135 results on '"Tunesi, S"'
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2. Environmental asbestos exposure and clustering of malignant mesothelioma in community: a spatial analysis in a population-based case–control study
- Author
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Airoldi, C., Magnani, C., Lazzarato, F., Mirabelli, D., Tunesi, S., and Ferrante, D.
- Published
- 2021
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3. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19
- Author
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Matuozzo, D, Talouarn, E, Marchal, A, Zhang, P, Manry, J, Seeleuthner, Y, Zhang, Y, Bolze, A, Chaldebas, M, Milisavljevic, B, Gervais, A, Bastard, P, Asano, T, Bizien, L, Barzaghi, F, Abolhassani, H, Abou Tayoun, A, Aiuti, A, Alavi Darazam, I, Allende, L, Alonso-Arias, R, Arias, A, Aytekin, G, Bergman, P, Bondesan, S, Bryceson, Y, Bustos, I, Cabrera-Marante, O, Carcel, S, Carrera, P, Casari, G, Chaibi, K, Colobran, R, Condino-Neto, A, Covill, L, Delmonte, O, El Zein, L, Flores, C, Gregersen, P, Gut, M, Haerynck, F, Halwani, R, Hancerli, S, Hammarstrom, L, Hatipoglu, N, Karbuz, A, Keles, S, Kyheng, C, Leon-Lopez, R, Franco, J, Mansouri, D, Martinez-Picado, J, Metin Akcan, O, Migeotte, I, Morange, P, Morelle, G, Martin-Nalda, A, Novelli, G, Novelli, A, Palabiyik, F, Pan-Hammarstrom, Q, de Diego, R, Planas-Serra, L, Pleguezuelo, D, Prando, C, Pujol, A, Reyes, L, Riviere, J, Rodriguez-Gallego, C, Rojas, J, Rovere-Querini, P, Schluter, A, Shahrooei, M, Sobh, A, Soler-Palacin, P, Tandjaoui-Lambiotte, Y, Tipu, I, Tresoldi, C, Troya, J, van de Beek, D, Zatz, M, Zawadzki, P, Al-Muhsen, S, Alosaimi, M, Alsohime, F, Baris-Feldman, H, Butte, M, Constantinescu, S, Cooper, M, Dalgard, C, Fellay, J, Heath, J, Lau, Y, Lifton, R, Maniatis, T, Mogensen, T, von Bernuth, H, Lermine, A, Vidaud, M, Boland, A, Deleuze, J, Nussbaum, R, Kahn-Kirby, A, Mentre, F, Tubiana, S, Gorochov, G, Tubach, F, Hausfater, P, Al-Mulla, F, Anderson, M, Andreakos, E, Feldman, H, Belot, A, Biggs, C, Bogunovic, D, Bondarenko, A, Bousfiha, A, Brodin, P, Bustamante, C, Chakravorty, S, Christodoulou, J, Desai, M, Drolet, B, Baghdadi, J, Espinosa-Padilla, S, Froidure, A, Hagin, D, Henrickson, S, Hsieh, E, Husebye, E, Imai, K, Itan, Y, Jarvis, E, Karamitros, T, Kisand, K, Ku, C, Ling, Y, Lucas, C, Marodi, L, Milner, J, Mironska, K, Morio, T, Ng, L, O'Farrelly, C, Okada, S, Planas, A, Quintana-Murci, L, Renia, L, Resnick, I, Sancho-Shimizu, V, Sediva, A, Seppanen, M, Shcherbina, A, Slaby, O, Snow, A, Spaan, A, Tancevski, I, Tangye, S, Ramaswamy, S, Turvey, S, Uddin, F, Uddin, M, Vinh, D, Casanova, J, Vacher, Y, Gysembergh-Houal, A, Demerville, L, Chachoua, A, Abad, S, Abassi, R, Abdellaoui, A, Abdelmalek, A, Abdoul, H, Abergel, H, Abeud, F, Abgrall, S, Abisror, N, Adechian, M, Aderdour, N, Admane, H, Adnet, F, Afritt, S, Agostini, H, Aguilar, C, Agut, S, Aiello, T, Kaci, M, Oufella, H, Ajeenthiravasan, G, Alauzy, V, Alby-Laurent, F, Allard, L, Alyanakian, M, Borrero, B, Amam, S, Amrouche, L, Andronikof, M, Anglicheau, D, Anguel, N, Annane, D, Aounzou, M, Aparicio, C, Aratus, G, Arlet, J, Arzoine, J, Aslangul, E, Assefi, M, Aubry, A, Audiffred, L, Audureau, E, Auger, C, Auregan, J, Awotar, C, Milla, S, Azan, D, Azemar, L, Azzouguen, B, Elrufaai, M, Badsi, A, Bakouboula, P, Balcerowiak, C, Balde, F, Baldivia, E, Bangamingo, E, Baptiste, A, Baran-Marszak, F, Barau, C, Barget, N, Baronnet, F, Barthelemy, R, Baudel, J, Baudry, C, Baudry, E, Beaugerie, L, Belamri, A, Belaube, N, Belilita, R, Bellassen, P, Belmokhtar, R, Beltran, I, Benainous, R, Benallaoua, M, Benamouzig, R, Benbara, A, Benhida, J, Benkhelouf, A, Benlagha, J, Benmostafa, C, Benothmane, S, Bentifraouine, M, Berard, L, Bernier, Q, Berti, E, Bertier, A, Berton, L, Bessis, S, Beurton, A, Bianco, C, Bianquis, C, Bidar, F, Blanche, P, Blayau, C, Bleibtreu, A, Blin, E, Bloch-Queyrat, C, Boissier, M, Bollens, D, Bolzoni, M, Bompard, R, Bonnet, N, Bonnouvrier, J, Botha, S, Boucenna, W, Bouchama, F, Bouchaud, O, Bouchghoul, H, Boudjebla, T, Boudjema, N, Bouffard, C, Bougle, A, Bouguerra, M, Bouras, L, Bourcier, A, Durand, A, Bourrier, A, Bouscarat, F, Bouvry, D, Bouziri, N, Bouzrara, O, Bribier, S, Brugier, D, Brunel, M, Bui, E, Buisson, A, Bukreyeva, I, Bureau, C, Cadranel, J, Cailhol, J, Calin, R, Vega, C, Canavaggio, P, Cancella, M, Cantin, D, Cao, A, Carbillon, L, Carlier, N, Cassard, C, Castor, G, Cauchy, M, Cha, O, Chaigne, B, Challal, S, Champion, K, Chariot, P, Chas, J, Chauveau, S, Chauvin, A, Chauvin, C, Chavarot, N, Chebbout, K, Cherai, M, Cherubini, I, Chevalier, A, Chiarabini, T, Chinet, T, Chocron, R, Choinier, P, Chommeloux, J, Choquet, C, Choupeaux, L, Chousterman, B, Ciocan, D, Clarke, A, Clavere, G, Clavier, F, Clement, K, Clerc, S, Cohen, Y, Cohen, F, Cohen, A, Coilly, A, Colboc, H, Colin, P, Collet, M, Comarmond, C, Combacon, E, Combes, A, Comparon, C, Constantin, J, Cordel, H, Cordier, A, Costantini, A, Chalumeau, N, Couffignal, C, Coupeau, D, Creange, A, Lamarre, Y, Da Silveira, C, Kayani, S, De Castro, N, De Rycke, Y, Del Pozo, L, Delannoy, Q, Delay, M, Deleris, R, Delforge, J, Delphine, L, Demare, N, Demeret, S, Demoule, A, Deniau, A, Depret, F, Derolez, S, Derradji, O, Derridj, N, Descamps, V, Deschamps, L, Desconclois, C, Desnos, C, Desongins, K, Dhote, R, Diallo, B, Didier, M, Diemer, M, Diez, S, Djadi-Prat, J, Monnory, F, Djebara, S, Djebra, N, Djietcheu, M, Djillali, H, Djouadi, N, Donneger, S, Dos Santos, C, Dournon, N, Dres, M, Droctove, L, Drogrey, M, Dropy, M, Drouet, E, Dubosq, V, Dubreucq, E, Dubus, E, Duchemann, B, Duchenoy, T, Dudoignon, E, Dufau, R, Dumas, F, Duran, C, Duron, E, Durrbach, A, Duvivier, C, Ebstein, N, Khalifa, J, Elabbadi, A, Elie, C, Ernotte, G, Esling, A, Etienne, M, Eyer, X, Fartoukh, M, Fayali, T, Fermaut, M, Fiorentino, A, Fliss, S, Fournier, M, Fournier, B, Francois, H, Freynet, O, Frigout, Y, Fromont, I, Fuentes, A, Furet, T, Galand, J, Garnier, M, Gaubert, A, Gaudry, S, Gaugain, S, Gauthier, D, Gautier, M, Georgin-Lavialle, S, Geromin, D, Ghalayini, M, Ghaleh, B, Ghezal, M, Gibelin, A, Gimeno, L, Girard, B, Leprieur, B, Gomes, D, Gomes-Pires, E, Gouge, A, Gouja, A, Goulet, H, Goupil, S, De