181 results on '"Tymiak, Adrienne A."'
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2. The role of chromatographic and chiroptical spectroscopic techniques and methodologies in support of drug discovery for atropisomeric drug inhibitors of Bruton’s tyrosine kinase
3. Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry
4. Chromatography-based methods for determining molar extinction coefficients of cytotoxic payload drugs and drug antibody ratios of antibody drug conjugates
5. Characterization and quantification of histidine degradation in therapeutic protein formulations by size exclusion-hydrophilic interaction two dimensional-liquid chromatography with stable-isotope labeling mass spectrometry
6. Metabolomics in the pharmaceutical industry
7. Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry
8. Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization
9. Mass Spectrometric Characterization in Protein Therapeutics Discovery
10. Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications
11. Utility of Ion Mobility Mass Spectrometry for Drug-to-Antibody Ratio Measurements in Antibody-Drug Conjugates
12. Structural mass spectrometry in biologics discovery: advances and future trends
13. The Influence of Adnectin Binding on the Extracellular Domain of Epidermal Growth Factor Receptor
14. Fast Photochemical Oxidation of Proteins (FPOP) Maps the Epitope of EGFR Binding to Adnectin
15. Utility of Hydrogen Exchange Mass Spectrometry in Epitope Mapping
16. Search for an Endogenous Mammalian Cardiotonic Factor
17. Characterization of protein therapeutics by mass spectrometry: recent developments and future directions
18. Physicochemical Characterization of a Ouabain Isomer Isolated from Bovine Hypothalamus
19. Using Hydrogen/Deuterium Exchange Mass Spectrometry to Study Conformational Changes in Granulocyte Colony Stimulating Factor upon PEGylation
20. Attribution of the discrepancy between ELISA and LC-MS/MS assay results of a PEGylated scaffold protein in post-dose monkey plasma samples due to the presence of anti-drug antibodies
21. NMR-based metabolomics of mammalian cell and tissue cultures
22. Development and implementation of a stereoselective normal-phase liquid chromatography–tandem mass spectrometry method for the determination of intrinsic metabolic clearance in human liver microsomes
23. A tris (2-carboxyethyl) phosphine (TCEP) related cleavage on cysteine-containing proteins
24. Characterization of Impurities and Degradation Products in Small Molecule Pharmaceuticals and Biologics
25. Supercritical Fluid Chromatography
26. Dual universal peptide approach to bioanalysis of human monoclonal antibody protein drug candidates in animal studies
27. High-resolution MS for structural characterization of protein therapeutics: advances and future directions
28. Quantitation of therapeutic proteins following direct trypsin digestion of dried blood spot samples and detection by LC–MS-based bioanalytical methods in drug discovery
29. Pellet digestion: a simple and efficient sample preparation technique for LC–MS/MS quantification of large therapeutic proteins in plasma
30. Evaluating and defining sample preparation procedures for DBS LC–MS/MS assays
31. Enantioselective chromatography in drug discovery
32. Na,K-ATPase inhibitors from bovine hypothalamus and human plasma are different from ouabain: nanogram scale CD structural analysis
33. Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project
34. Slow Off-Rate Modified Aptamer (SOMAmer) as a Novel Reagent in Immunoassay Development for Accurate Soluble Glypican-3 Quantification in Clinical Samples
35. Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry
36. Orthogonal Mass Spectrometry-Based Footprinting for Epitope Mapping and Structural Characterization: The IL-6 Receptor upon Binding of Protein Therapeutics
37. Mapping the Energetic Epitope of an Antibody/Interleukin-23 Interaction with Hydrogen/Deuterium Exchange, Fast Photochemical Oxidation of Proteins Mass Spectrometry, and Alanine Shave Mutagenesis
38. Characterization of Aggregation Propensity of a Human Fc-Fusion Protein Therapeutic by Hydrogen/Deuterium Exchange Mass Spectrometry
39. LC–MS/MS multiplexed assay for the quantitation of a therapeutic protein BMS-986089 and the target protein Myostatin
40. Slow Off-Rate Modified Aptamer (SOMAmer) as a Novel Reagent in Immunoassay Development for Accurate Soluble Glypican-3 Quantification in Clinical Samples.
41. Correction to “Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development”
42. Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development
43. Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics
44. Bioanalysis of biomarkers in support of drug discovery and development
45. Introduction to NMR and Its Application in Metabolite Structure Determination
46. Challenges in accurate quantitation of lysophosphatidic acids in human biofluids
47. Development of a highly sensitive liquid chromatography/tandem mass spectrometry method to quantify total and free levels of a target protein, interferon-gamma-inducible protein-10, at picomolar levels in human serum
48. Characterization of disulfide linkages in recombinant human granulocyte-colony stimulating factor
49. A universal surrogate peptide to enable LC‐MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc‐fusion protein drug candidates in pre‐clinical animal studies
50. Attribution of the discrepancy between ELISA and LC-MS/MS assay results of a PEGylated scaffold protein in post-dose monkey plasma samples due to the presence of anti-drug antibodies
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