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242 results on '"Tvrzická E"'

13. Polymorphisms rs2167444 and rs508384 in the SCD1 Gene Are Linked with High ApoB-48 Levels and Adverse Profile of Cardiometabolic Risk Factors.

Author

STAŇKOVÁ, B., MACÁŠEK, J., ZEMAN, M., VECKA, M., TVRZICKÁ, E., JÁCHYMOVÁ, M., SLABÝ, A., and ŽÁK, A.

Subjects
SYSTOLIC blood pressure, DISEASE risk factors, HYPERTENSION, PATHOLOGY, INSULIN resistance, APOLIPOPROTEIN E4
Abstract

Elevated plasma concentration of apolipoprotein B-48 (apoB-48) is an independent risk factor of cardiovascular disease. Stearoyl-CoA desaturase-1 (SCD1) is a rate-limiting lipogenic enzyme and a key regulator of fuel metabolism. The aim of this study was to analyse associations between clinical, biochemical, and genetic factors and different apoB-48 levels in subjects at increased cardiometabolic risk. We examined 220 subjects exhibiting at least one metabolic syndrome (MetS) component. In conjunction with basic clinical, anthropometric and laboratory measurements, we analysed various polymorphisms of stearoyl-CoA desaturase-1 (SCD1). Subjects were divided into two groups according to the median apoB-48 level: (1) high apoB-48 (≥ 7.9 mg/l, N = 112) and (2) low apoB-48 (< 7.9 mg/l, N = 108). Neither group differed significantly in anthropometric measures. High plasma apoB-48 levels were associated with increased systolic blood pressure (+3 %; P < 0.05), MetS prevalence (59.8 vs. 32.4 %; P < 0.001), small-dense LDL frequency (46.4 vs. 20.4 %; P < 0.001), triglycerides (+97 %; P < 0.001), non-HDLcholesterol (+27 %; P < 0.001), and lower concentrations of HDL-cholesterol (-11 %; P < 0.01). This group was further characterized by a higher HOMA-IR index (+54 %; P < 0.001) and increased concentrations of conjugated dienes (+11 %; P < 0.001) and oxidatively modified LDL (+ 38 %; P < 0.05). Lower frequencies of SCD1 minor genotypes (rs2167444, rs508384, P < 0.05) were observed in subjects with elevated plasma concentrations of apoB-48. Elevated plasma concentrations of apoB-48 are associated with an adverse lipid profile, higher systolic blood pressure, insulin resistance, and oxidative stress. Lower proportions of minor SCD1 genotypes (rs2167444, rs508384) implicate the role of genetic factors in the pathogenesis of elevated levels of apoB-48. [ABSTRACT FROM AUTHOR]

Published
2019
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14. Fatty Acid Composition of Adipose Tissue Triglycerides in Obese Diabetic Women After Bariatric Surgery: a 2-Year Follow up

Author

KUNEŠOVÁ, M., primary, SEDLÁČKOVÁ, B., additional, BRADNOVÁ, O., additional, TVRZICKÁ, E., additional, STAŇKOVÁ, B., additional, ŠRÁMKOVÁ, P., additional, DOLEŽALOVÁ, K., additional, KALOUSKOVÁ, P., additional, HLAVATÝ, P., additional, HILL, M., additional, BENDLOVÁ, B., additional, FRIED, M., additional, HAINER, V., additional, and VRBÍKOVÁ, J., additional

Published
2015
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16. Fatty acid composition of adipose tissue triglycerides after weight loss and weight maintenance:the DIOGENES study

Author

Kunešová, M, Hlavatý, P, Tvrzická, E, Stanková, B, Kalousková, P, Viguerie, N, Larsen, Thomas Meinert, van Baak, M A, Jebb, S A, Martinez, J A, Pfeiffer, A F H, Kafatos, A, Handjieva-Darlenska, T, Hill, M, Langin, D, Zák, A, Astrup, Arne, Saris, W H M, Kunešová, M, Hlavatý, P, Tvrzická, E, Stanková, B, Kalousková, P, Viguerie, N, Larsen, Thomas Meinert, van Baak, M A, Jebb, S A, Martinez, J A, Pfeiffer, A F H, Kafatos, A, Handjieva-Darlenska, T, Hill, M, Langin, D, Zák, A, Astrup, Arne, and Saris, W H M

