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1. OP0193 BITEING MULTI-DRUG RESISTANT RHEUMATOID ARTHRITIS WITH CD19-T CELL ENGAGERS

Author

Bucci, L., primary, Hagen, M., additional, Rothe, T., additional, Raimondo, M. G., additional, Fagni, F., additional, Tur, C., additional, Wirsching, A., additional, Wacker, J., additional, Wilhelm, A., additional, Auger, J. P., additional, Eckstein, M., additional, Alivernini, S., additional, Zoli, A., additional, Bozec, A., additional, D’agostino, M. A., additional, Schett, G., additional, and Grieshaber-Bouyer, R., additional

Published
2024
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2. OP0320 EFFICACY OF CD19-TARGETING CAR T CELL TREATMENT IN PATIENTS WITH DIFFUSE SYSTEMIC SCLEROSIS (dSSc) – AN OPEN LABEL, SINGLE-CENTER PILOT STUDY

Author

Auth, J., primary, Müller, F., additional, Taubmann, J., additional, Völkl, S., additional, Chenguiti Fakhouri, S., additional, Bucci, L., additional, Aigner, M., additional, Atzinger, A., additional, Bayerl, N., additional, Wirsching, A., additional, Dees, C., additional, Raimondo, M. G., additional, Tur, C., additional, Distler, J., additional, Mackensen, A., additional, Schett, G., additional, and Bergmann, C., additional

Published
2024
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3. OP0027 LONG-TERM SAFETY AND EFFICACY OF CAR-T CELL TREATMENT IN SEVERE AND TREATMENT REFRACTORY AUTOIMMUNE DISEASE

Author

Taubmann, J., primary, Müller, F., additional, Fagni, F., additional, Bergmann, C., additional, Tur, C., additional, Bucci, L., additional, Völkl, S., additional, Aigner, M., additional, Hagen, M., additional, Grieshaber-Bouyer, R., additional, Krönke, G., additional, Mougiakakos, D., additional, Korganow, A. S., additional, Farge, D., additional, Bozec, A., additional, Mackensen, A., additional, and Schett, G., additional

Published
2024
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4. POS0340 EFFECTS OF CAR-T CELL TREATMENT ON B CELL IMMUNITY IN SYSTEMIC AUTOIMMUNE DISEASES

Author

Bucci, L., primary, Rothe, T., additional, Müller, F., additional, Taubmann, J., additional, Hagen, M., additional, Bergmann, C., additional, Tur, C., additional, Munoz, L., additional, Wilhelm, A., additional, Gerlach, R., additional, Schäfer, S., additional, Völkl, S., additional, Aigner, M., additional, Grieshaber-Bouyer, R., additional, Krönke, G., additional, Bozec, A., additional, Winkler, T., additional, Mackensen, A., additional, and Schett, G., additional

Published
2024
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5. POS0030 SAFETY AND PRELIMINARY EFFICACY OF CD19 CAR-T CELL TREATMENT IN RHEUMATIC DISEASE- DATA FROM THE FIRST PART OF THE PHASE I/II CASTLE BASKET STUDY

Author

Schett, G., primary, Bohr, D., additional, Mueller, F., additional, Hagen, M., additional, Bergmann, C., additional, Tur, C., additional, Völkl, S., additional, Aigner, M., additional, Krestchmann, S., additional, Spörl, S., additional, Vasova, I., additional, Aletaha, D., additional, Kiener, H., additional, Natalello, G., additional, Grieshaber-Bouyer, R., additional, Bozec, A., additional, Locatelli, F., additional, D`agostino, M. A., additional, and Mackensen, A., additional

Published
2024
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7. Plant survival and keystone pollinator species in stochastic coextinction models: role of intrinsic dependence on animal-pollination

Author

Traveset, A, Tur, C, and Eguíluz, VM

Subjects
Quantitative Biology - Populations and Evolution
Abstract

Coextinction models are useful to understand community robustness to species loss and resilience to disturbances. We simulated pollinator extinctions in pollination networks by using a hybrid model that combined a recently developed stochastic coextinction model (SCM) for plant extinctions and a topological model (TCM) for animal extinctions. Our model accounted for variation in interaction strengths and included empirical estimates of plant dependence on pollinators to set seeds. The stochastic nature of such model allowed us determining plant survival to single (and multiple) extinction events, and identifying which pollinators (keystone species) were more likely to trigger secondary extinctions. Consistently across three different pollinator removal sequences, plant robustness was lower than in a pure TCM, and plant survival was more determined by dependence on the mutualism than by interaction strength. As expected, highly connected and dependent plants were the most sensitive to pollinator loss and collapsed faster in extinction cascades. We predict that the relationship between dependence and plant connectivity is crucial to determine network robustness to interaction loss. Finally, we showed that honeybees and several beetles were keystone species in our communities. This information is of great value to foresee consequences of pollinator losses facing current global change and to identify target species for effective conservation., Comment: (37 pages, 9 figures, including supplementary information)

Published
2017
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10. The $^{150}$Nd($^3$He,$t$) and $^{150}$Sm($t$,$^3$He) reactions with applications to $\beta\beta$ decay of $^{150}$Nd

Author

Guess, C. J., Adachi, T., Akimune, H., Algora, A., Austin, Sam M., Bazin, D., Brown, B. A., Caesar, C., Deaven, J. M., Ejiri, H., Estevez, E., Fang, D., Faessler, A., Frekers, D., Fujita, H., Fujita, Y., Fujiwara, M., Grinyer, G. F., Harakeh, M. N., Hatanaka, K., Herlitzius, C., Hirota, K., Hitt, G. W., Ishikawa, D., Matsubara, H., Meharchand, R., Molina, F., Okamura, H., Ong, H. J., Perdikakis, G., Rodin, V., Rubio, B., Shimbara, Y., Süsoy, G., Suzuki, T., Tamii, A., Thies, J. H., Tur, C., Verhanovitz, N., Yosoi, M., Yurkon, J., Zegers, R. G. T., and Zenihiro, J.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The $^{150}$Nd($^3$He,$t$) reaction at 140 MeV/u and $^{150}$Sm($t$,$^3$He) reaction at 115 MeV/u were measured, populating excited states in $^{150}$Pm. The transitions studied populate intermediate states of importance for the (neutrinoless) $\beta\beta$ decay of $^{150}$Nd to $^{150}$Sm. Monopole and dipole contributions to the measured excitation-energy spectra were extracted by using multipole decomposition analyses. The experimental results were compared with theoretical calculations obtained within the framework of Quasiparticle Random-Phase Approximation (QRPA), which is one of the main methods employed for estimating the half-life of the neutrinoless $\beta\beta$ decay ($0\nu\beta\beta$) of $^{150}$Nd. The present results thus provide useful information on the neutrino responses for evaluating the $0\nu\beta\beta$ and $2\nu\beta\beta$ matrix elements. The $2\nu\beta\beta$ matrix element calculated from the Gamow-Teller transitions through the lowest $1^{+}$ state in the intermediate nucleus is maximally about half of that deduced from the half-life measured in $2\nu\beta\beta$ direct counting experiments and at least several transitions through $1^{+}$ intermediate states in $^{150}$Pm are required to explain the $2\nu\beta\beta$ half-life. Because Gamow-Teller transitions in the $^{150}$Sm($t$,$^3$He) experiment are strongly Pauli-blocked, the extraction of Gamow-Teller strengths was complicated by the excitation of the $2\hbar\omega$, $\Delta L=0$, $\Delta S=1$ isovector spin-flip giant monopole resonance (IVSGMR). However, the near absence of Gamow-Teller transition strength made it possible to cleanly identify this resonance, and the strength observed is consistent with the full exhaustion of the non-energy-weighted sum rule for the IVSGMR., Comment: 18 pages, 13 figures, 2 tables

Published
2011
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11. Gamow-Teller Unit Cross Sections for (t,3He) and (3He,t) Reactions

Author

Perdikakis, G., Zegers, R. G. T., Austin, Sam M., Bazin, D., Caesar, C., Deaven, J. M., Gade, A., Galaviz, D., Grinyer, G., Guess, C. J., Herlitzius, C., Hitt, G. W., Howard, M. E., Meharchand, R., Noji, S., Sakai, H., Shimbara, Y., Smith, E. E., and Tur, C.