Bouille, J, Gras, J, Greffe, S, Grimaldi, L, Guedeney, P, Guidet, B, Guillo, M, Gulczynski, M, Hadjam, T, Haguenauer, D, Hammal, S, Hammoudi, N, Hanon, O, Harrois, A, Hautem, C, Hekimian, G, Heming, N, Hermine, O, Ho, S, Houllier, M, Huot, B, Huscenot, T, Saied, W, Ikherbane, G, Imarazene, M, Ingiliz, P, Iratni, L, Jaureguiberry, S, Jean-Marc, J, Jeyarajasingham, D, Jouany, P, Jouis, V, Jourdaine, C, Kafif, O, Kallala, R, Katsahian, S, Kelesyan, L, Keo, V, Ketz, F, Khamis, W, Khelili, E, Khellaf, M, Youkou, C, Kounis, I, Kpalma, G, Krause, J, Labbe, V, Lacombe, K, Lacorte, J, Lafont, A, Lafont, E, Lagha, L, Lamhaut, L, Lancelot, A, Landman, C, Lanternier, F, Larcheveque, C, Combe, C, Lassel, L, Laverdant, B, Lavergne, C, Lavillegrand, J, Lazureanu, P, Le Guennec, L, Leberre, L, Leblanc, C, Leboyer, M, Lecomte, F, Lecorre, M, Leenhardt, R, Lefebvre, M, Lefebvre, B, Legendre, P, Leger, A, Legros, L, Legrosse, J, Lehuunghia, S, Lemarec, J, Leporrier-Ext, J, Lesein, M, Lesur, H, Levy, V, Levy, A, Lopes, E, Lopes, A, Lopez, V, Lopinto, J, Lortholary, O, Louadah, B, Loze, B, Lucas, M, Lucasamichi, A, Luong, L, Magazimama-Ext, A, Maingret, D, Mameri, L, Manivet, P, Mansouri, C, Marcault, E, Marey, J, Marin, N, Marois, C, Martin, O, Martineau, L, Martinez-Lopez, C, Martyniuck, P, De Farcy, P, Marzouk, N, Masmoudi, R, Mebazaa, A, Mechai, F, Mecozzi, F, Mediouni, C, Megarbane, B, Meghadecha, M, Mejean, E, Mekinian, A, Abdelhadi, N, Mekni, R, Meliti, T, Lima, B, Meng, P, Merbah, S, Messani, F, Messaoudi, Y, Mewasing, B, Meziane, L, Michelot-Burger, C, Mignot, F, Minka, F, Miyara, M, Moine, P, Molina, J, Montegnies-Boulet, A, Monti, A, Montlahuc, C, Montout, A, Moores, A, Morbieu, C, Mortelette, H, Mouly, S, Muzaffar, R, Nacerddine, C, Nadal, M, Nadif, H, Nassarmadji, K, Natella, P, Ndingamondze, S, Neraal, S, Nguyen, C, N'Guyen, B, Larmurier, I, Nlomenyengue, L, Noel, N, Nunes, H, Omar, E, Ouazene, Z, Ouedraogo, E, Ouelaa, W, Oukhedouma, A, Amara, Y, Oya, H, Oziel, J, Padilla, T, Paillaud, E, Paiva, S, Parfait, B, Parize, P, Parizot, C, Parrot, A, Pavot, A, Peaudecerf, L, Pene, F, Pepin, M, Pernet, J, Pernin, C, Petit, M, Peyrony, O, Pietri, M, Pietri, O, De Chambrun, M, Pinson, M, Pintado, C, Pires, C, Planquette, B, Poirier, S, Pomel, A, Pons, S, Ponscarme, D, Pourcelot, A, Pourcher, V, Pouvaret, A, Prever, F, Previlon, M, Prevost, M, Provoost, M, Quemeneur, C, Rafat, C, Rami, A, Ranque, B, Raphael, M, Raphalen, J, Rastoin, A, Raux, M, Rebai, A, Reby, M, Regent, A, Regrag, A, Resche-Rigon, M, Ressaire, Q, Richard, C, Richard, M, Robert, M, Rohaut, B, Rolland-Debord, C, Ropers, J, Roque-Afonso, A, Rosso, C, Rousseaux, M, Rousseaux, N, Roux, S, Roux, L, Rouzaud, C, Rozes, A, Rubenstein, E, Sabate, J, Sabet, S, Sacleux, S, Kermanach, N, Saliba, F, Salmon, D, Savale, L, Savary, G, Sberro, R, Scemla, A, Schlemmer, F, Schwartz, M, Sedfi, S, Sefir-Kribel, S, Seksik, P, Sellier, P, Selves, A, Sembach, N, Semerano, L, Senat, M, Sene, D, Serris, A, Sese, L, Sghiouar, N, Sigaux, J, Siguier, M, Silvain, J, Simon, N, Simon, T, Skandri, L, Slimani, M, Snauwaert, A, Sokol, H, Soliman, H, Soltani, N, Soyer, B, Steg, G, Suarez, L, Szwebel, T, Taffame, K, Tantet, C, Tateo, M, Theodose, I, Thiebaud, P, Thomas, C, Tiercelet, K, Tisserand, J, Tomczak, C, Torelino, K, Touam-Ext, F, Toumi, L, Toury, G, Toy-Miou, M, Lien, O, Trandinh, A, Treluyer