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16 results on '"Turi, Angelo"'

6. Placental thrombomodulin expression in recurrent miscarriage

Author

Turi Angelo, Sartini Davide, Giannubilo Stefano R, Cecati Monia, Stortoni Piergiorgio, Emanuelli Monica, and Tranquilli Andrea L

Subjects
Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Abstract Background Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds and it's also a cofactor of the protein C anticoagulant pathway. Discussion We evaluate the Thrombomodulin expression in placental tissue from spontaneous recurrent miscarriage and voluntary abortion as controls. Thrombomodulin mRNA was determined using real-time quantitative polymerase chain reaction. Reduced expression levels of thrombomodulin were found in recurrent miscarriage group compared to controls (1.82-fold of reduction), that corresponds to a reduction of 45% (from control group Delta CT) of thrombomodulin expression in spontaneous miscarriage group respect the control groups. Summary We cannot state at present the exact meaning of a reduced expression of Thrombomodulin in placental tissue. Further studies are needed to elucidate the biological pathway of this important factor in the physiopathology of the trophoblast and in reproductive biology.

Published
2010
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8. Possible role of placental CD100, CD72 and CD45 molecules in human miscarriage

Author

Lorenzi, Teresa, Turi, Angelo, Lorenzi, Maria, Paolinelli, Francesca, Mancioli, Francesca, La Sala, Lucia, Morroni, Manrico, Ciarmela, Pasquapina, Tranquilli, Andrea Luigi, Castellucci, Mario, and Marzioni, Daniela

Subjects
CD100, CD72, CD45, placenta, human, miscarriage
Abstract

The precise mechanism for recurrent miscarriage is unclear. A lot of metabolic alterations are involved in the missed intercommunication between mother and its foetus, causing their reciprocal intolerance. The identification of new molecules involved in pregnancy loss represents the main objective of our study. We analysed the semaphorin CD100, its natural receptor CD72 and the glycoprotein CD45, physically and functionally associated to CD100 in the placental tissues from recurrent miscarriages by real-time PCR, western blotting and immunohistochemistry. Placental tissue was obtained during surgical uterine evacuation in 72 caucasian women with early spontaneous pregnancy loss between 8th and 12th week of gestation and classified in four groups defined as first, second, third and fourth miscarriages. Other two normal placental groups were recruited: a) first trimester placentas (n = 18), matched for gestational age with placentas from spontaneous pregnancy loss; b) third trimester placentas (n = 6) at 38-40 weeks of gestation. We demonstrated that CD72, CD45 and CD100 mRNA were detectable in placental tissues with different expression in normal and pathological conditions. In addition, we demonstrated that CD72 and CD45 molecules were expressed in foetal macrophages and that their protein levels were especially deregulated in first and second miscarriages at about 10 weeks of gestation. On the contrary, CD100 cleaved protein appeared to be absent in placenta. In conclusion, our findings underline a possible role for CD100, CD72 and CD45 molecules in recurrent miscarriages, showing an important foetal involvement in the occurring of pregnancy loss., Italian Journal of Anatomy and Embryology, Vol 116, No 1 (Supplement) 2011

Published
2011
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10. Placental Expression of CD100, CD72 and CD45 Is Dysregulated in Human Miscarriage

Author

Lorenzi, Teresa, primary, Turi, Angelo, additional, Lorenzi, Maria, additional, Paolinelli, Francesca, additional, Mancioli, Francesca, additional, La Sala, Lucia, additional, Morroni, Manrico, additional, Ciarmela, Pasquapina, additional, Mantovani, Angelo, additional, Tranquilli, Andrea Luigi, additional, Castellucci, Mario, additional, and Marzioni, Daniela, additional

Published
2012
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