Subjects
Nuclear Experiment
Abstract

The proportionality between differential cross sections at vanishing linear momentum transfer and Gamow-Teller transition strength, expressed in terms of the \textit{unit cross section} ($\hat{\sigma}_{GT}$) was studied as a function of target mass number for ($t$,$^{3}$He) and ($^{3}$He,$t$) reactions at 115 $A$MeV and 140 $A$MeV, respectively. Existing ($^{3}$He,$t$) and ($t$,$^{3}$He) data on targets with mass number $12\leq A\leq 120$ were complemented with new and reevaluated ($t$,$^{3}$He) data on proton, deuteron, $^{6}$Li and $^{12}$C targets. It was found that in spite of the small difference in beam energies between the two probes, the unit cross sections have a nearly identical and simple dependence on target mass number $A$, for $A\geq 12$: $\hat{\sigma}_{GT}=109/A^{0.65}$. The factorization of the unit cross sections in terms of a kinematical factor, a distortion factor and the strength of the effective spin-isospin transfer nucleus-nucleus interaction was investigated. Simple phenomenological functions depending on mass number $A$ were extracted for the latter two. By comparison with plane and distorted-wave Born approximation calculations, it was found that the use of a short-range approximation for knock-on exchange contributions to the transition amplitude results in overestimated cross sections for reactions involving the composite ($^{3}$He,$t$) and ($t$,$^{3}$He) probes., Comment: 14 pages, 10 figures

Published
2011
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12. Spectroscopy of 13B via the 13C(t,3He) reaction at 115 AMeV

Author

Guess, C. J., Zegers, R. G. T., Brown, B. A., Austin, Sam M., Bazin, D., Caesar, C., Deaven, J. M., Grinyer, G. F., Herlitzius, C., Hitt, G. W., Noji, S., Meharchand, R., Perdikakis, G., Sakai, H., Shimbara, Y., and Tur, C.

Subjects
Nuclear Experiment
Abstract

Gamow-Teller and dipole transitions to final states in 13B were studied via the 13C(t,3He) reaction at Et = 115 AMeV. Besides the strong Gamow-Teller transition to the 13B ground state, a weaker Gamow-Teller transition to a state at 3.6 MeV was found. This state was assigned a spin-parity of 3/2- by comparison with shell-model calculations using the WBP and WBT interactions which were modified to allow for mixing between nhw and (n+2)hw configurations. This assignment agrees with a recent result from a lifetime measurement of excited states in 13B. The shell-model calculations also explained the relatively large spectroscopic strength measured for a low-lying 1/2+ state at 4.83 MeV in 13B. The cross sections for dipole transitions up to Ex(13B)= 20 MeV excited via the 13C(t,3He) reaction were also compared with the shell-model calculations. The theoretical cross sections exceeded the data by a factor of about 1.8, which might indicate that the dipole excitations are "quenched". Uncertainties in the reaction calculations complicate that interpretation., Comment: 11 pages, 6 figures

Published
2009
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13. Gamow-Teller transitions to 64-Cu measured using the 64-Zn(t,3-He) reaction

Author

Hitt, G. W., Zegers, R. G. T., Austin, Sam M., Bazin, D., Gade, A., Galaviz, D., Guess, C. J., Horoi, M., Howard, M. E., Shimbara, Y., Smith, E. E., and Tur, C.

Subjects
Nuclear Experiment
Abstract

The 64-Zn(t,3-He) reaction has been studied using a secondary triton beam of 115 MeV/nucleon to extract the Gamow-Teller transition-strength distribution to 64-Cu. The results were compared with shell-model calculations using the pf-shell effective interactions KB3G and GXPF1A and with existing data from the 64-Zn(d,2-He) reaction. Whereas the experimental results exhibited good consistency, neither of the theoretical predictions managed to reproduce the data. The implications for electron-capture rates during late stellar evolution were investigated. The rates based on the theoretical strength distributions are lower by factors of 3.5-5 compared to the rates based on experimental strength distributions., Comment: 10 pages, 8 figures

Published
2009
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14. A high efficiency, low background detector for measuring pair-decay branches in nuclear decay

Author

Tur, C., Wuosmaa, A. H., Austin, S. M., Starosta, K., Yurkon, J., Estrade, A., Goodman, N., Lighthall, J. C., Lorusso, G., Marley, S. T., and Snyder, J.

Subjects
Physics - Instrumentation and Detectors
Abstract

We describe a high efficiency detector for measuring electron-positron pair transitions in nuclei. The device was built to be insensitive to gamma rays and to accommodate high overall event rates. The design was optimized for total pair kinetic energies up to about 7 MeV., Comment: Accepted for publication by Nucl. Inst. & Meth. in Phys. Res. A (NIM A)

Published
2008
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15. Light Vector Mesons in the Nuclear Medium

Author

Wood, M. H., Nasseripour, R., Weygand, D. P., Djalali, C., Tur, C., Mosel, U., Muehlich, P., and Collaboration, CLAS

Subjects
Nuclear Experiment
Abstract

The light vector mesons ($\rho$, $\omega$, and $\phi$) were produced in deuterium, carbon, titanium, and iron targets in a search for possible in-medium modifications to the properties of the $\rho$ meson at normal nuclear densities and zero temperature. The vector mesons were detected with the CEBAF Large Acceptance Spectrometer (CLAS) via their decays to $e^{+}e^{-}$. The rare leptonic decay was chosen to reduce final-state interactions. A combinatorial background was subtracted from the invariant mass spectra using a well-established event-mixing technique. The $\rho$ meson mass spectrum was extracted after the $\omega$ and $\phi$ signals were removed in a nearly model-independent way. Comparisons were made between the $\rho$ mass spectra from the heavy targets ($A > 2$) with the mass spectrum extracted from the deuterium target. With respect to the $\rho$-meson mass, we obtain a small shift compatible with zero. Also, we measure widths consistent with standard nuclear many-body effects such as collisional broadening and Fermi motion., Comment: 15 pages, 18 figures, 3 tables

Published
2008
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16. Search for medium modification of the $\rho$ meson

Author

Nasseripour, R., Wood, M. H., Djalali, C., Weygand, D. P., Tur, C., Mosel, U., Muehlich, P., and Collaboration, CLAS

