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Abstract Young individuals with post‐traumatic stress disorder (PTSD) display peripheral vascular and autonomic nervous system dysfunction, two factors potentially stemming from a redox imbalance. It is currently unclear if these aforementioned factors, observed at rest, alter peripheral haemodynamic responses to exercise in this population. This study examined haemodynamic responses to handgrip exercise in young individuals with PTSD following acute antioxidant (AO) supplementation. Thirteen young individuals with PTSD (age 23 ± 3 years), and 13 age‐ and sex‐matched controls (CTRL) participated in the study. Exercise‐induced changes to arm blood flow (BF), mean arterial pressure (MAP) and vascular conductance (VC) were evaluated across two workloads of rhythmic handgrip exercise (3 and 6 kg). The PTSD group participated in two visits, consuming either a placebo (PL) or AO prior to their visits. The PTSD group demonstrated significantly lower VC (P = 0.04) across all exercise workloads (vs. CTRL), which was significantly improved following AO supplementation. In the PTSD group, AO supplementation improved VC in participants possessing the lowest VC responses to handgrip exercise, with AO supplementation significantly improving VC responses (3 and 6 kg: P

Monkeypox is an emerging zoonotic viral disease caused by the Monkeypox virus, traditionally confined to central and west Africa, which has recently spread to other regions worldwide, making it a global health concern...

To the Editor, Bladder cancer is one of the most common cancers in humans, representing the 7th and 17th type of neoplasm in both genders. Its incidence and mortality are quite heterogeneous in different countries and are due to different risk factors, quality and prevalence of healthcare and the possibility of early diagnosis and treatment of the tumor and its potential recurrences. [...]

To the Editor, In recent years, alternative solutions have been proposed to obtain effective results comparable to TURP, which is currently considered the gold standard, and laser vapo-enucleation techniques (1, 2), but with the possibility of maintaining sexual functions. In recent years there has been a growing trend towards ejaculation preservation. Although the results of TURP (3), and most laser enucleation techniques are undoubted in the Benign Prostatic Hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS) management, they often lack in the preservation of ejaculation. All the alternative recently proposed interventions (Rezum, AquaBeam, Urolift, TPLA, i-TIND, LEST) are procedures considered by some authors to be promising in both managing BPO and preserving sexual functions. However, all these methods are limited by a lack of long-term follow-up that would evaluate the efficacy over time, possible complications related to the method and the correct patient selection for a specific method. The aim of this letter is to summarize the available evidence and provide clinicians with practical recommendations on the use of the brand new minimally invasive techniques for the management of BPO. [...]

Background: The aim of our study was to develop a radiomic tool for the prediction of clinically significant prostate cancer. Methods: From September 2020 to December 2021, 91 patients who underwent magnetic resonance imaging prostate fusion biopsy at our institution were selected. Prostate cancer aggressiveness was assessed by combining the three orthogonal planes-Llocal binary pattern the 3Dgray level co-occurrence matrix, and other first order statistical features with clinical (semantic) features. The 487 features were used to predict whether the Gleason score was clinically significant (≥7) in the final pathology. A feature selection algorithm was used to determine the most predictive features, and at the end of the process, nine features were chosen through a 10-fold cross validation. Results: The feature analysis revealed a detection accuracy of 83.5%, with a clinically significant precision of 84.4% and a clinically significant sensitivity of 91.5%. The resulting area under the curve was 80.4%. Conclusions: Radiomic analysis allowed us to develop a tool that was able to predict a Gleason score of ≥7. This new tool may improve the detection rate of clinically significant prostate cancer and overcome the limitations of the subjective interpretation of magnetic resonance imaging, reducing the number of useless biopsies.

Objective: To assess the efficacy and safety of a treatment regimen based on rectal administration of Boswellia resin extract and propolis derived polyphenols in patients with type IIIa and type IIIb chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS). Methods: Patients with type IIIa and type IIIb CP/CPPS received one rectal suppository a day for 15 days per month for 3 consecutive months. Participants were evaluated with National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), the International Prostate Symptom Scores (IPSS), International Index of Erectile Function (IIEF), four-glass test, uroflowmetry, and prostate-specific antigen assessments at baseline and at Week 4, and Week 12. Primary endpoints were improvement in pain domain of NIH-CPSI and improvement of NIH-CPSI total score. Secondary outcomes included improvement of micturition and quality of life (QoL) domains of NIH-CPSI questionnaire. Results: A total of 61 males were enrolled. No adverse events were reported. Significant improvements from baseline to Day 30 were reported for NIH-CPSI total score (mean difference: −9.2; p

Abstract Background and study aims First case start (FCS) time is often a key metric used to gauge efficiency in an endoscopy suite. There are limited data on tools and methods to improve the FCS time in the endoscopy suite. Methods A prospective observational cohort study was conducted in an academic tertiary care endoscopy suite examining the effect of badge sign-in (Period 2) and badge sign-in coupled with report cards (Period 3) compared to an initial observational period (Period 1). Results After the badge sign-in reader was introduced in P2, the unit experienced a mean time savings of 5 ± 18 minutes in FCS delays compared to P1 (P = .03). In P3, an 8 ± 17-minute time savings in FCS time delay was observed compared to P1 (P = 0.0006). Sign-in compliance significantly increased for the overall unit between P2 and P3 (49 % vs. 59 %, P = .002). Increases in first case on-time start (FCOTS) rates compared to P1 were observed for the unit, with a 14% absolute increase in P2 (P

