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1. The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer—novel use of a large administrative database

Author

White, M J, primary, Sheka, A C, additional, LaRocca, C J, additional, Irey, R L, additional, Ma, S, additional, Wirth, K M, additional, Benner, A, additional, Denbo, J W, additional, Jensen, E H, additional, Ankeny, J S, additional, Ikramuddin, S, additional, Tuttle, T M, additional, Hui, J Y C, additional, and Marmor, S, additional

Published
2022
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3. The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer—novel use of a large administrative database.

Author

White, M J, Sheka, A C, LaRocca, C J, Irey, R L, Ma, S, Wirth, K M, Benner, A, Denbo, J W, Jensen, E H, Ankeny, J S, Ikramuddin, S, Tuttle, T M, Hui, J Y C, and Marmor, S

Subjects
PANCREATIC tumors, ADENOCARCINOMA, AGE distribution, EARLY detection of cancer, RETROSPECTIVE studies, MANN Whitney U Test, TYPE 2 diabetes, RISK assessment, DUCTAL carcinoma, AGE factors in disease, KAPLAN-Meier estimator, OBSTRUCTIVE lung diseases, DESCRIPTIVE statistics, RESEARCH funding, CHI-squared test, DATA analysis software, PROPORTIONAL hazards models, AFRICAN Americans, LONGITUDINAL method, DISEASE risk factors, DISEASE complications
Abstract

Background Screening options for pancreatic ductal adenocarcinoma (PDAC) are limited. New-onset type 2 diabetes (NoD) is associated with subsequent diagnosis of PDAC in observational studies and may afford an opportunity for PDAC screening. We evaluated this association using a large administrative database. Methods Patients were identified using claims data from the OptumLabs® Data Warehouse. Adult patients with NoD diagnosis were matched 1:3 with patients without NoD using age, sex and chronic obstructive pulmonary disease (COPD) status. The event of PDAC diagnosis was compared between cohorts using the Kaplan–Meier method. Factors associated with PDAC diagnosis were evaluated with Cox's proportional hazards modeling. Results We identified 640 421 patients with NoD and included 1 921 263 controls. At 3 years, significantly more PDAC events were identified in the NoD group vs control group (579 vs 505; P  < 0.001). When controlling for patient factors, NoD was significantly associated with elevated risk of PDAC (HR 3.474, 95% CI 3.082–3.920, P  < 0.001). Other factors significantly associated with PDAC diagnosis were increasing age, increasing age among Black patients, and COPD diagnosis (P  ≤ 0.05). Conclusions NoD was independently associated with subsequent diagnosis of PDAC within 3 years. Future studies should evaluate the feasibility and benefit of PDAC screening in patients with NoD. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement

Author

Esquivel, J., Sticca, R., Sugarbaker, P., Levine, E., Yan, T. D., Alexander, R., Baratti, D., Bartlett, D., Barone, R., Barrios, P., Bieligk, S., Bretcha-Boix, P., Chang, C. K., Chu, F., Chu, Q., Daniel, S., de Bree, E., Deraco, M., Dominguez-Parra, L., Elias, D., Flynn, R., Foster, J., Garofalo, A., Gilly, F. N., Glehen, O., Gomez-Portilla, A., Gonzalez-Bayon, L., Gonzalez-Moreno, S., Goodman, M., Gushchin, V., Hanna, N., Hartmann, J., Harrison, L., Hoefer, R., Kane, J., Kecmanovic, D., Kelley, S., Kuhn, J., LaMont, J., Lange, J., Li, B., Loggie, B., Mahteme, H., Mann, G., Martin, R., Misih, R. A., Moran, B., Morris, D., Onate-Ocana, L., Petrelli, N., Philippe, G., Pingpank, J., Pitroff, A., Piso, P., Quinones, M., Riley, L., Rutstein, L., Saha, S., Alrawi, S., Sardi, A., Schneebaum, S., Shen, P., Shibata, D., Spellman, J., Stojadinovic, A., Stewart, J., Torres-Melero, J., Tuttle, T., Verwaal, V., Villar, J., Wilkinson, N., Younan, R., Zeh, H., Zoetmulder, F., and Sebbag, G.

