Search

Your search keyword '"Tygstrup N"' showing total 493 results
Start Over Author "Tygstrup N"
493 results on '"Tygstrup N"'

2. Hepatic, renal, and total body galactose elimination in the pig

Author

Winkler, K., Henriksen, J.H., and Tygstrup, N.

Subjects
Galactose -- Analysis, Biological sciences
Abstract

The extent of Hepatic galactose removal, when determined from whole body elimination curves, does not account for loss of galactose due to renal removal. Hepatic and extrahepatic galactose elimination was correlated by conducting uninterrupted galactose induction in anesthetized pigs. Renal and hepatic elimination account for a substantial percentage of galactose removal which remains unaffected by concentration.

Published
1993

6. International Autoimmune Hepatitis Group* Report: review of criteria for diagnosis of autoimmune hepatitis

Author

Alvarez, F., Berg, P. A., Bianchi, F. B., Bianchi, L., Burroughs, A. K., Cancado, E. L., Chapman, R. W., Cooksley, W. G. E., Czaja, A. J., Desmet, V. J., Donaldson, P. T., Eddleston, A. L. W. F., Fainboim, L., Heathcote, J., Homberg, J.-C., Hoofnagle, J. H., Kakumu, S., Krawitt, E. L., Mackay, I. R., MacSween, R. N. M., Maddrey, W. C., Manns, M. P., McFarlane, I. G., Meyer zum Büschenfelde, K.-H., Mieli-Vergani, G., Nakanuma, Y., Nishioka, M., Penner, E., Porta, G., Portmann, B. C., Reed, W. D., Rodes, J., Schalm, S. W., Scheuer, P. J., Schrumpf, E., Seki, T., Toda, G., Tsuji, T., Tygstrup, N., Vergani, D., and Zeniya, M.

Published
1999

17. GH decreases hepatic amino acid degradation after small bowel resection in rats without enhancing bowel adaptation

Author

LJUNGMANN, K., GROFTE, T., KISSMEYER-NIELSEN, P., FLYVBJERG, A., VILSTRUP, H., TYGSTRUP, N., and LAURBERG, S.

Subjects
Somatotropin -- Physiological aspects, Intestine, Small, Urea -- Physiological aspects, Amino acid metabolism -- Physiological aspects, Biological sciences
Abstract

Ljungmann, K., T. Grofte, P. Kissmeyer-Nielsen, A. Flyvbjerg, H. Vilstrup, N. Tygstrup, and S. Laurberg. GH decreases hepatic amino acid degradation after small bowel resection in rats without enhancing bowel adaptation. Am J Physiol Gastrointest Liver Physiol 279: G700-G706, 2000.--Growth hormone (GH) treatment in short bowel syndrome is controversial, and the mechanisms of a possible positive effect remain to be elucidated. Rats were randomly subjected to either an 80% jejunoileal resection or sham operation and were given either placebo (NaCl) or biosynthetic rat GH (brGH). The in vivo capacity of urea nitrogen synthesis (CUNS) and the expression of urea cycle enzymes were measured and related to changes in body weight and adaptive growth in ileal segments on days 7 and 14. Ileal segments were examined by unbiased stereological techniques. brGH treatment decreased CUNS among the resected rats by 19% (P [is less than] 0.05) and 36% (P [is less than] 0.05) on days 7 and 14, respectively. The mRNA levels of urea cycle enzyme genes were not influenced by brGH treatment, brGH treatment did not increase the adaptive growth in the ileal segments. In conclusion, we found that GH treatment decreased the accelerated postoperative hepatic amino acid degradation in experimental short bowel syndrome without enhancing the morphological intestinal adaptation. insulin-like growth factor-I; urea metabolism; mRNA levels; short bowel syndrome; stereology

Published
2000

50. Hepatic, renal, and total body galactose elimination in the pig

Author

Winkler, K, Henriksen, Jens Henrik Sahl, Tygstrup, N, Winkler, K, Henriksen, Jens Henrik Sahl, and Tygstrup, N

Abstract

Udgivelsesdato: 1993-Jul, Galactose elimination capacity is used as a quantitative measure of liver function on the assumption that galactose elimination outside the liver is negligible or easily corrected for. The relationship between hepatic and extrahepatic removal of galactose was studied in anesthetized pigs during quasi-steady-state conditions by continuous infusion of galactose. The hepatic removal approximated a constant [maximal velocity = 585 +/- 41 mumol/min, Michaelis constant (Km) = 0.24 +/- 0.07 mmol/l, mean +/- SE, n = 20]. The renal removal was less than the amount filtered, showing maximal tubular reabsorption (Tm 178 +/- 3.0 mumol/min, Km 3.8 +/- 0.9 mmol/l, n = 20). Metabolic conversion of galactose in the kidney was not demonstrable. At all concentrations studied (0.4-5.8 mmol/l), total galactose elimination from the body exceeded the sum of hepatic and renal elimination by approximately 100 mumol/min, independent of the concentration. At blood concentrations usually used for clinical estimation of the galactose elimination capacity (approximately 4 mmol/l), hepatic removal in the pig accounted for 55% and renal removal for 30% of total removal; 15% of removal occurred in other organs. We conclude that estimation of the hepatic galactose elimination capacity from whole body elimination curves requires correction for renal removal of galactose.

Published
1993

Catalog

Books, media, physical & digital resources
See catalog results