ABSTRACT Purpose: to provide an update on the management of a Urology Department during the COVID-19 outbreak, suggesting strategies to optimize assistance to the patients, to implement telemedicine and triage protocols, to define pathways for hospital access, to reduce risk of contagious inside the hospital and to determine the role of residents during the pandemic. Materials and Methods: In May the 6th 2020 we performed a review of the literature through online search engines (PubMed, Web of Science and Science Direct). We looked at recommendations provided by the EAU and ERUS regarding the management of urological patients during the COVID-19 pandemic. The main aspects of interest were: the definition of deferrable and non-deferrable procedures, Personal Protective Equipment (PPE) and hospital protocols for health care providers, triage, hospitalization and surgery, post-operative care training and residents' activity. A narrative summary of guidelines and current literature for each point of interest was performed. Conclusion: In the actual Covid-19 scenario, while the number of positive patients globally keep on rising, it is fundamental to embrace a new way to deliver healthcare and to overcome challenges of physical distancing and self-isolation. The use of appropriate PPE, definite pathways to access the hospital, the implementation of telemedicine protocols can represent effective strategies to carry on delivering healthcare.

This study aimed at performing a comparative analysis of the fracture resistance of implants, evaluating extra-narrow, narrow, and regular implants. Four groups containing 15 implants each were evaluated. Group 1 (G1): single-piece extra-narrow implants; Group 2 (G2): single-piece narrow implants; Group 3 (G3): Morse taper narrow implants with solid abutments; Group 4 (G4): Morse taper conventional implants with solid abutments. The implants were tested using a universal testing machine for their maximum force limit and their maximum bending moment. After obtaining the data, the Shapiro–Wilk, ANOVA, and Tukey (p < 0.05) statistical tests were applied. Samples from all the groups were analyzed by scanning electron microscopy and Groups 3 and 4 were analyzed by profilometry. The means and the standard deviation values for the maximum force limit (N) and the maximum bending moment (Nmm) were respectively: G1:134.29 N (10.27); G2:300.61 N (24.26); G3:360.64 N (23.34); G4:419.10 N (18.87); G1:1612.02 Nmm (100.6); G2:2945 Nmm (237.97); G3:3530.38 Nmm (228.75); G4:4096.7 Nmm (182.73). The groups behaved statistically different from each other, showing that the smallest diameter implants provided less fracture resistance, both in the tensile strength tests and in the maximum bending moment between all groups. Furthermore, single-piece implants, with 2.5 mm and 3.0 mm diameters, deformed in the implant body region area, rather than in the abutment region.

Currently, there has been a growing demand for restorations of anterior teeth in the routine of doctors in dental offices. With advances in adhesive technology and good properties of the available ceramics, the use of ceramic veneers has been offered as a treatment option for cases where teeth have minor color changes and shape and position changes. Through careful treatment planning, it is possible to conservatively use ceramic veneers in the treatments, applying techniques with minimal wear of the teeth and obtaining excellent aesthetic results with mechanical stability and biocompatibility with the periodontal tissues and clinical longevity. This clinical case report was used to design the digital smile, which guided the production of the diagnostic waxing of the superior model. Silicone guides were then made to create the mock-up, orienting enamel/dentin wear and assisting the preparation of the crowns with bis-acryl resin. When the wear was finished, the gingival separation was performed using the double-thread technique. In the molding process, the second wire was withdrawn and the molding material flowed into the gingival groove, copying the terminal region. After analysis of the quality of the impression, the temporary crowns were made with bis-acryl resin, using the guide. The color of the cementing agent was chosen using a glycerin-based compound which simulates the final color of the cement. After two hours of drying, two different layers of silane were applied for 60 seconds. After the preparation of the piece, gingival isolation and separation were done. The dental substrate was degreased with detergent solution and conditioned with 37% phosphoric acid for 15 seconds and then washed for 45 seconds for subsequent drying, leaving the substrate moistened. The adhesive system was applied for 30 seconds, waiting for the adhesive to penetrate into the conditioned dentinal tubules. A light air jet was applied, and then each tooth was photopolymerized for 30 seconds. The resin cement was placed inside the pieces and placed in position and photopolymerized. The excess cement was removed; after a layer of glycerin in the cervical region, aiming to block the entry of oxygen and polishing was performed. The purpose of this case report was to describe a sequence of clinical steps, from planning to cementation, in a case of aesthetic correction using feldspathic ceramic veneers.

After a state take-over of most local schools, the fate of public education in New Orleans has been clouded by uncertainty. However, many problems are already clear. The community has expressed outrage on numerous occasions about the management, conditions, policies, and practices of the RSD schools. One fundamental concern has been about the lack of basic resources essential for success in any educational environment let alone one formed after the worst natural disaster in American history. These resources include: textbooks; desks for students; a sufficient number of experienced and well-trained teachers; to the failure to deliver services to children with special learning needs; counseling services to help children cope with trauma and grief extra-curricular activities; and hot lunches for children, many of whom continue to live in or near poverty. Another prominent concern is that many RSD schools exhibit what students have referred to as a prison-like atmosphere while their discipline policies penalize and remove students instead of providing support them and facilitating positive growth. Prior to Katrina, harsh discipline policies and school arrests forced many children out of New Orleans schools, putting them at-risk or directly involved in the juvenile justice system. While this phenomenon pre-dated Katrina, it is now being replicated in the new "network" of schools operated by local and state officials and various charter groups. The confluence of these factors--lack of resources and the failure to provide quality education, combined with overly harsh and punitive discipline policies that criminalize and exclude youth from traditional education settings--has created what many now call the School-to-Prison Pipeline. It is this issue that juvenile justice and education advocates alike believe to be at the forefront of the fight for children's rights in post-Katrina New Orleans. (Contains 27 notes.)