, J, Trinque, B, Truchot, J, Tunesi, S, Turpin, M, Turpin, A, Urbina, T, Narvaez, R, Uzunhan, Y, Vaittinadaayar, P, Valent, A, Valentian, M, Valin, N, Vallet, H, Vaz, M, Vazquezibarra, M, Vedie, B, Velly, L, Verstuyft, C, Viallette, C, Vicaut, E, Vignes, D, Vimpere, D, Virlouvet, M, Voiriot, G, Voisot, L, Weiss, E, Weiss, N, Winchenne, A, Yordanov, Y, Zafrani, L, Zaidan, M, Zaidi, W, Zak, C, Zarhrate-Ghoul, A, Zatout, O, Zeino, S, Zeitouni, M, Zemirli, N, Zerah, L, Zia, O, Ziol, M, Zolario, O, Zuber, J, Andrejak, C, Angoulvant, F, Bachelet, D, Bartoli, M, Basmaci, R, Behilill, S, Beluze, M, Benkerrou, D, Bhavsar, K, Bouadma, L, Bouchez, S, Bouscambert, M, Cervantes-Gonzalez, M, Chair, A, Coelho, A, D'Ortenzio, E, Debray, M, Deconinck, L, Deplanque, D, Descamps, D, Desvallee, M, Diallo, A, Diouf, A, Dorival, C, Dubos, F, Duval, X, Elharrar, B, Eloy, P, Enouf, V, Esperou, H, Esposito-Farese, M, Devouge, E, Gault, N, Gaymard, A, Ghosn, J, Gigante, T, Gilg, M, Guedj, J, Hoctin, A, Hoffmann, I, Houas, I, Hulot, J, Jaafoura, S, Kaguelidou, F, Kali, S, Khalil, A, Khan, C, Laouenan, C, Laribi, S, Le, M, Le Hingrat, Q, Le Mestre, S, Le Nagard, H, Lescure, F, Levy, Y, Lingas, G, Lucet, J, Malvy, D, Mambert, M, Meziane, A, Mouquet, H, Mullaert, J, Neant, N, Nguyen, D, Noret, M, Nseir, S, Papadopoulos, A, Paul, C, Peiffer-Smadja, N, Perpoint, T, Petrov-Sanchez, V, Peytavin, G, Pham, H, Picone, O, Puechal, O, Rabaud, C, Rosa-Calatrava, M, Rossignol, B, Rossignol, P, Roy, C, Schneider, M, Su, R, Tardivon, C, Tellier, M, Teoule, F, Terrier, O, Timsit, J, Tual, C, Van Der Werf, S, Vanel, N, Veislinger, A, Visseaux, B, Wiedemann, A, Yazdanpanah, Y, Alavoine, L, Behillil, S, Burdet, C, Charpentier, C, Dechanet, A, Ecobichon, J, Frezouls, W, Houhou, N, Lehacaut, J, Letrou, S, Lina, B, Manchon, P, Nouroudine, M, Piquard, V, Quintin, C, Thy, M, Vignali, V, Chahine, A, Waucquier, N, Migaud, M, Djossou, F, Mergeay-Fabre, M, Lucarelli, A, Demar, M, Bruneau, L, Gerardin, P, Maillot, A, Payet, C, Laviolle, B, Laine, F, Paris, C, Desille-Dugast, M, Fouchard, J, Pistone, T, Perreau, P, Gissot, V, Goas, C, Montagne, S, Richard, L, Chirouze, C, Bouiller, K, Desmarets, M, Meunier, A, Bourgeon, M, Lefevre, B, Jeulin, H, Legrand, K, Lomazzi, S, Tardy, B, Gagneux-Brunon, A, Bertholon, F, Botelho-Nevers, E, Christelle, K, Nicolas, L, Roufai, L, Amat, K, Couffin-Cadiergues, S, Hendou, S, Foti, G, Bellani, G, Citerio, G, Contro, E, Pesci, A, Valsecchi, M, Cazzaniga, M, Abad, J, Accordino, G, Achille, C, Aguilera-Albesa, S, Aguilo-Cucurull, A, Ozkan, E, Albisures, J, Aldave, J, Ramos, M, Khan, T, Aliberti, A, Nadji, S, Alkan, G, Alkhater, S, Allardet-Servent, J, Alshahrani, M, Alsina, L, Amoura, Z, Antoli, A, Arrestier, R, Aubart, M, Auguet, T, Avramenko, I, Azot, A, Bahram, S, Bajolle, F, Baldanti, F, Baldolli, A, Ballester, M, Barrou, B, Basso, S, Bayhan, G, Bezrodnik, L, Bilbao, A, Blanchard-Rohner, G, Blanco, I, Blandinieres, A, Blazquez-Gamero, D, Bloomfield, M, Bolivar-Prados, M, Borghesi, A, Borie, R, Botdhlo-Nevers, E, Bousquet, A, Boutolleau, D, Bouvattier, C, Boyarchuk, O, Bravais, J, Briones, M, Brunner, M, Bruno, R, Bueno, M, Bukhari, H, Bustamante, J, Agra, J, Capra, R, Carapito, R, Carrabba, M, Casasnovas, C, Caseris, M, Cassaniti, I, Castelle, M, Castelli, F, de