George, Tyrovola, Dimitra, Piscopo, Suzanne, Valacchi, Giuseppe, Tsakountakis, Nikos, Zeimbekis, Akis, Tur, Josep-Antoni, Matalas, Antonia-Leda, Polychronopoulos, Evangelos, Lionis, Chritos, Sidossis, Labros, Panagiotakos, Demosthenes, and Group, MEDIS Study

Abstract

Background: Metabolic Syndrome (MetS) as a combination of features has been known to significantly increase Cardiovascular Disease (CVD) risk, whilst MetS presence is linked to lifestyle parameters including physical activity and dietary habits; recently, the potential impact of sleeping habits has also become an issue under consideration. The aim of this study was to investigate the role of sleep quantity in several MetS components. Methods: Design:Cross-sectional observational study. Setting: 26 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece. Participants: during 2005-2017, 3130 older (aged 65-100 years) Mediterranean residents were voluntarily enrolled. Measurements: Dietary habits (including MedDietScore assessment), physical activity status, socio-demographic characteristics, lifestyle parameters (sleeping and smoking habits) and clinical profile aspects including Metabolic Syndrome (MetS) components (i.e., waist circumference, systolic and diastolic blood pressure, fasting glucose, triglycerides, LDL and HDL-cholesterol) were derived through standard procedures. Results: The number of daily hours of sleep was independently associated with greater waist circumference (b coefficient per 1 hour=0.91, 95% Confidence Interval (CI); 0.34, 1.49), higher LDL-cholesterol levels (b per 1 hour=3.84, 95%CI; 0.63, 7.05) and lower diastolic blood pressure levels (b per 1 hour=-0.98, 95%CI; - 1.57, -0.39) after adjusting for participants’ age, gender, body mass index, daily walking time, level of adherence to Mediterranean diet and smoking status. No association was revealed between hours of sleep per day and fasting glucose, triglycerides, HDL-cholesterol and systolic blood pressure. Conclusions: Increased hours of sleep is an indicator of metabolic disorders among elderly inviduals, and further research is needed to identify the paths through which sleep quantity is linked to MetS features in different age-groups.

Published
2018

10. Is car use related with successful aging of older adults? Results from the multinational Mediterranean islands study

Author

Tyrovolas, Stefanos, Polychronopoulos, Evangelos, Morena, Marianthi, Mariolis, Anargiros, Piscopo, Suzanne, Valacchi, Giuseppe, Bountziouka, Vassiliki, Anastasiou, Foteini, Zeimbekis, Akis, Tyrovola, Dimitra, Foscolou, Alexandra, Gotsis, Efthimios, Metallinos, George, Soulis, George, Tur, Josep-Antoni, Matalas, Antonia, Lionis, Christos, Sidossis, Labros S., and Panagiotakos, Demosthenes

Published
2017
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11. Lifestyle determinants of healthy ageing in a Mediterranean population: The multinational MEDIS study

Author

Foscolou, Alexandra, primary, Magriplis, Emmanuella, additional, Tyrovolas, Stefanos, additional, Soulis, George, additional, Bountziouka, Vassiliki, additional, Mariolis, Anargiros, additional, Piscopo, Suzanne, additional, Valacchi, Giuseppe, additional, Anastasiou, Foteini, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Tyrovola, Dimitra, additional, Polystipioti, Anna, additional, Polychronopoulos, Evangelos, additional, Matalas, Antonia-Leda, additional, Lionis, Christos, additional, Zeimbekis, Akis, additional, Tur, Josep-Antoni, additional, Sidossis, Labros S., additional, and Panagiotakos, Demosthenes, additional

Published
2018
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12. Mediterranean diet and depression among older individuals: The multinational MEDIS study

