24 results on '"Turchi, D."'
Search Results
2. P-261 Morphokinetics-oriented embryo selection for day 2 transfers: adapting transfer strategy to the times of Covid-19
- Author
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Dal Canto, M, primary, Vitali, M, additional, Guglielmo, M.C, additional, Turchi, D, additional, De Ponti, E, additional, Mignini Renzini, M, additional, and Buratini, J, additional
- Published
- 2022
- Full Text
- View/download PDF
3. P–152 Morphokinetic and maternal profiles of embryos derived from centrally granulated oocytes vary with their ability to implant
- Author
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Moutier, C, primary, Bartolacci, A, additional, Turchi, D, additional, Lain, M, additional, Pignataro, D, additional, Mignin. Renzini, M R, additional, Buratini, J, additional, and Da. Canto, M, additional
- Published
- 2021
- Full Text
- View/download PDF
4. Embryo culture in the presence of GM-CSF is associated to a reduced abortion rate in IVF treatments of patients with a previous history of pregnancy loss: O-021
- Author
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Renzini, M. Mignini, Canto, M. Dal, Coticchio, G., Novara, P., Turchi, D., Lain, M., Guarnieri, T., Brambillasca, F., and Fadini, R.
- Published
- 2012
5. Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A 2A receptors reduces transmitter outflow
- Author
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Gianfriddo, M., Melani, A., Turchi, D., Giovannini, M.G., and Pedata, F.
- Published
- 2004
- Full Text
- View/download PDF
6. Focused time-lapse analysis reveals novel aspects of human fertilization and suggests new parameters of embryo viability
- Author
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Coticchio, G, primary, Mignini Renzini, M, additional, Novara, P V, additional, Lain, M, additional, De Ponti, E, additional, Turchi, D, additional, Fadini, R, additional, and Dal Canto, M, additional
- Published
- 2017
- Full Text
- View/download PDF
7. Magnetic tweezers measurements of the nanomechanical properties of DNA in the presence of drugs
- Author
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Salerno, D, Brogioli, D, Cassina, V, Turchi, D, Beretta, G, Seruggia, D, Ziano, R, Zunino, F, Mantegazza, F, SALERNO, DOMENICO, BROGIOLI, DORIANO COSTANTINO, CASSINA, VALERIA, ZIANO, ROBERTO, MANTEGAZZA, FRANCESCO, Beretta, GL, Salerno, D, Brogioli, D, Cassina, V, Turchi, D, Beretta, G, Seruggia, D, Ziano, R, Zunino, F, Mantegazza, F, SALERNO, DOMENICO, BROGIOLI, DORIANO COSTANTINO, CASSINA, VALERIA, ZIANO, ROBERTO, MANTEGAZZA, FRANCESCO, and Beretta, GL
- Abstract
Herein, we study the nanomechanical characteristics of single DNA molecules in the presence of DNA binders, including intercalating agents (ethidium bromide and doxorubicin), a minor groove binder (netropsin) and a typical alkylating damaging agent (cisplatin). We have used magnetic tweezers manipulation techniques, which allow us to measure the contour and persistence lengths together with the bending and torsional properties of DNA. For each drug, the specific variations of the nanomechanical properties induced in the DNA have been compared. We observed that the presence of drugs causes a specific variation in the DNA extension, a shift in the natural twist and a modification of bending dependence on the imposed twist. By introducing a naive model, we have justified an anomalous correlation of torsion data observed in the presence of intercalators. Finally, a data analysis criterion for discriminating between different molecular interactions among DNA and drugs has been suggested.
- Published
- 2010
8. Embryology
- Author
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Gandhi, G., primary, Allahbadia, G., additional, Kagalwala, S., additional, Allahbadia, A., additional, Ramesh, S., additional, Patel, K., additional, Hinduja, R., additional, Chipkar, V., additional, Madne, M., additional, Ramani, R., additional, Joo, J. K., additional, Jeung, J. E., additional, Go, K. R., additional, Lee, K. S., additional, Goto, H., additional, Hashimoto, S., additional, Amo, A., additional, Yamochi, T., additional, Iwata, H., additional, Morimoto, Y., additional, Koifman, M., additional, Lahav-Baratz, S., additional, Blais, E., additional, Megnazi-Wiener, Z., additional, Ishai, D., additional, Auslender, R., additional, Dirnfeld, M., additional, Zaletova, V., additional, Zakharova, E., additional, Krivokharchenko, I., additional, Zaletov, S., additional, Zhu, L., additional, Li, Y., additional, Zhang, H., additional, Ai, J., additional, Jin, L., additional, Zhang, X., additional, Rajan, N., additional, Kovacs, A., additional, Foley, C., additional, Flanagan, J., additional, O'Callaghan, J., additional, Waterstone, J., additional, Dineen, T., additional, Dahdouh, E. M., additional, St-Michel, P., additional, Granger, L., additional, Carranza-Mamane, B., additional, Faruqi, F., additional, Kattygnarath, T. V., additional, Gomes, F. L. A. F., additional, Christoforidis, N., additional, Ioakimidou, C., additional, Papas, C., additional, Moisidou, M., additional, Chatziparasidou, A., additional, Klaver, M., additional, Tilleman, K., additional, De Sutter, P., additional, Lammers, J., additional, Freour, T., additional, Splingart, C., additional, Barriere, P., additional, Ikeno, T., additional, Nakajyo, Y., additional, Sato, Y., additional, Hirata, K., additional, Kyoya, T., additional, Kyono, K., additional, Campos, F. B., additional, Meseguer, M., additional, Nogales, M., additional, Martinez, E., additional, Ariza, M., additional, Agudo, D., additional, Rodrigo, L., additional, Garcia-Velasco, J. A., additional, Lopes, A. S., additional, Frederickx, V., additional, Vankerkhoven, G., additional, Serneels, A., additional, Roziers, P., additional, Puttermans, P., additional, Campo, R., additional, Gordts, S., additional, Fragouli, E., additional, Alfarawati, S., additional, Spath, K., additional, Wells, D., additional, Liss, J., additional, Lukaszuk, K., additional, Glowacka, J., additional, Bruszczynska, A., additional, Gallego, S. C., additional, Lopez, L. O., additional, Vila, E. O., additional, Garcia, M. G., additional, Canas, C. L., additional, Segovia, A. G., additional, Ponce, A. G., additional, Calonge, R. N., additional, Peregrin, P. C., additional, Ito, K., additional, Nakaoka, Y., additional, Alcoba, D. D., additional, Valerio, E. G., additional, Conzatti, M., additional, Tornquist, J., additional, Kussler, A. P., additional, Pimentel, A. M., additional, Corleta, H. E., additional, Brum, I. S., additional, Boyer, P., additional, Montjean, D., additional, Tourame, P., additional, Gervoise-Boyer, M., additional, Cohen, J., additional, Lefevre, B., additional, Radio, C. I., additional, Wolf, J. P., additional, Ziyyat, A., additional, De