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Objectives : The purpose of this study is to compare the effects of Hwangryunhaedok-tang pharmacopuncture therapy with Hominis Placenta pharmacopncture therapy in hospitalized patients with peripheral facial paralysis. Methods : We investigated 34 cases of patients with peripheral facial paralysis who were admitted into the Dept. of Acupuncture & Moxibustion of Dongshin University Suncheon Oriental Hospital from February 1, 2014 to June 31, 2015. Subjects were divided into two groups, Hwangryunhaedok-tang pharmacopuncture group(HR group), and Hominis Placenta Pharmacopuncture group(JH group). HR group was treated by Hwangryunhaedok-tang pharmacopuncture five times a week and JH group was treated by Hominis Placenta Pharmacopuncture five times a week. And both groups were treated by acupuncture, electroacupuncture, herbal medicine therapy, western drug therapy equally. To investigate the effectiveness of treatment, we used House-Brackmann Grading System, Yanagihara's unweighted grading system and Sunnybrook facial grading scale at before admission and after admission. Results : Each scores by 3 evaluation methods improved both in two groups. However, there were no significant differences in improvement between two groups. Conclusions : These results suggest that the Hwangryunhaedok-tang pharmacopuncture therapy is as effective as Hominis Placenta pharmacopuncture therapy to improve symptoms of peripheral facial paralysis.

Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongshin University 2 Department of Oriental Neuropsychiatry, College of Oriental Medicine, Dongshin University College of Oriental Medicine, Dongshin University Department of Oriental Opthalmology, Otolaryngology & Dermatology, College of Oriental Medicine, Dongshin University Department of Oriental Gynecology, College of Oriental Medicine, Dongshin University Department of Oriental Internal Medicine, College of Oriental Medicine, Dongshin University 7 Department of Acupoint & Meridian, College of Oriental Medicine, Dongshin University

Objectives : This study was performed to investigate the effect of herbal steam therapy on peripheral facial paralysis. Methods : 55 patients with peripheral facial paralysis were treated with Korean Medicine therapy including herbal steam therapy. We evaluated the effect of Korean Medicine therapy including herbal steam therapy by Yanagihara grading system. Results : 1. 55 patients were treated with Korean Medicine therapy and 23.27±14.11 times of herbal steam therapy. 2. After treatment, Y-system score was significantly increased(p-value＜0.001) from 18.00±6.5514 to 35.00±6.3404. Conclusions : Herbal stream therapy seem to be effective to improve symptoms of peripheral facial paralysis. Further studies will be needed to identify the beneficial of herbal steam therapy on peripheral facial paralysis.

Objectives : Herba on lipid levels in serum and lipid accumulation in liver tissue in high fat diet-induced hyperlipidemic mice. Methods : Experimental groups were subdivided into four; Normal diet group (Nor), Hyperlipidemic mice (Con), Lysimachiae Herba water extract administered mice (LWE), Lysimachiae Herba methanol extract administered mice (LME). Thereafter the changes in body weight, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, AST, ALT, fasting blood glucose in serum were measured. In addition histopathological changes in liver tissue was also observed. Results : Body weight, AST and ALT were not affected by the administration of water or methanol extracts of Lysimachiae Herba. However, methanol extracts of Lysimachiae Herba down regulated the total cholesterol and triglyceride in high fat diet - induced hyperlipidemic mice. Conclusions : In this study, results of total cholesterol and triglyceride showed significant effect in LME compared with LWE, but other results didn’t. Therefore, it is necessary to have more study of Lysimachiae Herba to apply hyperlipidemia.

Objectives: Banhahoobak-tang has been used to treat plum-pit qi, chest and hypochondriac dis-tension, moist or greasy tongue coat, and wiry slow or wiry slippery pulse. It might be used to control coughing and vomiting. We observed that Banhahoobak-tang extract (BHTe) had anti-psychological stress effect. The objective of this study was to determine the effect of BHTe on restoring the transcrip-tional regulation of genes related to psychological stress. Methods: After giving psychological stress to mice, BHTe was orally administered at 100 mg/kg/day for five days. After extracting whole brain tissue from the mice, the gene expression changes were de-termined by microarray. Transcription factor binding site (TFBS) analysis showed up- and down-regu-lated genes related to psychological stress were protected by BHTe and segregated according to the structure of TFBS. We performed text based Pubmed search to select significant target genes involved in psychological stress affected by BHTe.Results: 1. Serum corticosterone level was decreased in the BHTe administered group, although the psychological stress was increased. 2. The BHTe administered group had no significant change in nora-drenaline content in brain tissue, but the psychological stress group had decreased level. 3. The BHTe administered group had increased time of staying at open-arm than the psychological stress group. 4. Microarray revealed that TANK and RARA genes were up-regulated genes while AES, CDC42, FOS, NCL, and PVR were down-regulated genes by psychological stress but restored by BHTe.Key Words: Banhahoobak-tang extract (BHTe), Psychological stress, Anti-anxiety effect, Microarray.