Author

Masana, Maria F., primary, Haro, Josep Maria, additional, Mariolis, Anargiros, additional, Piscopo, Suzanne, additional, Valacchi, Giuseppe, additional, Bountziouka, Vassiliki, additional, Anastasiou, Foteini, additional, Zeimbekis, Akis, additional, Tyrovola, Dimitra, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Polystipioti, Anna, additional, Tur, Josep-Antoni, additional, Matalas, Antonia-Leda, additional, Lionis, Christos, additional, Polychronopoulos, Evangelos, additional, Sidossis, Labros S., additional, Tyrovolas, Stefanos, additional, and Panagiotakos, Demosthenes B., additional

Published
2018
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13. Mediterranean lifestyle and cardiovascular disease prevention

Author

Georgousopoulou, Ekavi, Mellor, Duane, Naumovski, Nenad, Polychronopoulos, Evangelos, Tyrovolas, Stefanos, Piscopo, Suzanne, Valacchi, Giuseppe, Anastasiou, Foteini, Zeimbekis, Akis, Bountziouka, Vassiliki, Gotsis, Efthimios, Metallinos, George, Tyrovola, Dimitra, Foscolou, Alexander, Tur, Josep-Antoni, Matalas, Antonia-Leda, Lionis, Christos, Sidossis, Labros, Panagiotakos, Demosthenes, Georgousopoulou, Ekavi, Mellor, Duane, Naumovski, Nenad, Polychronopoulos, Evangelos, Tyrovolas, Stefanos, Piscopo, Suzanne, Valacchi, Giuseppe, Anastasiou, Foteini, Zeimbekis, Akis, Bountziouka, Vassiliki, Gotsis, Efthimios, Metallinos, George, Tyrovola, Dimitra, Foscolou, Alexander, Tur, Josep-Antoni, Matalas, Antonia-Leda, Lionis, Christos, Sidossis, Labros, and Panagiotakos, Demosthenes

Published
2017

14. Mediterranean lifestyle and cardiovascular disease prevention

Author

Georgousopoulou, Ekavi N., primary, Mellor, Duane D., additional, Naumovski, Nenad, additional, Polychronopoulos, Evangelos, additional, Tyrovolas, Stefanos, additional, Piscopo, Suzanne, additional, Valacchi, Giuseppe, additional, Anastasiou, Foteini, additional, Zeimbekis, Akis, additional, Bountziouka, Vassiliki, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Tyrovola, Dimitra, additional, Foscolou, Alexandra, additional, Tur, Josep-Antoni, additional, Matalas, Antonia-Leda, additional, Lionis, Christos, additional, Sidossis, Labros, additional, and Panagiotakos, Demosthenes, additional

Published
2017
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15. The Impact of the Financial Crisis on Lifestyle Health Determinants Among Older Adults Living in the Mediterranean Region: The Multinational MEDIS Study (2005-2015)

Author

Foscolou, Alexandra, primary, Tyrovolas, Stefanos, additional, Soulis, George, additional, Mariolis, Anargiros, additional, Piscopo, Suzanne, additional, Valacchi, Giuseppe, additional, Anastasiou, Foteini, additional, Lionis, Christos, additional, Zeimbekis, Akis, additional, Tur, Josep-Antoni, additional, Bountziouka, Vassiliki, additional, Tyrovola, Dimitra, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Matalas, Antonia-Leda, additional, Polychronopoulos, Evangelos, additional, Sidossis, Labros, additional, and Panagiotakos, Demosthenes B., additional

Published
2017
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16. Skeletal muscle mass and body fat in relation to successful ageing of older adults: The multi-national MEDIS study

Author

Tyrovolas, Stefanos, primary, Haro, Josep-Maria, additional, Mariolis, Anargiros, additional, Piscopo, Suzanne, additional, Valacchi, Giuseppe, additional, Bountziouka, Vassiliki, additional, Anastasiou, Foteini, additional, Zeimbekis, Akis, additional, Tyrovola, Dimitra, additional, Foscolou, Alexandra, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Tur, Josep-Antoni, additional, Matalas, Antonia, additional, Lionis, Christos, additional, Polychronopoulos, Evangelos, additional, and Panagiotakos, Demosthenes, additional

