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4. Prevalence and bleeding risk associated with the concomitant use of direct oral anticoagulants and antiarrhythmic drugs in patients with atrial fibrillation, based on the French healthcare insurance database

Author

Gosselin, L., Vilcu, A. M., Souty, C., Olivier Steichen, Launay, T., Conte, C., Saint-Salvi, B., Turbelin, C., Sarazin, M., Blanchon, T., Hanslik, T., Lapeyre-Mestre, M., and Rossignol, L.

Subjects
Pharmacology, Pharmacology (medical), General Medicine
Published
2023
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15. Estimation of seasonal influenza vaccine effectiveness using data collected in primary care in France: comparison of the test-negative design and the screening method

Author

Vilcu, A.M., primary, Souty, C., additional, Enouf, V., additional, Capai, L., additional, Turbelin, C., additional, Masse, S., additional, Behillil, S., additional, Valette, M., additional, Guerrisi, C., additional, Rossignol, L., additional, Blanchon, T., additional, Lina, B., additional, Hanslik, T., additional, and Falchi, A., additional

Published
2018
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16. The potential risks and impact of the start of the 2015-2016 influenza season in the WHO European Region: a rapid risk assessment

Author

Tjon‐Kon‐Fat, Raïssa, Meerhoff, Tamara, Nikisins, Sergejs, Pires, João, Pereyaslov, Dmitriy, Gross, Diane, Brown, Caroline, Drishti, A., Hasibra, I., Kota, M., Simaku, A., Sarkisian, S., Torosyan, L., El Belazi, G., Hain, C., Lachner, P., Muchl, R., Popow‐Kraupp, T., Redlberger‐Fritz, M., Strauss, R., Abdullayeva, N., Salimov, O., Gribkova, N., Shimanovich, V., Bossuyt, N., Hombrouck, A., Moreels, S., Thomas, I., an Casteren, ., Bastinac, D., Dedejic Ljubovic, A., Kojic, D., Kovacevic Suljkanovic, M., Kuzmanovic, M., Vukmir Rodic, N., Georgieva, T., Kojouharova, M., Korsun, N., Drazenovic, V., Erceg, M., Kurecic‐Filipovic, S., Simunovic, A., Visekruna, V.V., Bagatzouni, D., Elia, A., Koliou, M., Havlickova, M., Jirincova, H., Kyncl, J., Bragstad, K., Kolsen Fischer, T., Krause, K.L., Mazick, A., Trebbien, R., Dontsenko, I., Dotsenko, L., Pokras, L., Sadikova, O., Ikonen, N., Lyytikainen, O., Murtopuro, S., Ruutu, P., Behillil, S., Belchior, E., Blanchon, T., Bonmarin, I., Bruno, L., Cohen, J.M., Enouf, V., Levy, B.D., Mosnier, A., Turbelin, C., Valette, M., an der Werf, ., Chakhunashvili, G., Machablishvili, A., Zakhashvili, K., Andreas, G., Buda, S., Eckmanns, T., Krause, G., Poggensee, G., Schweiger, B., Kossivakis, A., Malisiovas, N., Mentis, A., Spala, G., Csohan, A., Jankovics, I., Kaszas, K., Molnar, Z., Rozsa, M., Gudnason, T., Löve, A., Sigmundsdottir, G., Coughlan, S., Domegan, L., Duffy, M., Igoe, D., O'Donnell, J., O'Flanagan, D., Waters, A., Kaufman, Z., Mandelboim, M., Bella, A., Donatelli, I., Pompa, M.G., Rizzo, C., Amandosova, D., Kuatbaeva, A., Nusupbaeva, G., Smagulova, M., Smagul, M., Sultanova, M., Otorbaeva, D., Saparova, G., Butirina, R., Nikiforova, R., Storozenko, J., Zamjatina, N., Griskevicius, A., Lipnickiene, V., Muralyte, S., Mossong, J., Opp, M., Barbara, C., Graziella, Z., Maistre, M.J., Melillo, T., Rakocevic, B., Vratnica, Z., Hooiveld, I., de Lange, M., Dijkstra, F., Donker, G., Meijer, A., Rimmelzwaan, G., Teirlinck, A., van der Hoek, W., Dudman, S., Hauge, S.H., Hungnes, O., Kilander, A., Tonnessen, R., Bednarska, K., Brydak, L., Wozniak‐Kosek, A., Zielinski, A., Guiomar, R., Nunes, B., Eder, V., Spinu, C., Alexandrescu, V., Lupulescu, E., Popovici, F., Burtseva, E., Komissarov, A., Smorodintseva, E., Sominina, A., Dimitrijevic, D., Filipovic, S., Staronova, E., Berginc, N., Prosenc, K., Socan, M., Ucakar, V., Grgic Vitek, M., Casas, I., de Lejarazu, R. Ortiz, Larrauri, A., Pozo, F., Vega, T., Ali, M., Brytting, M., Dahl, H., Englund, H., Tegnell, A., Wallensten, A., Wiman, A., Born, R., Cordey, S., Kamolov, M., Bosevska, G., Karadzovski, Z., Kuzmanovska, G., Mikik, V., Korukluoglu, G., Topal, S., Ashyrova, A., Ovliyakulova, G., Demchyshyna, I., Dykhanovska, T., Mironenko, A., Blatchford, O., Carman, W., Coyle, P., Gunson, R., Kearns, C., MacLean, A., Mcmenamin, J., Moore, C., Nugent, C., Pebody, R., Phin, N., Reynolds, A., Smyth, B., Watson, J., Zambon, M., Dzemileva, S., and Rakhimov, R.

