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2. Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy

Author

Aitken, Jim, Allen, Zoe, Ambler, Rachel, Ambrose, Karen, Ashton, Emma, Avola, Alida, Balakrishnan, Samutheswari, Barns-Jenkins, Caitlin, Barr, Genevieve, Barrell, Sam, Basu, Souradeep, Beale, Rupert, Beesley, Clare, Bhardwaj, Nisha, Bibi, Shahnaz, Bineva-Todd, Ganka, Biswas, Dhruva, Blackman, Michael J., Bonnet, Dominique, Bowker, Faye, Broncel, Malgorzata, Brooks, Claire, Buck, Michael D., Buckton, Andrew, Budd, Timothy, Burrell, Alana, Busby, Louise, Bussi, Claudio, Butterworth, Simon, Byott, Matthew, Byrne, Fiona, Byrne, Richard, Caidan, Simon, Campbell, Joanna, Canton, Johnathan, Cardoso, Ana, Carter, Nick, Carvalho, Luiz, Carzaniga, Raffaella, Chandler, Natalie, Chen, Qu, Cherepanov, Peter, Churchward, Laura, Clark, Graham, Clayton, Bobbi, Cobolli Gigli, Clementina, Collins, Zena, Cottrell, Sally, Crawford, Margaret, Cubitt, Laura, Cullup, Tom, Davies, Heledd, Davis, Patrick, Davison, Dara, Dearing, Vicky, Debaisieux, Solene, Diaz-Romero, Monica, Dibbs, Alison, Diring, Jessica, Driscoll, Paul C., D'Avola, Annalisa, Earl, Christopher, Edwards, Amelia, Ekin, Chris, Evangelopoulos, Dimitrios, Faraway, Rupert, Fearns, Antony, Ferron, Aaron, Fidanis, Efthymios, Fitz, Dan, Fleming, James, Frampton, Daniel, Frederico, Bruno, Gaiba, Alessandra, Gait, Anthony, Gamblin, Steve, Gärtner, Kathleen, Gaul, Liam, Golding, Helen M., Goldman, Jacki, Goldstone, Robert, Gomez Dominguez, Belen, Gong, Hui, Grant, Paul R., Greco, Maria, Grobler, Mariana, Guedan, Anabel, Gutierrez, Maximiliano G., Hackett, Fiona, Hall, Ross, Halldorsson, Steinar, Harris, Suzanne, Hashim, Sugera, Hatipoglu, Emine, Healy, Lyn, Heaney, Judith, Herbst, Susanne, Hewitt, Graeme, Higgins, Theresa, Hindmarsh, Steve, Hirani, Rajnika, Hope, Joshua, Horton, Elizabeth, Hoskins, Beth, Howell, Michael, Howitt, Louise, Hoyle, Jacqueline, Htun, Mint R., Hubank, Michael, Huerga Encabo, Hector, Hughes, Deborah, Hughes, Jane, Huseynova, Almaz, Hwang, Ming-Shih, Instrell, Rachael, Jackson, Deborah, Jamal-Hanjani, Mariam, Jenkins, Lucy, Jiang, Ming, Johnson, Mark, Jones, Leigh, Kanu, Nnennaya, Kassiotis, George, Kelly, Gavin, Kiely, Louise, Teixeira, Anastacio King Spert, Kirk, Stuart, Kjaer, Svend, Knuepfer, Ellen, Komarov, Nikita, Kotzampaltiris, Paul, Kousis, Konstantinos, Krylova, Tammy, Kucharska, Ania, Labrum, Robyn, Lambe, Catherine, Lappin, Michelle, Lee, Stacey-Ann, Levett, Andrew, Levett, Lisa, Levi, Marcel, Liu, Hon Wing, Loughlin, Sam, Lu, Wei-Ting, MacRae, James I., Madoo, Akshay, Marczak, Julie A., Martensson, Mimmi, Martinez, Thomas, Marzook, Bishara, Matthews, John, Matz, Joachim M., McCall, Samuel, McCoy, Laura E., McKay, Fiona, McNamara, Edel C., Minutti, Carlos M., Mistry, Gita, Molina-Arcas, Miriam, Montaner, Beatriz, Montgomery, Kylie, Moore, Catherine, Moore, David, Moraiti, Anastasia, Moreira-Teixeira, Lucia, Mukherjee, Joyita, Naceur-Lombardelli, Cristina, Nelson, Aileen, Nicod, Jerome, Nightingale, Luke, Nofal, Stephanie, Nurse, Paul, Nutan, Savita, Oedekoven, Caroline, O'Garra, Anne, O'Leary, Jean D., Olsen, Jessica, O'Neill, Olga, O'Reilly, Nicola, Suarez, Paula Ordonez, Osborne, Neil, Pabari, Amar, Pajak, Aleksandra, Papayannopoulos, Venizelos, Paraskevopoulou, Stavroula M, Patel, Namita, Patel, Yogen, Paun, Oana, Peat, Nigel, Peces-Barba Castano, Laura, Caballero, Ana Perez, Perez-Lloret, Jimena, Perrault, Magali S., Perrin, Abigail, Poh, Roy, Poirier, Enzo Z., Polke, James M., Pollitt, Marc, Prieto-Godino, Lucia, Proust, Alize, Puvirajasinghe, Clinda, Queval, Christophe, Ramachandran, Vijaya, Ramaprasad, Abhinay, Ratcliffe, Peter, Reed, Laura, Reis e Sousa, Caetano, Richardson, Kayleigh, Ridewood, Sophie, Roberts, Fiona, Roberts, Rowenna, Rodgers, Angela, Romero Clavijo, Pablo, Rosa, Annachiara, Rossi, Alice, Roustan, Chloe, Rowan, Andrew, Sahai, Erik, Sait, Aaron, Sala, Katarzyna, Sanchez, Emilie, Sanderson, Theo, Santucci, Pierre, Sardar, Fatima, Sateriale, Adam, Saunders, Jill A., Sawyer, Chelsea, Schlott, Anja, Schweighoffer, Edina, Segura-Bayona, Sandra, Shah Punatar, Rajvee, Shahmanesh, Maryam, Shaw, Joe, Silva Dos Santos, Mariana, Silvestre, Margaux, Singer, Matthew, Snell, Daniel M., Song, Ok-Ryul, Spyer, Moira J., Steel, Louisa, Strange, Amy, Sullivan, Adrienne E., Tan, Michele S.Y., Tautz-Davis, Zoe H., Taylor, Effie, Taylor, Gunes, Taylor, Harriet B., Taylor-Beadling, Alison, Teixeira Subtil, Fernanda, Terré Torras, Berta, Toolan-Kerr, Patrick, Torelli, Francesca, Toteva, Tea, Treeck, Moritz, Trojer, Hadija, Tsai, Ming-Han C., Turner, James M.A., Turner, Melanie, Ule, Jernej, Ulferts, Rachel, Vanloo, Sharon P., Veeriah, Selvaraju, Venkatesan, Subramanian, Vousden, Karen, Wack, Andreas, Walder, Claire, Walker, Philip A., Wang, Yiran, Ward, Sophia, Wenman, Catharina, Williams, Luke, Williams, Matthew J., Keong Wong, Wai, Wright, Joshua, Wu, Mary, Wynne, Lauren, Xiang, Zheng, Yap, Melvyn, Zagalak, Julian A., Zecchin, Davide, Zillwood, Rachel, Carthiyaniamma, Santhakumari, DeTisi, Jane, Dick, Julie, Hill, Andrea, Kipper, Karin, Kullar, Birinder, Norris, Sarah, Rugg-Gunn, Fergus, Salvatierra, Rebecca, Shaya, Gabriel, Sloan, Astrid, Singh, Priyanka, Varley, James, Whatley, Ben, Balestrini, Simona, Koepp, Matthias J., Gandhi, Sonia, Rickman, Hannah M., Shin, Gee Yen, Houlihan, Catherine F., Anders-Cannon, Jonny, Silvennoinen, Katri, Xiao, Fenglai, Zagaglia, Sara, Hudgell, Kirsty, Ziomek, Mariusz, Haimes, Paul, Sampson, Adam, Parker, Annie, Helen Cross, J., Pardington, Rosemarie, Nastouli, Eleni, Swanton, Charles, Sander, Josemir W., and Sisodiya, Sanjay M.