Subjects
Nuclear Experiment
Abstract

The photoproduction of vector mesons on various nuclei has been studied using the CEBAF Large Acceptance Spectrometer (CLAS) at Jefferson Laboratory. The vector mesons, $\rho$, $\omega$, and $\phi$, are observed via their decay to $e^+e^-$, in order to reduce the effects of final state interactions in the nucleus. Of particular interest are possible in-medium effects on the properties of the $\rho$ meson. The $\rho$ spectral function is extracted from the data on various nuclei, carbon, iron, and titanium, and compared to the spectrum from liquid deuterium, which is relatively free of nuclear effects. We observe no significant mass shift for the $\rho$ meson; however, there is some widening of the resonance in titanium and iron, which is consistent with expected collisional broadening., Comment: 8 pages, 4 figures

Published
2007
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18. POS0026 THE INDEPENDENT INFLUENCE OF SEX ON THE DISEASE IMPACT DOMAINS IN PSORIATIC ARTHRITIS IS MODEST, ONCE CONFOUNDERS ARE TAKEN INTO ACCOUNT

Author

Ortolan, A., primary, Capacci, A., additional, Zoli, A., additional, DI Murro, S., additional, Cristiano, F., additional, Cerasuolo, P., additional, La Ferrara, R., additional, Lanzo, L., additional, Tur, C., additional, Rubortone, P., additional, Verardi, L., additional, Calabrese, G., additional, Aquilino, P., additional, Peluso, G., additional, and D’agostino, M. A., additional

Published
2023
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22. An internet-based treatment for flying phobia using 360° images: A feasibility pilot study

Author

Mor, S., Botella, C., Campos, D., Carlbring, P., Tur, C., and Quero, S.

Subjects
treatment preferences, reality judgment, sense of presence, exposure therapy, Health Informatics, Internet-based intervention
Abstract

Registered at Clinicaltrials.gov (NCT03900559) on April 9, 2019. Retrospectively registered. Background: More research is needed in the field of Internet-delivered Cognitive Behavioral Treatments (ICBTs) for specific phobia in order to understand which characteristics are important in online exposure scenarios. The aim of the present work was to conduct a feasibility pilot study to explore participants' opinions, preferences, and acceptability ratings of two types of images (still images vs 360◦ navigable images) in an ICBT for Flying Phobia (FP). A secondary aim was to test the potential effectiveness of the two active treatment arms compared to a waiting list control group. An exploratory aim was to compare the role of navigable images vs. still images in the level of sense of presence and reality judgment and explore their possible mediation in treatment effectiveness. Methods: Participants were randomly allocated to three conditions: NO-FEAR Airlines with still images (n = 26), NO-FEAR Airlines with still and navigable images (n = 26), and a waiting list group (n = 26). Primary outcome measures were participants' opinions, preferences, satisfaction, and acceptance regarding the images used in the exposure scenarios. Secondary outcome measures included FP symptomatology outcomes and measures of sense of presence and reality judgment. Results: Participants in the study preferred navigable images over still images before and after treatment (over 84%), and they considered them more effective and logical for the treatment of their problem. However, adherence in the experimental conditions was low (42.3% dropout rate), and more participants withdrew from the group that included navigable images compared to the group that only included still images (14 vs. 8), with no statistical differences in attrition between the two conditions. NO-FEAR Airlines proved to be effective in reducing FP symptomatology compared to the control group, with large between-group effect sizes on all FP measures (ranging from 0.76 to 2.79). No significant mediation effect was found for sense of presence or reality judgment in treatment effectiveness. Discussion: The results of the current study suggest that participants prefer more immersive images in exposure scenarios, providing data that can help to design useful exposure scenarios to treat specific phobias in the future. They also provide evidence supporting the effectiveness of an ICBT for FP.

Published
2021

23. Mind the gap: from neurons to networks to outcomes in multiple sclerosis

Author

Chard, D. T., Alahmadi, A. A. S., Audoin, B., Charalambous, T., Enzinger, C., Hulst, H. E., Rocca, M. A., Rovira, A., Sastre-Garriga, J., Schoonheim, M. M., Tijms, B., Tur, C., Gandini Wheeler-Kingshott, C. A. M., Wink, A. M., Ciccarelli, O., Barkhof, F., De Stefano, N., Filippi, M., Frederiksen, J. L., Gasperini, C., Kappos, L., Palace, J., Yousry, T., Vrenken, H., University College of London [London] (UCL), Department of Diagnostic Radiology, Faculty of Applied Medical Science, King Abdulaziz University (KAU), Jeddah, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), AP-HM, CHU Timone, Pole de Neurosciences Cliniques, Department of Neurology, Marseille, France., Department of Neurology, Research Unit for Neuronal Repair and Plasticity, Medical University of Graz, Graz, Department of Radiology, Division of Neuroradiology, Vascular and Interventional Radiology, Medical University of Graz, Graz, Department of Anatomy and Neurosciences, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Neuroimaging Research Unit and Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Universitat Autònoma de Barcelona (UAB), Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Department of Neurology, Luton and Dunstable University Hospital, Luton, Università degli Studi di Pavia = University of Pavia (UNIPV), Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia, Department of Radiology & Nuclear Medicine, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, Faculty of Brain Sciences, University College London, London, National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre, London, Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - AP-HM] (CEMEREM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)- Hôpital de la Timone [CHU - APHM] (TIMONE), Section of Neuroradiology, Department of Radiology Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Servei de Neurologia/Neuroimmunologia, Multiple Sclerosis Centre of Catalonia (Cemcat), Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Institutes of Neurology and Healthcare Engineering, University College London, London, Chard, Declan T, Alahmadi, Adnan A S, Audoin, Bertrand, Charalambous, Thali, Enzinger, Christian, Hulst, Hanneke E, Rocca, Maria A, Rovira, Àlex, Sastre-Garriga, Jaume, Schoonheim, Menno M, Tijms, Betty, Tur, Carmen, Gandini Wheeler-Kingshott, Claudia A M, Wink, Alle Meije, Ciccarelli, Olga, Barkhof, Frederik, MAGNIMS Study, Group, and Filippi, Massimo

Subjects
Multiple Sclerosis, Grey matter, Network topology, 030218 nuclear medicine & medical imaging, White matter, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Alzheimer Disease, medicine, Humans, Default mode network, ComputingMilieux_MISCELLANEOUS, Inflammation, Neurons, Artificial neural network, business.industry, Multiple sclerosis, [SCCO.NEUR]Cognitive science/Neuroscience, Brain, medicine.disease, medicine.anatomical_structure, Neurology (clinical), Disconnection, Alzheimer's disease, Nerve Net, business, Neuroscience, 030217 neurology & neurosurgery
Abstract

MRI studies have provided valuable insights into the structure and function of neural networks, particularly in health and in classical neurodegenerative conditions such as Alzheimer disease. However, such work is also highly relevant in other diseases of the CNS, including multiple sclerosis (MS). In this Review, we consider the effects of MS pathology on brain networks, as assessed using MRI, and how these changes to brain networks translate into clinical impairments. We also discuss how this knowledge can inform the targeting of MS treatments and the potential future directions for research in this area. Studying MS is challenging as its pathology involves neurodegenerative and focal inflammatory elements, both of which could disrupt neural networks. The disruption of white matter tracts in MS is reflected in changes in network efficiency, an increasingly random grey matter network topology, relative cortical disconnection, and both increases and decreases in connectivity centred around hubs such as the thalamus and the default mode network. The results of initial longitudinal studies suggest that these changes evolve rather than simply increase over time and are linked with clinical features. Studies have also identified a potential role for treatments that functionally modify neural networks as opposed to altering their structure.