Croo, I., additional, Tolpe, A., additional, Degheselle, S., additional, Van de Velde, A., additional, Van den Abbeel, E., additional, Gandhi, G., additional, Kuwayama, M., additional, Khatoon, A., additional, Alsule, S., additional, Inaba, M., additional, Ohgaki, A., additional, Ohtani, A., additional, Matsumoto, H., additional, Mizuno, S., additional, Mori, R., additional, Fukuda, A., additional, Umekawa, Y., additional, Yoshida, A., additional, Tanigiwa, S., additional, Seida, K., additional, Suzuki, H., additional, Tanaka, M., additional, Vahabi, Z., additional, Yazdi, P. E., additional, Dalman, A., additional, Ebrahimi, B., additional, Mostafaei, F., additional, Niknam, M. R., additional, Watanabe, S., additional, Kamihata, M., additional, Tanaka, T., additional, Matsunaga, R., additional, Yamanaka, N., additional, Kani, C., additional, Ishikawa, T., additional, Wada, T., additional, Morita, H., additional, Miyamura, H., additional, Nishio, E., additional, Ito, M., additional, Kuwahata, A., additional, Ochi, M., additional, Horiuchi, T., additional, Dal Canto, M., additional, Guglielmo, M. C., additional, Fadini, R., additional, Renzini, M. M., additional, Albertini, D. F., additional, Novara, P., additional, Lain, M., additional, Brambillasca, F., additional, Turchi, D., additional, Sottocornola, M., additional, Coticchio, G., additional, Kato, M., additional, Fukunaga, N., additional, Nagai, R., additional, Kitasaka, H., additional, Yoshimura, T., additional, Tamura, F., additional, Hasegawa, N., additional, Nakayama, K., additional, Takeuchi, M., additional, Ohno, H., additional, Aoyagi, N., additional, Kojima, E., additional, Itoi, F., additional, Hashiba, Y., additional, Asada, Y., additional, Kikuchi, H., additional, Iwasa, Y., additional, Kamono, T., additional, Suzuki, A., additional, Yamada, K., additional, Kanno, H., additional, Sasaki, K., additional, Murakawa, H., additional, Matsubara, M., additional, Yoshida, H., additional, Valdespin, C., additional, Elhelaly, M., additional, Chen, P., additional, Pangestu, M., additional, Catt, S., additional, Hojnik, N., additional, Kovacic, B., additional, Roglic, P., additional, Taborin, M., additional, Zafosnik, M., additional, Knez, J., additional, Vlaisavljevic, V., additional, Mori, C., additional, Yabuuchi, A., additional, Ezoe, K., additional, Takayama, Y., additional, Aono, F., additional, Kato, K., additional, Radwan, P., additional, Krasinski, R., additional, Chorobik, K., additional, Radwan, M., additional, Stoppa, M., additional, Maggiulli, R., additional, Capalbo, A., additional, Ievoli, E., additional, Dovere, L., additional, Scarica, C., additional, Albricci, L., additional, Romano, S., additional, Sanges, F., additional, Barnocchi, N., additional, Papini, L., additional, Vivarelli, A., additional, Ubaldi, F. M., additional, Rienzi, L., additional, Bono, S., additional, Spizzichino, L., additional, Rubio, C., additional, Fiorentino, F., additional, Ferris, J., additional, Favetta, L. A., additional, MacLusky, N., additional, King, W. A., additional, Madani, T., additional, Jahangiri, N., additional, Aflatoonian, R., additional, Cater, E., additional, Hulme, D., additional, Berrisford, K., additional, Jenner, L., additional, Campbell, A., additional, Fishel, S., additional, Zhang, X. Y., additional, Yilmaz, A., additional, Hananel, H., additional, Ao, A., additional, Vutyavanich, T., additional, Piromlertamorn, W., additional, Saenganan, U., additional, Samchimchom, S., additional, Wirleitner, B., additional, Lejeune, B., additional, Zech, N. H., additional, Vanderzwalmen, P., additional, Albani, E., additional, Parini, V., additional, Smeraldi, A., additional, Menduni, F., additional, Antonacci, R., additional, Marras, A., additional, Levi, S., additional, Morreale, G., additional, Pisano, B., additional, Di Biase, A., additional, Di Rosa, A., additional, Setti, P. E. L., additional, Puard, V., additional, Cadoret, V., additional, Tranchant, T., additional, Gauthier, C., additional, Reiter, E., additional, Guerif, F., additional, Royere, D., additional, Yoon, S. Y., additional, Eum, J. H., additional, Park, E. A., additional, Kim, T. Y., additional, Yoon, T. K., additional, Lee, D. R., additional, Lee, W. S., additional, Cabal, A. C., additional, Vallejo, B., additional, Campos, P., additional, Sanchez, E., additional, Serrano, J., additional, Remohi, J., additional, Nagornyy, V., additional, Mazur, P., additional, Mykytenko, D., additional, Semeniuk, L., additional, Zukin, V., additional, Guilherme, P., additional, Madaschi, C., additional, Bonetti, T. C. S., additional, Fassolas, G., additional, Izzo, C. R., additional, Santos, M. J. D. L., additional, Beltran, D., additional, Garcia-Laez, V., additional, Escriba, M. J., additional, Grau, N., additional, Escrich, L., additional, Albert, C., additional, Zuzuarregui, J. L., additional, Pellicer, A., additional, LU, Y., additional, Nikiforaki, D., additional, Meerschaut, F. V., additional, Neupane, J., additional, De