Published
2021
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3. A conserved transcriptional program for MAIT cells across mammalian evolution

Author

Bugaut, Hélène, primary, El Morr, Yara, additional, Mestdagh, Martin, additional, Darbois, Aurélie, additional, Paiva, Rafael A., additional, Salou, Marion, additional, Perrin, Laetitia, additional, Fürstenheim, Mariela, additional, du Halgouet, Anastasia, additional, Bilonda-Mutala, Linda, additional, Le Gac, Anne-Laure, additional, Arnaud, Manon, additional, El Marjou, Ahmed, additional, Guerin, Coralie, additional, Chaiyasitdhi, Atitheb, additional, Piquet, Julie, additional, Smadja, David M., additional, Cieslak, Agata, additional, Ryffel, Bernhard, additional, Maciulyte, Valdone, additional, Turner, James M.A., additional, Bernardeau, Karine, additional, Montagutelli, Xavier, additional, Lantz, Olivier, additional, and Legoux, François, additional

Published
2023
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5. Contributors

Author

Albakri, Aref, primary, AlMahameed, Soufian T., additional, Andršová, Irena, additional, Asirvatham, Samuel J., additional, Avari Silva, Jennifer N., additional, Bacharova, Ljuba, additional, Bagliani, Giuseppe, additional, Barakat, Rody, additional, Barakat, Michel M., additional, Barletta, Valentina, additional, Barthel, Petra, additional, Bébarová, Markéta, additional, Beck, Hiroko, additional, Belhassen, Bernard, additional, Bende, Girish, additional, Berkefeld, Anna, additional, Birgersdotter-Green, Ulrika, additional, Blinova, Ksenia, additional, Blomström-Lundqvist, Carina, additional, Bongiorni, Maria Grazia, additional, Brand, Thomas, additional, Bugiardini, Raffaele, additional, Bunch, T. Jared, additional, Castiglione, Alessandro, additional, Cenko, Edina, additional, Chatzidou, Sofia, additional, Chee, Jennifer, additional, Chelu, Mihail G., additional, Chen, Shih Ann, additional, Ciconte, Giuseppe, additional, Curtis, Anne B., additional, Curtis, Stephanie, additional, Cygankiewicz, Iwona, additional, Dalal, Aarti S., additional, Day, John D., additional, Della Tommasina, Veronica, additional, Deshmukh, Abhishek J., additional, Dilaveris, Polychronis, additional, Di Summa, Roberto, additional, Dogan, Mehmet, additional, Dong, Jun, additional, du Fay de Lavallaz, Jeanne, additional, Eckhardt, Lee L., additional, Efimova, Elena, additional, Ernst, Sabine, additional, Fawzy, Ameenathul M., additional, Gaita, Fiorenzo, additional, Garber, Libet, additional, Garnett, Christine, additional, Georgiopoulos, Georgios, additional, Gillis, Anne M., additional, Giustetto, Carla, additional, Gonzalez Corcia, M. Cecilia, additional, Haim, Moti, additional, Halliday, Brian P., additional, Hamdan, Mohamed H., additional, Hammersley, Daniel J., additional, Hartikainen, Juha E.K., additional, Haugaa, Kristina H., additional, Haukilahti, M. Anette E., additional, Hautala, Arto J., additional, Helánová, Kateřina, additional, Hnatkova, Katerina, additional, Hu, Yu-Feng, additional, Hu, Xiao, additional, Hurley, David, additional, Iwai, Sei, additional, Jacobs, Victoria, additional, Jacobson, Jason T., additional, James, Cynthia A., additional, Jiang, Hongying, additional, Jones, Camelle, additional, Jones, Richard E., additional, Junttila, M. Juhani, additional, Kadish, Alan H., additional, Karavirta, Laura, additional, Karim, Saima, additional, Karnad, Dilip, additional, Karunatilleke, Anne, additional, Kaufman, Elizabeth S., additional, Kenttä, Tuomas V., additional, Kezerle, Louise, additional, Khalil, Fouad M., additional, Klingenheben, Thomas, additional, Kloosterman, M., additional, Kontogiannis, Christos, additional, Kowlgi, Gurukripa N., additional, Kroman, Anne M., additional, Kutyifa, Valentina, additional, Lampert, Rachel, additional, Laukkanen, Jari, additional, Lee, Hyon Jae, additional, Leinveber, Pavel, additional, Leren, Ida S., additional, Lima, Fabio V., additional, Linde, Cecilia, additional, Locati, Emanuela T., additional, Macfarlane, Peter W., additional, Maclachlan, Hamish, additional, Mäkikallio, Timo H., additional, Malik, Marek, additional, Manfrini, Olivia, additional, Marashly, Qussay, additional, Margioula, Eleni, additional, McCaffrey, James A., additional, Mehra, Nandini S., additional, Milman, Anat, additional, Moharem-Elgamal, Sarah, additional, Mujović, Nebojša, additional, Nagarajan, Darbhamulla V., additional, Nemec, Petr, additional, Novotný, Tomáš, additional, O'Neill, Louisa, additional, Odening, Katja E., additional, Panicker, Gopi Krishna, additional, Pappone, Carlo, additional, Patton, Kristen K., additional, Pelter, Michele M., additional, Peyracchia, Mattia, additional, Potpara, Tratjana, additional, Powell, Benjamin E., additional, Preben, Bjerregaard, additional, Sarkozy, Andrea, additional, Schneider, Birke, additional, Segreti, Luca, additional, Selzman, Kimberly A., additional, Sharma, Sanjay, additional, Šišáková, Martina, additional, Spears, D.A., additional, Spera, Francesco Raffaele, additional, Špinarová, Lenka, additional, Stein, Phyllis K., additional, Stergiopoulos, Kathleen, additional, Sticherling, Christian, additional, Stuart, Graham, additional, Sugrue, Alan M., additional, Svennberg, Emma, additional, Tada, Hiroshi, additional, Tampakis, Konstantinos, additional, Tereshchenko, Larisa G., additional, Terho, Henri, additional, te Riele, Anneline S.J.M., additional, Tikkanen, Jani T., additional, Toman, Ondřej, additional, Toso, Elisabetta, additional, Tracy, Cynthia M., additional, Trifunovic, Danijela, additional, Turner, James M.A., additional, Vaidya, Vaibhav R., additional, Van Gelder, Isabelle C., additional, Vasavan, Tharni, additional, Verrier, Richard L., additional, Veseli, Granit, additional, Vicente, Jose, additional, Williamson, Catherine, additional, Wu, Wendy W., additional, YH. Lip, Gregory, additional, Younis, Arwa, additional, Zabel, Markus, additional, Zathar, Zafraan, additional, Zegre-Hemsey, Jessica K., additional, Zheng, Nan, additional, and Zucchelli, Giulio, additional

Published
2020
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8. CRISPR-Cas9 effectors facilitate generation of single-sex litters and sex-specific phenotypes

Author

Douglas, Charlotte, Maciulyte, Valdone, Zohren, Jasmin, Snell, Daniel M., Mahadevaiah, Shantha K., Ojarikre, Obah A., Ellis, Peter J.I., Turner, James M.A., Douglas, Charlotte, Maciulyte, Valdone, Zohren, Jasmin, Snell, Daniel M., Mahadevaiah, Shantha K., Ojarikre, Obah A., Ellis, Peter J.I., and Turner, James M.A.