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Epidemiology, Influenza season, Influenza A(H1N1)pdm09 virus, influenza A(H1N1)pdm09 virus, Seasonal influenza, 03 medical and health sciences, Environmental protection, Virology, Environmental health, Estado de Saúde, 2015–2016 Influenza season, Public Health, Environmental and Occupational Health, virus diseases, 1103 Clinical Sciences, European region, 030112 virology, Europe, 030104 developmental biology, Infectious Diseases, Geography, 1117 Public Health And Health Services, 2015-2016 Influenza season, Original Article, seasonal influenza, Determinantes da Saúde e da Doença, WHO European Region, Risk assessment
Abstract

WHO European Region Influenza Network: P.Conde, I. Costa, P. Crostovão, R. Guiomar, B. Nunes, P.Pechirra, A. Rodrigues (Portugal) BACKGROUND: Countries in the World Health Organization (WHO) European Region are reporting more severe influenza activity in the 2015-2016 season compared to previous seasons. OBJECTIVES: To conduct a rapid risk assessment to provide interim information on the severity of the current influenza season METHODS: Using the WHO manual for rapid risk assessment of acute public health events and surveillance data available from Flu News Europe, an assessment of the current influenza season from 28 September 2015 (week 40/2015) up to 31 January 2016 (week 04/2016) was made compared with the 4 previous seasons. RESULTS: The current influenza season started around week 51/2015 with higher influenza activity reported in eastern Europe compared to Western Europe. There is a strong predominance of influenza A(H1N1)pdm09 compared to previous seasons, but the virus is antigenically similar to the strain included in the seasonal influenza vaccine. Compared to the 2014/2015 season, there was a rapid increase in the number of severe cases in eastern European countries with the majority of such cases occurring among adults aged

Published
2016

21. Pertussis incidence among adolescents and adults surveyed in general practices in the Paris area, France, May 2008 to March 2009

Author

Lasserre A, Laurent E, Turbelin C, Hanslik T, Thierry BLANCHON, and Guiso N

Subjects
Adult, Aged, 80 and over, Male, Adolescent, Whooping Cough, Incidence, Enzyme-Linked Immunosorbent Assay, Pilot Projects, Middle Aged, Polymerase Chain Reaction, Bordetella pertussis, Young Adult, Age Distribution, Pertussis Toxin, General Practitioners, Immunoglobulin G, Humans, Female, France, Sex Distribution, Sentinel Surveillance, Aged
Abstract

