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2. Evaluating Hepatotoxicity: A Comparative Analysis of New Generation versus Historical Antiretroviral Agents.

Author

Abu-Awwad, Simona-Alina, Abu-Awwad, Ahmed, Suba, Madalina-Ianca, Lazureanu, Voichita Elena, Bolovan, Andrei-Daniel, Rosca, Ovidiu, Turaiche, Mirela-Mădălina, Benea, Adela-Teodora, and Hogea, Bogdan

Subjects
ANTIRETROVIRAL agents, HEPATOTOXICOLOGY, LIVER function tests, PATIENT compliance, COMPARATIVE studies, AIDS serodiagnosis, IMMUNE reconstitution inflammatory syndrome
Abstract

(1) Background: Since the advent of zidovudine in 1987, antiretroviral therapy has undergone significant evolution, marked by the introduction of 34 antiretroviral drugs and 24 fixed-dose combinations. Despite these advances, hepatotoxicity remains a formidable challenge, influencing morbidity, mortality, and treatment adherence in HIV-infected patients. This study aims to compare the hepatotoxic effects of latest-generation antiretroviral medications with those of older-generation therapies, assessing their long-term impact on liver health in HIV patients. (2) Methods: This retrospective study analyzed data from 304 HIV patients treated with either latest-generation or older-generation antiretroviral drugs over four years. Patients were monitored for hepatotoxicity through liver function tests at diagnosis, six months, and one-year post-treatment initiation. (3) Results: Initial and six-month liver function tests showed no significant differences between the two groups. However, at one-year post-treatment, patients on latest-generation antiretrovirals exhibited significant improvements in ALT, AST, and ALP levels, suggesting a better safety profile regarding hepatotoxicity. Additionally, a significantly lower incidence of splenomegaly was observed in patients treated with newer medications. (4) Conclusions: The findings suggest that the latest-generation antiretroviral medications may offer a safer profile in terms of hepatotoxicity compared to older therapies, with potential benefits for long-term liver health. This study underscores the importance of continuous monitoring and further research to optimize ART strategies, ensuring improved patient outcomes and quality of life for individuals living with HIV. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Assessment of Gastrointestinal Adverse Effects during the First Six Months of “Biktarvy” Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period

Author

Suba, Madalina-Ianca, primary, Abu-Awwad, Simona-Alina, additional, Rosca, Ovidiu, additional, Turaiche, Mirela-Mădălina, additional, Hogea, Bogdan, additional, Abu-Awwad, Ahmed, additional, Nitu, Razvan, additional, and Lazureanu, Voichita Elena, additional

Published
2023
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4. Assessment of Gastrointestinal Adverse Effects during the First Six Months of "Biktarvy" Antiretroviral Therapy: Age-Related Patterns and Their Relation with Changes of 5 kg Weight Loss/Gain in the Initial Treatment Period.

Author

Suba, Madalina-Ianca, Abu-Awwad, Simona-Alina, Rosca, Ovidiu, Turaiche, Mirela-Mădălina, Hogea, Bogdan, Abu-Awwad, Ahmed, Nitu, Razvan, and Lazureanu, Voichita Elena

Subjects
WEIGHT loss, ANTIRETROVIRAL agents, PATIENT compliance, PATIENT satisfaction, CD4 lymphocyte count, HIV
Abstract

Background: The battle against HIV has led to the development of antiretroviral therapy (ART), including BIKTARVY®, which combines three potent agents. However, concerns about gastrointestinal side effects during the early phases of treatment have emerged, potentially impacting patient adherence and outcomes. Materials and Methods: This retrospective cohort study, conducted over four years in Romania, examined 222 patients initiated on BIKTARVY® therapy. Data were collected from electronic medical records, and stringent inclusion and exclusion criteria were applied to ensure data accuracy and relevance. Statistical analysis was performed to assess age-related patterns in gastrointestinal symptoms and their relation with significant weight loss. Results: This study revealed significant differences in the prevalence of gastrointestinal symptoms between age groups, with older patients experiencing more symptoms. Notably, diarrhea did not exhibit a statistically significant age-related difference. Furthermore, weight loss exceeding 5 kg was more common in older patients. Of the patients who continued BIKTARVY® therapy, 84.9% showed an increase in CD4 cell counts, and most expressed satisfaction with treatment. Conclusion: Understanding age-related patterns and gastrointestinal side effects of BIKTARVY® is crucial for optimizing HIV patient care. Future research should aim to corroborate and expand upon these findings, potentially leading to improved therapeutic approaches in the ongoing fight against HIV. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review

