Search

ORLANDO -- Improvements in cardiovascular and renal outcomes seen after nearly 10 years of improved glucose control among participants in the Veterans Affairs Diabetes Trial (VADT) who received intensive glucose-lowering [...]

Taking ownership of one's diabetes begins by making small, daily lifestyle changes that are sustainable for the long term. Here are office strategies pediatricians can use to motivate their patients [...]

We previously established that the intestinal sweet taste receptors (STRs), T1R2 and T1R3, were expressed in distinct epithelial cells in the human proximal intestine and that their transcript levels varied with glycemic status in patients with type 2 diabetes. Here we determined whether STR expression was 1) acutely regulated by changes in luminal and systemic glucose levels, 2) disordered in type 2 diabetes, and 3) linked to glucose absorption. Fourteen healthy subjects and 13 patients with type 2 diabetes were studied twice, at euglycemia (5.2 ± 0.2 mmol/L) or hyperglycemia (12.3 ± 0.2 mmol/L). Endoscopic biopsy specimens were collected from the duodenum at baseline and after a 30-min intraduodenal glucose infusion of 30 g/150 mL water plus 3 g 3-O-methylglucose (3-OMG). STR transcripts were quantified by RT-PCR, and plasma was assayed for 3-OMG concentration. Intestinal STR transcript levels at baseline were unaffected by acute variations in glycemia in healthy subjects and in type 2 diabetic patients. T1R2 transcript levels increased after luminal glucose infusion in both groups during euglycemia (+5.8 x [10.sup.4] and +5.8 x [10.sup.4] copies, respectively) but decreased in healthy subjects during hyperglycemia (-1.4 x [10.sup.4] copies). T1R2 levels increased significantly in type 2 diabetic patients under the same conditions (+6.9 x [10.sup.5] copies). Plasma 3-OMG concentrations were significantly higher in type 2 diabetic patients than in healthy control subjects during acute hyperglycemia. Intestinal T1R2 expression is reciprocally regulated by luminal glucose in health according to glycemic status but is disordered in type 2 diabetes during acute hyperglycemia. This defect may enhance glucose absorption in type 2 diabetic patients and exacerbate postprandial hyperglycemia., Glucose in the small intestinal lumen induces feedback that regulates gastric emptying, absorptive function, and energy intake (1-3), mediated both by vagal nerve pathways and secretion of gut peptides (4), [...]

Normal physiologic pattern of insulin secretion There are two characteristic features of the normal pattern of insulin secretion in healthy individuals (1,2): a low-level basal insulin secretion that occurs continuously [...]

Diets with increased protein and reduced carbohydrates have been shown to improve body composition, lipid and lipoprotein profiles, and glycemic regulations associated with treatment of obesity and weight loss. Derived from these outcomes, high-protein, low-carbohydrate diets are also being examined for treatment of heart disease, metabolic syndrome, and type 2 diabetes. High-protein, low-carbohydrate diets have been found to have positive effects on reducing risk factors for heart disease, including reducing serum triacylglycerol, increasing HDL cholesterol, increasing LDL particle size, and reducing blood pressure. These diets appear particularly attractive for use with individuals exhibiting the atherogenic dyslipidemia of metabolic syndrome. High-protein, low-carbohydrate diets have also been investigated for treatment of type 2 diabetes with positive effects on glycemic regulation, including reducing fasting blood glucose, postprandial glucose and insulin responses, and the percentage of glycated hemoglobin. Specific effects of increasing protein compared with reducing carbohydrates have not been extensively investigated. Additional research is needed to determine specific levels of protein, carbohydrate, and fat for optimum health of individuals who differ in age, physical activity, and metabolic phenotypes.

The flashy, party-centric Southern rapper Lil Jon has had his hand, and distinctive voice, in nearly every pop hit since the early 2000s, from Usher's 'Yeah!' to LMFAO's 'Shots.' Maybe [...]

Diabetes is a major risk factor for coronary heart disease and is the sixth leading cause of death in the United States. The most prevalent form of diabetes, type 2 [...]

Introduction: Obesity and diabetes are related disease with genetics, environmental and dietary factors implicated in there genesis. Basic anthropometric measeurements are use as indicators for the presence of these diseases. Derived measurements from these basic measures are being use more frequently with some of the basic ones at the verge of been discarded as assessment in clinical practice. The study assesses the correlations between the basic and the derived measurement in Type 2 Diabetic subjects. Materials and Method: Diabetic patients were recruited from the investigative clinic of the hospital for this cross-sectional study. The basic anthropometric measurement of height, weight, hip circumference, waist circumference and the derived measures BMI, WHR, WHtR were determined from this basic measures. Results: Correlations between the derived and basic measures were determined using SPSS statistical software was use. There was a significant correlation between WC and HC and the derived variables BMI, WHR and WHtR among the nonobese DM compared to the obese DM. HC has a poor correlation with the the derived variables among the obese DM. Conclusion: The HC assessment in nonobese DM patients is more relevant than in the obese DM patients. Keywords: Ocimum gratissimum | litter size | serum progesterone, Introduction The World Health Organisation (WHO) estimates that 4 billion people, i.e. 80% of the world population, use herbal medicine for some aspect of primary health care (Farnsworth et al., [...]

