Search

OBJECTIVE: Factor 2 and Factor 5 mutations are among the most common procoagulant genetic disorders and are routinely evaluated in donor preparation. Homozygous mutations are contraindicated for surgery, but heterozygous mutations cannot be said to be an impediment. We aimed to investigate the effect of heterozygous gene mutation of F2 and/or F5 on complications. METHODS: In our study, 210 living liver donors were examined. The available data of Factor 2 and 5 heterozygous positive donors were evaluated in terms of 21 donor patients and 30 liver recipients. The heterozygous positive group and the control group were statistically compared in terms of age, gender, length of hospital stay, post-operative deep vein thrombosis, pulmonary embolism, portal vein thrombosis, bile duct stenosis and bile leakage complications, lung infection and atelectasis, and wound infection. In addition, these patients were statistically compared in terms of laboratory tests. In addition, complications in recipients implanted with mutant grafts were evaluated statistically and numerically. RESULTS: Hospital staying was longer statistically in the donor group with heterozygous mutations than in the control group. Hemoglobin and albumin blood levels were lower (p=0.031, p=0.016); INR and ALT levels were higher (p=0.005, p=0.047) statistically in the control group than in the donor group with heterozygous mutations. There was no statistically significant difference between heterozygous mutant groups in terms of biliary tract complications and hepatic vessel thrombosis in recipients. CONCLUSION: Considering the longer hospital stay in the presence of these mutations, the increased need for treatment in this process and the close follow-up of liver functions should be considered. [ABSTRACT FROM AUTHOR]

(CHC) requires attention clinically and pathologically after liver transplantation (LT) because of its unique biology, difficulties in diagnosis, and being rare. We aimed to present our single-center experience for this incidental combined tumor. It is aimed to present our single-center experience for this incidental combined tumor. Materials and Methods: Seventeen patients with CHC were included in the study. There were 260 hepatocellular carcinoma (HCC) patients determined as the control group. Patients were evaluated for demographic, etiological, pathological features, and survival. Results: Macrovascular and microvascular invasion levels were significantly higher in the CHC group (p<0.05). P53, CK19, and CK7 levels were significantly higher in the CHC group (p<0.05). Hepatocyte-specific antigen level was significantly higher in the HCC group. The mean overall survival was significantly higher in the HCC group (p<0.05). Conclusion: Even though CHC is a rare liver tumor, it has features that need to be clarified regarding both survival and tumor biology. İnvestigating prognostic factors, especially in terms of survival and recurrence, will be very beneficial to identify candidates who will benefit from LT and be included in the indications for LT for CHC. This study evaluated the outcomes of patients showing combined HCC-intrahepatic cholangiocarcinoma in explant pathology. [ABSTRACT FROM AUTHOR]

Aim: To evaluate the reasons for dermatology consultations in hospitalized patients in the internal medicine services and the treatments recommended based on these consultations. Methods: The data of patients who were hospitalized in the internal medicine services between June 2018 and June 2020 were evaluated retrospectively including patients' demographics, reasons for the consultation, recommended additional tests and treatments by the dermatologist. Results: A total of 510 patients (8.6%) (51% male, 49% female, mean age 67.3±16.0 years) requested dermatology consultations were reviewed among patients hospitalized in internal medicine services. The most common reason for the dermatology consultation was cutaneous and subcutaneous infections (n=156, 30.6%) followed by decubitus ulcer (n=94, 18.4%) and vascular diseases (n=50, 9.8%). Topical and/or systemic treatments were recommended to 87.1% of the patients. Duration of hospitalization was longer in patients who requested dermatology consultations than patients not requested (p<0.001). Conclusion: Infectious causes and decubitus ulcer were the two most common reasons for dermatology consultations. Dermatology consultations are of great importance in hospitalized patients to decrease morbidity and the duration of hospitalization. [ABSTRACT FROM AUTHOR]