Published
2007
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11. Elucidation of the bonding of a near infrared dye to hollow gold nanospheres – a chalcogen tripod† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc00068a

Author

Kearns, H., Sengupta, S., Sasselli, I. Ramos, Bromley III, L., Faulds, K., Tuttle, T., Bedics, M. A., Detty, M. R., Velarde, L., Graham, D., and Smith, W. E.

Subjects
Chemistry
Abstract

Determining how Raman labels orientate on the surface of HGNs to aid in future advancements of designing NIR nanosensors., Infrared surface enhanced Raman scattering (SERS) is an attractive technique for the in situ detection of nanoprobes in biological samples due to the greater depth of penetration and reduced interference compared to SERS in the visible region. A key challenge is to understand the surface layer formed in suspension when a specific label is added to the SERS substrate in aqueous suspension. SERS taken at different wavelengths, theoretical calculations, and surface-selective sum frequency generation vibrational spectroscopy (SFG-VS) were used to define the surface orientation and manner of attachment of a new class of infrared SERS labels with a thiopyrylium core and four pendant 2-selenophenyl rings. Hollow gold nanospheres (HGNs) were used as the enhancing substrate and two distinct types of SERS spectra were obtained. With excitation close to resonance with both the near infrared electronic transition in the label (max 826 nm) and the plasmon resonance maximum (690 nm), surface enhanced resonance Raman scattering (SERRS) was obtained. SERRS indicates that the major axis of the core is near to perpendicular to the surface plane and SFG-VS obtained from a dried gold film gave a similar orientation with the major axis at an angle 64–85° from the surface plane. Longer excitation wavelengths give SERS with little or no molecular resonance contribution and new vibrations appeared with significant displacements between the thiopyrylium core and the pendant selenophene rings. Analysis using calculated spectra with one or two rings rotated indicates that two rings on one end are rotated towards the metal surface to give an arrangement of two selenium and one sulphur atoms directly facing the gold structure. The spectra, together with a space filled model, indicate that the molecule is strongly adsorbed to the surface through the selenium and sulphur atoms in an arrangement which will facilitate layer formation.

Published
2016

12. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement

Author

Esquivel, J., Sticca, R., Sugarbaker, P., Levine, E., Yan, T. D., Alexander, R., Baratti, D., Bartlett, D., Barone, R., Barrios, P., Bieligk, S., Bretcha-Boix, P., Chang, C. K., Chu, F., Chu, Q., Daniel, S., deBree, E., Deraco, M., Dominguez-Parra, L., Elias, D., Flynn, R., Foster, J., Garofalo, A., Gilly, F. N., Glehen, O., Gomez-Portilla, A., Gonzalez-Bayon, L., Gonzalez-Moreno, S., Goodman, M., Gushchin, V., Hanna, N., Hartmann, J., Harrison, L., Hoefer, R., Kane, J., Kecmanovic, D., Kelley, S., Kuhn, J., LaMont, J., Lange, J., Li, B., Loggie, B., Mahteme, H., Mann, G., Martin, R., Misih, R. A., Moran, B., Morris, D., Onate-Ocana, L., Petrelli, N., Philippe, G., Pingpank, J., Pitroff, A., Piso, P., Quinones, M., Riley, L., Rutstein, L., Saha, S., Alrawi, S., Sardi, A., Schneebaum, S., Shen, P., Shibata, D., Spellman, J., Stojadinovic, A., Stewart, J., Torres-Melero, J., Tuttle, T., Verwaal, V., Villar, J., Wilkinson, N., Younan, R., Zeh, H., Zoetmulder, F., and Sebbag, G.

Published
2011
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13. Molecular dynamics simulations reveal disruptive self-assembly in dynamic peptide libraries

Author

Sasselli, I. R., Moreira, I. P., Ulijn, R. V., and Tuttle, T.