Vera, M, Castro, M, Catherinot, E, Celik, J, Ceschi, A, Chalumeau, M, Charbit, B, Cheng, M, Clave, P, Clotet, B, Codina, A, Comoli, P, Corsico, A, Sozeri, B, Coskuner, T, Cvetkovski, A, Cyrus, C, Dalmau, D, Danion, F, Darley, D, Das, V, Dauby, N, Dauger, S, De Munter, P, de Pontual, L, Dehban, A, Delplancq, G, Desguerre, I, Di Sabatino, A, Diehl, J, Dobbelaere, S, Dominguez-Garrido, E, Dubost, C, Ekwall, O, Bozdemir, S, Elnagdy, M, Emiroglu, M, Endo, A, Erdeniz, E, Aytekin, S, Lasa, M, Euvrard, R, Fabio, G, Faivre, L, Falck, A, Faure, M, Arquero, M, Ferrer, R, Ferreres, J, Francois, B, Fumado, V, Fung, K, Fusco, F, Gagro, A, Solis, B, Garcon, P, Gaussem, P, Gayretli, Z, Gil-Herrera, J, Gilardin, L, Gatineau, A, Girona-Alarcon, M, Godinez, K, Goffard, J, Gonzales, N, Gonzalez-Granado, L, Gonzalez-Montelongo, R, Guerder, A, Gulhan, B, Gumucio, V, Hanitsch, L, Gunst, J, Hadjadj, J, Hariyan, T, Heppekcan, D, Hernandez-Brito, E, Ho, P, Holanda-Pena, M, Horcajada, J, Hraiech, S, Humbert, L, Hung, I, Iglesias, A, Inigo-Campos, A, Jamme, M, Arranz, M, Jimeno, M, Jordan, I, Yuksek, S, Kara, Y, Karahan, A, Yasar, K, Kasapcopur, O, Kashimada, K, Demirkol, Y, Kido, Y, Kizil, C, Kilic, A, Klocperk, A, Koutsoukou, A, Krol, Z, Ksouri, H, Kuentz, P, Kwan, A, Kwan, Y, Kwok, J, Lagier, J, Lam, D, Lampropoulou, V, Le Bourgeois, F, Leo, Y, Leung, D, Levin, M, Levy, M, Levy, R, Li, Z, Lilleri, D, Lima, E, Linglart, A, Lopez-Collazo, E, Lorenzo-Salazar, J, Louapre, C, Lubetzki, C, Lung, K, Luyt, C, Lye, D, Magnone, C, Marchioni, E, Marioli, C, Marjani, M, Marques, L, Pereira, J, Pueyo, D, Marzana, I, Mata-Martinez, C, Mathian, 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U., Uzunhan Y., Vaittinadaayar P., Valent A., Valentian M., Valin N., Vallet H., Vaz M., Vazquezibarra M. -A., Vedie B., Velly L., Verstuyft C., Viallette C., Vicaut E., Vignes D., Vimpere D., Virlouvet M., Voiriot G., Voisot L., Weiss E., Weiss N., Winchenne A., Yordanov Y., Zafrani L., Zaidan M., Zaidi W., Zak C., Zarhrate-Ghoul A., Zatout O., Zeino S., Zeitouni M., Zemirli N., Zerah L., Zia O., Ziol M., Zolario O., Zuber J., Andrejak C., Angoulvant F., Bachelet D., Bartoli M., Basmaci R., Behilill S., Beluze M., Benkerrou D., Bhavsar K., Bouadma L., Bouchez S., Bouscambert M., Cervantes-Gonzalez M., Chair A., Coelho A., d'Ortenzio E., Debray M. -P., Deconinck L., Deplanque D., Descamps D., Desvallee M., Diallo A., Diouf A., Dorival C., Dubos F., Duval X., Elharrar B., Eloy P., Enouf V., Esperou H., Esposito-Farese M., Devouge E. F., Gault N., Gaymard A., Ghosn J., Gigante T., Gilg M., Guedj J., Hoctin A., Hoffmann I., Houas I., Hulot J. -S., Jaafoura S., Kaguelidou F., Kali S., Khalil A., Khan C., Laouenan C., Laribi S., Le M., Le Hingrat Q., Le Mestre S., Le Nagard H., Lescure F. -X., Levy Y., Lingas G., Lucet J. C., Malvy D., Mambert M., Meziane A., Mouquet H., Mullaert J., Neant N., Nguyen D., Noret M., Nseir S., Papadopoulos A., Paul C., Peiffer-Smadja N., Perpoint T., Petrov-Sanchez V., Peytavin G., Pham H., Picone O., Puechal O., Rabaud C., Rosa-Calatrava M., Rossignol B., Rossignol