Published
2016
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17. Is Parental Longevity Associated With the Cardiovascular Risk and the Successful Aging of Their Offspring? Results From the Multinational MEDIS Study

Author

Tyrovolas, Stefanos, primary, Polychronopoulos, Evangelos, additional, Mariolis, Anargiros, additional, Piscopo, Suzanne, additional, Valacchi, Giuseppe, additional, Makri, Kornilia, additional, Zeimbekis, Akis, additional, Tyrovola, Dimitra, additional, Bountziouka, Vassiliki, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Tur, Josep-Antoni, additional, Matalas, Antonia, additional, Lionis, Christos, additional, Haro, Josep Maria, additional, and Panagiotakos, Demosthenes B., additional

Published
2016
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18. Comparative study on successful aging between the elderly inhabitants of Mani and those living on the Mediterranean islands: The MEDIS study

Author

Foscolou, Alexandra, primary, Panagiotakos, Demosthenes, additional, Mariolis, Anargiros, additional, Tyrovolas, Stefanos, additional, Tsakountakis, Nikos, additional, Zeimbekis, Akis, additional, Bountziouka, Vassiliki, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Tyrovola, Dimitra, additional, Matalas, Antonia-Leda, additional, Lionis, Christos, additional, and Polychronopoulos, Evangelos, additional

Published
2016
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19. Successful Aging among Elders Living in the Mani Continental Region vs. Insular Areas of the Mediterranean: the MEDIS Study

Author

Mariolis, Anargiros, primary, Foscolou, Alexandra, primary, Tyrovolas, Stefanos, primary, Piscopo, Suzanne, primary, Valacchi, Giuseppe, primary, Tsakountakis, Nikos, primary, Zeimbekis, Akis, primary, Bountziouka, Vassiliki, primary, Gotsis, Efthimios, primary, Metallinos, George, primary, Tyrovola, Dimitra, primary, Tur, Josep-Antoni, primary, Matalas, Antonia-Leda, primary, Lionis, Christos, primary, Polychronopoulos, Evangelos, primary, and Panagiotakos, Demosthenes, primary

Published
2016
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20. The Association Between Sleeping Time and Metabolic Syndrome Features, Among Older Adults Living in Mediterranean Region: The MEDIS Study.

Author

Georgousopoulou, Ekavi N., D'Cunha, Nathan M., Mellor, Duane D., Tyrovolas, Stefanos, Naumovski, Nenad, Foscolou, Alexandra, Bountziouka, Vassiliki, Gotsis, Efthimios, Metallinos, George, Tyrovola, Dimitra, Piscopo, Suzanne, Valacchi, Giuseppe, Tsakountakis, Nikos, Zeimbekis, Akis, Tur, Josep-Antoni, Matalas, Antonia-Leda, Polychronopoulos, Evangelos, Lionis, Christos, Sidossis, Labros, and Panagiotakos, Demosthenes B.

Abstract

Background: Metabolic syndrome (MetS) as a combination of features has been known to significantly increase cardiovascular disease risk, while MetS presence is linked to lifestyle parameters, including physical activity and dietary habits; recently, the potential impact of sleeping habits has also become an issue under consideration. The aim of this study was to investigate the role of sleep quantity in several MetS components. Methods: Design: a cross-sectional observational study. Setting: 26 Mediterranean islands (MEDIS) and the rural Mani region (Peloponnesus) of Greece. Participants: during 2005-2017, 3130 older (aged 65-100 years) Mediterranean residents were voluntarily enrolled. Measurements: dietary habits (including MedDietScore assessment), physical activity status, sociodemographic characteristics, lifestyle parameters (sleeping and smoking habits), and clinical profile aspects, including MetS components [ i.e., waist circumference, systolic and diastolic blood pressure, fasting glucose, triglycerides, and low-density lipoprotein (LDL) and high-density lipoprotein cholesterol (HDL-C)], were derived through standard procedures. Results: The number of daily hours of sleep was independently associated with greater waist circumference [b coefficient/hr = 0.91, 95% confidence interval (CI): 0.34-1.49], higher LDL-cholesterol levels (b/hr = 3.84, 95% CI: 0.63-7.05), and lower diastolic blood pressure levels (b/hr = −0.98, 95% CI: −1.57 to −0.39) after adjusting for participants' age, gender, body mass index, daily walking time, level of adherence to Mediterranean diet, and smoking status. No association was revealed between hours of sleep per day and fasting glucose, triglycerides, HDL-C, and systolic blood pressure. Conclusions: Increased hours of sleep is an indicator of metabolic disorders among elderly individuals, and further research is needed to identify the paths through which sleep quantity is linked to MetS features in different age groups. [ABSTRACT FROM AUTHOR]