Abstract

Animals are essential genetic tools in scientific research and global resources in agriculture. In both arenas, a single sex is often required in surplus. The ethical and financial burden of producing and culling animals of the undesired sex is considerable. Using the mouse as a model, we develop a synthetic lethal, bicomponent CRISPR-Cas9 strategy that produces male-or female-only litters with one hundred percent efficiency. Strikingly, we observe a degree of litter size compensation relative to control matings, indicating that our system has the potential to increase the yield of the desired sex in comparison to standard breeding designs. The bicomponent system can also be repurposed to generate postnatal sex-specific phenotypes. Our approach, harnessing the technological applications of CRISPR-Cas9, may be applicable to other vertebrate species, and provides strides towards ethical improvements for laboratory research and agriculture.

Published
2021

9. Rsx is a metatherian RNA with Xist-like properties in X-chromosome inactivation

Author

Grant, Jennifer, Mahadevaiah, Shantha K., Khil, Pavel, Sangrithi, Mahesh N., Royo, Helene, Duckworth, Janine, McCarrey, John R., VandeBerg, John L., Renfree, Marilyn B., Taylor, Willie, Elgar, Greg, Camerini-Otero, R. Daniel, Gilchrist, Mike J., and Turner, James M.A.

Subjects
Gene expression -- Research, RNA sequencing -- Methods, X chromosome inactivation -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

In female (XX) mammals, one of the two X chromosomes is inactivated to ensure an equal dose of X-linked genes with males (XY) (1). X-chromosome inactivation in eutherian mammals is [...]