P., Roy C., Schneider M., Su R., Tardivon C., Tellier M. -C., Teoule F., Terrier O., Timsit J. -F., Tual C., Van Der Werf S., Vanel N., Veislinger A., Visseaux B., Wiedemann A., Yazdanpanah Y., Alavoine L., Behillil S., Burdet C., Charpentier C., Dechanet A., Ecobichon J. -L., Frezouls W., Houhou N., Lehacaut J., Letrou S., Lina B., Manchon P., Nouroudine M., Piquard V., Quintin C., Thy M., Vignali V., Chahine A., Waucquier N., Migaud M. -C., Djossou F., Mergeay-Fabre M., Lucarelli A., Demar M., Bruneau L., Gerardin P., Maillot A., Payet C., Laviolle B., Laine F., Paris C., Desille-Dugast M., Fouchard J., Pistone T., Perreau P., Gissot V., Goas C. L. E., Montagne S., Richard L., Chirouze C., Bouiller K., Desmarets M., Meunier A., Bourgeon M., Lefevre B., Jeulin H., Legrand K., Lomazzi S., Tardy B., Gagneux-Brunon A., Bertholon F., Botelho-Nevers E., Christelle K., Nicolas L., Roufai L., Amat K., Couffin-Cadiergues S., Hendou S., Foti G., Bellani G., Citerio G., Contro E., Pesci A., Valsecchi M. G., Cazzaniga M., Abad J., Accordino G., Achille C., Aguilera-Albesa S., Aguilo-Cucurull A., Ozkan E. A., Albisures J. A. R., Aldave J. C., Ramos M. A., Khan T. A., Aliberti A., Nadji S. A., Alkan G., AlKhater S. A., Allardet-Servent J., Alshahrani M. S., Alsina L., Amoura Z., Antoli A., Arrestier R., Aubart M., Auguet T., Avramenko I., Azot A., Bahram S., Bajolle F., Baldanti F., Baldolli A., Ballester M., Barrou B., Basso S., Bayhan G. I., Bezrodnik L., Bilbao A., Blanchard-Rohner G., Blanco I., Blandinieres A., Blazquez-Gamero D., Bloomfield M., Bolivar-Prados M., Borghesi A., Borie R., Botdhlo-Nevers E., Bousquet A., Boutolleau D., Bouvattier C., Boyarchuk O., Bravais J., Briones M. L., Brunner M. -E., Bruno R., Bueno M. R. P., Bukhari H., Bustamante J., Agra J. J. C., Capra R., Carapito R., Carrabba M., Casasnovas C., Caseris M., Cassaniti I., Castelle M., Castelli F., de Vera M. C., Castro M. V., Catherinot E., Celik J. B., Ceschi A., Chalumeau M., Charbit B., Cheng M. P., Clave P., Clotet B., Codina A., Comoli P., Corsico A. G., Sozeri B., Coskuner T., Cvetkovski A., Cyrus C., Dalmau D., Danion F., Darley D. R., Das V., Dauby N., Dauger S., De Munter P., de Pontual L., Dehban A., Delplancq G., Desguerre I., Di Sabatino A., Diehl J. -L., Dobbelaere S., Dominguez-Garrido E., Dubost C., Ekwall O., Bozdemir S. E., Elnagdy M. H., Emiroglu M., Endo A., Erdeniz E. H., Aytekin S. E., Lasa M. P. E., Euvrard R., Fabio G., Faivre L., Falck A., Faure M., Arquero M. F., Ferrer R., Ferreres J., Francois B., Fumado V., Fung K. S. C., Fusco F., Gagro A., Solis B. G., Garcon P., Gaussem P., Gayretli Z., Gil-Herrera J., Gilardin L., Gatineau A. G., Girona-Alarcon M., Godinez K. A. C., Goffard J. -C., Gonzales N., Gonzalez-Granado L. I., Gonzalez-Montelongo R., Guerder A., Gulhan B., Gumucio V. D., Hanitsch L. G., Gunst J., Hadjadj J., Hariyan T., Heppekcan D., Hernandez-Brito E., Ho P. -K., Holanda-Pena M. S., Horcajada J. P., Hraiech S., Humbert L., Hung I. F. N., Iglesias A. D., Inigo-Campos A., Jamme M., Arranz M. J., Jimeno M. -T., Jordan I., Yuksek S. K., Kara Y. B., Karahan A., Yasar K. K., Kasapcopur O., Kashimada K., Demirkol Y. K., Kido Y., Kizil C., Kilic