Subjects
QD
Abstract

There is a significant interest in the use of unmodified self-assembling peptides as building blocks for functional, supramolecular biomaterials. Recently, dynamic peptide libraries (DPLs) have been proposed to select self-assembling materials from dynamically exchanging mixture of dipeptide inputs in the presence of a nonspecific protease enzyme, where peptide sequences are selected and amplified based on their self-assembling tendencies. It was shown that the results of DPL of mixed sequences (e.g. starting from a mixture of dileucine, L2 and diphenylalanine, F2) did not give the same outcome as the separate L2 and F2 libraries (which give rise to formation of F6 and L6), implying that interaction between these sequences could disrupt the self-assembly. In this study, coarse grained molecular dynamic (CG-MD) simulations are used to understand the DPL results for F2, L2 and mixed libraries. CG-MD simulations demonstrate that interactions between precursors can cause the low formation yield of hexapeptides in mixtures of dipeptides and show that this ability to disrupt is influenced by the concentration of the different species in the DPL. The disrupting self-assembly effect between the species in DPL is an important effect to take into account in dynamic combinatorial chemistry as it affects the possible discovery of new materials. The work shows that combined computational and experimental screening can be used complementary and in combination provide a powerful means to discover new supramolecular peptide nanostructures.

Published
2017

17. Abstracts of the 26th international isotope society (UK group) symposium: Synthesis & applications of labelled compounds 2017

Author

Aboagye, E., primary, Aigbirhio, F., additional, Allott, L., additional, Anderson, E.A., additional, Artelsmair, M., additional, Audisio, D., additional, Audisio, J., additional, Bragg, R., additional, Brindle, K., additional, Bulat, F., additional, Bürli, R., additional, Carroll, L., additional, Chapdelaine, M., additional, Collins, S., additional, Cortezon-Tamarit, F., additional, Da Pieve, C., additional, Davies, J.R., additional, Decuypere, E., additional, Defay, T., additional, DeFrees, S., additional, Dilworth, J., additional, Duckett, S.B., additional, Dugave, C., additional, Elhabiri, M., additional, Elmore, C.S., additional, Fairlamb, I.J.S., additional, Fenwick, A., additional, Forsback, S., additional, Ge, H., additional, Geach, N., additional, Gouverneur, V., additional, Gregson, T., additional, Gu, C., additional, Ivanov, P., additional, Kagoro, M.P., additional, Kerr, W.J., additional, Kidd, G.L., additional, Knox, G., additional, Kolodych, S., additional, Koniev, O., additional, Krzyczmonik, A., additional, Lawrie, K.W.M., additional, Leeper, F., additional, Lewis, R., additional, Little, G., additional, Liu, H., additional, Lockley, W.J.S., additional, Mekareeya, A., additional, Mirabello, V., additional, Morrissey, C., additional, Neves, A., additional, Pascu, S.I., additional, Paton, R.S., additional, Plougastel, L., additional, Poot, A.J., additional, Puhalo, N., additional, Read, D., additional, Reid, M., additional, Robinson, A., additional, Sardana, M., additional, Sarpaki, S., additional, Schou, M., additional, Simmonds, A., additional, Smith, G., additional, Solin, J.C..O., additional, Soloviev, D., additional, Talbot, E.P., additional, Taran, F., additional, Turton, D.R., additional, Tuttle, T., additional, Venanzi, N.A.E., additional, Vugts, D.J., additional, Wagner, A., additional, Wang, L., additional, Webster, B., additional, White, R., additional, Willis, C.L., additional, Windhorst, A.D., additional, Winfield, C., additional, and Xie, B., additional

Published
2018
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19. Abstracts of the 25th International Isotope Society (UK Group) symposium: Synthesis and applications of labelled compounds 2016

Author

Aboagye, E., primary, Alger, K., additional, Archibald, S.J., additional, Bakar, N.B.A., additional, Barton, N., additional, Bergare, J., additional, Bloom, J., additional, Bragg, R., additional, Burke, B.P., additional, Burns, M.J., additional, Carroll, L., additional, Calatayud, D.G., additional, Cawthorne, C., additional, Cortezon-Tamarit, F., additional, Crean, C., additional, Crump, M.P., additional, Dilworth, J.R., additional, Domarkas, J., additional, Duckett, S.B., additional, Eggleston, I., additional, Elmore, C.S., additional, van Es, E.M., additional, Fekete, M., additional, Goodwin, M., additional, Green, G.G.R., additional, Grönberg, G., additional, Hayes, C.J., additional, Hayes, M.A., additional, Hollis, S., additional, Hueting, R., additional, Ivanov, P., additional, Johnston, G., additional, Kerr, W.J., additional, Kohler, A., additional, Knox, G., additional, Lawrie, K., additional, Lee, R.E., additional, Lewis, W., additional, Lin, B., additional, Lockley, W.J.S., additional, López-Torres, E., additional, Lv, K., additional, Maddocks, S., additional, Marsh, B.J., additional, Mendiola, A., additional, Mirabello, V., additional, Miranda, C.S., additional, Norcott, P.L., additional, O'Hagan, D., additional, Olaru, A.M., additional, Pascu, S.I., additional, Rayner, P.J., additional, Read, D., additional, Ridge, K., additional, Ritter, T., additional, Roberts, I., additional, Samuri, N., additional, Sarpaki, S., additional, Somers, D., additional, Taylor, R., additional, Tuttle, T., additional, Varcoe, J.R., additional, and Willis, C.L., additional