Since the introduction in 1998 of an adolescent pertussis vaccine booster (for persons aged 11-13 years) in France, the incidence of pertussis in adolescents and adults has been unknown. We therefore undertook a study to estimate the incidence of pertussis in these population groups and to evaluate the feasibility of a real-time electronic surveillance system for pertussis in general practices in France. The general practitioners selected for the study were located in Paris and the surrounding area. Polymerase chain reaction (PCR) or measurement of anti-pertussis toxin IgG levels by enzyme-linked immunosorbent assay (ELISA) was used to confirm the infection. Among the 204 patients enrolled in the study, 46 (23%) were diagnosed as having pertussis: 21 were confirmed cases, 24 were clinical cases and one was an epidemiological case. The median age of the 204 patients was 44 years and 134 (66%) were female. The median duration of the patients' cough at enrolment was 24 days. No clinical difference was observed between those with and without a pertussis diagnosis. The incidence of pertussis was estimated to be 145 (95% confidence interval: 121-168) per 100,000 population based on the results from the 10-month study period (calculated for 12 months). Problems in sample collection were identified: pertussis sentinel surveillance cannot be developed without training the staff of medical laboratories who take the biological samples. French health authorities were alerted and training procedures were developed.

Published
2011

22. Using multivariate changepoint and analogues methods in influenza-like illness surveillance related to drug sales data

Author

Vergu, Elisabeta, Chandra, W., Nembhard, H.B., Lambert, B., Turbelin, C., Flahault, A., Unité de biométrie et intelligence artificielle de jouy, Institut National de la Recherche Agronomique (INRA), Pennsylvania State University (Penn State), Penn State System, University of Pennsylvania, International Metal Service of Health (IMS Health), Institut National de la Santé et de la Recherche Médicale (INSERM), and École des Hautes Études en Santé Publique [EHESP] (EHESP)

Subjects
[INFO]Computer Science [cs], [MATH]Mathematics [math], predictive methods, ComputingMilieux_MISCELLANEOUS, statistical inference
Abstract

National audience

Published
2008

23. An analogues-changepoint methodology for influenza-like-illeness and drug sales surveillance

Author

Nembhard, H.B., Vergu, Elisabeta, Lambert, B., Turbelin, C., Chandra, Wenny, Flahault, A., Pennsylvania State University (Penn State), Penn State System, Unité de biométrie et intelligence artificielle de jouy, Institut National de la Recherche Agronomique (INRA), International Metal Service of Health (IMS Health), Institut National de la Santé et de la Recherche Médicale (INSERM), and École des Hautes Études en Santé Publique [EHESP] (EHESP)

Subjects
changepoint, [INFO]Computer Science [cs], [MATH]Mathematics [math], influenza-like-illness, analogues, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

24. Épidémie hivernale de gastro-entérites aiguës en France, 2006-2007

Author

Jourdan-Da Silva , N., Delmas , G., Balay , K., Poujol , I., Josseran , L., Blanchon , T., Turbelin , C., Pothier , P., Vaillant , V., Laboratoire Interactions Muqueuses Agents Transmissibles ( LIMA ), Université de Bourgogne ( UB ), Laboratoire de sérologie-virologie (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), and Humbert, Murielle

Subjects
[SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

30. Influence of environmental factors on disease activity in spondyloarthritis: A prospective cohort study

Author

Zeboulon-Ktorza, N., Boelle, P. Y., Said Nahal, R., D'Agostino, Maria Antonietta, Vibert, J. F., Turbelin, C., Madrakian, H., Durand, E., Launay, O., Mahr, A., Flahault, A., Breban, M., Hanslik, T., D'Agostino M. A. (ORCID:0000-0002-5347-0060), Zeboulon-Ktorza, N., Boelle, P. Y., Said Nahal, R., D'Agostino, Maria Antonietta, Vibert, J. F., Turbelin, C., Madrakian, H., Durand, E., Launay, O., Mahr, A., Flahault, A., Breban, M., Hanslik, T., and D'Agostino M. A. (ORCID:0000-0002-5347-0060)