Abstract

Fatty acid composition of adipose tissue changes with weight loss. Palmitoleic acid as a possible marker of endogenous lipogenesis or its functions as a lipokine are under debate. Objective was to assess the predictive role of adipose triglycerides fatty acids in weight maintenance in participants of the DIOGENES dietary intervention study. After an 8-week low calorie diet (LCD) subjects with > 8 % weight loss were randomized to 5 ad libitum weight maintenance diets for 6 months: low protein (P)/low glycemic index (GI) (LP/LGI), low P/high GI (LP/HGI), high P/low GI (HP/LGI), high P/high GI (HP/HGI), and a control diet. Fatty acid composition in adipose tissue triglycerides was determined by gas chromatography in 195 subjects before the LCD (baseline), after LCD and weight maintenance. Weight change after the maintenance phase was positively correlated with baseline adipose palmitoleic (16:1n-7), myristoleic (14:1n-5) and trans-palmitoleic acid (16:1n-7t). Negative correlation was found with baseline oleic acid (18:1n-9). Lower baseline monounsaturated fatty acids (14:1n-5, 16:1n-7 and trans 16:1n-7) in adipose tissue triglycerides predict better weight maintenance. Lower oleic acid predicts lower weight decrease. These findings suggest a specific role of monounsaturated fatty acids in weight management and as weight change predictors.

Published
2012

17. Fatty Acid Composition of Adipose Tissue Triglycerides After Weight Loss and Weight Maintenance: the DIOGENES Study

Author

KUNEŠOVÁ, M., primary, HLAVATÝ, P., additional, TVRZICKÁ, E., additional, STAŇKOVÁ, B., additional, KALOUSKOVÁ, P., additional, VIGUERIE, N., additional, LARSEN, T. M., additional, VAN BAAK, M. A., additional, JEBB, S. A., additional, MARTINEZ, J. A., additional, PFEIFFER, A. F. H., additional, KAFATOS, A., additional, HANDJIEVA-DARLENSKA, T., additional, HILL, M., additional, LANGIN, D., additional, ŽÁK, A., additional, ASTRUP, A., additional, and SARIS, W. H. M., additional

Published
2012
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21. Change in Fatty Acid Composition of Serum Lipids in Obese Females after Short-Term Weight Reducing Regimen with the Addition of n-3 Long Chain Polyunsaturated Fatty Acids In Comparison To Controls

Author

Hlavatý, P, primary, Kunešová, M, additional, Gojová, M, additional, Tvrzická, E, additional, Vecka, M, additional, Roubal, P, additional, Hill, M, additional, Hlavatá, K, additional, Kalousková, P, additional, Hainer, V, additional, Žák, A, additional, and Drbohlav, J, additional

Published
2008
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25. The influence of n-3 polyunsaturated fatty acids and very low calorie diet (VLCD) during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women

Author

Kunešová, M, primary, Braunerová, R, additional, Hlavatý, P, additional, Tvrzická, E, additional, Staňková, B, additional, Škrha, J, additional, Hilgertová, J, additional, Hill, M, additional, Kopecký, J, additional, Wagenknecht, M, additional, Hainer, V, additional, Matoulek, M, additional, Pařizková, J, additional, Žák, A, additional, and Svačina, Š, additional

Published
2006
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31. Determination of free bile acids in pharmaceuticals by thin layer cromatography and high performance liquid chromatography

Author

Novaković, J, Novaković, J, Tvrzická, E, Ražić, Slavica, Novaković, J, Novaković, J, Tvrzická, E, and Ražić, Slavica

Abstract

High-performance liquid chromatography with evaporative light scattering detection (HPLC-ELSD) and thin layer chromatography with flame ionization detection (TLC-FID) have been applied to the separation of five main free bile acids present in humans : cholic (CA), chenodeoxycholic (CDCA), deoxycholic (DCA), lithocholic (LCA) and ursodeoxycholic (UDCA) acid. HPLC separation was performed on Biospher Si 100 column using a mixture of n- heptane, isopropanol, ethylacetate, methanol and glacial acetic acid as a mobile phase. All the compounds were separate in less than 12 minutes by using a gradient elution mode. TLC-FID separation was performed on S-II Chromarods with a mixture of isooctane, ethylacetate and glacial acetic acid as a mobile phase. HPLC-ELSD method was applied to the determination of CDCA and UDCA in pharmaceuticals and their purity control when LCA, DCA, and CA were considered as impurities.