Published
2012

11. Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy

Author

Balestrini, Simona, primary, Koepp, Matthias J., additional, Gandhi, Sonia, additional, Rickman, Hannah M., additional, Shin, Gee Yen, additional, Houlihan, Catherine F., additional, Anders-Cannon, Jonny, additional, Silvennoinen, Katri, additional, Xiao, Fenglai, additional, Zagaglia, Sara, additional, Hudgell, Kirsty, additional, Ziomek, Mariusz, additional, Haimes, Paul, additional, Sampson, Adam, additional, Parker, Annie, additional, Helen Cross, J., additional, Pardington, Rosemarie, additional, Nastouli, Eleni, additional, Swanton, Charles, additional, Sander, Josemir W., additional, Sisodiya, Sanjay M., additional, Aitken, Jim, additional, Allen, Zoe, additional, Ambler, Rachel, additional, Ambrose, Karen, additional, Ashton, Emma, additional, Avola, Alida, additional, Balakrishnan, Samutheswari, additional, Barns-Jenkins, Caitlin, additional, Barr, Genevieve, additional, Barrell, Sam, additional, Basu, Souradeep, additional, Beale, Rupert, additional, Beesley, Clare, additional, Bhardwaj, Nisha, additional, Bibi, Shahnaz, additional, Bineva-Todd, Ganka, additional, Biswas, Dhruva, additional, Blackman, Michael J., additional, Bonnet, Dominique, additional, Bowker, Faye, additional, Broncel, Malgorzata, additional, Brooks, Claire, additional, Buck, Michael D., additional, Buckton, Andrew, additional, Budd, Timothy, additional, Burrell, Alana, additional, Busby, Louise, additional, Bussi, Claudio, additional, Butterworth, Simon, additional, Byott, Matthew, additional, Byrne, Fiona, additional, Byrne, Richard, additional, Caidan, Simon, additional, Campbell, Joanna, additional, Canton, Johnathan, additional, Cardoso, Ana, additional, Carter, Nick, additional, Carvalho, Luiz, additional, Carzaniga, Raffaella, additional, Chandler, Natalie, additional, Chen, Qu, additional, Cherepanov, Peter, additional, Churchward, Laura, additional, Clark, Graham, additional, Clayton, Bobbi, additional, Cobolli Gigli, Clementina, additional, Collins, Zena, additional, Cottrell, Sally, additional, Crawford, Margaret, additional, Cubitt, Laura, additional, Cullup, Tom, additional, Davies, Heledd, additional, Davis, Patrick, additional, Davison, Dara, additional, Dearing, Vicky, additional, Debaisieux, Solene, additional, Diaz-Romero, Monica, additional, Dibbs, Alison, additional, Diring, Jessica, additional, Driscoll, Paul C., additional, D'Avola, Annalisa, additional, Earl, Christopher, additional, Edwards, Amelia, additional, Ekin, Chris, additional, Evangelopoulos, Dimitrios, additional, Faraway, Rupert, additional, Fearns, Antony, additional, Ferron, Aaron, additional, Fidanis, Efthymios, additional, Fitz, Dan, additional, Fleming, James, additional, Frampton, Daniel, additional, Frederico, Bruno, additional, Gaiba, Alessandra, additional, Gait, Anthony, additional, Gamblin, Steve, additional, Gärtner, Kathleen, additional, Gaul, Liam, additional, Golding, Helen M., additional, Goldman, Jacki, additional, Goldstone, Robert, additional, Gomez Dominguez, Belen, additional, Gong, Hui, additional, Grant, Paul R., additional, Greco, Maria, additional, Grobler, Mariana, additional, Guedan, Anabel, additional, Gutierrez, Maximiliano G., additional, Hackett, Fiona, additional, Hall, Ross, additional, Halldorsson, Steinar, additional, Harris, Suzanne, additional, Hashim, Sugera, additional, Hatipoglu, Emine, additional, Healy, Lyn, additional, Heaney, Judith, additional, Herbst, Susanne, additional, Hewitt, Graeme, additional, Higgins, Theresa, additional, Hindmarsh, Steve, additional, Hirani, Rajnika, additional, Hope, Joshua, additional, Horton, Elizabeth, additional, Hoskins, Beth, additional, Howell, Michael, additional, Howitt, Louise, additional, Hoyle, Jacqueline, additional, Htun, Mint R., additional, Hubank, Michael, additional, Huerga Encabo, Hector, additional, Hughes, Deborah, additional, Hughes, Jane, additional, Huseynova, Almaz, additional, Hwang, Ming-Shih, additional, Instrell, Rachael, additional, Jackson, Deborah, additional, Jamal-Hanjani, Mariam, additional, Jenkins, Lucy, additional, Jiang, Ming, additional, Johnson, Mark, additional, Jones, Leigh, additional, Kanu, Nnennaya, additional, Kassiotis, George, additional, Kelly, Gavin, additional, Kiely, Louise, additional, Teixeira, Anastacio King Spert, additional, Kirk, Stuart, additional, Kjaer, Svend, additional, Knuepfer, Ellen, additional, Komarov, Nikita, additional, Kotzampaltiris, Paul, additional, Kousis, Konstantinos, additional, Krylova, Tammy, additional, Kucharska, Ania, additional, Labrum, Robyn, additional, Lambe, Catherine, additional, Lappin, Michelle, additional, Lee, Stacey-Ann, additional, Levett, Andrew, additional, Levett, Lisa, additional, Levi, Marcel, additional, Liu, Hon