Vos, W. H., additional, Lierman, S., additional, Deroo, T., additional, Heindryckx, B., additional, Li, J., additional, Chen, X. Y., additional, Lin, G., additional, Huang, G. N., additional, Sun, Z. Y., additional, Zhong, Y., additional, Zhang, B., additional, Li, T., additional, Zhang, S. P., additional, Ye, H., additional, Han, S. B., additional, Liu, S. Y., additional, Zhou, J., additional, Lu, G. X., additional, Zhuang, G. L., additional, Muela, L., additional, Roldan, M., additional, Gadea, B., additional, Martinez, M., additional, Perez, I., additional, Munoz, M., additional, Castello, C., additional, Asensio, M., additional, Fernandez, P., additional, Farreras, A., additional, Rovira, S., additional, Capdevila, J. M., additional, Velilla, E., additional, Lopez-Teijon, M., additional, Kovacs, P., additional, Matyas, S. Z., additional, Forgacs, V., additional, Reichart, A., additional, Rarosi, F., additional, Bernard, A., additional, Torok, A., additional, Kaali, S. G., additional, Sajgo, A., additional, Pribenszky, C. S., additional, Sozen, B., additional, Ozturk, S., additional, Yaba-Ucar, A., additional, Demir, N., additional, Gelo, N., additional, Stanic, P., additional, Hlavati, V., additional, ogoric, S., additional, Pavicic-Baldani, D., additional, prem-Goldtajn, M., additional, Radakovic, B., additional, Kasum, M., additional, Strelec, M., additional, Canic, T., additional, imunic, V., additional, Vrcic, H., additional, Ajina, M., additional, Negra, D., additional, Ben-Ali, H., additional, Jallad, S., additional, Zidi, I., additional, Meddeb, S., additional, Bibi, M., additional, Khairi, H., additional, Saad, A., additional, Gamiz, P., additional, Viloria, T., additional, Lima, E. T., additional, Fernandez, M. P., additional, Prieto, J. A. A., additional, Varela, M. O., additional, Kassa, D., additional, Munoz, E. M., additional, Kani, K., additional, Nor-Ashikin, M. N. K., additional, Norhazlin, J. M. Y., additional, Norita, S., additional, Wan-Hafizah, W. J., additional, Mohd-Fazirul, M., additional, Razif, D., additional, Hoh, B. P., additional, Dale, S., additional, Woodhead, G., additional, Andronikou, S., additional, Francis, G., additional, Tailor, S., additional, Vourliotis, M., additional, Almeida, P. A., additional, Krivega, M., additional, Van de Velde, H., additional, Lee, R. K., additional, Hwu, Y. M., additional, Lu, C. H., additional, Li, S. H., additional, Vaiarelli, A., additional, Desgro, M., additional, Baggiani, A., additional, Zannoni, E., additional, Kermavner, L. B., additional, Klun, I. V., additional, Pinter, B., additional, Vrtacnik-Bokal, E., additional, De Paepe, C., additional, Cauffman, G., additional, Verheyen, G., additional, Stoop, D., additional, Liebaers, I., additional, Stecher, A., additional, Zintz, M., additional, Neyer, A., additional, Bach, M., additional, Baramsai, B., additional, Schwerda, D., additional, Wiener-Megnazi, Z., additional, Fridman, M., additional, Blais, I., additional, Akerud, H., additional, Lindgren, K., additional, Karehed, K., additional, Wanggren, K., additional, Hreinsson, J., additional, Freijomil, B., additional, Weiss, A., additional, Neril, R., additional, Geslevich, J., additional, Beck-Fruchter, R., additional, Lavee, M., additional, Golan, J., additional, Ermoshkin, A., additional, Shalev, E., additional, Shi, W., additional, Zhang, S., additional, Zhao, W., additional, Xue, X. I. A., additional, Wang, M. I. N., additional, Bai, H., additional, Shi, J., additional, Smith, H. L., additional, Shaw, L., additional, Kimber, S., additional, Brison, D., additional, Boumela, I., additional, Assou, S., additional, Haouzi, D., additional, Ahmed, O. A., additional, Dechaud, H., additional, Hamamah, S., additional, Dasiman, R., additional, Nor-Shahida, A. R., additional, Salina, O., additional, Gabriele, R. A. F., additional, Ben-Yosef, D., additional, Shwartz, T., additional, Cohen, T., additional, Carmon, A., additional, Raz, N. M., additional, Malcov, M., additional, Frumkin, T., additional, Almog, B., additional, Vagman, I., additional, Kapustiansky, R., additional, Reches, A., additional, Azem, F., additional, Amit, A., additional, Cetinkaya, M., additional, Pirkevi, C., additional, Yelke, H., additional, Kumtepe, Y., additional, Atayurt, Z., additional, Kahraman, S., additional, Risco, R., additional, Hebles, M., additional, Saa, A. M., additional, Vilches-Ferron, M. A., additional, Sanchez-Martin, P., additional, Lucena, E., additional, Lucena, M., additional, Heras, M. D. L., additional, Agirregoikoa, J. A., additional, Barrenetxea, G., additional, De Pablo, J. L., additional, Lehner, A., additional, Pribenszky, C., additional, Murber, A., additional, Rigo, J., additional, Urbancsek, J., additional, Fancsovits, P., additional, Bano, D. G., additional, Sanchez-Leon, A., additional, Marcos, J., additional, Molla, M., additional, Amorocho, B., additional, Nicolas, M., additional, Fernandez, L., additional, Landeras, J., additional, Adeniyi, O. A., additional, Ehbish, S. M., additional, Brison, D. R., additional, Egashira, A., additional, Murakami, M., additional, Nagafuchi, E., additional, Tanaka, K., additional, Tomohara, A., additional, Mine, C., additional, Otsubo, H., additional, Nakashima, A., additional, Otsuka, M., additional, Yoshioka, N., additional, Kuramoto, T., additional, Choi, D., additional, Yang, H., additional, Park, J. H., additional, Jung, J. H., additional, Hwang, H. G., additional, Lee, J. H., additional, Lee, J. E., additional, Kang, A. S., additional, Yoo, J. H., additional, Kwon, H. C., additional, Lee, S. J., additional, Bang, S., additional, Shin, H., additional, Lim, H. J., additional, Min, S. H., additional, Yeon, J. Y., additional, Koo, D. B., additional, Higo, S., additional, Ruvalcaba, L., additional, Kobayashi, M., additional, Takeuchi, T., additional, Miwa, A., additional, Nagai, Y., additional, Momma, Y., additional, Takahashi, K., additional, Chuko, M., additional, Nagai, A., additional, Otsuki, J., additional, Kim, S. G., additional, Kim, Y. Y., additional, Kim, H. J., additional, Park, I. H., additional, Sun, H. G., additional, Lee, K. H., additional, Song, H. J., additional, Costa-Borges, N., additional, Belles, M., additional, Herreros, J., additional, Teruel, J., additional, Ballesteros, A., additional, Calderon, G., additional, Vossaert, L., additional, Qian, C., additional, Lu, Y., additional, Parys, J. B., additional, Deforce, D., additional, Leybaert, L., additional, Surlan, L., additional, Otasevic, V., additional, Velickovic, K., additional, Golic, I., additional, Vucetic, M., additional, Stankovic, V., additional, Stojnic, J., additional, Radunovic, N., additional, Tulic, I., additional, Korac, B., additional, Korac, A., additional, Elias, R., additional, Neri, Q. V., additional, Fields, T., additional, Schlegel, P. N., additional, Rosenwaks, Z., additional, Palermo, G. D., additional, Gilson, A., additional, Piront, N., additional, Heens, B., additional, Vastersaegher, C., additional, Vansteenbrugge, A., additional, Pauwels, P. C. P., additional, Abdel-Raheem, M. F., additional, Abdel-Rahman, M. Y., additional, Abdel-Gaffar, H. M., additional, Sabry, M., additional, Kasem, H., additional, Rasheed, S. M., additional, Amin, M., additional, Abdelmonem, A., additional, Ait-Allah, A. S., additional, VerMilyea, M., additional, Anthony, J., additional, Bucci, J., additional, Croly, S., additional, Coutifaris, C., additional, Cimadomo, D., additional, Dusi, L., additional, Colamaria, S., additional, Baroni, E., additional, Giuliani, M., additional, Sapienza, F., additional, Buffo, L., additional, Zivi, E., additional, Aizenman, E., additional, Barash, D., additional, Gibson, D., additional, Shufaro, Y., additional, Perez, M., additional, Aguilar, J., additional, Taboas, E., additional, Ojeda, M., additional, Suarez, L., additional, Munoz, E., additional, Casciani, V., additional, Minasi, M. G., additional, Scarselli, F., additional, Terribile, M., additional, Zavaglia, D., additional, Colasante, A., additional, Franco, G., additional, Greco, E., additional, Hickman, C., additional, Cook, C., additional, Gwinnett, D., additional, Trew, G., additional, Carby, A., additional, Lavery, S., additional, Asgari, L., additional, Paouneskou, D., additional, Jayaprakasan, K., additional, Maalouf, W., additional, Campbell, B. K., additional, Rega, E., additional, Alteri, A., additional, Cotarelo, R. P., additional, Rubino, P., additional, Colicchia, A., additional, Giannini, P., additional, Devjak, R., additional, Papler, T. B., additional, Tacer, K. F., additional, Verdenik, I., additional, Iussig, B., additional, Gala, A., additional, Ferrieres, A., additional, Vincens, C., additional, Bringer-Deutsch, S., additional, Brunet, C., additional, Conaghan, J., additional, Tan, L., additional, Gvakharia, M., additional, Ivani, K., additional, Chen, A., additional, Pera, R. R., additional, Bowman, N., additional, Montgomery, S., additional, Best, L., additional, Duffy, S., additional, Hirata, R., additional, Aoi, Y., additional, Habara, T., additional, Hayashi, N., additional, Dinopoulou, V., additional, Partsinevelos, G. A., additional, Bletsa, R., additional, Mavrogianni, D., additional, Anagnostou, E., additional, Stefanidis, K., additional, Drakakis, P., additional, Loutradis, D., additional, Hernandez, J., additional, Leon, C. L., additional, Puopolo, M., additional, Palumbo, A., additional, Atig, F., additional, Kerkeni, A., additional, D'Ommar, G., additional, Herrera, A. K., additional, Lozano, L., additional, Majerfeld, M., additional, Ye, Z., additional, Zaninovic, N., additional, Clarke, R., additional, Bodine, R., additional, Nagorny, V., additional, Zabala, A., additional, Pessino, T., additional, Outeda, S., additional, Blanco, L., additional, Leocata, F., additional, Asch, R., additional, Rajikin, M. H., additional, Nuraliza, A. S., additional, Machac, S., additional, Hubinka, V., additional, Larman, M., additional, Koudelka, M., additional, Budak, T. P., additional, Membrado, O. O., additional, Martinez, E. S., additional, Wilson, P., additional, McClure, A., additional, Nargund, G., additional, Raso, D., additional, Insua, M. F., additional, Lotti, B., additional, Giordana, S., additional, Baldi, C., additional, Barattini, J., additional, Cogorno, M., additional, Peri, N. F., additional, Neuspiller, F., additional, Resta, S., additional, Filannino, A., additional, Maggi, E., additional, Cafueri, G., additional, Ferraretti, A. P., additional, Magli, M. C., additional, Gianaroli, L., additional, Sioga, A., additional, Oikonomou, Z., additional, Chatzimeletiou, K., additional, Oikonomou, L., additional, Kolibianakis, E., additional, Tarlatzis, B. C., additional, Sarkar, M. R., additional, Ray, D., additional, Bhattacharya, J., additional, Alises, J. M., additional, Gumbao, D., additional, Hickman, C. F. L., additional, Fiorentino, I., additional, Gualtieri, R., additional, Barbato, V., additional, Braun, S., additional, Mollo, V., additional, Netti, P., additional, Talevi, R., additional, Bayram, A., additional, Findikli, N., additional, Serdarogullari, M., additional, Sahin, O., additional, Ulug, U., additional, Tosun, S. B., additional, Bahceci, M., additional, Leon, A. S., additional, Cardoso, M. C. A., additional, Aguiar, A. P. S., additional, Sartorio, C., additional, Evangelista, A., additional, Gallo-Sa, P., additional, Erthal-Martins, M. C., additional, Mantikou, E., additional, Jonker, M. J., additional, de Jong, M., additional, Wong, K. M., additional, van Montfoort, A. P. A., additional, Breit, T. M., additional, Repping, S., additional, Mastenbroek, S., additional, Power, E., additional, Jordan, K., additional, Aksoy, T., additional, Gultomruk, M., additional, Aktan, A., additional, Goktas, C., additional, Petracco, R., additional, Okada, L., additional, Azambuja, R., additional, Badalotti, F., additional, Michelon, J., additional, Reig, V., additional, Kvitko, D., additional, Tagliani-Ribeiro, A., additional, Badalotti, M., additional, Petracco, A., additional, Aydin, B., additional, Cepni, I., additional, Rodriguez-Arnedo, D., additional, Ten, J., additional, Guerrero, J., additional, Ochando, I., additional, and Bernabeu, R., additional
- Published
- 2013
- Full Text
- View/download PDF
9. Early pregnancy
- Author