A. O., Klocperk A., Koutsoukou A., Krol Z. J., Ksouri H., Kuentz P., Kwan A. M. C., Kwan Y. W. M., Kwok J. S. Y., Lagier J. -C., Lam D. S. Y., Lampropoulou V., Le Bourgeois F., Leo Y. -S., Leung D., Levin M., Levy M., Levy R., Li Z., Lilleri D., Lima E. J. A. B., Linglart A., Lopez-Collazo E., Lorenzo-Salazar J. M., Louapre C., Lubetzki C., Lung K. -C., Luyt C. -E., Lye D. C., Magnone C., Marchioni E., Marioli C., Marjani M., Marques L., Pereira J. M., Pueyo D. M., Marzana I., Mata-Martinez C., Mathian A., Matos L. R. B., Matthews G. V., Mayaux J., McLaughlin-Garcia R., Meersseman P., Mege J. -L., Mekontso-Dessap A., Melki I., Meloni F., Meritet J. -F., Merlani P., Akcan O. M., Mezidi M., Millereux M., Million M., Mirault T., Mircher C., Mirsaeidi M., Mizoguchi Y., Modi B. P., Mojoli F., Moncomble E., Melian A. M., Martinez A. M., Morandeira F., Mordacq C., Mouly S. J., Munoz-Barrera A., Nafati C., Nagashima S., Nakagama Y., Neven B., Neves J. F., Ng Y. -Y., Nielly H., Medina Y. N., Cuadros E. N., Ocejo-Vinyals J. G., Okamoto K., Oualha M., Ouedrani A., Ozcelik T., Ozkaya-Parlakay A., Pagani M., Papadaki M., Parola P., Pascreau T., Paul S., Paz-Artal E., Pedraza S., Pellecer N. C. G., Pellegrini S., Perez-Fernandez X. L., Philippe A., Philippot Q., Picod A., Piralla A., Ploin D., Poissy J., Poncelet G., Poulakou G., Pouletty M. S., Pourshahnazari P., Qiu-Chen J. L., Quentric P., Rambaud T., Raoult D., Raoult V., Rebillat A. -S., Redin C., Resmini L., Ricart P., Richard J. -C., Rigo-Bonnin R., rivet N., Rocamora-Blanch G., Rodero M. P., Rodrigo C., Rodriguez L. A., Rodriguez-Palmero A., Romero C. S., Rothenbuhler A., Roux D., Rovina N., Rozenberg F., Ruch Y., Ruiz M., del Prado M. Y. R., Ruiz-Rodriguez J. C., Sabater-Riera J., Saks K., Salagianni M., Sanchez O., Sanchez-Montalva A., Sanchez-Ramon S., Schidlowski L., Schmidt J., Schmidt M., Schuetz C., Schweitzer C. E., Scolari F., Seijo L., Seminario A. G., Seng P., Senoglu S., Seppanen M., Llovich A. S., Siguret V., Siouti E., Smadja D. M., Smith N., Solanich X., Sole-Violan J., Soler C., Stella G. M., Stepanovskiy Y., Stoclin A., Taccone F., Taupin J. -L., Tavernier S. J., Tello L. V., Terrier B., Thiery G., Thorball C., Thorn K., Thumerelle C., Tolstrup M., Tomasoni G., Toubiana J., Alvarez J. T., Triantafyllia V., Trouillet-Assant S., Tsang O. T. Y., Tserel L., Tso E. Y. K., Tucci A., Oz S. K. T., Ursini M. V., Utsumi T., Vabres P., Valencia-Ramos J., Van Den Rym A. M., Vandernoot I., Velez-Santamaria V., Veliz S. P. Z., Vidigal M. C., Viel S., Villain C., Vilaire-Meunier M. E., Villar-Garcia J., Vincent A., Volokha A., Vuotto F., Wauters E., Wauters J., Wu A. K. L., Wu T. -C., Yahsi A., Yesilbas O., Yildiz M., Young B. E., Yukselmis U., Zecca M., Zuccaro V., Van Praet J., Lambrecht B. N., Van Braeckel E., Bosteels C., Hoste L., Hoste E., Bauters F., De Clercq J., Heijmans C., Slabbynck H., Naesens L., Florkin B., Boulanger C., Vanderlinden D., Berkell M., Carelli V., Malhotra S., Mattiaccio A., Pippucci T., Seri M., Tacconelli E., van Agtmael M., Algera A. G., Appelman B., van Baarle F., Bax D., Beudel M., Bogaard H. J., Bomers M., Bonta P., Bos L., Botta M., de Brabander J., de Bree G., de