Published
2017
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28. A single emitting layer white OLED based on exciplex interface emission

Author

Angioni, E., primary, Chapran, M., additional, Ivaniuk, K., additional, Kostiv, N., additional, Cherpak, V., additional, Stakhira, P., additional, Lazauskas, A., additional, Tamulevičius, S., additional, Volyniuk, D., additional, Findlay, N. J., additional, Tuttle, T., additional, Grazulevicius, J. V., additional, and Skabara, P. J., additional

Published
2016
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29. Response

Author

Portschy, P. R., primary, Kuntz, K. M., additional, and Tuttle, T. M., additional

Published
2015
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35. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in the management of peritoneal surface malignancies of colonic origin : a consensus statement

Author

Esquivel, J, Sticca, R, Sugarbaker, P, Levine, E, Yan, T D, Alexander, R, Baratti, D, Bartlett, D, Barone, R, Barrios, P, Bieligk, S, Bretcha-Boix, P, Chang, C K, Chu, F, Chu, Q, Daniel, S, Debree, E, Deraco, M, Dominguez-Parra, L, Elias, D, Flynn, R, Foster, J, Garofalo, A, Gilly, F N, Glehen, O, Gomez-Portilla, A, Gonzalez-Bayon, L, Gonzalez-Moreno, S, Goodman, M, Gushchin, V, Hanna, N, Hartmann, J, Harrison, L, Hoefer, R, Kane, J, Kecmanovic, D, Kelley, S, Kuhn, J, Lamont, J, Lange, J, Li, B, Loggie, B, Mahteme, Haile, Mann, G, Martin, R, Misih, R A, Moran, B, Morris, D, Onate-Ocana, L, Petrelli, N, Philippe, G, Pingpank, J, Pitroff, A, Piso, P, Quinones, M, Riley, L, Rutstein, L, Saha, S, Alrawi, S, Sardi, A, Schneebaum, S, Shen, P, Shibata, D, Spellman, J, Stojadinovic, A, Stewart, J, Torres-Melero, J, Tuttle, T, Verwaal, V, Villar, J, Wilkinson, N, Younan, R, Zeh, H, Zoetmulder, F, Sebbag, G, Esquivel, J, Sticca, R, Sugarbaker, P, Levine, E, Yan, T D, Alexander, R, Baratti, D, Bartlett, D, Barone, R, Barrios, P, Bieligk, S, Bretcha-Boix, P, Chang, C K, Chu, F, Chu, Q, Daniel, S, Debree, E, Deraco, M, Dominguez-Parra, L, Elias, D, Flynn, R, Foster, J, Garofalo, A, Gilly, F N, Glehen, O, Gomez-Portilla, A, Gonzalez-Bayon, L, Gonzalez-Moreno, S, Goodman, M, Gushchin, V, Hanna, N, Hartmann, J, Harrison, L, Hoefer, R, Kane, J, Kecmanovic, D, Kelley, S, Kuhn, J, Lamont, J, Lange, J, Li, B, Loggie, B, Mahteme, Haile, Mann, G, Martin, R, Misih, R A, Moran, B, Morris, D, Onate-Ocana, L, Petrelli, N, Philippe, G, Pingpank, J, Pitroff, A, Piso, P, Quinones, M, Riley, L, Rutstein, L, Saha, S, Alrawi, S, Sardi, A, Schneebaum, S, Shen, P, Shibata, D, Spellman, J, Stojadinovic, A, Stewart, J, Torres-Melero, J, Tuttle, T, Verwaal, V, Villar, J, Wilkinson, N, Younan, R, Zeh, H, Zoetmulder, F, and Sebbag, G

