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The periodic performance of quality cytopathological exams in currently the way used word wide in the screening of cervical cancer (CCU), however during the COVID-19 pandemic the exams were suspended, giving priority to urgencies and emergencies in the units of health care. Objective: Evaluate the quality of cervical cytopathological exams in triple-border municipality in Paraná, through the indicators recommended by the Ministry of Health, comparing them between the periods before and during the COVID-19 pandemic. Method: Quantitative study, based on the cancer information system, of the results of 106.029 cervical cytopathologic exams of women residing in the municipality of Foz do Iguaçu-PR, from January 2014 to October 2021, through the internal quality monitoring analysis. Results: The percentage of unsatisfactory exams was 1,6%, the JEC ranged from de 36,5% to 89,3%, and the total number of exams performed during the COVID-19 pandemic ranged from 26% to 40%. The total number of exams with altered results was 3.377, with an IP% variation reaching more than six and a half time, from 1,0% to 6,5%, and HSIL% varied six times, from 0,2% to 1,2%. Conclusion: During the COVID-19 pandemic, our study showed a greater number of altered exams, and a preponderance of in situ and invasive carcinomas and adenocarcinomas. These data can help local managers in strategies for an adequate follow-up and treatment of these women with precursor lesions and/or cervical cancer. La realización periódica de exámenes citopatológicos de calidad es actualmente la vía utilizada a nivel mundial en el tamizaje de cáncer de cuello uterino (UCC), sin embargo, durante la pandemia del COVID-19 los exámenes fueron suspendidos temporalmente, dando prioridad a las urgencias y emergencias en las unidades de salud. Objetivo: Evaluar la calidad de los exámenes citopatológicos cervicales en un municipio de la triple frontera de Paraná, utilizando los indicadores recomendados por el Ministerio de Salud, comparándolos entre los períodos antes y durante la pandemia de COVID-19. Método: Estudio cuantitativo, basado en el sistema de información del cáncer, de los resultados de 106.029 exámenes citopatológicos cervicales de mujeres residentes en el municipio de Foz do Iguaçu-PR, de enero de 2014 a octubre de 2021, a través de análisis de seguimiento de calidad interna. Resultados: El porcentaje de exámenes insatisfactorios fue de 1,6%, la JEC tuvo un rango de 36,5% a 89,3% y el total de exámenes realizados durante la pandemia de COVID-19 varió de 26% a 40%. El número total de exámenes con resultados alterados fue de 3.377, con una variación IP% superior a seis veces y media, de 1,0% a 6,5%, y HSIL% varió seis veces, de 0,2% a 1,2%. Conclusión: Durante la pandemia de COVID-19, nuestro estudio mostró un mayor número de exámenes alterados, y una preponderancia de carcinomas y adenocarcinomas in situ e invasivos. Estos datos pueden ayudar a los gestores locales en estrategias para un adecuado seguimiento y tratamiento de estas mujeres con lesiones precursoras y/o cáncer de cuello uterino. A realização periódica de exames citopatológicos com qualidade é atualmente a forma utilizada mundialmente no rastreamento do câncer do colo do útero (CCU), entretanto durante a pandemia do COVID-19 os exames foram suspensos temporariamente dando-se prioridade as urgências e emergências nas unidades de saúde. Objetivo: Avaliar a qualidade dos exames citopatológicos do colo do útero em um município de tríplice fronteira no Paraná, por meio dos indicadores preconizados pelo Ministério da Saúde, comparando-os entre os períodos antes e durante a pandemia de COVID-19. Método: Pesquisa quantitativa, com base no sistema de informação do câncer, dos resultados de 106.029 exames citopatológicos de colo do útero das mulheres residentes no município de Foz do Iguaçu- PR, de janeiro 2014 a outubro 2021, através da análise do monitoramento interno da qualidade. Resultados: A porcentagem de exames insatisfatórios foi a 1,6%, a JEC teve uma amplitude de 36,5% a 89,3% e o total de exames realizados no período da pandemia COVID-19 reduziu com variação de 26% a 40%. O total de exames com resultados alterados foram 3.377, tendo uma variação IP% chegando a mais de seis vezes e meia, 1,0% a 6,5%, e HSIL% variou seis vezes, de 0,2% a 1,2%. Conclusão: Durante a pandemia do COVID-19, nosso estudo evidenciou um maior número de exames alterados, e uma preponderância dos carcinomas e adenocarcinomas in situ e invasivos. Esses dados podem auxiliar os gestores locais em estratégias para um adequado acompanhamento e tratamento dessas mulheres com lesões precursoras e/ou câncer do colo útero.

Background: Human papillomavirus (HPV) infection is associated with cervical cancer; however, it is controversial whether it is involved in non-cervical genital cancers. Objective: This study aimed to evaluate articles on the prevalence of HPV in penile cancer, vulvar cancer, colorectal cancer, prostate cancer and anal canal cancer in studies conducted in Brazil. Methods: The study was conducted in accordance with the Preferred Reporting of Systematic Reviews and Meta-Analysis Statement. Comprehensive searches for HPV and cancer for the years 2006 to 2016 were conducted in two databases (PubMed and Web of Knowledge) and Google Scholar system. We also tracked the references of all eligible articles to identify additional non-captured publications through online surveys. Results: Eighteen studies, with a combined sample size of 1,552 patients were analyzed. The overall prevalence of HPV was 43% (95% CI: 36–51%; p < 0.001). The pooled prevalence of HPV in penile cancer was 42% (95% CI: 32–55%; p < 0.001), in colorectal cancer it was 67% (95% CI: 64–70%; p < 0.001) and in vulvar cancer 43% (95% CI: 34–55%; p < 0.001). HPV 16 was the most prevalent in all sites evaluated, with prevalence estimated at 54% (95% CI: 44–66%; p < 0.001), followed by genotypes 33 (21%; 95% CI: 17–28; p < 0.001), 6 (15%; 95% CI: 8–26%; p < 0.001), 11 (13%; 95% CI: 5–32%; p < 0.001) and 18 (12%; 95% CI: 7–22%; p < 0.001), respectively. The pooled prevalence of single infection was 82% and infection by multiple genotypes of HPV was 22%. Conclusion: Our study demonstrated a high prevalence of HPV in non-cervical genital cancers in Brazil, with predominance of genotype 16, providing evidence for the need for preventive and control measures to avoid future harm to the population.