A temporal relation exists between hypertension and diabetes, characterised by presence of several common risk factors. Apart from the causal commonality existing between the two, another aspect that relates the two is the use of antihypertensive drugs (AHDs). Population based data exists in number that shows varied levels of influence of various different classes of AHDs on carbohydrate metabolism, insulin resistance and subsequent risk to develop diabetes. But on the other hand, there are potential limitations that limit the representativeness of these data to population across borders, race, and ethnicity. Severity of illness, restricting characteristics of the included population, differences in prescription and practice patterns, and cost-utility differences, family history of diabetes, lifestyle habits, genetic factors, and fasting insulin and blood glucose levels measurement practices, all may highly influence the risk of diabetes development and all of these may not have been completely controlled in these studies. No AHD drug class has been evaluated in a placebo-controlled trial with diabetes incidence as a blinded, predefined primary endpoint. Also, there are chances that a population which has high baseline risk of developing diabetes may have been directed more to some specific high diabetes risk anti-hypertensive drug classes more often than the rest. Also, alpha-blocker drugs seem to have a significant protection to diabetes. Currently these are not used as first-cut therapy and also not as mono-therapy. And due to the fact that these drugs appear late in the algorithmic arrangements of AHDs, chances are that the added risk to the development of diabetes seen with polypharmacy use (2 or more) may not have emerged from their use in these combinations. As most of other AHD therapies increase the risk of developing diabetes, it will be important to address their independent effect on the development of diabetes by suitably controlled randomized trials targeted at suitable population. Also, their use and benefit in polypharmacy with 3 or more drugs should also be looked into., Background Diabetes is an epidemic disease characterised by the human body's inability to sufficiently use or sufficiently produce insulin. The disease can now be identified at almost all the nook [...]

--A high legume intake led to a roughly 40% lower risk of developing Type 2 diabetes in Chinese women, according to research from VANDERBILT UNIVERSITY MEDICAL CENTER and the SHANGHAI [...]

Early intensive insulin therapy may restore blood glucose control in patients with newly diagnosed type 2 diabetes. A randomised controlled trial of 382 patients reported in the diabetes special issue [...]

Erythropoietin and Cancer Death Rates harmacology Watch In this issue: Does erythropoietin worsen cancer death rates? Most hypothyroid patients can be replaced with levothyroxine alone without additional T3. Does aggressive [...]

Besides the well-known benefits of calcium and vitamin D (see story, page 1), new research suggests that getting enough of these two nutrients may also be key for reducing the [...]

Source: El-Kebbi IM, et al. Diabetes Care. 2004;27:335-339. TIGHT CONTROL OF TYPE DIAbetes (DM2) has been proven to reduce microvascular complications. Use of the hemoglobin Alc to assess long-term control [...]

Cinnamon may have more to offer than its trademark sweet aroma and flavor. Scientists know that cinnamon provides antioxidant, anti-inflammatory, and antimicrobial effects. And now some studies suggest it may [...]

ADJUSTING TO LIFE with diabetes can take some time. The American Diabetes Association has information and resources to help those who have been recently diagnosed with type 2 diabetes. Living [...]

LISBON -- Snacking throughout the day might not be the best way to help control type 2 diabetes, especially if the snacks contain much fat. A high-fat meal in people [...]

GRAPEVINE, TEX. -- Greater initial weight loss following surgery and the ability to keep much of that excess weight off over time distinguished patients who achieved long-term remission of type [...]

Diabetes is out of control in America. According to the American Diabetes Association, an astounding 21 million Americans have diabetes. One-third of those with diabetes are unaware they have it [...]

In contemporary America, there is little question that we are facing an epidemic of diabetes mellitus. In 2007, the Centers for Disease Control and Prevention (CDC) estimated that 23.6 million [...]

More than half of adolescents with type 2 diabetes underestimate their weight, and so do their parents, according to results from interviews with 104 child-parent pairs. "Clinicians should recognize that [...]

WASHINGTON -- A formula can be used to determine how many calories a patient with type 2 diabetes must cut per day to avoid gaining weight when high glucose levels [...]

Researchers at the Howard Hughes Medical Institute find a genetic link between a high-fat diet and the onset of type 2 diabetes. A single gene in a key enzyme seems […]

WASHINGTON -- A report released last month by the American Association of Clinical Endocrinologists (AACE) concludes two out of three Americans with type 2 diabetes are not in control of [...]