Published
2018
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21. Anti-Inflammatory Nutrition and Successful Ageing in Elderly Individuals: The Multinational MEDIS Study.

Author

Haro, Josep Maria, Tyrovolas, Stefanos, Foscolou, Alexandra, Tyrovola, Dimitra, Bountziouka, Vassiliki, Gotsis, Efthimios, Metallinos, George, Papairakleous, Natassa, Polychronopoulos, Evangelos, Matalas, Antonia-Leda, Panagiotakos, Demosthenes B., Mariolis, Anargiros, Piscopo, Suzanne, Valacchi, Giuseppe, Anastasiou, Foteini, Lionis, Christos, Zeimbekis, Akis, Tur, Josep-Antoni, Sidossis, Labros S., and MEDIS Study Group

Subjects
INFLAMMATION, FOOD habits, AGING
Abstract

Background: The role of diet and inflammation in successful ageing is not transparent, and as such, is still being investigated. The aim of the present work was to evaluate the inflammatory potential of dietary habits in the successful ageing of a random sample of older adults living in the Mediterranean basin and who participated in the MEDIS (MEDiterranean ISlands) study.Methods: During 2005-2016, 3,128 older adults (aged 65-100 years) from 24 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were enrolled in the study. A multidimensional successful ageing index consisting of 10 components was employed. A validated and reproducible Food Frequency Questionnaire (FFQ) was used to evaluate the dietary habits of the older adults. A nutrition anti-inflammatory (NAI) score based on the participants' specific dietary habits was assessed.Results: Participants with high NAI scores (proinflammatory nutrition) had a higher prevalence of hypercholesterolemia and lower levels of successful ageing. After adjusting for several confounders, the NAI score was associated with successful ageing (-0.03, 95% CI -0.5 to -0.006). Stratified analysis by gender and advanced age revealed heterogeneity in the NAI score, predicting successful ageing.Conclusions: The inflammatory potential of nutrition was reported as an important factor for successful ageing, suggesting that further research is needed on the role of anti- and proinflammatory dietary habits in healthy and successful ageing. [ABSTRACT FROM AUTHOR]

Published
2017
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22. The Role of Energy Balance in Successful Aging Among Elderly Individuals

Author

Tyrovolas, Stefanos, primary, Haro, Josep Maria, additional, Mariolis, Anargiros, additional, Piscopo, Suzanne, additional, Valacchi, Giuseppe, additional, Makri, Kornilia, additional, Zeimbekis, Akis, additional, Tyrovola, Dimitra, additional, Bountziouka, Vassiliki, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Tur, Josep-Antoni, additional, Matalas, Antonia, additional, Lionis, Christos, additional, Polychronopoulos, Evangelos, additional, and Panagiotakos, Demosthenes, additional

Published
2015
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23. Successful aging, dietary habits and health status of elderly individuals: A k-dimensional approach within the multi-national MEDIS study

Author

Tyrovolas, Stefanos, primary, Haro, Josep Maria, additional, Mariolis, Anargiros, additional, Piscopo, Suzanne, additional, Valacchi, Giuseppe, additional, Tsakountakis, Nikos, additional, Zeimbekis, Akis, additional, Tyrovola, Dimitra, additional, Bountziouka, Vassiliki, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Tur, Josep-Antoni, additional, Matalas, Antonia-Leda, additional, Lionis, Christos, additional, Polychronopoulos, Evangelos, additional, and Panagiotakos, Demosthenes, additional