Published
1998

47. The Influence of n-3 Polyunsaturated Fatty Acids and Very Low Calorie Diet during a Short-term Weight Reducing Regimen on Weight Loss and Serum Fatty Acid Composition in Severely Obese Women.

Author

Kunešova, M., Braunerová, R., Hlavatý, P., Tvrzická, E., Staňková, B., Škrha, J., Hilgertová, J., Hill, M., Kopecký, J., Wagenknecht, M., Hainer, V., Matoulek, M., Pařízková, J., Žák, A., and Svačina, Š.

Subjects
UNSATURATED fatty acids, OXIDATION, WEIGHT loss, SERUM, BLOOD plasma, ARACHIDONIC acid
Abstract

Polyunsaturated fatty acids of n-3 series (n-3 PUFA) were shown to increase basal fat oxidation in humans. The aim of the study was to compare the effect of n-3 PUFA added to a very low calorie diet (VLCD), with VLCD only during three-week inpatient weight reduction. Twenty severely obese women were randomly assigned to VLCD with n-3 PUFA or with placebo. Fatty acids in serum lipid fractions were quantified by gas chromatography. Differences between the groups were determined using ANOVA. Higher weight (7.55±1.77 vs. 6.07±2.16 kg, NS), BMI (2.82± 0.62 vs. 2.22±0.74, p<0.05) and hip circumference losses (4.8±1.81 vs. 2.5±2.51cm, p<0.05) were found in the n-3 group as compared to the control group. Significantly higher increase in beta-hydroxybutyrate was found in the n-3 group showing higher ketogenesis and possible higher fatty acid oxidation. The increase in beta-hydroxybutyrate significantly correlated with the increase in serum phospholipid arachidonic acid (20:4n-6; r = 0.91, p<0.001). In the n-3 group significantly higher increase was found in n-3 PUFA (eicosapentaenoic acid, 20:5n-3, docosahexaenoic acid, 22:6n-3) in trigycerides and phospholipids. The significant decrease of palmitoleic acid (16:1n-7) and vaccenic acid (18:1n-7) in triglycerides probably reflected lower lipogenesis. A significant negative correlation between BMI change and phospholipid docosahexaenoic acid change was found (r = -0.595, p<0.008). The results suggest that long chain n-3 PUFA enhance weight loss in obese females treated by VLCD. Docosahexaenoate (22:6n-3) seems to be the active component. [ABSTRACT FROM AUTHOR]

Published
2006
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48. Pleiotropic effects of niacin: Current possibilities for its clinical use

Author

Zeman Miroslav, Vecka Marek, Perlík František, Staňková Barbora, Hromádka Robert, Tvrzická Eva, Širc Jakub, Hrib Jakub, and Žák Aleš

Subjects
niacin, pleiotropic effects, hca2 receptor, dyslipidemia, cardiovascular mortality/morbidity, Pharmaceutical industry, HD9665-9675
Abstract

Niacin was the first hypolipidemic drug to significantly reduce both major cardiovascular events and mortality in patients with cardiovascular disease. Niacin favorably influences all lipoprotein classes, including lipoprotein[a],and belongs to the most potent hypolipidemic drugs for increasing HDL-C. Moreover, niacin causes favorable changes to the qualitative composition of lipoprotein HDL. In addition to its pronounced hypolipidemic action, niacin exerts many other, non-hypolipidemic effects (e.g., antioxidative, anti-inflammatory, antithrombotic), which favorably influence the development and progression of atherosclerosis. These effects are dependent on activation of the specific receptor HCA2. Recent results published by the two large clinical studies, AIM-HIGH and HPS2-THRIVE, have led to the impugnation of niacin’s role in future clinical practice. However, due to several methodological flaws in the AIM-HIGH and HPS2-THRIVE studies, the pleiotropic effects of niacin now deserve thorough evaluation. This review summarizes the present and possible future use of niacin in clinical practice in light of its newly recognized pleiotropic effects.

Published
2016
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