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Zeadna, A., primary, Holzer, H., additional, Son, W. Y., additional, Demirtas, E., additional, Reinblatt, S., additional, Dahan, M. H., additional, Colleselli, V., additional, D'Costa, E., additional, Wildt, L., additional, Seeber, B., additional, Kashevarova, A. A., additional, Skryabin, N. A., additional, Nikitina, T. V., additional, Lebedev, I. N., additional, Bordignon, P. P., additional, Mugione, A., additional, Vanni, V. S., additional, Vigano, P., additional, Papaleo, E., additional, Candiani, M., additional, Somigliana, E., additional, Amodio, G., additional, Gregori, S., additional, Guo, Y. H., additional, Li, R., additional, Wang, L. L., additional, Chen, S. L., additional, Chen, X., additional, Guo, W., additional, Ye, D. S., additional, Liu, Y. D., additional, Renzini, M. M., additional, Dal Canto, M., additional, Coticchio, G., additional, Comi, R., additional, Brigante, C., additional, Caliari, I., additional, Brambillasca, F., additional, Merola, M., additional, Lain, M., additional, Turchi, D., additional, Karagouga, G., additional, Sottocornola, M., additional, Fadini, R., additional, Wekker, M. Z., additional, Mol, F., additional, van Wely, M., additional, Ankum, W. M., additional, Mol, B. W., additional, van der Veen, F., additional, Hajenius, P. J., additional, van Mello, N. M., additional, Verlengia, C., additional, Alviggi, E., additional, Rampini, M. R., additional, Alfano, P., additional, Pergolini, I., additional, Marconi, D., additional, Iacobelli, N., additional, Muzi, M. C., additional, Gelli, G., additional, Alviggi, C., additional, Colicchia, A., additional, Herraiz-Nicuesa, L., additional, Tejera-Alhambra, M., additional, Garcia-Segovia, A., additional, Ramos-Medina, R., additional, Alonso, B., additional, Gil-Pulido, J., additional, Martin, L., additional, Caballero, M., additional, Rodriguez-Mahou, M., additional, Sanchez-Ramon, S., additional, de Jong, P. G., additional, Kaandorp, S. P., additional, Di Nisio, M., additional, Goddijn, M., additional, Middeldorp, S., additional, Lledo, B., additional, Turienzo, A., additional, Ortiz, J. A., additional, Morales, R., additional, Ten, J., additional, Llacer, J., additional, Bernabeu, R., additional, Gil, J., additional, Leon, J. A., additional, Seyfferth, A., additional, Aguaron, A., additional, Alonso, J., additional, de Albornoz, E. C., additional, Carbone, J., additional, Caballero, P., additional, Fernandez-Cruz, E., additional, Ortiz-Quintana, L., additional, Lou, Y. Y., additional, Jin, F., additional, Zheng, Y. M., additional, Li, L. J., additional, Le, F., additional, Wang, L. Y., additional, Liu, S. Y., additional, Pan, P. P., additional, Hu, C. X., additional, Akoum, A., additional, Bourdiec, A., additional, Shao, R., additional, Rao, C. V., additional, Scarpellini, F., additional, Sbracia, M., additional, Jancar, N., additional, Bokal, E. V., additional, Ban-Frangez, H., additional, Drobnic, S., additional, Korosec, S., additional, Pinter, B., additional, Salamun, V., additional, Yamaguchi, M., additional, Honda, R., additional, Uchino, K., additional, Ohba, T., additional, Katabuchi, H., additional, Leylek, O., additional, Tiras, B., additional, Saltik, A. Y. S. E., additional, Halicigil, C., additional, Kavci, N., additional, Wiser, A., additional, Gilbert, A., additional, Nahum, R., additional, Orvieto, R., additional, Hass, J., additional, Hourvitz, A., additional, Weissman, A., additional, Younes, G., additional, Dirnfeld, M., additional, Hershko, A., additional, Shulma, A., additional, Shalom-Paz, E., additional, Tulandi, T., additional, O'Neill, S. M., additional, Agerbo, E., additional, Kenny, L. C., additional, Henriksen, T. B., additional, Kearney, P. M., additional, Greene, R. A., additional, Mortensen, P. B., additional, Khashan, A. S., additional, Talaulikar, V. S., additional, Bax, B. E., additional, Manyonda, I., additional, and Van Mello, N., additional
- Published
- 2013
- Full Text
- View/download PDF
10. SESSION 05: EARLY PREGNANCY
- Author
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Mignini Renzini, M., primary, Dal Canto, M., additional, Coticchio, G., additional, Novara, P., additional, Turchi, D., additional, Lain, M., additional, Guarnieri, T., additional, Brambillasca, F., additional, Fadini, R., additional, Lash, G. E., additional, Innes, B. A., additional, Drury, J. A., additional, Quenby, S., additional, Bulmer, J. N., additional, Goddijn, M., additional, Boogaard van den, E., additional, Scheenjes, E., additional, Kremer, J. A. M., additional, Veen van der, F., additional, Hermens, R. P. M. G., additional, Vansenne, F., additional, De Borgie, C. A. J. M., additional, Snijder, S., additional, Redeker, E. J. W., additional, Van Maarle, M. C., additional, Wouters, C. H., additional, Bruggenwirth, H. T., additional, Van der Veen, F., additional, Bossuyt, P. M. M., additional, Ledger, W., additional, Alsbjerg, B., additional, Tomas, C., additional, Martikainen, H., additional, and Humaidan, P., additional
- Published
- 2012
- Full Text
- View/download PDF
11. Magnetic tweezers measurements of the nanomechanical properties of DNA in the presence of drugs
- Author
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Salerno, D., primary, Brogioli, D., additional, Cassina, V., additional, Turchi, D., additional, Beretta, G. L., additional, Seruggia, D., additional, Ziano, R., additional, Zunino, F., additional, and Mantegazza, F., additional
- Published
- 2010
- Full Text
- View/download PDF
12. Educazione scolastica e motivazione allo studio
- Author
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Baraldi, Claudio and Turchi, D.
- Subjects
disagio ,adolescenti ,motivazione ,comunicazione educativa ,educazione scolastica - Published
- 1990
13. The protective effect of adenosine A2Areceptor antagonism in cerebral ischemia
- Author
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Pedata, F., primary, Gianfriddo, M., additional, Turchi, D., additional, and Melani, A., additional
- Published
- 2005
- Full Text
- View/download PDF
14. Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflow
- Author
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Gianfriddo, M., primary, Melani, A., additional, Turchi, D., additional, Giovannini, M.G., additional, and Pedata, F., additional
- Published
- 2004
- Full Text
- View/download PDF
15. The protective effect of adenosine A2A receptor antagonism in cerebral ischemia.
- Author
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Pedata, F., Gianfriddo, M., Turchi, D., and Melani, A.