Published
2014
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24. Factors Associated With Components of Arterial Pressure Among Older Individuals (the Multinational MEDIS Study): The Role of the Mediterranean Diet and Alcohol Consumption

Author

Tyrovolas, Stefanos, primary, Haro, Josep Maria, additional, Polychronopoulos, Evangelos, additional, Mariolis, Anargiros, additional, Piscopo, Suzanne, additional, Valacchi, Giuseppe, additional, Makri, Kornilia, additional, Zeimbekis, Akis, additional, Tyrovola, Dimitra, additional, Bountziouka, Vassiliki, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Katsoulis, Yannis, additional, Tur, Josep-Antoni, additional, Matalas, Antonia, additional, Lionis, Christos, additional, and Panagiotakos, Demosthenes, additional

Published
2014
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25. Depressive Symptoms in Postmenopausal Women: Results from the MEDIS Study

Author

Tsiligianni, Ioanna G., primary, Tyrovolas, Stefanos, additional, Bountziouka, Vassiliki, additional, Zeimbekis, Akis, additional, Gotsis, Efthimios, additional, Metallinos, George, additional, Tyrovola, Dimitra, additional, Polychronopoulos, Evangelos, additional, Lionis, Christos, additional, and Panagiotakos, Demosthenes, additional

Published
2014
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26. Anti-Inflammatory Nutrition and Successful Ageing in Elderly Individuals: The Multinational MEDIS Study

Author

Tyrovolas, Stefanos, Haro Abad, Josep Maria, Foscolou, Alexandra, Tyrovola, Dimitra, Mariolis, Anargiros, Bountziouka, Vassiliki, Piscopo, Suzanne, Valacchi, Giuseppe, Anastasiou, Foteini, Gotsis, Efthimios, Metallinos, George, Papairakleous, Natassa, Polychronopoulos, Evangelos, Matalas, Antonia Leda, Lionis, Christos, Zeimbekis, Akis, Tur, Josep Antoni, Sidossis, Labros S., Panagiotakos, Demosthenes, MEDIS Study Group, and Universitat de Barcelona

Subjects
Male, Rural Population, 0301 basic medicine, Gerontology, Aging, Urban Population, Mediterranean diet, Cross-sectional study, Dietary habits, Inflammation, Mediterranean basin, Older adults, Successful ageing, 030204 cardiovascular system & hematology, Persones grans, 0302 clinical medicine, Surveys and Questionnaires, Medicine, Nutritional Physiological Phenomena, Aged, 80 and over, 2. Zero hunger, education.field_of_study, Greece, biology, Mediterranean Region, Confounding, Food frequency questionnaire, Inflamació, Female, Dieta, Population, Nutritional Status, Socio-culturale, Mediterrània (Regió), Stratified analysis, Mediterranean Islands, 03 medical and health sciences, Envelliment, Humans, education, Life Style, Aged, 030109 nutrition & dietetics, business.industry, C-reactive protein, Feeding Behavior, Diet, Cross-Sectional Studies, biology.protein, Geriatrics and Gerontology, Older people, business
Abstract

Background: The role of diet and inflammation in successful ageing is not transparent, and as such, is still being investigated. The aim of the present work was to evaluate the inflammatory potential of dietary habits in the successful ageing of a random sample of older adults living in the Mediterranean basin and who participated in the MEDIS (MEDiterranean ISlands) study. Methods: During 2005-2016, 3,128 older adults (aged 65-100 years) from 24 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were enrolled in the study. A multidimensional successful ageing index consisting of 10 components was employed. A validated and reproducible Food Frequency Questionnaire (FFQ) was used to evaluate the dietary habits of the older adults. A nutrition anti-inflammatory (NAI) score based on the participants' specific dietary habits was assessed. Results: Participants with high NAI scores (proinflammatory nutrition) had a higher prevalence of hypercholesterolemia and lower levels of successful ageing. After adjusting for several confounders, the NAI score was associated with successful ageing (-0.03, 95% CI -0.5 to -0.006). Stratified analysis by gender and advanced age revealed heterogeneity in the NAI score, predicting successful ageing. Conclusions: The inflammatory potential of nutrition was reported as an important factor for successful ageing, suggesting that further research is needed on the role of anti- and proinflammatory dietary habits in healthy and successful ageing.

