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1. Utilizing Pharmacogenomics Results to Determine Opioid Appropriateness and Improve Pain Management in a Patient with Osteoarthritis

Author

Pizzolato K, Thacker D, Del Toro-Pagán NM, Amin NS, Hanna A, Turgeon J, and Michaud V

Subjects
cyp2d6, cyp2c9, drug-gene interactions, opioids, pain management, pharmacogenomics, Therapeutics. Pharmacology, RM1-950
Abstract

Katie Pizzolato,1 David Thacker,2 Nicole Marie Del Toro-Pagán,1 Nishita S Amin,1 Abeer Hanna,3 Jacques Turgeon,2,4 Veronique Michaud2,4,5 1Tabula Rasa Healthcare, Office of Translational Research and Residency Programs, Moorestown, NJ, 08057, USA; 2Tabula Rasa HealthCare, Precision Pharmacotherapy Research and Development Institute, Orlando, FL, 32827, USA; 3VieCare Butler, Program of All-Inclusive Care for the Elderly (PACE), Butler, PA, 16001, USA; 4Faculty of Pharmacy, Université de Montréal, Montréal, QC, H2L, Canada; 5University of Montreal Hospital Research Center (CRCHUM), Montréal, QC, H2X 0A9, CanadaCorrespondence: Veronique Michaud, Precision Pharmacotherapy Research and Development Institute, 13485 Veterans Way, Orlando, FL, 32827, USA, Tel +856-938-8697, Email vmichaud@trhc.comAbstract: The opioid epidemic in the United States has exposed the need for providers to limit opioid dispensing and identify at-risk patients prior to prescribing opioids. With pharmacogenomic testing, clinicians can analyze hundreds of medications—including commonly prescribed opioids—against genetic results to understand and predict risk and response. Moreover, knowledge of genotypic variants and altered function can help decrease trial and error prescribing, identify patients at-risk for adverse drug events, and improve pain control. This patient case demonstrates how pharmacogenomic test results identified drug–gene interactions and provided insight about a patient’s inadequate opioid therapy response. With pharmacogenomic information, the patient’s healthcare team discontinued opioid therapy and selected a more appropriate regimen for osteoarthritis (ie, celecoxib), resulting in improved pain control and quality of life.Keywords: CYP2D6, CYP2C9, drug–gene interactions, opioids, pain management, pharmacogenomics

Published
2022

3. Stress Index During Mechanical Ventilation Post-lung Transplantation

Author

Morales Castro, D., primary, Wong, I., additional, Tisminetzky, M., additional, Turgeon, J., additional, Ratano, D., additional, Dragoi, L., additional, Teijeiro-Paradis, R., additional, Jurado-Camacho, L.F., additional, Morris, I., additional, Brochard, L.J., additional, Slutsky, A., additional, Ferguson, N., additional, Cypel, M., additional, Keshavjee, S., additional, Fan, E., additional, and del Sorbo, L., additional

Published
2024
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14. Caspase-3-dependent peritubular capillary dysfunction is pivotal for the transition from acute to chronic kidney disease after acute ischemia-reperfusion injury.

Author

Lan S., Yang B., Migneault F., Turgeon J., Bourgault M., Dieude M., Cardinal H., Hickey M.J., Patey N., Hebert M.-J., Lan S., Yang B., Migneault F., Turgeon J., Bourgault M., Dieude M., Cardinal H., Hickey M.J., Patey N., and Hebert M.-J.