Results: Treatment with CRVP decreased proliferation rates in a dose dependent manner. ID50 (50% inhibitory dosage) was 175.4 μg/ml. In the CRVP treated group, cell volumes showed smaller than non-treated normal. In addition, CRVP increased percentage of apoptotic and sub G1 arrested cells respectively. 200 μg/ml of CRVP treatment increased intracellular ROS level significantly. Finaly the expression level of caspase 3 and Bax/Bcl-2 ratio were elevated by treatment with CRVP respectively. Conclusions: These results suggest that CRVP can trigger intrinsic apoptotic pathway in MDA-MB-231 cells.

A multi-cup electric cupping system (MECS) was proposed, based on the ancient cupping method. MECS consisted of several cups that could be used simultaneously to treat 85 lumbago patients. Each cup was equipped with its own pump and pressure-monitoring system. The vacuum pressure of the cups was controlled using fuzzy logic. Through automated control of the vacuum pressure, long-term relief of muscle tightness was achieved. To develop a scientific foundation for this alternative treatment, we compared the Oswestry Disability Index (ODI) scores from conventional basic cupping to the ODI scores for our proposed MECS. The ODI scores using MECS decreased from 11.71 ± 1.61 before treatment to 4.81 ± 1.48 and 1.87 ± 1.61 after three and five treatments, respectively. The improvement rate in the ODI scores using MECS after three treatments was higher than that achieved by basic cupping. These results, combined with the convenience offered by enhanced information technology and fuzzy logic capabilities, should increase the efficiency of this device, and facilitate the opportunity to further explore the potential of Oriental medical practices.

Objectives : The purpose of this report is to show the effectiveness of traditional korean medical treatment with Hwangryunhaedok-tang pharmacopuncture. Methods : Twenty five patients were treated by korean medical treatment including Hwangryunhaedok-tang pharmacopuncture. We measured valuation standards such as House-Brackmann Grade(H-B Grade) and Numeric Rating Scale(NRS) to assess the effectiveness of treatments. These valuation standards were measured at admisson and discharge. Results : The results were obtained as below. 1. In House-Brackmann Grade, 60.0% of patients were improved and 36.0% were maintained at the same level. 4.0% of patients were worsen. 2. Average of Numeric Rating Scale was changed from 8.5 to 3.0 after whole treatment. Conclusions : Korean medical treatments including Hwangryunhaedok-tang pharmacopunture can be effective for improving symptoms of facial paralysis.

Objectives : The purpose of this report is to show the clinical efficiency of korean medical treatments with Bee Venom pharmacopuncture therapy on patient of Trigeminal Neuralgia. Methods : The patient was treated with Bee Venom pharmacopuncture, acupuncture, electroacupuncture, cupping venesection treatment, and herbal medicine. Visual Analog Scale was used to evaluate the improvement of pain after all treatments. Results : Visual Analog Scale was improved from 10 to 2 after korean medical treatment including Bee Venom pharmacopuncture. Conclusions : Korean medical treatments with Bee Venom pharmacopuncture can be effective for improving symptoms of Trigeminal Neuralgia.

In this study, a hybrid multi-cup electric cupping system (HMECS) was proposed, based on the ancient cupping method. HMECS consisted of several cups that could be used simultaneously to treat different areas of the patient’s body. Each cup was equipped with its own pump and pressure-monitoring system. Moreover, the vacuum pressure of the cups was controlled using fuzzy logic. Through automated control of the vacuum pressure, long-term relief of muscle tightness was achieved. To develop a scientific foundation for this alternative treatment, we compared the VAS(Visual Analog Scale) and ODI(Oswestry Disability Index) scores from conventional basic cupping to the VAS and ODI scores for our proposed HMECS. The improvement rate in the VAS and ODI scores using HMECS after three treatments was higher than that achieved by basic cupping. These results, combined with the convenience offered by enhanced IT capabilities, should increase the popularity of this device among an aging society, and facilitate the opportunity to further explore the potential of Oriental medical practices.