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27. His Bundle Pacing: A promising alternative strategy for Antibradycardic-pacing. Report of a single center-experience.

Author

Archontakis, Stefanos, Sideris, Konstantinos, Laina, Ageliki, Arsenos, Petros, Paraskevopoulou, Dimitra, Tyrovola, Dimitra, Gatzoulis, Konstantinos, Tousoulis, Dimitrios, Tsioufis, Konstantinos, and Sideris, Skevos

Abstract

His Bundle Pacing (HBP) is proven to be a safe and effective alternative pacing modality that, in addition, avoids Pacemaker-induced Cardiomyopathy (PICM) by achieving a ‘’physiological’’ ventricular stimulation, via the native conduction system. Indications include various causes of bradycardia requiring antibradycardic pacing, inadequately controlled Atrial Fibrillation requiring AV node ablation and established PICM. In addition, HBP may also be used as an alternative therapy for patients with Heart Failure (HF) and an indication for Cardiac Resynchronization Therapy. Available data show a benefit from HBP with regard to preservation or restoration of intra- and inter-ventricular synchronization, improvement in Left Ventricular Ejection Fraction, functional status and Quality of Life, decrease in atrial fibrillation incidence and improvement in HF hospitalization rates, compared to conventional pacing. Nevertheless, superiority in terms of mortality rates has not been consistently demonstrated and long-term efficacy and safety remains to be proven. In the present manuscript, we review the status of HBP and we present our current experience with this novel pacing modality.

Published
2021
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29. Anti-Inflammatory Nutrition and Successful Ageing in Elderly Individuals: The Multinational MEDIS Study.

Author

Tyrovolas S, Haro JM, Foscolou A, Tyrovola D, Mariolis A, Bountziouka V, Piscopo S, Valacchi G, Anastasiou F, Gotsis E, Metallinos G, Papairakleous N, Polychronopoulos E, Matalas AL, Lionis C, Zeimbekis A, Tur JA, Sidossis LS, and Panagiotakos DB

Subjects
Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Greece, Humans, Life Style, Male, Mediterranean Islands, Nutritional Physiological Phenomena, Nutritional Status, Rural Population, Surveys and Questionnaires, Urban Population, Aging physiology, Feeding Behavior, Inflammation prevention & control
Abstract

Background: The role of diet and inflammation in successful ageing is not transparent, and as such, is still being investigated. The aim of the present work was to evaluate the inflammatory potential of dietary habits in the successful ageing of a random sample of older adults living in the Mediterranean basin and who participated in the MEDIS (MEDiterranean ISlands) study., Methods: During 2005-2016, 3,128 older adults (aged 65-100 years) from 24 Mediterranean islands and the rural Mani region (Peloponnesus) of Greece were enrolled in the study. A multidimensional successful ageing index consisting of 10 components was employed. A validated and reproducible Food Frequency Questionnaire (FFQ) was used to evaluate the dietary habits of the older adults. A nutrition anti-inflammatory (NAI) score based on the participants' specific dietary habits was assessed., Results: Participants with high NAI scores (proinflammatory nutrition) had a higher prevalence of hypercholesterolemia and lower levels of successful ageing. After adjusting for several confounders, the NAI score was associated with successful ageing (-0.03, 95% CI -0.5 to -0.006). Stratified analysis by gender and advanced age revealed heterogeneity in the NAI score, predicting successful ageing., Conclusions: The inflammatory potential of nutrition was reported as an important factor for successful ageing, suggesting that further research is needed on the role of anti- and proinflammatory dietary habits in healthy and successful ageing., (© 2017 S. Karger AG, Basel.)

Published
2018
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