Wing, additional, Loughlin, Sam, additional, Lu, Wei-Ting, additional, MacRae, James I., additional, Madoo, Akshay, additional, Marczak, Julie A., additional, Martensson, Mimmi, additional, Martinez, Thomas, additional, Marzook, Bishara, additional, Matthews, John, additional, Matz, Joachim M., additional, McCall, Samuel, additional, McCoy, Laura E., additional, McKay, Fiona, additional, McNamara, Edel C., additional, Minutti, Carlos M., additional, Mistry, Gita, additional, Molina-Arcas, Miriam, additional, Montaner, Beatriz, additional, Montgomery, Kylie, additional, Moore, Catherine, additional, Moore, David, additional, Moraiti, Anastasia, additional, Moreira-Teixeira, Lucia, additional, Mukherjee, Joyita, additional, Naceur-Lombardelli, Cristina, additional, Nelson, Aileen, additional, Nicod, Jerome, additional, Nightingale, Luke, additional, Nofal, Stephanie, additional, Nurse, Paul, additional, Nutan, Savita, additional, Oedekoven, Caroline, additional, O'Garra, Anne, additional, O'Leary, Jean D., additional, Olsen, Jessica, additional, O'Neill, Olga, additional, O'Reilly, Nicola, additional, Suarez, Paula Ordonez, additional, Osborne, Neil, additional, Pabari, Amar, additional, Pajak, Aleksandra, additional, Papayannopoulos, Venizelos, additional, Paraskevopoulou, Stavroula M, additional, Patel, Namita, additional, Patel, Yogen, additional, Paun, Oana, additional, Peat, Nigel, additional, Peces-Barba Castano, Laura, additional, Caballero, Ana Perez, additional, Perez-Lloret, Jimena, additional, Perrault, Magali S., additional, Perrin, Abigail, additional, Poh, Roy, additional, Poirier, Enzo Z., additional, Polke, James M., additional, Pollitt, Marc, additional, Prieto-Godino, Lucia, additional, Proust, Alize, additional, Puvirajasinghe, Clinda, additional, Queval, Christophe, additional, Ramachandran, Vijaya, additional, Ramaprasad, Abhinay, additional, Ratcliffe, Peter, additional, Reed, Laura, additional, Reis e Sousa, Caetano, additional, Richardson, Kayleigh, additional, Ridewood, Sophie, additional, Roberts, Fiona, additional, Roberts, Rowenna, additional, Rodgers, Angela, additional, Romero Clavijo, Pablo, additional, Rosa, Annachiara, additional, Rossi, Alice, additional, Roustan, Chloe, additional, Rowan, Andrew, additional, Sahai, Erik, additional, Sait, Aaron, additional, Sala, Katarzyna, additional, Sanchez, Emilie, additional, Sanderson, Theo, additional, Santucci, Pierre, additional, Sardar, Fatima, additional, Sateriale, Adam, additional, Saunders, Jill A., additional, Sawyer, Chelsea, additional, Schlott, Anja, additional, Schweighoffer, Edina, additional, Segura-Bayona, Sandra, additional, Shah Punatar, Rajvee, additional, Shahmanesh, Maryam, additional, Shaw, Joe, additional, Silva Dos Santos, Mariana, additional, Silvestre, Margaux, additional, Singer, Matthew, additional, Snell, Daniel M., additional, Song, Ok-Ryul, additional, Spyer, Moira J., additional, Steel, Louisa, additional, Strange, Amy, additional, Sullivan, Adrienne E., additional, Tan, Michele S.Y., additional, Tautz-Davis, Zoe H., additional, Taylor, Effie, additional, Taylor, Gunes, additional, Taylor, Harriet B., additional, Taylor-Beadling, Alison, additional, Teixeira Subtil, Fernanda, additional, Terré Torras, Berta, additional, Toolan-Kerr, Patrick, additional, Torelli, Francesca, additional, Toteva, Tea, additional, Treeck, Moritz, additional, Trojer, Hadija, additional, Tsai, Ming-Han C., additional, Turner, James M.A., additional, Turner, Melanie, additional, Ule, Jernej, additional, Ulferts, Rachel, additional, Vanloo, Sharon P., additional, Veeriah, Selvaraju, additional, Venkatesan, Subramanian, additional, Vousden, Karen, additional, Wack, Andreas, additional, Walder, Claire, additional, Walker, Philip A., additional, Wang, Yiran, additional, Ward, Sophia, additional, Wenman, Catharina, additional, Williams, Luke, additional, Williams, Matthew J., additional, Keong Wong, Wai, additional, Wright, Joshua, additional, Wu, Mary, additional, Wynne, Lauren, additional, Xiang, Zheng, additional, Yap, Melvyn, additional, Zagalak, Julian A., additional, Zecchin, Davide, additional, Zillwood, Rachel, additional, Carthiyaniamma, Santhakumari, additional, DeTisi, Jane, additional, Dick, Julie, additional, Hill, Andrea, additional, Kipper, Karin, additional, Kullar, Birinder, additional, Norris, Sarah, additional, Rugg-Gunn, Fergus, additional, Salvatierra, Rebecca, additional, Shaya, Gabriel, additional, Sloan, Astrid, additional, Singh, Priyanka, additional, Varley, James, additional, and Whatley, Ben, additional

