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16 results on '"Tustin, Nancy B"'

3. Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption

Author

Bar, Katharine J., primary, Sneller, Michael C., additional, Harrison, Linda J., additional, Justement, J. Shawn, additional, Overton, Edgar T., additional, Petrone, Mary E., additional, Salantes, D. Brenda, additional, Seamon, Catherine A., additional, Scheinfeld, Benjamin, additional, Kwan, Richard W., additional, Learn, Gerald H., additional, Proschan, Michael A., additional, Kreider, Edward F., additional, Blazkova, Jana, additional, Bardsley, Mark, additional, Refsland, Eric W., additional, Messer, Michael, additional, Clarridge, Katherine E., additional, Tustin, Nancy B., additional, Madden, Patrick J., additional, Oden, KaSaundra, additional, O’Dell, Sijy J., additional, Jarocki, Bernadette, additional, Shiakolas, Andrea R., additional, Tressler, Randall L., additional, Doria-Rose, Nicole A., additional, Bailer, Robert T., additional, Ledgerwood, Julie E., additional, Capparelli, Edmund V., additional, Lynch, Rebecca M., additional, Graham, Barney S., additional, Moir, Susan, additional, Koup, Richard A., additional, Mascola, John R., additional, Hoxie, James A., additional, Fauci, Anthony S., additional, Tebas, Pablo, additional, and Chun, Tae-Wook, additional

Published
2016
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6. Optimization of storage and shipment of cryopreserved peripheral blood mononuclear cells from HIV-infected and uninfected individuals for ELISPOT assays

Author

Weinberg, Adriana, primary, Song, Lin Ye, additional, Wilkening, Cindy L., additional, Fenton, Terry, additional, Hural, John, additional, Louzao, Raul, additional, Ferrari, Guido, additional, Etter, Paige E., additional, Berrong, Mark, additional, Canniff, Jennifer D., additional, Carter, Donald, additional, Defawe, Olivier D., additional, Garcia, Ambrosia, additional, Garrelts, Tania L., additional, Gelman, Rebecca, additional, Lambrecht, Linda K., additional, Pahwa, Savita, additional, Pilakka-Kanthikeel, Sudheesh, additional, Shugarts, David L., additional, and Tustin, Nancy B., additional

Published
2010
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8. Validation of Rapid HIV Antibody Tests in 5 African Countries

Author

Piwowar-Manning, Estelle M., primary, Tustin, Nancy B., additional, Sikateyo, Physiwell, additional, Kamwendo, Debbie, additional, Chipungu, Chifundo, additional, Maharaj, Rashika, additional, Mushanyu, Jabulani, additional, Richardson, Barbra A., additional, Hillier, Sharon, additional, and Brooks Jackson, J., additional

Published
2010
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13. Programmed Death 1 Receptor Changes Ex Vivoin HIV-Infected Adults following Initiation of Highly Active Antiretroviral Therapy

Author

Spitsin, Sergei, Tustin, Nancy B., Riedel, Eric, Tustin, Richard, Murray, Jennifer B., Peck, Lauren M., Khan, Mohammad, Quinn, Joseph, and Douglas, Steven D.

Abstract

ABSTRACTThis study investigates the short-term effects of highly active antiretroviral therapy (HAART) on programmed death 1 receptor (PD-1) expression and lymphocyte function. We compared lymphocytes from human immunodeficiency virus (HIV)-infected adults prior to the initiation of HAART with lymphocytes from the same subjects following 2 months of treatment. Short-term HAART resulted in a moderate increase in the expression of PD-1 on both CD4+and CD8+T cells; yet, there was still a significant reduction in viral load and recovery of CD4+T cells. After 2 months of HAART, lymphocytes from the subjects had a reduction in lymphoproliferative responses to phytohemagglutinin (PHA) and an increased response to the Candidarecall antigen and the HIV antigen p24 compared to pretreatment lymphocytes. PHA-stimulated peripheral blood mononuclear cells (PBMCs) from samples obtained 2 months after HAART produced higher levels of Th-1 cytokines (gamma interferon [IFN-?] and tumor necrosis factor alpha[TNF-a]) than the levels observed for samples taken before treatment was initiated. There were no significant changes in the proinflammatory cytokine interleukin-2 (IL-2) or Th-2 cytokines (IL-4, IL-5, and IL-10) in the corresponding samples. Ex vivoPD-1 blockade significantly augmented PHA-induced lymphoproliferation as well as the levels of Th-1 cytokines and to a lesser extent the levels of Th-2 cytokines in PBMC cultures. The ability to downregulate PD-1 expression may be important in enhancing immune recovery in HIV infection.

Published
2012
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16. Programmed death 1 receptor changes ex vivo in HIV-infected adults following initiation of highly active antiretroviral therapy.

Author

Spitsin S, Tustin NB, Riedel E, Tustin R 3rd, Murray JB, Peck LM, Khan M, Quinn J, and Douglas SD

Subjects
Adult, Antigens, Fungal immunology, CD4 Lymphocyte Count, Candida immunology, Cell Proliferation, Female, Humans, Male, Middle Aged, Viral Load, Anti-Retroviral Agents administration & dosage, Antiretroviral Therapy, Highly Active, CD4-Positive T-Lymphocytes immunology, CD8-Positive T-Lymphocytes immunology, HIV Infections drug therapy, HIV Infections immunology, Programmed Cell Death 1 Receptor biosynthesis
Abstract

This study investigates the short-term effects of highly active antiretroviral therapy (HAART) on programmed death 1 receptor (PD-1) expression and lymphocyte function. We compared lymphocytes from human immunodeficiency virus (HIV)-infected adults prior to the initiation of HAART with lymphocytes from the same subjects following 2 months of treatment. Short-term HAART resulted in a moderate increase in the expression of PD-1 on both CD4(+) and CD8(+) T cells; yet, there was still a significant reduction in viral load and recovery of CD4(+) T cells. After 2 months of HAART, lymphocytes from the subjects had a reduction in lymphoproliferative responses to phytohemagglutinin (PHA) and an increased response to the Candida recall antigen and the HIV antigen p24 compared to pretreatment lymphocytes. PHA-stimulated peripheral blood mononuclear cells (PBMCs) from samples obtained 2 months after HAART produced higher levels of Th-1 cytokines (gamma interferon [IFN-γ] and tumor necrosis factor alpha[TNF-α]) than the levels observed for samples taken before treatment was initiated. There were no significant changes in the proinflammatory cytokine interleukin-2 (IL-2) or Th-2 cytokines (IL-4, IL-5, and IL-10) in the corresponding samples. Ex vivo PD-1 blockade significantly augmented PHA-induced lymphoproliferation as well as the levels of Th-1 cytokines and to a lesser extent the levels of Th-2 cytokines in PBMC cultures. The ability to downregulate PD-1 expression may be important in enhancing immune recovery in HIV infection.

Published
2012
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