Author

Budea, Camelia, primary, Bratosin, Felix, additional, Bogdan, Iulia, additional, Bota, Adrian, additional, Turaiche, Mirela, additional, Tirnea, Livius, additional, Stoica, Carmen, additional, Csep, Andrei, additional, Feciche, Bogdan, additional, Pescariu, Silvius, additional, Popa, Malina, additional, Mavrea, Adelina, additional, Bumbu, Bogdan, additional, Bandi, Satya, additional, and Marincu, Iosif, additional

Published
2023
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6. Disease Progression, Clinical Features, and Risk Factors for Pneumonia in Unvaccinated Children and Adolescents with Measles: A Re-Emerging Disease in Romania

Author

Turaiche, Mirela, primary, Grigoras, Mirela Loredana, additional, Bratosin, Felix, additional, Bogdan, Iulia, additional, Bota, Adrian Vasile, additional, Cerbu, Bianca, additional, Gurban, Camelia Vidita, additional, Wulandari, Prima Hapsari, additional, Gurumurthy, Srivathsava, additional, Hemaswini, Kakarla, additional, Citu, Cosmin, additional, and Marincu, Iosif, additional

Published
2022
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7. Biological Profile and Clinical Features as Determinants for Prolonged Hospitalization in Adult Patients with Measles: A Monocentric Study in Western Romania

Author

Turaiche, Mirela, primary, Feciche, Bogdan, additional, Gluhovschi, Adrian, additional, Bratosin, Felix, additional, Bogdan, Iulia, additional, Bota, Adrian Vasile, additional, Grigoras, Mirela Loredana, additional, Gurban, Camelia Vidita, additional, Cerbu, Bianca, additional, Toma, Ana-Olivia, additional, Gurumurthy, Srivathsava, additional, Wulandari, Prima Hapsari, additional, and Marincu, Iosif, additional

Published
2022
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8. Listeria Monocytogenes Meningitis in an Immunocompetent Patient

Author

Magiar,Oana, Vulpie,Silvana, Musuroi,Corina, Iosif,Marincu, Murariu,Alina, Turaiche,Mirela, Musuroi,Silvia Ioana, Muntean,Delia, Licker,Monica, Magiar,Oana, Vulpie,Silvana, Musuroi,Corina, Iosif,Marincu, Murariu,Alina, Turaiche,Mirela, Musuroi,Silvia Ioana, Muntean,Delia, and Licker,Monica

Abstract

Oana Magiar,1 Silvana Vulpie,1,2 Corina Musuroi,1,3 Iosif Marincu,4,5 Alina Murariu,6 Mirela Turaiche,4,5 Silvia Ioana Musuroi,7 Delia Muntean,1,3,8 Monica Licker1,3,8 1Clinical Laboratory, “Pius Brînzeu” County Clinical Emergency Hospital Timisoara, Timis, Romania; 2Doctoral School, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Timis, Romania; 3Microbiology Department, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Timis, Romania; 4”Victor Babeș” Clinical Hospital of Infectious Diseases, Methodological and Infectious Diseases Research Centre Timisoara, Timis, Romania; 5Infectious Diseases Department, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Timis, Romania; 6Neurology II Department, “Pius Brînzeu” County Clinical Emergency Hospital Timisoara, Timis, Romania; 7Internal Medicine Department, Clinical Emergency Municipal Hospital, Timisoara, Romania; 8Multidisciplinary Research Centre for Antibiotic Resistance, “Victor Babeș” University of Medicine and Pharmacy Timisoara, Timis, RomaniaCorrespondence: Silvana Vulpie, Clinical Laboratory, “Pius Brînzeu” County Clinical Emergency Hospital Timisoara, Liviu Rebreanu, No. 156, Timișoara, Timis, 300723, Romania, Tel +40 727248701, Email vulpie.silvana@umft.comAbstract: Listeria monocytogenes (LM), one of the most important foodborne pathogens, is an intracellular bacterium found in food and the environment. It causes listeriosis, a potentially severe disease, particularly for pregnant women, the elderly and immunocompromised patients, but in rare cases, it can cause invasive disease in immunocompetent adults and children. Community-acquired bacterial meningitis caused by LM is rare and difficult to diagnose. It carries a high mortality rate; therefore, it is essential to start appropriate antibiotic treatment as soon as possible. The first case of LM meningitis identified in our hospital over the last 10 years is that of a previously

Published
2022

9. The Impact of Multiplex PCR in Diagnosing and Managing Bacterial Infections in COVID-19 Patients Self-Medicated with Antibiotics

Author

Bogdan, Iulia, primary, Citu, Cosmin, additional, Bratosin, Felix, additional, Malita, Daniel, additional, Romosan, Ioan, additional, Gurban, Camelia Vidita, additional, Bota, Adrian Vasile, additional, Turaiche, Mirela, additional, Bratu, Melania Lavinia, additional, Pilut, Ciprian Nicolae, additional, and Marincu, Iosif, additional

Published
2022
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