Abstract

Objective. Spondyloarthritis (SpA) is a complex inflammatory disorder. We investigated the influence of environmental factors on SpA disease activity. Methods. A prospective cohort of adults with SpA was followed for 3 years. Patients logged on to a secured Website every 3 months to complete a questionnaire. They reported whether they had been exposed to environmental factors such as stressful or traumatic life events, infections, or vaccinations. Outcome variables included the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), and pain and patient global assessment (PGA) on visual numerical scales (each rated 0-10). Analyses were performed using a generalized estimating equation for repeated measures, adjusted for the outcome variable collected by the previous questionnaire. Results. In total, 272 patients were included in the analysis, completing the questionnaire on 2240 occasions. The average time (mean ± SD) between 2 connections to the Website was 4.0 ± 2.0 months. Occurrence of life events was followed by an increase of 0.5 (95% CI 0.4-0.7) in the BASDAI, 0.5 (95% CI 0.3-0.6) in the BASFI, 0.7 (95% CI 0.5-0.9) in the PGA, and 0.8 (95% CI 0.6-1.0) for pain (p < 0.0001 for all variations). A moderately statistically significant link was found between vaccination and an elevation of the BASDAI of 0.3 (95% CI 0.0-0.5; p = 0.032). No influence of other factors was detected. Conclusion. This prospective study in a dedicated SpA cohort shows for the first time a link between stressful events and disease activity. Although this link was statistically highly significant, its clinical meaning remains to be determined because the average magnitude of variation of the different variables studied was rather mild. The Journal of Rheumatology Copyright © 2013. All rights reserved.

Published
2013

44. Dementia management in France: health care and support services in the community.

Author

Cantegreil-Kallen I, Turbelin C, Angel P, Flahault A, and Rigaud A

Abstract

In France, a wide range of care and support services exist for community dwelling people with Alzheimer's disease (AD). These are coordinated by the general practitioner (GP). We investigated interventions that were 'prescribed' by French GPs and analysed their perceived barriers to arranging these. Thirty-nine percent of GPs responded to a postal survey, which was sent to 1105 physicians belonging to the Sentinel GP Research Network and to 524 GPs consulting in the Rhône-Alpes region of France. Fifty percent of patients were treated with acetyl-cholinesterase inhibitors and the following other support services were used: home help (63%), nursing care (48%) and physiotherapy (35%). Although GPs acknowledged carers' need for emotional support, only minimal levels of other interventions such as day care (12%) and psychotherapeutic interventions (12%) were prescribed. Reasons for under-use included non-availability and carers' reluctance to undergo psychotherapy. Lack of integrated community care services, insufficient information on services, lack of collaboration between health professionals and the frequent absence of a reliable carer were considered the most important barriers to the effective support of people with dementia in primary health care settings. [ABSTRACT FROM AUTHOR]

Published
2006
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45. Disclosure of diagnosis of Alzheimer's disease in French general practice.

Author

Cantegreil-Kallen I, Turbelin C, Olaya E, Blanchon T, Moulin F, Rigaud A, and Flahault A

Abstract

Most practitioners find disclosing the diagnosis of Alzheimer s disease (AD) to an individual with dementia very difficult. Literature results show a wide variability in attitudes and clinicalpractice, and diagnosis seems to be more often disclosed to caregivers than to patients. The objective of this study was to examine whether and how diagnosis of AD is disclosed in French general practice and which issues are addressed with the patient. A questionnaire was sent via mail to 1,629 general practitioners (GPs), 1,105 belonging to the Sentinel's network and 524 specially recruited doctors practicing in the Rhone-Alpes region. A total of 631 questionnaires were returned (response rate, 39 percent), of which 616 were eligible for analysis. Twenty-eight percent of GPs reported having disclosed diagnosis to the patient (25 percent mentioned 'Alzheimer's disease'), whereas 88 percent considered it their role to announce the diagnosis to the patient. Regarding the type of information provided to the patient, only 25 percent discussed the nature of the illness, 23 percent behavioral problems, and 47 percent depression, mainly for psychological reasons (63 percent). Stress was discussed with 79 percent of the caregivers. We concluded that GPs do not discuss the consquences of AD and symptoms (e.g., behavioral disorders) with patients, mainly for psychological reasons, whereas they have a less-reluctant attitude toward caregivers. As the GP has the weighty task of providing ropriate community care and psychological support to the patient, it is of utmost importance to reflect on how disclosure of diagnosis can be facilitated. [ABSTRACT FROM AUTHOR]