- Subjects
ADENOSINES ,RECEPTOR antibodies ,CEREBRAL ischemia ,NEUROLOGY ,AMINO acids ,LATHES - Abstract
Objectives: We reviewed our most recent work on the protective effect of adenosine A
2A antagonism in cerebral ischemia. Methods: Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin. Results: A2A antagonism was found protective in the model of permanent focal ischemia induced by the monofilament technique. This methodology provides the possibility of evaluating the protection against the outflow of excitatory amino acids and against an acute motor disturbance, i.e.contralateral turning to the ischemic side in the first hours after ischemia in awake rats. Hours later, a definite neurological deficit and necrotic neuronal damage can be evaluated. Discussion: Our results suggest that A2A antagonism may be protective from the earliest up to several hours after the ischemic event. [ABSTRACT FROM AUTHOR]- Published
- 2005
- Full Text
- View/download PDF
16. Adenosine and glutamate extracellular concentrations and mitogen-activated protein kinases in the striatum of Huntington transgenic mice. Selective antagonism of adenosine A2A receptors reduces transmitter outflow
- Author
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Gianfriddo, M., Melani, A., Turchi, D., Giovannini, M.G., and Pedata, F.
- Subjects
- *
HUNTINGTON disease , *BRAIN , *GABA , *AMINO acids - Abstract
The basal ganglia and deep layers of cerebral cortex neurodegeneration typically characterize the postmortem brain of Huntington disease (HD) patients. In this study, we employed 10- to 11-week-old transgenic HD mice (R6/2 line), in which the striatal adenosine extracellular levels, measured using the microdialysis technique, are significantly increased in comparison to wild-type mice. An increase in striatal adenosine is probably a precocious index of mitochondrial dysfunction that is described in both the postmortem brain of HD patients and transgenic mice striatal cells. The adenosine increase is matched by activation of the p38 mitogen-activated protein kinase (MAPK) in the striatal neurons of R6/2 mouse but not in the cortex. This result indicates that p38 MAPK is a correlate of striatal damage and suggests a role for p38 in the striatal neuron suffering and apoptosis described in this disease. The selective adenosine A2A receptor antagonist SCH 58261, administered through microdialysis fiber into the striatum, significantly decreases the outflow of glutamate in R6/2 mice. Antagonism of adenosine A2A receptors might be regarded as potentially useful in the treatment of this disease to control striatal excitotoxicity. [Copyright &y& Elsevier]
- Published
- 2004
- Full Text
- View/download PDF
17. Magnetic tweezers measurements of the nanomechanical properties of DNA in the presence of drugs
- Author
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Valeria Cassina, Doriano Brogioli, Diana Turchi, Franco Zunino, Davide Seruggia, Giovanni Luca Beretta, Francesco Mantegazza, Domenico Salerno, Roberto Ziano, Salerno, D, Brogioli, D, Cassina, V, Turchi, D, Beretta, G, Seruggia, D, Ziano, R, Zunino, F, and Mantegazza, F
- Subjects
Magnetic tweezers ,Magnetic ,Intercalation (chemistry) ,Biomechanic ,Ligand ,Biology ,Ligands ,chemistry.chemical_compound ,Magnetics ,Ethidium ,Genetics ,medicine ,Molecule ,Twist ,Molecular Biology ,Antineoplastic Agents, Alkylating ,Cisplatin ,Intercalating Agent ,Netropsin ,DNA ,Intercalating Agents ,Biomechanical Phenomena ,chemistry ,Biochemistry ,Doxorubicin ,Biophysics ,Nucleic Acid Conformation ,Ethidium bromide ,medicine.drug - Abstract
Herein, we study the nanomechanical characteristics of single DNA molecules in the presence of DNA binders, including intercalating agents (ethidium bromide and doxorubicin), a minor groove binder (netropsin) and a typical alkylating damaging agent (cisplatin). We have used magnetic tweezers manipulation techniques, which allow us to measure the contour and persistence lengths together with the bending and torsional properties of DNA. For each drug, the specific variations of the nanomechanical properties induced in the DNA have been compared. We observed that the presence of drugs causes a specific variation in the DNA extension, a shift in the natural twist and a modification of bending dependence on the imposed twist. By introducing a naive model, we have justified an anomalous correlation of torsion data observed in the presence of intercalators. Finally, a data analysis criterion for discriminating between different molecular interactions among DNA and drugs has been suggested.
- Published
- 2010
18. The impact of oocyte central granularity on ICSI practice: developmental competence of dysmorphic and morphologically normal companion oocytes.
- Author
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Buratini J, Moutier C, Guglielmo MC, Turchi D, Webb R, De Ponti E, Renzini MM, and Canto MD
- Subjects
- Pregnancy, Female, Humans, Pregnancy Rate, Retrospective Studies, Oocytes, Follicle Stimulating Hormone pharmacology, Fertilization in Vitro, Sperm Injections, Intracytoplasmic, Ovulation Induction
- Abstract
Purpose: To assess the effects of oocyte central granularity and its underlying endocrine environment on developmental competence of dysmorphic and morphologically normal oocytes., Methods: Retrospective cohort study including 1,082 patients undergoing autologous ICSI cycles. Of these, 211 patients provided 602 oocytes with central granularity (CG) and 427 morphologically normal cycle companion oocytes (NCG). The remaining 871 patients provided only morphologically normal oocytes in cycles not yielding dysmorphic oocytes (N). Patient profile associated with CG was characterized, and fertilization rates, early morphokinetics and live birth rates were compared between N, CG and NCG groups. Patient characteristics associated with implantation and delivery performance of CG-derived embryos were assessed., Results: CG was associated with higher maternal age, basal FSH concentrations and total FSH dose, but with lower circulating AMH (p ≤ 0.035). Fertilization rates were reduced and early morphokinetic parameters were delayed in CG (p < 0.025) and NCG (p < 0.05) groups as compared to the N group. Embryos derived from CG oocytes achieved a markedly lower live birth rate (14.9%) as compared to those derived from NCG (36.8%; p = 0.03) and N oocytes (29.8%; p = 0.002). The negative relationship between CG and live birth was confirmed by a multivariate analysis controlling for potential confounders (OR:2.59, IC:1.27-5.31; P = 0.009). Implantation and delivery rates following transfers of CG-derived embryos were inversely associated with maternal age., Conclusion: CG oocytes, but not their morphologically normal cycle companions, have severely compromised developmental competence. Maternal age should be a key parameter in deciding whether or not to utilize CG oocytes in ICSI cycles., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
- Published
- 2023
- Full Text
- View/download PDF
19. Faster fertilization and cleavage kinetics reflect competence to achieve a live birth after intracytoplasmic sperm injection, but this association fades with maternal age.