Published
2011
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49. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Peritoneal Surface Malignancies of Colonic Origin: A Consensus Statement

Author

Esquivel, J., primary, Sticca, R., additional, Sugarbaker, P., additional, Levine, E., additional, Yan, T. D., additional, Alexander, R., additional, Baratti, D., additional, Bartlett, D., additional, Barone, R., additional, Barrios, P., additional, Bieligk, S., additional, Bretcha-Boix, P., additional, Chang, C. K., additional, Chu, F., additional, Chu, Q., additional, Daniel, S., additional, deBree, E., additional, Deraco, M., additional, Dominguez-Parra, L., additional, Elias, D., additional, Flynn, R., additional, Foster, J., additional, Garofalo, A., additional, Gilly, F. N., additional, Glehen, O., additional, Gomez-Portilla, A., additional, Gonzalez-Bayon, L., additional, Gonzalez-Moreno, S., additional, Goodman, M., additional, Gushchin, V., additional, Hanna, N., additional, Hartmann, J., additional, Harrison, L., additional, Hoefer, R., additional, Kane, J., additional, Kecmanovic, D., additional, Kelley, S., additional, Kuhn, J., additional, LaMont, J., additional, Lange, J., additional, Li, B., additional, Loggie, B., additional, Mahteme, H., additional, Mann, G., additional, Martin, R., additional, Misih, R. A., additional, Moran, B., additional, Morris, D., additional, Onate-Ocana, L., additional, Petrelli, N., additional, Philippe, G., additional, Pingpank, J., additional, Pitroff, A., additional, Piso, P., additional, Quinones, M., additional, Riley, L., additional, Rutstein, L., additional, Saha, S., additional, Alrawi, S., additional, Sardi, A., additional, Schneebaum, S., additional, Shen, P., additional, Shibata, D., additional, Spellman, J., additional, Stojadinovic, A., additional, Stewart, J., additional, Torres-Melero, J., additional, Tuttle, T., additional, Verwaal, V., additional, Villar, J., additional, Wilkinson, N., additional, Younan, R., additional, Zeh, H., additional, Zoetmulder, F., additional, and Sebbag, G., additional

Published
2008
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50. Axillary web syndrome following breast cancer surgery: symptoms, complications, and management strategies

Author

Koehler LA, Haddad TC, Hunter DW, and Tuttle TM

Subjects
Axillary Web Syndrome, Breast Cancer, Lymphedema, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

LA Koehler,1–3 TC Haddad,4 DW Hunter,5 TM Tuttle3,6 1Division of Physical Therapy, 2Division of Rehabilitation Medicine, Department of Rehabilitation Medicine, Medical School, University of Minnesota, Minneapolis, MN, USA; 3University of Minnesota, Masonic Cancer Center, Minneapolis, MN, USA; 4Mayo Clinic, Division of Medical Oncology, Department of Oncology, Rochester, MN, USA; 5Department of Radiology, Medical School, University of Minnesota, Minneapolis, MN, USA; 6Department of Surgery, Medical School, University of Minnesota, Minneapolis, MN, USA Abstract: Axillary web syndrome (AWS) is a common condition occurring in up to 86% of patients following breast cancer surgery with ipsilateral lymphadenectomy of one or more nodes. AWS presents as a single cord or multiple thin cords in the subcutaneous tissues of the ipsilateral axilla. The cords may extend variable distances “down” the ipsilateral arm and/or chest wall. The cords frequently result in painful shoulder abduction and limited shoulder range of motion. AWS most frequently becomes symptomatic between 2 and 8 weeks postoperatively but can also develop and recur months to years after surgery. Education about and increased awareness of AWS should be promoted for patients and caregivers. Assessments for AWS should be performed on a regular basis following breast cancer surgery especially if there has been associated lymphadenectomy. Physical therapy, which consists of manual therapy, exercise, education, and other rehabilitation modalities to improve range of motion and decrease pain, is recommended in the treatment of AWS. Keywords: cording, Mondor’s disease, rehabilitation, axillary lymphadenectomy

Published
2018

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