Abstract

Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an effector responsible for apoptosis execution, is activated within the peritubular capillary (PTC) in the early stage of IRI-induced acute kidney injury (AKI). Recently, we showed that caspase-3-dependent microvascular rarefaction plays a key role in fibrosis development after mild renal IRI. Here, we further characterized the role of caspase-3 in microvascular dysfunction and progressive renal failure in both mild and severe AKI, by performing unilateral renal artery clamping for 30/60 min with contralateral nephrectomy in wild-type (C57BL/6) or caspase-3-/- mice. In both forms of AKI, caspase-3-/- mice showed better long-term outcomes despite worse initial tubular injury. After 3 wk, they showed reduced PTC injury, decreased PTC collagen deposition and a-smooth muscle actin expression, and lower tubular injury scores compared with wild-type animals. Caspase-3-/- mice with severe IRI also showed better preservation of long-term renal function. Intravital imaging and microcomputed tomography revealed preserved PTC permeability and better terminal capillary density in caspase-3-/- mice. Collectively, these results demonstrate the pivotal importance of caspase- 3 in regulating long-term renal function after IRI and establish the predominant role of PTC dysfunction as a major contributor to progressive renal dysfunction. NEW & NOTEWORTHY Our findings demonstrate the pivotal importance of caspase-3 in regulating renal microvascular dysfunction, fibrogenesis, and long-term renal impairment after acute kidney injury induced by ischemia-reperfusion injury. Furthermore, this study establishes the predominant role of peritubular capillary integrity as a major contributor to progressive renal dysfunction after ischemia-reperfusion injury. Copyright © 2021 the American Physiological Society.

Published
2021

17. Silver-Russell syndrome with unusual clinical features: A case report

Author

Nagalo K, Douamba S, Kaboré A, Turgeon J, Laberge JM, and Yé D

Subjects
congenital malformation, parasitic diseases, lcsh:R, lcsh:RJ1-570, lcsh:Medicine, lcsh:Pediatrics, Silver-Russell syndrome
Abstract

The Silver-Russell syndrome (SRS) is a rare heterogeneous genetic disorder whose pathogenesis remains controversial. The diagnosis is mainly based on the clinical association of characteristic signs, including intrauterine growth retardation, postnatal short stature, relative macrocephaly, triangular facies, clinodactyly of the fifth finger and asymmetry of the body. In this case report, we focused on a patient with SRS, who was spotted during a routine paediatric plastic surgery campaign in Ouagadougou, Burkina Faso (West Africa). The propositus is a young male with evident poor weight gain, relative macrocephaly, large and fibrous anterior fontanel, triangular facies, frontal bossing, hypertelorism, kypho-lordosis, clinodactyly, and camptodactyly. The specific SRS features in this patient included flat feet and clubbing digit. In the subsequent follow-up, the patient revealed a few alterations in the craniofacial anomalies, but with heightened intellectual and psychological issues. The diagnosis, evolution and prognosis of this syndrome are discussed in the report, including the necessity for a clinical diagnostic score for SRS and other congenital malformations to aid clinicians in developing countries that are deprived of access to molecular or genetic diagnostics.

Published
2018

20. Comparative efficacy of terbutaline sulphate delivered by Turbuhaler dry powder inhaler or pressurised metered dose inhaler with Nebuhaler spacer in children during an acute asthmatic episode. (Original Article)

Author

Drblik, S., Lapierre, G., Thivierge, R., Turgeon, J., Gaudreault, P., Cummins-McManus, B., Verdy, I., Haddon, J., Lee, J., and Spier, S.

Subjects
AstraZeneca Canada Inc. -- Testing -- Product development, Nebuhaler (Drug-delivery device) -- Evaluation, Turbuhaler (Drug-delivery device) -- Evaluation, Children -- Diseases, Terbutaline -- Dosage and administration -- Evaluation -- Product development -- Research -- Product/service Evaluations, Pharmaceutical industry -- Product development, Asthma -- Drug therapy -- Care and treatment -- Research, Inhalers -- Evaluation -- Product development -- Product/service Evaluations, Family and marriage, Health, Drug therapy, Testing, Diseases, Evaluation, Care and treatment, Research, Dosage and administration, Product development
Abstract

Aims: To compare the efficacy of terbutaline sulphate delivered via Turbuhaler with a pressurised metered dose inhaler (pMDI) connected to Nebuhaler spacer in a population of asthmatic children presenting to [...]

Published
2003

50. CORRESPONDENCE

Author

Hoover, Wm., Fleming, Geo., and Turgeon, J. F.

Published
1879

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