- Author
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Dal Canto M, Bartolacci A, Turchi D, Pignataro D, Lain M, De Ponti E, Brigante C, Mignini Renzini M, and Buratini J
- Subjects
- Adult, Cohort Studies, Embryo Transfer methods, Embryo Transfer trends, Female, Fertilization in Vitro methods, Fertilization in Vitro trends, Humans, Pregnancy, Retrospective Studies, Sperm Injections, Intracytoplasmic methods, Cleavage Stage, Ovum physiology, Fertilization physiology, Live Birth epidemiology, Maternal Age, Sperm Injections, Intracytoplasmic trends
- Abstract
Objective: To assess the relationship of early developmental kinetics with competence to provide a live birth and the impact of maternal age in this context., Design: Retrospective cohort study including 4,915 embryos, of which 1,390 were transferred and provided a clinical outcome paired with morphokinetic data; 168 of them resulted in a live birth (LB), and 1,222 did not (NLB). Early morphokinetic parameters were compared between LB and NLB embryos from patients stratified into two age groups (<37 and ≥37 years), and between embryos at the same competence group from patients aged <37 and ≥37 years. The association of morphokinetic parameters with live birth was tested by univariate and multivariate analyses., Setting: Fertility clinic., Patient(s): The study population included 1,066 patients undergoing autologous intracytoplasmic sperm injection cycles with fresh single (SET), double (DET) or triple (TET) embryo transfers on day 2 or 3. Of them, 669 patients produced NLB embryos and 134 produced LB embryos., Intervention(s): None., Main Outcome Measure(s): Fertilization and cleavage morphokinetic parameters and live birth., Result(s): In the total patient population, all morphokinetic parameters were achieved earlier in LB compared with NLB embryos. The same was observed in patients aged <37 years (P<.015), but not ≥37 years. Except for the t8 (time at which an 8-blastomere embryo was identified), all morphokinetic parameters were reached earlier in LB embryos from patients aged <37 years compared with LB embryos from patients aged ≥37 years. Univariate analysis revealed that earlier occurrence of all morphokinetic parameters was associated with live birth, although only earlier t2 (time at which two separate and distinct cells were identified) was associated with live birth independently from maternal age in the multivariate analysis., Conclusion(s): Despite its retrospective nature and performance in a single IVF center, this study presents novel data indicating that embryos competent to provide a live birth display overall faster early developmental kinetics compared with embryos that do not achieve a live birth after transfer, a difference that, however, narrows as maternal age advances. The findings suggest that fertilization and cleavage morphokinetic parameters may constitute valuable references for embryo selection strategies aiming to improve live birth rates, specifically before advanced maternal age while holding limited usefulness in advanced maternal age., (Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2021
- Full Text
- View/download PDF
20. Face Recognition, Musical Appraisal, and Emotional Crossmodal Bias.
- Author
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Invitto S, Calcagnì A, Mignozzi A, Scardino R, Piraino G, Turchi D, De Feudis I, Brunetti A, Bevilacqua V, and de Tommaso M
- Abstract
Recent research on the crossmodal integration of visual and auditory perception suggests that evaluations of emotional information in one sensory modality may tend toward the emotional value generated in another sensory modality. This implies that the emotions elicited by musical stimuli can influence the perception of emotional stimuli presented in other sensory modalities, through a top-down process. The aim of this work was to investigate how crossmodal perceptual processing influences emotional face recognition and how potential modulation of this processing induced by music could be influenced by the subject's musical competence. We investigated how emotional face recognition processing could be modulated by listening to music and how this modulation varies according to the subjective emotional salience of the music and the listener's musical competence. The sample consisted of 24 participants: 12 professional musicians and 12 university students (non-musicians). Participants performed an emotional go/no-go task whilst listening to music by Albeniz, Chopin, or Mozart. The target stimuli were emotionally neutral facial expressions. We examined the N170 Event-Related Potential (ERP) and behavioral responses (i.e., motor reaction time to target recognition and musical emotional judgment). A linear mixed-effects model and a decision-tree learning technique were applied to N170 amplitudes and latencies. The main findings of the study were that musicians' behavioral responses and N170 is more affected by the emotional value of music administered in the emotional go/no-go task and this bias is also apparent in responses to the non-target emotional face. This suggests that emotional information, coming from multiple sensory channels, activates a crossmodal integration process that depends upon the stimuli emotional salience and the listener's appraisal.
- Published
- 2017
- Full Text
- View/download PDF
21. Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization.