Published
2005
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46. Start of the 2014/15 influenza season in Europe: Drifted influenza A(H3N2) viruses circulate as dominant subtype

Author

Broberg, E., Snacken, R., Adlhoch, C., Beauté, J., Galinska, M., Pereyaslov, D., Brown, C., Penttinen, P., Kota, M., Simaku, A., Sarkisian, S., Torosyan, L., Popow-Kraupp, T., Rendi-Wagner, P., Schmid, D., Abdullayeva, N., Salimov, O., Gribkova, N., Shimanovich, V., Thomas, I., Hombrouck, A., Bossuyt, N., Moreels, S., Casteren, V., Ljubovic, A. D., Rodic, N. V., Korsun, N., Kojouharova, M., Georgieva, T., Drazenovic, V., Bagatzouni, D., Koliou, M., Havlickova, M., Jiřincová, H., Kyncl, J., Knudsen, L. K., Mazick, A., Ramona Trebbien, Fischer, T. K., Lilje, L., Pokras, L., Kuznetsova, N., Sadikova, O., Ikonen, N., Lyytikäinen, O., Murtopuro, S., Enouf, V., Lina, B., Valette, M., Werf, S., Bonmarin, I., Sylvie, B., Thierry, B., Turbelin, C., Belchior, E., Machablishvili, A., Zakhashvili, K., Buda, S., Schweiger, B., Kossivakis, A., Georgia, S., Mentis, A., Malisiovas, N., Csohán, Á, Rózsa, M., Jankovics, I., Molnár, Z., Löve, A., Sigmundsdóttir, G., Gudnason, T., Domegan, L., O’flanagan, D., Igoe, D., Waters, A., Duffy, M., Coughlan, S., O Donnell, J., Kaufman, Z., Mandelboim, M., Donatelli, I., Bella, A., Rizzo, C., Pompa, M. G., Puzelli, S., Castrucci, M. R., Katrenova, A., Nusupbaeva, G., Kasymbekova, K., Otorbaeva, D., Nikiforova, R., Zamjatina, N., Erne, S., Griškevicius, A., Lipnickiene, V., Mossong, J., Opp, M., Barbara, C., Melillo, T., Melillo, J. M., Zahra, G., Rakocevic, B., Vratnica, Z., Meijer, A., Teirlinck, A., Dijkstra, F., Donker, G., Rimmelzwaan, G., Lange, M. D., Hungnes, O., Bragstad, K., Hauge, S. H., Tønnessen, R., Dudman, S. G., Bednarska, K., Brydak, L. B., Zielinski, A., Guiomar, R., Pechirra, P., Cristovão, P., Costa, I., Nunes, B., Rodrigues, A., Eder, V., Spinu, C., Alexandrescu, V., Lupulescu, E., Popovici, F., Burtseva, E., Sominina, A., Dimitrijevic, D., Adrovic, S. R., Staronová, E., Mikas, J., Prosenc, K., Berginc, N., Socan, M., Casas, I., Larrauri, A., Pozo, F., Lejarazu, R. O., Pumarola, T., Brytting, M., Englund, H., Wiman, Å, Mahmud, N. N., Born, R., Cordey, S., Tishkova, F., Kamolov, M., Bosevska, G., Kuzmanovska, G., Topal, S., Korukluoglu, G., Ashirova, A., Ovliyakulova, G., Demchyshyna, I., Dykhanovska, T., Mironenko, A., Coyle, P., Maclean, A., Gunson, R., Green, H., Kearns, C., Zambon, M., Nugent, C., Moore, C., Phin, N., Pebody, R., Cottrell, S., Mcmenamin, J., Jessop, L., Dzemileva, S., Rakhimov, R., Mccauley, J., and Daniels, R.

