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Your search keyword '"Tyagi, Varalika"' showing total 6 results
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6 results on '"Tyagi, Varalika"'

1. Adjunctive glucocorticoid therapy for Pneumocystis jirovecii pneumonia in solid organ transplant recipients: A multicenter cohort, 2015-2020

Author

Hosseini-Moghaddam, Seyed M., Kothari, Sagar, Humar, Atul, Albasata, Hanan, Yetmar, Zachary A., Razonable, Raymund R., Neofytos, Dionysios, D’Asaro, Matilde, Boggian, Katia, Hirzel, Cedric, Khanna, Nina, Manuel, Oriol, Mueller, Nicolas J., Imlay, Hannah, Kabbani, Dima, Tyagi, Varalika, Smibert, Olivia C., Nasra, Mohamed, Fontana, Lauren, Obeid, Karam M., Apostolopoulou, Anna, Zhang, Sean X., Permpalung, Nitipong, Alhatimi, Hind, Silverman, Michael S., Guo, Henry, Rogers, Benjamin A., MacKenzie, Erica, Pisano, Jennifer, Gioia, Francesca, Rapi, Lindita, Prasad, G.V. Ramesh, Banegas, Marcela, Alonso, Carolyn D., Doss, Kathleen, Rakita, Robert M., and Fishman, Jay A.

Published
2024
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2. Adjunctive glucocorticoid therapy for Pneumocystis jirovecii pneumonia in solid organ transplant recipients: A multicenter cohort, 2015-2020

Author

Hosseini-Moghaddam, Seyed M., primary, Kothari, Sagar, additional, Humar, Atul, additional, Albasata, Hanan, additional, Yetmar, Zachary A., additional, Razonable, Raymund R., additional, Neofytos, Dionysios, additional, D’Asaro, Matilde, additional, Boggian, Katia, additional, Hirzel, Cedric, additional, Khanna, Nina, additional, Manuel, Oriol, additional, Mueller, Nicolas J., additional, Imlay, Hannah, additional, Kabbani, Dima, additional, Tyagi, Varalika, additional, Smibert, Olivia C., additional, Nasra, Mohamed, additional, Fontana, Lauren, additional, Obeid, Karam M., additional, Apostolopoulou, Anna, additional, Zhang, Sean X., additional, Permpalung, Nitipong, additional, Alhatimi, Hind, additional, Silverman, Michael S., additional, Guo, Henry, additional, Rogers, Benjamin A., additional, MacKenzie, Erica, additional, Pisano, Jennifer, additional, Gioia, Francesca, additional, Rapi, Lindita, additional, Prasad, G.V. Ramesh, additional, Banegas, Marcela, additional, Alonso, Carolyn D., additional, Doss, Kathleen, additional, Rakita, Robert M., additional, and Fishman, Jay A., additional

Published
2023
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3. Immunogenicity, Safety, and Breakthrough SARS-CoV-2 infections after COVID-19 Vaccination in Organ Transplant Recipients: A Prospective Multicenter Canadian Study

Author

Kabbani, Dima, primary, Yotis, Demitra M, additional, Ferreira, Victor H, additional, Shalhoub, Sarah, additional, Belga, Sara, additional, Tyagi, Varalika, additional, Ierullo, Matthew, additional, Kulasingam, Vathany, additional, Hébert, Marie-Josée, additional, West, Lori, additional, Delisle, Jean-Sébastien, additional, Racine, Normand, additional, De Serres, Sacha A, additional, Cardinal, Héloïse, additional, Dieudé, Mélanie, additional, Humar, Atul, additional, and Kumar, Deepali, additional

Published
2023
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5. Immunogenicity, Safety, and Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infections After Coronavirus Disease 2019 Vaccination in Organ Transplant Recipients: A Prospective Multicenter Canadian Study.

Author

Kabbani, Dima, Yotis, Demitra M, Ferreira, Victor H, Shalhoub, Sarah, Belga, Sara, Tyagi, Varalika, Ierullo, Matthew, Kulasingam, Vathany, Hébert, Marie-Josée, West, Lori, Delisle, Jean-Sébastien, Racine, Normand, Serres, Sacha A De, Cardinal, Héloïse, Dieudé, Mélanie, Humar, Atul, and Kumar, Deepali

Abstract

Background Solid organ transplant (SOT) recipients are at risk for severe coronavirus disease 2019 (COVID-19), despite vaccination. Our study aimed to elucidate COVID-19 vaccine immunogenicity and evaluate adverse events such as hospitalization, rejection, and breakthrough infection in a SOT cohort. Methods We performed a prospective, observational study on 539 adult SOT recipients (age ≥18 years old) recruited from 7 Canadian transplant centers. Demographics including transplant characteristics, vaccine types, and immunosuppression and events such as hospitalization, infection, and rejection were recorded. Follow ups occurred every 4–6 weeks postvaccination and at 6 and 12 months from first dose. Serum was processed from whole blood to measure anti-receptor binding domain (RBD) antibodies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein to assess immunogenicity. Results The COVID-19 vaccines were found to be safe in SOT recipients with low rates of rejection requiring therapy (0.7%). Immunogenicity improved after the third vaccine dose, yet 21% developed no anti-RBD response. Factors such as older age, lung transplantation, chronic kidney disease, and shorter duration from transplant were associated with decreased immunogenicity. Patients with at least 3 doses were protected from hospitalization when experiencing breakthrough infections. Significantly increased anti-RBD levels were observed in patients who received 3 doses and had breakthrough infection. Conclusions Three or four doses of COVID-19 vaccines were safe, increased immunogenicity, and protected against severe disease requiring hospitalization. Infection paired with multiple vaccinations significantly increased anti-RBD response. However, SOT populations should continue to practice infection prevention measures, and they should be prioritized for SARS-CoV-2 pre-exposure prophylactics and early therapeutics. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Adjunctive Glucocorticoid Therapy for Pneumocystis jiroveciiPneumonia in Solid Organ Transplant Recipients: A Multicenter Cohort, 2015-2020

Author

Hosseini-Moghaddam, Seyed M., Kothari, Sagar, Humar, Atul, Albasata, Hanan, Yetmar, Zachary A., Razonable, Raymund R., Neofytos, Dionysios, D’Asaro, Matilde, Boggian, Katia, Hirzel, Cedric, Khanna, Nina, Manuel, Oriol, Mueller, Nicolas J., Imlay, Hannah, Kabbani, Dima, Tyagi, Varalika, Smibert, Olivia C., Nasra, Mohamed, Fontana, Lauren, Obeid, Karam M., Apostolopoulou, Anna, Zhang, Sean X., Permpalung, Nitipong, Alhatimi, Hind, Silverman, Michael S., Guo, Henry, Rogers, Benjamin A., MacKenzie, Erica, Pisano, Jennifer, Gioia, Francesca, Rapi, Lindita, Prasad, G. V. Ramesh, Banegas, Marcela, Alonso, Carolyn D., Doss, Kathleen, Rakita, Robert M., and Fishman, Jay A.

Abstract

Solid organ transplant recipients (SOTRs) frequently receive adjunctive glucocorticoid therapy (AGT) for Pneumocystis jiroveciipneumonia (PJP). This multicenter cohort of SOTRs with PJP admitted to 20 transplant centers in Canada, the United States, Europe, and Australia, examined whether AGT was associated with a lower rate of all-cause intensive care unit (ICU) admission, 90-day in-hospital death, or a composite outcome (ICU admission or death).

Published
2023
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