Published
2021
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12. Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

Author

Mahadevaiah, Shantha K., Bourc'his, Deborah, de Rooij, Dirk G., Bestor, Timothy H., Turner, James M.A., and Burgoyne, Paul S.

Subjects
Chromatin -- Properties, Meiosis -- Evaluation, Gene silencing -- Methods, Sex chromosomes -- Identification and classification, Sex chromosomes -- Properties, Biological sciences
Abstract

Chromosome synapsis during zygotene is a prerequisite for the timely homologous recombinational repair of meiotic DNA double-strand breaks (DSBs). Unrepaired DSBs are thought to trigger apoptosis during midpachytene of male meiosis if synapsis fails. An early pachytene response to asynapsis is meiotic silencing of unsynapsed chromatin (MSUC), which, in normal males, silences the X and Y chromosomes (meiotic sex chromosome inactivation [MSCI]). In this study, we show that MSUC occurs in Spo11-null mouse spermatocytes with extensive asynapsis but lacking meiotic DSBs. In con trast, three mutants (Dnmt3I, Msh5, and Dmc1) with high levels of asynapsis and numerous persistent unrepaired DSBs have a severely impaired MSUC response. We suggest that MSUC-related proteins, including the MSUC initiator BRCA1, are sequestered at unrepaired DSBs. All four mutants fail to silence the X and Y chromosomes (MSCI failure), which is sufficient to explain the midpachytene apoptosis. Apoptosis does not occur in mice with a single additional asynapsed chromosome with unrepaired meiotic DSBs and no disturbance of MSCI.

Published
2008

20. DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line

Author

ElInati, Elias, Russell, Helen R., Ojarikre, Obah A., Sangrithi, Mahesh, Hirota, Takayuki, De Rooij, Dirk G., McKinnon, Peter J., Turner, James M.A., Developmental Biology, Sub Developmental Biology, Developmental Biology, Sub Developmental Biology, Obstetrics and Gynaecology, Center for Reproductive Medicine, and ARD - Amsterdam Reproduction and Development

Subjects
Male, 0301 basic medicine, Ataxia Telangiectasia Mutated Proteins, Histones, Mice, 03 medical and health sciences, Spermatocytes, X Chromosome Inactivation, Homologous chromosome, medicine, Animals, Gene silencing, DNA Breaks, Double-Stranded, Spermatogenesis, General, X chromosome, Mice, Knockout, Genetics, Sex Chromosomes, Multidisciplinary, biology, BRCA1 Protein, Tumor Suppressor Proteins, Synapsis, Biological Sciences, Spermatids, Spermatozoa, Meiotic silencing, Spermatogonia, Chromosome Pairing, Meiosis, 030104 developmental biology, Histone, medicine.anatomical_structure, H2AFX, Premature chromosome condensation, biology.protein, DNA damage, TOPBP1, Carrier Proteins, Germ cell
Abstract

Meiotic synapsis and recombination between homologs permits the formation of cross-overs that are essential for generating chromosomally balanced sperm and eggs. In mammals, surveillance mechanisms eliminate meiotic cells with defective synapsis, thereby minimizing transmission of aneuploidy. One such surveillance mechanism is meiotic silencing, the inactivation of genes located on asynapsed chromosomes, via ATR-dependent serine-139 phosphorylation of histone H2AFX (gamma H2AFX). Stimulation of ATR activity requires direct interaction with an ATR activation domain (AAD)-containing partner. However, which partner facilitates the meiotic silencing properties of ATR is unknown. Focusing on the best-characterized example of meiotic silencing, meiotic sex chromosome inactivation, we reveal this AAD-containing partner to be the DNA damage and checkpoint protein TOPBP1. Conditional TOPBP1 deletion during pachynema causes germ cell elimination associated with defective X chromosome gene silencing and sex chromosome condensation. TOPBP1 is essential for localization to the X chromosome of silencing "sensors," including BRCA1, and effectors, including ATR, gamma H2AFX, and canonical repressive histone marks. We present evidence that persistent DNA double-strand breaks act as silencing initiation sites. Our study identifies TOPBP1 as a critical factor in meiotic sex chromosome silencing