49. Dexamethasone in community-acquired pneumonia.

Author

Bharti, Bhavneet, Bharti, Sahul, Lee, NeIson, Hui, David S. C., Joseph, Leon, Goldberg, Shmuel, Picard, Elie, Meybeck, A., Turbelin, C., Delannoy, P. Y., Olive, O., Alfandari, S., Meijvis, S. C. A., Rikers, G. T., Grutters, J. C., Bos, W. J. W., Biesma, D. H., Rottier, Bart, Grasmeijer, Floris, and Hagedoorn, Paul

Subjects
*LETTERS to the editor, *DEXAMETHASONE, *CLINICAL drug trials, *DRUG efficacy, *PNEUMONIA treatment
Abstract

Several letters to the editor in response to an article by Sabine Meijvis, G. T. Rijkers, and J. C. Grutters in the June 11, 2011 issue on the significant role played by dexamethasone in treating community-acquired pneumonia and a response by the aforementioned authors to the letters to the editor are presented.

Published
2011
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50. Short-term effects of airborne pollens on asthma attacks as seen by general practitioners in the Greater Paris area, 2003-2007

Author

Clément Turbelin, Séverine Tual, Lorenzo Cecchi, Thierry Blanchon, Bich-Tram Huynh, Gennaro D'Amato, Isabella Annesi-Maesano, Camille Pelat, Polytech'Paris-UPMC, Université Pierre et Marie Curie - Paris 6 (UPMC), Epidémiologie des maladies infectieuses et modélisation (ESIM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Huynh BT, Tual S, Turbelin C, Pelat C, Cecchi L, D'Amato G, Blanchon T, Annesi-Maesano I., and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Male, Pediatrics, MESH: Asthma, 010504 meteorology & atmospheric sciences, General Practice, medicine.disease_cause, 01 natural sciences, 0302 clinical medicine, MESH: General Practice, MESH: Child, Poisson Distribution, MESH: Weather, Child, Betula, Original Research, MESH: Fraxinus, MESH: Risk, MESH: Paris, food and beverages, Fraxinus, MESH: Young Adult, Child, Preschool, General practice, Pollen, Female, Seasons, Adult, Risk, Pulmonary and Respiratory Medicine, Paris, MESH: Air Pollution, medicine.medical_specialty, MESH: Allergens, Adolescent, Poaceae, MESH: Poisson Distribution, MESH: Betula, Young Adult, 03 medical and health sciences, MESH: Poaceae, Air Pollution, otorhinolaryngologic diseases, medicine, Humans, MESH: Cupressaceae, Weather, 0105 earth and related environmental sciences, Asthma, MESH: Adolescent, MESH: Humans, Pollen season, business.industry, MESH: Child, Preschool, Public Health, Environmental and Occupational Health, Cupressaceae, MESH: Adult, Allergens, medicine.disease, MESH: Male, 030228 respiratory system, Relative risk, MESH: Pollen, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, MESH: Seasons, MESH: Female, Demography
Abstract

International audience; AIMS: To investigate for the first time the short-term effects of airborne pollen counts on general practitioner (GP) consultations for asthma attacks in the Greater Paris area between 2003-2007. METHODS: Counts were available for common pollens (Betula, Cupressa, Fraxinus and Poaceae). Weekly data on GP visits for asthma attacks were obtained from the French GP Sentinel Network. A quasi-Poisson regression with generalised additive models was implemented. Short-term effects of pollen counts were assessed using single and multi-pollen models after adjustment for air pollution and influenza. RESULTS: A mean weekly incidence rate of 25.4 cases of asthma attacks per 100,000 inhabitants was estimated during the study period. The strongest significant association between asthma attacks and pollen counts was registered for grass (Poaceae) in the same week of asthma attacks, with a slight reduction of the effect observed in the multi-pollen model. Adjusted relative risk for Poaceae was 1.54 (95% CI: 1.33-1.79) with an inter-quartile range increase of 17.6 grains/m3 during the pollen season. CONCLUSIONS: For the first time, a significant short-term association was observed between Poaceae pollen counts and consultations for asthma attacks as seen by GPs. These findings need to be confirmed by more consistent time-series and investigations on a daily basis.

Published
2010
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