Published
2021

25. Evidence for a backward peak in the γd → π0d cross section near the η threshold

Author

Ilieva, Y., Berman, B. L., Kudryavtsev, A. E., Strakovsky, I. I., Tarasov, V. E., Amarian, M., Ambrozewicz, P., Anghinolfi, M., Asryan, G., Avakian, H., Bagdasaryan, H., Baillie, N., Ball, J. P., Baltzell, N. A., Batourine, V., Battaglieri, M., Bedlinskiy, I., Bellis, M., Benmouna, N., Biselli, A. S., Bouchigny, S., Boiarinov, S., Bradford, R., Branford, D., Briscoe, W. J., Brooks, W. K., Bültmann, S., Burkert, V. D., Butuceanu, C., Calarco, J. R., Careccia, S. L., Carman, D. S., Chen, S., Cole, P. L., Collins, P., Coltharp, P., Crabb, D., Crede, V., De Masi, R., De Sanctis, E., De Vita, R., Degtyarenko, P. V., Deur, A., Dickson, R., Djalali, C., Dodge, G. E., Donnelly, J., Doughty, D., Dugger, M., Dzyubak, O. P., Egiyan, H., Egiyan, K. S., Elouadrhiri, L., Eugenio, P., Fedotov, G., Feldman, G., Funsten, H., Garçon, M., Gavalian, G., Gilfoyle, G. P., Giovanetti, K. L., Girod, F. X., Goetz, J. T., Gonenc, A., Gothe, R. W., Griffioen, K. A., Guidal, M., Guler, N., Guo, L., Gyurjyan, V., Hafidi, K., Hakobyan, R. S., Hersman, F. W., Hicks, K., Hleiqawi, I., Holtrop, M., Hyde-Wright, C. E., Ireland, D. G., Ishkhanov, B. S., Isupov, E. L., Ito, M. M., Jenkins, D., Jo, H. S., Joo, K., Juengst, H. G., Kalantarians, N., Kellie, J. D., Khandaker, M., Kim, W., Klein, A., Klein, F. J., Kossov, M., Krahn, Z., Kramer, L. H., Kubarovsky, V., Kuhn, J., Kuhn, S. E., Kuleshov, S. V., Lachniet, J., Laget, J. M., Langheinrich, J., Lawrence, D., Livingston, K., Lu, H., MacCormick, M., Markov, N., McKinnon, B., Mecking, B. A., Mestayer, M. D., Meyer, C. A., Mibe, T., Mikhailov, K., Mirazita, M., Miskimen, R., Mokeev, V., Moriya, K., Morrow, S. A., Moteabbed, M., Munevar, E., Mutchler, G. S., Nadel-Turonski, P., Nasseripour, R., Niccolai, S., Niculescu, G., Niculescu, I., Niczyporuk, B. B., Niroula, M. R., Niyazov, R. A., Nozar, M., Osipenko, M., Ostrovidov, A. I., Park, K., Pasyuk, E., Paterson, C., Pierce, J., Pivnyuk, N., Pogorelko, O., Pozdniakov, S., Price, J. W., Prok, Y., Protopopescu, D., Raue, B. A., Ricco, G., Ripani, M., Ritchie, B. G., Ronchetti, F., Rosner, G., Rossi, P., Sabatié, F., Salgado, C., Santoro, J. P., Sapunenko, V., Schumacher, R. A., Serov, V. S., Sharabian, Y. G., Shvedunov, N. V., Smith, E. S., Smith, L. C., Sober, D. I., Stavinsky, A., Stepanyan, S. S., Stepanyan, S., Stokes, B. E., Stoler, P., Strauch, S., Taiuti, M., Tedeschi, D. J., Thoma, U., Tkabladze, A., Tkachenko, S., Tur, C., Ungaro, M., Vineyard, M. F., Vlassov, A. V., Watts, D. P., Weinstein, L. B., Weygand, D. P., Williams, M., Wolin, E., Wood, M. H., Yegneswaran, A., Zana, L., Zhang, J., Zhao, B., Zhao, Z., and The CLAS Collaboration

Published
2010
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28. Exclusive ρ0 electroproduction on the proton at CLAS

Author

Morrow, S. A., Guidal, M., Garçon, M., Laget, J. M., Smith, E. S., Adams, G., Adhikari, K. P., Aghasyan, M., Amaryan, M. J., Anghinolfi, M., Asryan, G., Audit, G., Avakian, H., Bagdasaryan, H., Baillie, N., Ball, J. P., Baltzell, N. A., Barrow, S., Battaglieri, M., Bedlinskiy, I., Bektasoglu, M., Bellis, M., Benmouna, N., Berman, B. L., Biselli, A. S., Blaszczyk, L., Bonner, B. E., Bookwalter, C., Bouchigny, S., Boiarinov, S., Bradford, R., Branford, D., Briscoe, W. J., Brooks, W. K., Bültmann, S., Burkert, V. D., Butuceanu, C., Calarco, J. R., Careccia, S. L., Carman, D. S., Carnahan, B., Casey, L., Cazes, A., Chen, S., Cheng, L., Cole, P. L., Collins, P., Coltharp, P., Cords, D., Corvisiero, P., Crabb, D., Crannell, H., Crede, V., Cummings, J. P., Dale, D., Dashyan, N., De Masi, R., De Vita, R., De Sanctis, E., Degtyarenko, P. V., Denizli, H., Dennis, L., Deur, A., Dhamija, S., Dharmawardane, K. V., Dhuga, K. S., Dickson, R., Didelez, J. -P., Djalali, C., Dodge, G. E., Doughty, D., Dugger, M., Dytman, S., Dzyubak, O. P., Egiyan, H., Egiyan, K. S., El Fassi, L., Elouadrhiri, L., Eugenio, P., Fatemi, R., Fedotov, G., Fersch, R., Feuerbach, R. J., Forest, T. A., Fradi, A., Gavalian, G., Gevorgyan, N., Gilfoyle, G. P., Giovanetti, K. L., Girod, F. X., Goetz, J. T., Gohn, W., Gordon, C. I. O., Gothe, R. W., Graham, L., Griffioen, K. A., Guillo, M., Guler, N., Guo, L., Gyurjyan, V., Hadjidakis, C., Hafidi, K., Hakobyan, H., Hanretty, C., Hardie, J., Hassall, N., Heddle, D., Hersman, F. W., Hicks, K., Hleiqawi, I., Holtrop, M., Hourany, E., Hyde-Wright, C. E., Ilieva, Y., Ireland, D. G., Ishkhanov, B. S., Isupov, E. L., Ito, M. M., Jenkins, D., Jo, H. S., Johnstone, J. R., Joo, K., Juengst, H. G., Kalantarians, N., Keller, D., Kellie, J. D., Khandaker, M., Khetarpal, P., Kim, W., Klein, A., Klein, F. J., Klimenko, A. V., Kossov, M., Kramer, L. H., Kubarovsky, V., Kuhn, J., Kuhn, S. E., Kuleshov, S. V., Kuznetsov, V., Lachniet, J., Langheinrich, J., Lawrence, D., Li, Ji, Livingston, K., Lu, H. Y., MacCormick, M., Marchand, C., Markov, N., Mattione, P., McAleer, S., McCracken, M., McKinnon, B., McNabb, J. W. C., Mecking, B. A., Mehrabyan, S., Melone, J. J., Mestayer, M. D., Meyer, C. A., Mibe, T., Mikhailov, K., Minehart, R., Mirazita, M., Miskimen, R., Mokeev, V., Morand, L., Moreno, B., Moriya, K., Moteabbed, M., Mueller, J., Munevar, E., Mutchler, G. S., Nadel-Turonski, P., Nasseripour, R., Niccolai, S., Niculescu, G., Niculescu, I., Niczyporuk, B. B., Niroula, M. R., Niyazov, R. A., Nozar, M., O’Rielly, G. V., Osipenko, M., Ostrovidov, A. I., Park, K., Park, S., Pasyuk, E., Paterson, C., Anefalos Pereira, S., Philips, S. A., Pierce, J., Pivnyuk, N., Pocanic, D., Pogorelko, O., Polli, E., Popa, I., Pozdniakov, S., Preedom, B. M., Price, J. W., Procureur, S., Prok, Y., Protopopescu, D., Qin, L. M., Raue, B. A., Riccardi, G., Ricco, G., Ripani, M., Ritchie, B. G., Rosner, G., Rossi, P., Rubin, P. D., Sabatié, F., Saini, M. S., Salamanca, J., Salgado, C., Santoro, J. P., Sapunenko, V., Schott, D., Schumacher, R. A., Serov, V. S., Sharabian, Y. G., Sharov, D., Shvedunov, N. V., Skabelin, A. V., Smith, L. C., Sober, D. I., Sokhan, D., Stavinsky, A., Stepanyan, S. S., Stepanyan, S., Stokes, B. E., Stoler, P., Strakovsky, I. I., Strauch, S., Taiuti, M., Tedeschi, D. J., Tkabladze, A., Tkachenko, S., Todor, L., Tur, C., Ungaro, M., Vineyard, M. F., Vlassov, A. V., Watts, D. P., Weinstein, L. B., Weygand, D. P., Williams, M., Wolin, E., Wood, M. H., Yegneswaran, A., Yurov, M., Zana, L., Zhang, J., Zhao, B., Zhao, Z. W., and The CLAS Collaboration