Published
2017

23. A conserved transcriptional program for MAIT cells across mammalian evolution

Author

Bugaut, Hélène, El Morr, Yara, Mestdagh, Martin, Darbois, Aurélie, Paiva, Rafael A., Salou, Marion, Perrin, Laetitia, Fürstenheim, Mariela, du Halgouet, Anastasia, Bilonda-Mutala, Linda, Le Gac, Anne-Laure, Arnaud, Manon, El Marjou, Ahmed, Guerin, Coralie, Chaiyasitdhi, Atitheb, Piquet, Julie, Smadja, David M., Cieslak, Agata, Ryffel, Bernhard, Maciulyte, Valdone, Turner, James M.A., Bernardeau, Karine, Montagutelli, Xavier, Lantz, Olivier, and Legoux, François

Abstract

Mucosal-associated invariant T (MAIT) cells harbor evolutionarily conserved TCRs, suggesting important functions. As human and mouse MAIT functional programs appear distinct, the evolutionarily conserved MAIT functional features remain unidentified. Using species-specific tetramers coupled to single-cell RNA sequencing, we characterized MAIT cell development in six species spanning 110 million years of evolution. Cross-species analyses revealed conserved transcriptional events underlying MAIT cell maturation, marked by ZBTB16 induction in all species. MAIT cells in human, sheep, cattle, and opossum acquired a shared type-1/17 transcriptional program, reflecting ancestral features. This program was also acquired by human iNKT cells, indicating common differentiation for innate-like T cells. Distinct type-1 and type-17 MAIT subsets developed in rodents, including pet mice and genetically diverse mouse strains. However, MAIT cells further matured in mouse intestines to acquire a remarkably conserved program characterized by concomitant expression of type-1, type-17, cytotoxicity, and tissue-repair genes. Altogether, the study provides a unifying view of the transcriptional features of innate-like T cells across evolution.

Published
2024
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24. ATR is a multifunctional regulator of male mouse meiosis

Author

Widger, Alexander, primary, Mahadevaiah, Shantha K., additional, Lange, Julian, additional, ElInati, Elias, additional, Zohren, Jasmin, additional, Hirota, Takayuki, additional, Pacheco, Sarai, additional, Maldonado-Linares, Andros, additional, Stanzione, Marcello, additional, Ojarikre, Obah, additional, Maciulyte, Valdone, additional, de Rooij, Dirk G., additional, Tóth, Attila, additional, Roig, Ignasi, additional, Keeney, Scott, additional, and Turner, James M.A., additional

Published
2018
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25. DNA damage response protein TOPBP1 regulates X chromosome silencing in the mammalian germ line

Author

Developmental Biology, Sub Developmental Biology, ElInati, Elias, Russell, Helen R., Ojarikre, Obah A., Sangrithi, Mahesh, Hirota, Takayuki, De Rooij, Dirk G., McKinnon, Peter J., Turner, James M.A., Developmental Biology, Sub Developmental Biology, ElInati, Elias, Russell, Helen R., Ojarikre, Obah A., Sangrithi, Mahesh, Hirota, Takayuki, De Rooij, Dirk G., McKinnon, Peter J., and Turner, James M.A.

Published
2017

28. Enhancer Evolution across 20 Mammalian Species

Author

Villar, Diego, primary, Berthelot, Camille, additional, Aldridge, Sarah, additional, Rayner, Tim F., additional, Lukk, Margus, additional, Pignatelli, Miguel, additional, Park, Thomas J., additional, Deaville, Robert, additional, Erichsen, Jonathan T., additional, Jasinska, Anna J., additional, Turner, James M.A., additional, Bertelsen, Mads F., additional, Murchison, Elizabeth P., additional, Flicek, Paul, additional, and Odom, Duncan T., additional

Published
2015
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30. ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing

Author

Royo, Hélène, primary, Prosser, Haydn, additional, Ruzankina, Yaroslava, additional, Mahadevaiah, Shantha K., additional, Cloutier, Jeffrey M., additional, Baumann, Marek, additional, Fukuda, Tomoyuki, additional, Höög, Christer, additional, Tóth, Attila, additional, de Rooij, Dirk G., additional, Bradley, Allan, additional, Brown, Eric J., additional, and Turner, James M.A., additional

Published
2013
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31. Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids.

Author

Turner, James M.A., Mahadevaiah, Shantha K., Ellis, Peter J.I., Mitchell, Michael J., Burgoyne, Paul S., Turner, James M.A., Mahadevaiah, Shantha K., Ellis, Peter J.I., Mitchell, Michael J., and Burgoyne, Paul S.

