Huanliang Liu, Yon Hwangbo, Holte, Sarah, Lee, Jean, Chunhui Wang, Kaupp, Nicole, Haiying Zhu, Celum, Connie, Corey, Lawrence, McElrath, M. Juliana, and Tuotu Zhu
To determine the influence of host genetics on human immunodeficiency virus (HIV) type I infection, we examined 94 repeatedly exposed seronegative (ES) individuals for polymorphisms in multiple genes and compared the results with those fur 316 HIV-1-seropositive and 425 HIV-1-seronegative individuals. The frequency of homozygous C-C the mokine receptor (CCR) 5-Δ32 was higher in ES (3.2%) than in HIV-1-seropositive individuals (0.0%; P = .012). However, the CCR5-59029A, CCR2-64I, stromal cell-derived factor (SDF)-1-3A, RANTES (regulated on activation, normally T cell-expressed and secreted)-403A, and RANTES-28G polymorphisms were not associated with resistance to HIV-1 in- fection. Furthermore, we identified novel variants in the DC-SIGN (dendritic cell specific intercellular adhesion tool ecule-3-grabbing nonintegrin) repeat region and observed that heterozygous DC-SIGN reduced the risk of HIV-1-seroposfection (3.2% in ES individuals vs. 0.0% in HIV-1-seropositive individuals; P = .011). [ABSTRACT FROM AUTHOR]