Published
2009
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29. Single-subject structural cortical networks in clinically isolated syndrome

Author

Collorone S., Prados F., Hagens M. H. J., Tur C., Kanber B., Sudre C. H., Lukas C., Gasperini C., Oreja-Guevara C., Andelova M., Ciccarelli O., Wattjes M. P., Ourselin S., Altmann D. R., Tijms B. M., Barkhof F., Toosy A. T, Magnims SDtudy Group, Filippi M, Rocca MA, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Radiology and nuclear medicine, Collorone, S., Prados, F., Hagens, M. H. J., Tur, C., Kanber, B., Sudre, C. H., Lukas, C., Gasperini, C., Oreja-Guevara, C., Andelova, M., Ciccarelli, O., Wattjes, M. P., Ourselin, S., Altmann, D. R., Tijms, B. M., Barkhof, F., Toosy A., T, Magnims SDtudy, Group, Filippi, M, and Rocca, Ma

Subjects
graph theory, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Magnetic resonance imaging, 0302 clinical medicine, Cognition, Neural Pathways, medicine, Humans, Prospective Studies, structural cortical networks, Clinically isolated syndrome, medicine.diagnostic_test, business.industry, Multiple sclerosis, Brain, gray matter, medicine.disease, Magnetic Resonance Imaging, multicenter study, Neurology, Multicenter study, clinically isolated syndrome, multiple sclerosi, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery, Demyelinating Diseases
Abstract

Background: Structural cortical networks (SCNs) represent patterns of coordinated morphological modifications in cortical areas, and they present the advantage of being extracted from previously acquired clinical magnetic resonance imaging (MRI) scans. SCNs have shown pathophysiological changes in many brain disorders, including multiple sclerosis. Objective: To investigate alterations of SCNs at the individual level in patients with clinically isolated syndrome (CIS), thereby assessing their clinical relevance. Methods: We analyzed baseline data collected in a prospective multicenter (MAGNIMS) study. CIS patients ( n = 60) and healthy controls ( n = 38) underwent high-resolution 3T MRI. Measures of disability and cognitive processing were obtained for patients. Single-subject SCNs were extracted from brain 3D-T1 weighted sequences; global and local network parameters were computed. Results: Compared to healthy controls, CIS patients showed altered small-world topology, an efficient network organization combining dense local clustering with relatively few long-distance connections. These disruptions were worse for patients with higher lesion load and worse cognitive processing speed. Alterations of centrality measures and clustering of connections were observed in specific cortical areas in CIS patients when compared with healthy controls. Conclusion: Our study indicates that SCNs can be used to demonstrate clinically relevant alterations of connectivity in CIS.

Published
2019

30. Aggressive multiple sclerosis (2): Treatment

Author

Arrambide, G., Iacobaeus, E., Amato, M. P., Derfuss, T., Vukusic, S., Hemmer, B., Brundin, L., Tintore, M., Berger, J., Boyko, A., Brinar, V., Brownlee, W., Ciccarelli, O., Coles, A., Correale, J., Cutter, G., Edan, G., Evangelou, N., Fernandez, O., Frederiksen, J., Gold, R., Hacohen, Y., Hartung, H. -P., Hellwig, K., Hillert, J., Imitola, J., Kalincik, T., Kappos, L., Khoury, S., Kim, H. J., Havrdova, E. K., Liblau, R., Lycke, J., Montalban, X., Muraro, P., Reingold, S., Schmierer, K., Sellebjerg, F., Sorensen, P. S., Solari, A., Sormani, M. P., Thompson, A., Trapp, B., Tremlett, H., Trojano, M., Tur, C., Uccelli, A., van Pesch, V., and Waubant, E.

Subjects
Aggressive, medicine.medical_specialty, Treatment response, relapsing–remitting, Disease, Permanent disability, multiple sclerosis, disability, highly active, treatment response, Multiple sclerosis, 03 medical and health sciences, 0302 clinical medicine, 2018 ECTRIMS Focused Workshop Group, medicine, Relapsing-remitting, 030212 general & internal medicine, Intensive care medicine, Highly active, Therapeutic window, Neurology & Neurosurgery, Disability, business.industry, 1103 Clinical Sciences, medicine.disease, ddc, Natural history, Neurology, Relapsing remitting, Neurology (clinical), business, 1109 Neurosciences, 030217 neurology & neurosurgery, Meeting Reviews
Abstract

Altres ajuts: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The workshop on which the manuscript is based was supported in its entirety by the European Committee on Treatment and Research in Multiple Sclerosis (ECTRIMS). The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.

