Search

Your search keyword '"Turner, Briana S."' showing total 12 results
Start Over Author "Turner, Briana S."
12 results on '"Turner, Briana S."'

3. Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling

Author

Baumer, Yvonne, primary, Singh, Komudi, additional, Baez, Andrew S, additional, Gutierrez-Huerta, Cristhian A, additional, Cheng, Long, additional, Igboko, Muna, additional, Turner, Briana S, additional, Yeboah, Josette A, additional, Reger, Robert N, additional, Ortiz-Whittingham, Lola R, additional, Bleck, Christopher KE, additional, Mitchell, Valerie M, additional, Collins, Billy S, additional, Pirooznia, Mehdi, additional, Dagur, Pradeep K, additional, Allan, David SJ, additional, Schwartz, Daniella M, additional, Childs, Richard W, additional, and Powell-Wiley, Tiffany M, additional

Published
2023
Full Text
View/download PDF

4. Customizing Place-Tailored Messaging Using a Multilevel Approach: Pilot Study of the Step It Up Physical Activity Mobile App Tailored to Neighborhood Environment

Author

Vijayakumar, Nithya P., primary, Neally, Sam J., additional, Potharaju, Kameswari A., additional, Curlin, Kaveri, additional, Troendle, James F., additional, Collins, Billy S., additional, Mitchell, Valerie M., additional, Tamura, Kosuke, additional, Ayers, Colby, additional, Pita, Mario A., additional, Tarfa, Hannatu A., additional, Thompson, Keitra, additional, Osei Baah, Foster, additional, Baez, Andrew S., additional, Ortiz-Whittingham, Lola R., additional, Wills Gallagher, Jennifer, additional, McCoy, Regina, additional, Heist, Michael, additional, Gutierrez-Huerta, Cristhian A., additional, Turner, Briana S., additional, Baumer, Yvonne, additional, Farmer, Nicole, additional, Wallen, Gwenyth R., additional, Dodge, Tonya, additional, and Powell-Wiley, Tiffany M., additional

Published
2022
Full Text
View/download PDF

5. Dopamine D2‐Like Receptor Signaling and Downregulation of Filamin‐A May Drive the Association Between Neighborhood Socioeconomic Status and CCR2 Expression on Monocytes

Author

Pita, Mario A., primary, Baumer, Yvonne, additional, Turner, Briana S., additional, Gutierrez‐Huerta, Cristhian A., additional, Neally, Sam J., additional, Baez, Andrew S., additional, Farmer, Nicole, additional, Mitchell, Valerie M., additional, Collins, Billy S., additional, and Powell‐Wiley, Tiffany M., additional

Published
2022
Full Text
View/download PDF

6. Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women: Protocol for a Pilot Study

Author

Tamura, Kosuke, primary, Curlin, Kaveri, additional, Neally, Sam J, additional, Vijayakumar, Nithya P, additional, Mitchell, Valerie M, additional, Collins, Billy S, additional, Gutierrez-Huerta, Cristhian, additional, Troendle, James F, additional, Baumer, Yvonne, additional, Osei Baah, Foster, additional, Turner, Briana S, additional, Gray, Veronica, additional, Tirado, Brian A, additional, Ortiz-Chaparro, Erika, additional, Berrigan, David, additional, Mehta, Nehal N, additional, Vaccarino, Viola, additional, Zenk, Shannon N, additional, and Powell-Wiley, Tiffany M, additional

Published
2021
Full Text
View/download PDF

7. Abstract P190: Social Isolation Associates With The Expression Of NKp46 On Natural Killer Cells Through A Relationship Partially Mediated By RANTES In African-American Women

Author

Gray, Veronica C, primary, Turner, Briana S, additional, Gutierrez-Huerta, Cristhian A, additional, Neally, Sam, additional, Curlin, Kaveri, additional, Vijayakumar, Nithya, additional, Ortiz-Chaparro, Erika, additional, Tirado, Brian A, additional, Mitchell, Valerie, additional, Collins, Billy S, additional, Baumer, Yvonne, additional, and Powell-Wiley, Tiffany M, additional

Published
2021
Full Text
View/download PDF

9. Geospatial Analysis of Neighborhood Environmental Stress in Relation to Biological Markers of Cardiovascular Health and Health Behaviors in Women: Protocol for a Pilot Study (Preprint)

Author

Tamura, Kosuke, primary, Curlin, Kaveri, additional, Neally, Sam J, additional, Vijayakumar, Nithya P, additional, Mitchell, Valerie M, additional, Collins, Billy S, additional, Gutierrez-Huerta, Cristhian, additional, Troendle, James F, additional, Baumer, Yvonne, additional, Osei Baah, Foster, additional, Turner, Briana S, additional, Gray, Veronica, additional, Tirado, Brian A, additional, Ortiz-Chaparro, Erika, additional, Berrigan, David, additional, Mehta, Nehal N, additional, Vaccarino, Viola, additional, Zenk, Shannon N, additional, and Powell-Wiley, Tiffany M, additional