Abstract

Transcriptional silencing of the sex chromosomes during male meiosis (MSCI) is conserved among organisms with limited sex chromosome synapsis, including mammals. Since the 1990s the prevailing view has been that MSCI in mammals is transient, with sex chromosome reactivation occurring as cells exit meiosis. Recently, we found that any chromosome region unsynapsed during pachytene of male and female mouse meiosis is subject to transcriptional silencing (MSUC), and we hypothesized that MSCI is an inevitable consequence of this more general meiotic silencing mechanism. Here, we provide direct evidence that asynapsis does indeed drive MSCI. We also show that a substantial degree of transcriptional repression of the sex chromosomes is retained postmeiotically, and we provide evidence that this postmeiotic repression is a downstream consequence of MSCI/MSUC. While this postmeiotic repression occurs after the loss of MSUC-related proteins at the end of prophase, other histone modifications associated with transcriptional repression have by then become established.

Published
2006

32. Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms

Author

Wojtasz, Lukasz, primary, Cloutier, Jeffrey M., additional, Baumann, Marek, additional, Daniel, Katrin, additional, Varga, János, additional, Fu, Jun, additional, Anastassiadis, Konstantinos, additional, Stewart, A. Francis, additional, Reményi, Attila, additional, Turner, James M.A., additional, and Tóth, Attila, additional

Published
2012
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43. Recombinational DNA double-strand breaks in mice precede synapsis

Author

Mahadevaiah, Shantha K., primary, Turner, James M.A., additional, Baudat, Frédéric, additional, Rogakou, Emmy P., additional, de Boer, Peter, additional, Blanco-Rodríguez, Josefa, additional, Jasin, Maria, additional, Keeney, Scott, additional, Bonner, William M., additional, and Burgoyne, Paul S., additional

Published
2001
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44. Localisation of histone macroH2A1.2 to the XY-body is not a response to the presence of asynapsed chromosome axes.

Author

Hoyer-Fender, Sigrid, Czirr, Eva, Radde, Rebecca, Turner, James M.A., Mahadevaiah, Shantha K., Pehrson, John R., and Burgoyne, Paul S.

Subjects
HISTONES, BASIC proteins, NUCLEOPROTEINS, CHROMOSOMES, CELL nuclei, GENETICS
Abstract

Histone macroH2A1.2 and the murine heterochromatin protein 1, HP1β, have both been implicated in meiotic sex chromosome inactivation (MSCI) and the formation of the XY-body in male meiosis. In order to get a closer insight into the function of histone macroH2A1.2 we have investigated the localisation of macroH2A1.2 in surface spread spermatocytes from normal male mice and in oocytes of XX and XYTdym1 mice. Oocytes of XYTdym1 mice have no XY-body or MSCI despite having an XY chromosome constitution, so the presence or absence of 'XY-body' proteins in association with the X and/or Y chromosome of these oocytes enables some discrimination between potential functions of XY-body located proteins. We demonstrate here that macroH2A1.2 localises to the X and Y chromatin of spermatocytes as they condense to form the XY-body but is not associated with the X and Y chromatin of XYTdym1 early pachytene oocytes. MacroH2A1.2 and HP1β co-localise to autosomal pericentromeric heterochromatin in spermatocytes. However, the two proteins show temporally and spatially distinct patterns of association to X and Y chromatin. [ABSTRACT FROM AUTHOR]

Published
2004
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45. Expression Analysis of the Mouse Multi-Copy X-Linked Gene Xlr-Related, Meiosis-Regulated (Xmr), Reveals That XmrEncodes a Spermatid-Expressed Cytoplasmic Protein, SLX/XMR1

Author

Reynard, Louise N., Turner, James M.A., Cocquet, Julie, Mahadevaiah, Shantha K., Touré, Aminata, Höög, Christer, and Burgoyne, Paul S.

Abstract

The mouse multi-copy X-linked gene Xlr-related, meiosis-regulated (Xmr/Slx) has previously been described as encoding a testis-specific nuclear protein expressed during male meiotic prophase, and during which it becomes concentrated in the inactive X and Y chromatin domain. These conclusions were based on Western blot and immunolocalization analysis using an antibody raised against a related lymphocyte protein, XLR; however, our recently published RNA in situ for Xmrrevealed that transcripts are predominantly or exclusively postmeiotic, and this is supported by a growing body of microarray data. This led us to reanalyze the expression of Xmr, both at the RNA level by RT-PCR and by RNA fluorescence in situ hybridization, and at the protein level by using antibodies raised against XMR that do not recognize XLR. In agreement with our previous RNA in situ data, our further transcription analysis showed almost exclusive expression in spermatids, and Western blot and immunostaining with the XMR antibodies showed that the protein is cytoplasmic and restricted to spermatids. Furthermore, the previously used XLR antibody was shown not to cross-react with XMR, and it is suggested that the meiotically expressed nuclear protein recognized by this antibody is another member of the complex Xlrsuperfamily. As a result of these findings, the gene previously known as Xmris now officially know as Slx, Sycp3-like, X-linked.

Published
2007
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46. X-Inactivation: Close Encounters of the X Kind

Author

Turner, James M.A.

Subjects
*X chromosome, *SEX chromosomes, *GENE silencing, *MAMMALS
Abstract

X chromosome inactivation ensures equal dosage of X-linked genes between male and female mammals. Two new studies have shown that the initiation of inactivation is preceded by X chromosome pairing; their results implicate this pairing in the choice and counting functions of X chromosome inactivation. [Copyright &y& Elsevier]

Published
2006
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