Published
2020

31. Aggressive multiple sclerosis (1) : Towards a definition of the phenotype

Author

Iacobaeus, E., Arrambide, G., Amato, M. P., Derfuss, T., Vukusic, S., Hemmer, B., Tintore, M., Brundin, L., Berger, J., Boyko, A., Brinar, V., Brownlee, W., Ciccarelli, O., Coles, A., Correale, J., Cutter, G., Edan, G., Evangelou, N., Fernandez, O., Frederiksen, J., Gold, R., Hacohen, Y., Hartung, H. -P., Hellwig, K., Hillert, J., Imitola, J., Kalincik, T., Kappos, L., Khoury, S., Kim, H. J., Havrdova, E. K., Liblau, R., Lycke, J., Montalban, X., Muraro, P., Reingold, S., Schmierer, K., Sellebjerg, F., Sorensen, P. S., Solari, A., Sormani, M. P., Thompson, A., Trapp, B., Tremlett, H., Trojano, M., Tur, C., Uccelli, A., van Pesch, V., Waubant, E., UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, and UCL - (SLuc) Service de neurologie

Subjects
Disease subtype, Aggressive, medicine.medical_specialty, Severe disease, Aggressive disease, multiple sclerosis, Relapsing/remitting, Multiple sclerosis, 03 medical and health sciences, 0302 clinical medicine, disability, highly active, observational studies, relapsing/remitting, 2018 ECTRIMS Focused Workshop Group, medicine, Intensive care medicine, Secondary progressive, Highly active, Observational studies, 030304 developmental biology, 0303 health sciences, Neurology & Neurosurgery, Disability, business.industry, 1103 Clinical Sciences, medicine.disease, Phenotype, Additional research, ddc, Neurology, Observational study, Neurology (clinical), 1109 Neurosciences, business, 030217 neurology & neurosurgery, Meeting Reviews
Abstract

Altres ajuts: The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The workshop on which the manuscript is based was supported in its entirety by the European Committee on Treatment and Research in Multiple Sclerosis (ECTRIMS). While the major phenotypes of multiple sclerosis (MS) and relapsing-remitting, primary and secondary progressive MS have been well characterized, a subgroup of patients with an active, aggressive disease course and rapid disability accumulation remains difficult to define and there is no consensus about their management and treatment. The current lack of an accepted definition and treatment guidelines for aggressive MS triggered a 2018 focused workshop of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) on aggressive MS. The aim of the workshop was to discuss approaches on how to describe and define the disease phenotype and its treatments. Unfortunately, it was not possible to come to consensus on a definition because of unavailable data correlating severe disease with imaging and molecular biomarkers. However, the workshop highlighted the need for future research needed to define this disease subtype while also focusing on its treatment and management. Here, we review previous attempts to define aggressive MS and present characteristics that might, with additional research, eventually help characterize it. A companion paper summarizes data regarding treatment and management.

Published
2020

32. Deeply virtual and exclusive electroproduction of ω-mesons

Author

Morand, L., Doré, D., Garçon, M., Guidal, M., Laget, J. -M., Morrow, S., Sabatié, F., Smith, E., Adams, G., Ambrozewicz, P., Anghinolfi, M., Asryan, G., Audit, G., Avakian, H., Bagdasaryan, H., Ball, J., Ball, J. P., Baltzell, N. A., Barrow, S., Batourine, V., Battaglieri, M., Bektasoglu, M., Bellis, M., Benmouna, N., Berman, B. L., Biselli, A. S., Boiarinov, S., Bonner, B. E., Bouchigny, S., Bradford, R., Branford, D., Briscoe, W. J., Brooks, W. K., Bültmann, S., Burkert, V. D., Butuceanu, C., Calarco, J. R., Careccia, S. L., Carman, D. S., Cazes, A., Chen, S., Cole, P. L., Cords, D., Corvisiero, P., Crabb, D., Cummings, J. P., De Sanctis, E., DeVita, R., Degtyarenko, P. V., Denizli, H., Dennis, L., Deur, A., Dharmawardane, K. V., Dhuga, K. S., Djalali, C., Dodge, G. E., Donnelly, J., Doughty, D., Dugger, M., Dytman, S., Dzyubak, O. P., Egiyan, H., Egiyan, K. S., Elouadrhiri, L., Eugenio, P., Fatemi, R., Feldman, G., Fersch, R. G., Feuerbach, R. J., Funsten, H., Gavalian, G., Gilfoyle, G. P., Giovanetti, K. L., Girod, F. -X., Goetz, J. T., Gordon, C. I. O., Gothe, R. W., Griffioen, K. A., Guillo, M., Guler, N., Guo, L., Gyurjyan, V., Hadjidakis, C., Hakobyan, R. S., Hardie, J., Heddle, D., Hersman, F. W., Hicks, K., Hleiqawi, I., Holtrop, M., Hyde-Wright, C. E., Ilieva, Y., Ireland, D. G., Ito, M. M., Jenkins, D., Jo, H. -S., Joo, K., Juengst, H. G., Kellie, J. D., Khandaker, M., Kim, W., Klein, A., Klein, F. J., Klimenko, A. V., Kossov, M., Kubarovski, V., Kramer, L. H., Kuhn, S. E., Kuhn, J., Lachniet, J., Langheinrich, J., Lawrence, D., Lee, T., Li, Ji, Livingston, K., Marchand, C., Maximon, L. C., McAleer, S., McKinnon, B., McNabb, J. W. C., Mecking, B. A., Mehrabyan, S., Melone, J. J., Mestayer, M. D., Meyer, C. A., Mikhailov, K., Minehart, R., Mirazita, M., Miskimen, R., Mokeev, V., Mueller, J., Mutchler, G. S., Napolitano, J., Nasseripour, R., Niccolai, S., Niculescu, G., Niculescu, I., Niczyporuk, B. B., Niyazov, R. A., Nozar, M., O’Rielly, G. V., Osipenko, M., Ostrovidov, A. I., Park, K., Pasyuk, E., Philips, S. A., Pivnyuk, N., Pocanic, D., Pogorelko, O., Polli, E., Popa, I., Pozdniakov, S., Preedom, B. M., Price, J. W., Prok, Y., Protopopescu, D., Raue, B. A., Riccardi, G., Ricco, G., Ripani, M., Ritchie, B. G., Ronchetti, F., Rosner, G., Rossi, P., Rubin, P. D., Salgado, C., Santoro, J. P., Sapunenko, V., Schumacher, R. A., Serov, V. S., Sharabian, Y. G., Shaw, J., Skabelin, A. V., Smith, L. C., Sober, D. I., Stavinsky, A., Stepanyan, S., Stepanyan, S. S., Stokes, B. E., Stoler, P., Strakovsky, I. I., Strauch, S., Taiuti, M., Tedeschi, D. J., Thoma, U., Tkabladze, A., Todor, L., Tur, C., Ungaro, M., Vineyard, M. F., Vlassov, A. V., Weinstein, L. B., Weygand, D. P., Williams, M., Wolin, E., Wood, M. H., Yegneswaran, A., Zana, L., and The CLAS Collaboration

Published
2005
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36. Survey of [formula omitted] asymmetries in semi-exclusive electron scattering on 4He and 12C