Published
2021
Full Text
View/download PDF

10. Multilevel mobile health approach to improve cardiovascular health in resource-limited communities with Step It Up: a randomised controlled trial protocol targeting physical activity

Author

Tamura, Kosuke, primary, Vijayakumar, Nithya P, additional, Troendle, James F, additional, Curlin, Kaveri, additional, Neally, Sam J, additional, Mitchell, Valerie M, additional, Collins, Billy S, additional, Baumer, Yvonne, additional, Gutierrez-Huerta, Cristhian A, additional, Islam, Rafique, additional, Turner, Briana S, additional, Andrews, Marcus R, additional, Ceasar, Joniqua N, additional, Claudel, Sophie E, additional, Tippey, Kathryn G, additional, Giuliano, Shayne, additional, McCoy, Regina, additional, Zahurak, Jessica, additional, Lambert, Sharon, additional, Moore, Philip J, additional, Douglas-Brown, Mary, additional, Wallen, Gwenyth R, additional, Dodge, Tonya, additional, and Powell-Wiley, Tiffany M, additional

Published
2020
Full Text
View/download PDF

11. Obesity modulates NK cell activity via LDL and DUSP1 signaling for populations with adverse social determinants.

Author

Baumer Y, Singh K, Saurabh A, Baez AS, Gutierrez-Huerta CA, Chen L, Igboko M, Turner BS, Yeboah JA, Reger RN, Ortiz-Whittingham LR, Joshi S, Andrews MR, Aquino Peterson EM, Bleck CK, Mendelsohn LG, Mitchell VM, Collins BS, Redekar NR, Kuhn SA, Combs CA, Pirooznia M, Dagur PK, Allan DS, Schwartz DM, Childs RW, and Powell-Wiley TM

Subjects
Humans, Female, Adult, Middle Aged, Black or African American, Hyperlipidemias metabolism, Lipoproteins, LDL metabolism, TOR Serine-Threonine Kinases metabolism, White, Killer Cells, Natural metabolism, Killer Cells, Natural immunology, Obesity metabolism, Dual Specificity Phosphatase 1 metabolism, Dual Specificity Phosphatase 1 genetics, Signal Transduction, Social Determinants of Health
Abstract

African American (AA) women are disproportionately affected by obesity and hyperlipidemia, particularly in the setting of adverse social determinants of health (aSDoH) that contribute to health disparities. Obesity, hyperlipidemia, and aSDoH appear to impair NK cells. As potential common underlying mechanisms are largely unknown, we sought to investigate common signaling pathways involved in NK cell dysfunction related to obesity and hyperlipidemia in AA women from underresourced neighborhoods. We determined in freshly isolated NK cells that obesity and measures of aSDoH were associated with a shift in NK cell subsets away from CD56dim/CD16+ cytotoxic NK cells. Using ex vivo data, we identified LDL as a marker related to NK cell function in an AA population from underresourced neighborhoods. Additionally, NK cells from AA women with obesity and LDL-treated NK cells displayed a loss in NK cell function. Comparative unbiased RNA-sequencing analysis revealed DUSP1 as a common factor. Subsequently, chemical inhibition of Dusp1 and Dusp1 overexpression in NK cells highlighted its significance in NK cell function and lysosome biogenesis in a mTOR/TFEB-related fashion. Our data demonstrate a pathway by which obesity and hyperlipidemia in the setting of aSDoH may relate to NK cell dysfunction, making DUSP1 an important target for further investigation of health disparities.

Published
2024
Full Text
View/download PDF

12. Social Determinants modulate NK cell activity via obesity, LDL, and DUSP1 signaling.

Author

Baumer Y, Singh K, Baez AS, Gutierrez-Huerta CA, Chen L, Igboko M, Turner BS, Yeboah JA, Reger RN, Ortiz-Whittingham LR, Bleck CKE, Mitchell VM, Collins BS, Pirooznia M, Dagur PK, Allan DSJ, Muallem-Schwartz D, Childs RW, and Powell-Wiley TM

Abstract

Adverse social determinants of health (aSDoH) are associated with obesity and related comorbidities like diabetes, cardiovascular disease, and cancer. Obesity is also associated with natural killer cell (NK) dysregulation, suggesting a potential mechanistic link. Therefore, we measured NK phenotypes and function in a cohort of African-American (AA) women from resource-limited neighborhoods. Obesity was associated with reduced NK cytotoxicity and a shift towards a regulatory phenotype. In vitro , LDL promoted NK dysfunction, implicating hyperlipidemia as a mediator of obesity-related immune dysregulation. Dual specific phosphatase 1 (DUSP1) was induced by LDL and was upregulated in NK cells from subjects with obesity, implicating DUSP1 in obesity-mediated NK dysfunction. In vitro , DUSP1 repressed LAMP1/CD107a, depleting NK cells of functional lysosomes to prevent degranulation and cytokine secretion. Together, these data provide novel mechanistic links between aSDoH, obesity, and immune dysregulation that could be leveraged to improve outcomes in marginalized populations., Competing Interests: Declaration of Interest: None.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results