- Author
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Coticchio G, Dal Canto M, Mignini Renzini M, Guglielmo MC, Brambillasca F, Turchi D, Novara PV, and Fadini R
- Subjects
- Actin Cytoskeleton, Animals, Chromatin genetics, Cumulus Cells cytology, Cumulus Cells physiology, Cytoplasm physiology, Drosophila, Humans, Mice, Microtubules, Ovulation physiology, Rats, Reproductive Techniques, Assisted, Spindle Apparatus physiology, Blastocyst physiology, Meiosis genetics, Oocytes physiology, Oogenesis physiology, Sperm-Ovum Interactions
- Abstract
Background: In a growth phase occurring during most of folliculogenesis, the oocyte produces and accumulates molecules and organelles that are fundamental for the development of the preimplantation embryo. At ovulation, growth is followed by a phase of maturation that, although confined within a short temporal window, encompasses modifications of the oocyte chromosome complement and rearrangements of cytoplasmic components that are crucial for the achievement of developmental competence. Cumulus cells (CCs) are central to the process of maturation, providing the oocyte with metabolic support and regulatory cues., Methods: PubMed was used to search the MEDLINE database for peer-reviewed original articles and reviews concerning oocyte maturation in mammals. Searches were performed adopting 'oocyte' and 'maturation' as main terms, in association with other keywords expressing concepts relevant to the subject. The most relevant publications, i.e. those concerning major phenomena occurring during oocyte maturation in established experimental models and the human species, were assessed and discussed critically to offer a comprehensive description of the process of oocyte maturation., Results: By applying the above described search criteria, 6165 publications were identified, of which 543 were review articles. The number of publications increased steadily from 1974 (n = 7) to 2013 (n = 293). In 2014, from January to the time of submission of this manuscript, 140 original manuscripts and reviews were published. The studies selected for this review extend previous knowledge and shed new and astounding knowledge on oocyte maturation. It has long been known that resumption of meiosis and progression to the metaphase II stage is intrinsic to oocyte maturation, but novel findings have revealed that specific chromatin configurations are indicative of a propensity of the oocyte to resume the meiotic process and acquire developmental competence. Recently, genetic integrity has also been characterized as a factor with important implications for oocyte maturation and quality. Changes occurring in the cytoplasmic compartment are equally fundamental. Microtubules, actin filaments and chromatin not only interact to finalize chromosome segregation, but also crucially co-operate to establish cell asymmetry. This allows polar body extrusion to be accomplished with minimal loss of cytoplasm. The cytoskeleton also orchestrates the rearrangement of organelles in preparation for fertilization. For example, during maturation the distribution of the endoplasmic reticulum undergoes major modifications guided by microtubules and microfilaments to make the oocyte more competent in the generation of intracellular Ca(2+) oscillations that are pivotal for triggering egg activation. Cumulus cells are inherent to the process of oocyte maturation, emitting regulatory signals via direct cell-to-cell contacts and paracrine factors. In addition to nurturing the oocyte with key metabolites, CCs regulate meiotic resumption and modulate the function of the oocyte cytoskeleton., Conclusions: Although the importance of oocyte maturation for the achievement of female meiosis has long been recognized, until recently much less was known of the significance of this process in relation to other fundamental developmental events. Studies on chromatin dynamics and integrity have extended our understanding of female meiosis. Concomitantly, cytoskeletal and organelle changes and the ancillary role of CCs have been better appreciated. This is expected to inspire novel concepts and advances in assisted reproduction technologies, such as the development of novel in vitro maturation systems and the identification of biomarkers of oocyte quality., (© The Author 2015. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2015
- Full Text
- View/download PDF
22. ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia.
- Author
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Melani A, Turchi D, Vannucchi MG, Cipriani S, Gianfriddo M, and Pedata F
- Subjects
- 5'-Nucleotidase antagonists & inhibitors, 5'-Nucleotidase metabolism, Adenosine metabolism, Animals, Brain Infarction etiology, Brain Infarction metabolism, Brain Infarction physiopathology, Brain Ischemia physiopathology, Corpus Striatum physiopathology, Disease Models, Animal, Enzyme Inhibitors pharmacology, Infarction, Middle Cerebral Artery metabolism, Infarction, Middle Cerebral Artery physiopathology, Male, Microdialysis, Movement Disorders etiology, Movement Disorders metabolism, Movement Disorders physiopathology, Rats, Rats, Wistar, Receptors, Purinergic P2 metabolism, Up-Regulation drug effects, Adenosine Triphosphate metabolism, Brain Ischemia metabolism, Corpus Striatum metabolism, Extracellular Fluid metabolism, Up-Regulation physiology
- Abstract
Interest is growing in the role of adenosine triphosphate (ATP) on P2 receptors during hypoxic/ischemic events in the brain. However, there is no direct evidence of an increase in extracellular ATP levels during cerebral ischemia in vivo. The aim of the present study was to evaluate ATP outflow from the rat striatum by the microdialysis technique associated with focal cerebral ischemia in vivo by intraluminal occlusion of the right middle cerebral artery (MCA). Between 1 and 4h after ischemia, rats showed a clear turning behavior contralateral to the ischemic side. Twenty-four hour after MCA occlusion, ischemic rats had definite neurological deficit and striatal and cortical damage. The ATP concentration (mean+/-S.E.M.) in the striatum of normoxic rats (n = 8) was 3.10+/-0.34 nM. During 220 min after MCA occlusion, the extracellular ATP levels significantly increased two-fold, being 5.90+/-0.61 nM (p < 0.01 versus normoxic level). ATP outflow showed a tendency to increase over time during the 220 min of ischemia. Since extracellular ATP is rapidly metabolized to adenosine, we also assessed ATP outflow in the presence of the ecto-5'-nucleotidase inhibitor, alpha,beta-methylene-adenosine diphosphate (AOPCP, 1 mM) directly perfused into the striatum. The ATP concentration in normoxic rats (n = 8) was increased three-fold in the presence of the ecto-5'-nucleotidase inhibitor (9.57+/-0.26 nM). During 220 min of ischemia, extracellular ATP levels significantly increased 1.3-fold in AOPCP-treated rats (12.62+/-0.65 nM, p < 0.01 versus normoxic level). The present study confirms that ATP is continuously released in the brain and demonstrates for the first time that ATP outflow increases during ischemia in vivo. These results confirm that ATP may be an important mediator in brain ischemia.
- Published
- 2005
- Full Text
- View/download PDF
23. The protective effect of adenosine A2A receptor antagonism in cerebral ischemia.
- Author
-
Pedata F, Gianfriddo M, Turchi D, and Melani A
- Subjects
- Animals, Aspartic Acid metabolism, Brain Ischemia complications, Disease Models, Animal, Glutamic Acid metabolism, Hypoxia, Brain etiology, Hypoxia, Brain pathology, Receptor, Adenosine A2A physiology, Time Factors, Adenosine A2 Receptor Antagonists, Brain Ischemia prevention & control, Hypoxia, Brain prevention & control, Neuroprotective Agents therapeutic use
- Abstract
Objectives: We reviewed our most recent work on the protective effect of adenosine A(2A)antagonism in cerebral ischemia., Methods: Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin., Results: A(2A) antagonism was found protective in the model of permanent focal ischemia induced by the monofilament technique. This methodology provides the possibility of evaluating the protection against the outflow of excitatory amino acids and against an acute motor disturbance, i.e.contralateral turning to the ischemic side in the first hours after ischemia in awake rats. Hours later, a definite neurological deficit and necrotic neuronal damage can be evaluated., Discussion: Our results suggest that A(2A) antagonism may be protective from the earliest up to several hours after the ischemic event.
- Published
- 2005
- Full Text
- View/download PDF
24. [Hygienic-sanitary protection of waters: national and regional standards].
- Author
-
Alberani V, Petrelli G, Portoghesi F, Siepi G, and Turchi D
- Subjects
- Italy, Legislation as Topic, Public Health, Water Pollution prevention & control, Water Supply standards
- Published
- 1982
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