Author

Protopopescu, D., Hersman, F.W., Holtrop, M., Adams, G., Ambrozewicz, P., Anciant, E., Anghinolfi, M., Asavapibhop, B., Asryan, G., Audit, G., Auger, T., Avakian, H., Bagdasaryan, H., Ball, J.P., Barrow, S., Battaglieri, M., Beard, K., Bektasoglu, M., Bellis, M., Benmouna, N., Berman, B.L., Bertozzi, W., Bianchi, N., Biselli, A.S., Boiarinov, S., Bonner, B.E., Bouchigny, S., Bradford, R., Branford, D., Briscoe, W.J., Brooks, W.K., Burkert, V.D., Butuceanu, C., Calarco, J.R., Carman, D.S., Carnahan, B., Cetina, C., Chen, S., Cole, P.L., Coleman, A., Cords, D., Corvisiero, P., Crabb, D., Crannell, H., Cummings, J.P., Debruyne, D., De Sanctis, E., DeVita, R., Degtyarenko, P.V., Dennis, L., Dharmawardane, K.V., Dhuga, K.S., Djalali, C., Dodge, G.E., Doughty, D., Dragovitsch, P., Dugger, M., Dytman, S., Dzyubak, O.P., Egiyan, H., Egiyan, K.S., Elouadrhiri, L., Empl, A., Eugenio, P., Fatemi, R., Feuerbach, R.J., Forest, T.A., Funsten, H., Gavalian, G., Gilad, S., Gilfoyle, G.P., Giovanetti, K.L., Girard, P., Gordon, C.I.O., Gothe, R.W., Griffioen, K.A., Guidal, M., Guillo, M., Guler, N., Guo, L., Gyurjyan, V., Hadjidakis, C., Hakobyan, R.S., Hardie, J., Heddle, D., Hicks, K., Hleiqawi, I., Hu, J., Hyde-Wright, C.E., Ingram, W., Ireland, D., Ito, M.M., Jenkins, D., Joo, K., Juengst, H.G., Kelley, J.H., Kellie, J.D., Khandaker, M., Kim, K.Y., Kim, K., Kim, W., Klein, A., Klein, F.J., Klimenko, A.V., Klusman, M., Kossov, M., Kramer, L.H., Kuhn, S.E., Kuhn, J., Lachniet, J., Laget, J.M., Langheinrich, J., Lawrence, D., Lee, T., Li, Ji, Livingston, K., Lukashin, K., Manak, J.J., Marchand, C., McAleer, S., McLauchlan, S.T., McNabb, J.W.C., Mecking, B.A., Melone, J.J., Mestayer, M.D., Meyer, C.A., Mikhailov, K., Minehart, R., Mirazita, M., Miskimen, R., Morand, L., Morrow, S.A., Muccifora, V., Mueller, J., Mutchler, G.S., Napolitano, J., Nasseripour, R., Nelson, S.O., Niccolai, S., Niculescu, G., Niculescu, I., Niczyporuk, B.B., Niyazov, R.A., Nozar, M., O'Rielly, G.V., Osipenko, M., Ostrovidov, A., Park, K., Pasyuk, E., Peterson, G., Philips, S.A., Pivnyuk, N., Pocanic, D., Pogorelko, O., Polli, E., Pozdniakov, S., Preedom, B.M., Price, J.W., Prok, Y., Qin, L.M., Raue, B.A., Riccardi, G., Ricco, G., Ripani, M., Ritchie, B.G., Ronchetti, F., Rosner, G., Rossi, P., Rowntree, D., Rubin, P.D., Ryckebusch, J., Sabatié, F., Sabourov, K., Salgado, C., Santoro, J.P., Sapunenko, V., Schumacher, R.A., Serov, V.S., Sharabian, Y.G., Shaw, J., Simionatto, S., Skabelin, A.V., Smith, E.S., Smith, L.C., Sober, D.I., Spraker, M., Stavinsky, A., Stepanyan, S., Stokes, B.E., Stoler, P., Strauch, S., Taiuti, M., Taylor, S., Tedeschi, D.J., Thoma, U., Thompson, R., Tkabladze, A., Todor, L., Tur, C., Ungaro, M., Vineyard, M.F., Vlassov, A.V., Wang, K., Weinstein, L.B., Weller, H., Weygand, D.P., Whisnant, C.S., Williams, M., Wolin, E., Wood, M.H., Yegneswaran, A., Yun, J., Zana, L., and Zhang, B.

Published
2005
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37. Gestión de potencialidades formativas de escolares con discapacidad intelectual: pautas metodológicas desde la psicología positiva.

Author

Ramiro Gross-Tur, C., Martinez-Rosales, Yamilé, Angel Deroncele-Acosta, C., and Esther Miller-Contreras, Mirba

Subjects
*ATTENTION control, *POSITIVE psychology, *INTELLECTUAL disabilities, *EMOTIONS, *MINDFULNESS
Abstract

The present study is carried out with the objective of proposing methodological guidelines for the management of the educational potentialities of schoolchildren with intellectual disabilities (ID) from positive psychology. It is based on an optimistic conception of human development applied to the particularities of schoolchildren with ID. The proposal is operationalized in mindfulness and its specific mechanisms of action: attentional control and sustainability, cognitive distancing, and cognitive revaluation of emotions. It is concluded that understanding people with ID from a positive, optimistic and developmental perspective constitutes an unavoidable premise to manage their educational potentialities in a healthy, respectful and creative way. Operationally, positive psychology, through the application of mindfulness, constitutes a viable support for the management of training potential in people with ID. [ABSTRACT FROM AUTHOR]

Published
2021

41. Evidence-based guidelines: MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-establishing disease prognosis and monitoring patients

Author

Wattjes MP, Rovira A, Miller DH, Yousry TA, Sormani MP, De Stefano N, Tintoré M, Auger C, Tur C, Rocca MA, Fazekas F, Kappos L, Polman CH, Barkhof F, Montalban X. on behalf of the MAGNIMS study group, FILIPPI , MASSIMO, Wattjes, Mp, Rovira, A, Miller, Dh, Yousry, Ta, Sormani, Mp, De Stefano, N, Tintoré, M, Auger, C, Tur, C, Filippi, Massimo, Rocca, Ma, Fazekas, F, Kappos, L, Polman, Ch, Barkhof, F, and Montalban X., on behalf of the MAGNIMS study group

Published
2015

47. Evidence-Based Guidelines Magnims Consensus Guidelines on the Use of Mri in Multiple Sclerosis-Establishing Disease Prognosis and Monitoring Patients

Author

Wattjes, M.P., Rovira, A., Miller, D., Yousry, T.A., Sormani, M.P., De Stefano, N., Tintore, M., Auger, C., Tur, C., Filippi, M., Rocca, M.A., Fazekas, F., Kappos, L., Polman, C., Barkhof, F., Montalban, X., Radiology and nuclear medicine, Neurology, NCA - Neuroinflamation, and NCA - Brain imaging technology

Subjects
Cellular and Molecular Neuroscience, Consensus, Evidence-Based Medicine, Multiple Sclerosis, Neurology (clinical), Brain, Disease Progression, Humans, Immunotherapy, Magnetic Resonance Imaging, Prognosis
Published
2015

48. Measurement of the x- and Q2-dependence of the asymmetry A1 on the nucleon

Author

Dharmawardane, K.V., Kuhn, S.E., Bosted, P., Prok, Y., Adams, G., Ambrozewicz, P., Anghinolfi, M., Asryan, G., Avakian, H., Bagdasaryan, H., Baillie, N., Ball, J.P., Baltzell, N.A., Barrow, S., Batourine, V., Battaglieri, M., Beard, K., Bedlinskiy, I., Bektasoglu, M., Bellis, M., Benmouna, N., Biselli, A.S., Bonner, B.E., Bouchigny, S., Boiarinov, S., Bradford, R., Branford, D., Brooks, W.K., Bültmann, S., Burkert, V.D., Butuceanu, C., Calarco, J.R., Careccia, S.L., Carman, D.S., Carnahan, B., Cazes, A., Chen, S., Cole, P.L., Collins, P., Coltharp, P., Cords, D., Corvisiero, P., Crabb, D., Crannell, H., Crede, V., Cummings, J.P., De Masi, R., DeVita, R., De Sanctis, E., Degtyarenko, P.V., Denizli, H., Dennis, L., Deur, A., Djalali, C., Dodge, G.E., Donnelly, J., Doughty, D., Dragovitsch, P., Dugger, M., Dytman, S., Dzyubak, O.P., Egiyan, H., Egiyan, K.S., Elouadrhiri, L., Eugenio, P., Fatemi, R., Fedotov, G., Feuerbach, R.J., Forest, T.A., Funsten, H., Garçon, M., Gavalian, G., Gilfoyle, G.P., Giovanetti, K.L., Girod, F.X., Goetz, J.T., Golovatch, E., Gonenc, A., Gothe, R.W., Griffioen, K.A., Guidal, M., Guillo, M., Guler, N., Guo, L., Gyurjyan, V., Hadjidakis, C., Hafidi, K., Hakobyan, R.S., Hardie, J., Heddle, D., Hersman, F.W., Hicks, K., Hleiqawi, I., Holtrop, M., Huertas, M., Hyde-Wright, C.E., Ilieva, Y., Ireland, D.G., Ishkhanov, B.S., Isupov, E.L., Ito, M.M., Jenkins, D., Jo, H.S., Joo, K., Juengst, H.G., Keith, C., Kellie, J.D., Khandaker, M., Kim, K.Y., Kim, K., Kim, W., Klein, A., Klein, F.J., Klusman, M., Kossov, M., Kramer, L.H., Kubarovsky, V., Kuhn, J., Kuleshov, S.V., Lachniet, J., Laget, J.M., Langheinrich, J., Lawrence, D., Li, Ji, Lima, A.C.S., Livingston, K., Lu, H., Lukashin, K., MacCormick, M., Manak, J.J., Markov, N., McAleer, S., McKinnon, B., McNabb, J.W.C., Mecking, B.A., Mestayer, M.D., Meyer, C.A., Mibe, T., Mikhailov, K., Minehart, R., Mirazita, M., Miskimen, R., Mokeev, V., Morand, L., Morrow, S.A., Moteabbed, M., Mueller, J., Mutchler, G.S., Nadel-Turonski, P., Napolitano, J., Nasseripour, R., Niccolai, S., Niculescu, G., Niculescu, I., Niczyporuk, B.B., Niroula, M.R., Niyazov, R.A., Nozar, M., O'Rielly, G.V., Osipenko, M., Ostrovidov, A.I., Park, K., Pasyuk, E., Paterson, C., Philips, S.A., Pierce, J., Pivnyuk, N., Pocanic, D., Pogorelko, O., Polli, E., Pozdniakov, S., Preedom, B.M., Price, J.W., Protopopescu, D., Qin, L.M., Raue, B.A., Riccardi, G., Ricco, G., Ripani, M., Ritchie, B.G., Ronchetti, F., Rosner, G., Rossi, P., Rowntree, D., Rubin, P.D., Sabatié, F., Salgado, C., Santoro, J.P., Sapunenko, V., Schumacher, R.A., Serov, V.S., Sharabian, Y.G., Shaw, J., Shvedunov, N.V., Skabelin, A.V., Smith, E.S., Smith, L.C., Sober, D.I., Stavinsky, A., Stepanyan, S.S., Stepanyan, S., Stokes, B.E., Stoler, P., Strakovsky, I.I., Strauch, S., Suleiman, R., Taiuti, M., Taylor, S., Tedeschi, D.J., Thoma, U., Thompson, R., Tkabladze, A., Tkachenko, S., Todor, L., Tur, C., Ungaro, M., Vineyard, M.F., Vlassov, A.V., Weinstein, L.B., Weygand, D.P., Williams, M., Wolin, E., Wood, M.H., Yegneswaran, A., Yun, J., Zana, L., Zhang, J., Zhao, B., and Zhao, Z.

Subjects
Nuclear and High Energy Physics
Published
2006
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49. Combination antifungal therapy: A strategy for the management of invasive fungal infections

Author

Carrillo-Muñoz, A. J., Finquelievich, J., Tur-Tur, C., Eraso, E., Jauregizar, N., Quindós, G., and Gustavo Giusiano

Subjects
Enfermedades Infecciosas, purl.org/becyt/ford/3.3 [https], CIENCIAS MÉDICAS Y DE LA SALUD, Micosis invasoras, Tratamiento, Ciencias de la Salud, purl.org/becyt/ford/3 [https], Antifúngicos, Combinaciones
Abstract

The lack of an ideal antifungal drug or completely successful agent, suggests that combination therapy may be an appropriate option for the management of fungal infections. In this review, different antifungal combination therapy approaches will be discussed. In brief, the rationale for combination therapy is to maximize antifungal effects by attacking different fungal targets at the same time. However, the scientific basis for this approach requires evidence from prospective clinical trials of antifungal combinations. It is possible that real advantages will be seen for particular combinations only in particular mycoses and/or particular types of patient. Combination tends to reduce clinical failure when resistant strains could be recovered from patients, although drug interactions and cross-resistance may result. Synergy has been established between conventional antifungal agents and also between investigational molecules. Alternatively, combination of fluconazole and cyclosporine results fungicidal for fluconazole-susceptible strains of Candida albicans. An overall enhanced susceptibility is reached in intrinsically resistant Candida when combination of azole antifungal drugs or terbinafine with calcineurin inhibitors is used. Azoles, such as voriconazole, itraconazole, and fluconazole are being tested in combination with other antifungal agents such as amphotericin B, caspofungin, or terbinafine and. In addition, amphotericin B is actually administered in combined therapy with caspofungin. The traditional combinations of amphotericin B plus 5-fluorocytosine or amphotericin B plus rifampicin have been replaced by these newer combinations. Other combinations such as caspofungin plus amphotericin B or voriconazole have also been synergic against clinical isolates of Aspergillus and Fusarium. This has been confirmed in animal models in the case of caspofungin plus itraconazole in the treatment of invasive pulmonary aspergillosis and caspofungin plus liposomal amphotericin B in the management of invasive aspergillosis. Fil: Carrillo Muñoz, A. J.. Departamento de Micología; España Fil: Finquelievich, Jorge. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Tur Tur, Cristina. Departamento de Micología; España Fil: Eraso, Elena. Universidad del Pais Vasco; España Fil: Jaureguizar, Nerea. Universidad del Pais Vasco; España Fil: Quindós, Guillermo. Universidad del Pais Vasco; España Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina

Published
2014

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