Bruin S., Buis D. T. P., Bugiani M., Bulle E., Cloherty O. C. A., Dijkstra M., Dongelmans D. A., Dujardin R. W. G., Elbers P., Fleuren L., Geijtenbeek S. G. T., Girbes A., Goorhuis B., Grobusch M. P., Hafkamp F., Hagens L., Hamann J., Harris V., Hemke R., Heunks S. M. H. L., Hollmann M., Horn J., Hovius J. W., de Jong M. D., Koning R., Lim E. H. T., van Mourik N., Nellen J., Nossent E. J., Paulus F., Peters E., Pina-Fuentes D. A. I., van der Poll T., Preckel B., Prins J. M., Raasveld J., Reijnders T., de Rotte M. C. F. J., Schinkel M., Schultz M. J., Schrauwen F. A. P., Schuurmans A., Schuurmans J., Sigaloff K., Slim M. A., Smeele P., Smit M., Stijnis C. S., Stilma W., Teunissen C., Thoral P., Tsonas A. M., Tuinman P. R., van der Valk M., Veelo D., Volleman C., de Vries H., Vught L. A., van Vugt M., Wouters D., Zwinderman A. H., Brouwer M. C., Wiersinga W. J., Vlaar A. P. J., Tompkins M. F., Alba C., Hupalo D. N., Rosenberger J., Sukumar G., Wilkerson M. D., Zhang X., Lack J., Oler A. J., Dobbs K., Danielson J. J., Biondi A., Bettini L. R., D'Angio' M., Beretta I., Imberti L., Sottini A., Quaresima V., Quiros-Roldan E., Rossi C., Meyts I., Zhang S. -Y., Puel A., Notarangelo L. D., Boisson-Dupuis S., Su H. C., Boisson B., Jouanguy E., Zhang Q., Abel L., and Cobat A.
- Abstract
Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.
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- 2023
4. Prevalence and features of peripheral neuropathy in Parkinson's disease patients under different therapeutic regimens
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Mancini, F., Comi, C., Oggioni, G.D., Pacchetti, C., Calandrella, D., Coletti Moja, M., Riboldazzi, G., Tunesi, S., Dal Fante, M., Manfredi, L., Lacerenza, M., Cantello, R., and Antonini, A.
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- 2014
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5. T-SPOT.TB performed in lymphnodal tissue for the diagnosis of lymphadenitic TB
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Tunesi, S., primary, Salah, E. B., additional, Taybaly, M., additional, Litvinova, E., additional, Sellier, N., additional, Guihot, A., additional, and Bourgarit, A., additional
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- 2022
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6. A Comparison Between Omicron and Earlier COVID-19 Variants' Disease Severity in the Milan Area, Italy
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Consolazio, D, Murtas, R, Tunesi, S, Lamberti, A, Senatore, S, Faccini, M, Russo, A, Consolazio, David, Murtas, Rossella, Tunesi, Sara, Lamberti, Anna, Senatore, Sabrina, Faccini, Marino, Russo, Antonio Giampiero, Consolazio, D, Murtas, R, Tunesi, S, Lamberti, A, Senatore, S, Faccini, M, Russo, A, Consolazio, David, Murtas, Rossella, Tunesi, Sara, Lamberti, Anna, Senatore, Sabrina, Faccini, Marino, and Russo, Antonio Giampiero
- Abstract
Background: In the context of the fourth wave of the COVID-19 pandemic in Italy, which occurred in correspondence with the outbreak of the Omicron variant, it became fundamental to assess differences in the risk of severe disease between the Omicron variant and the earlier SARS-CoV-2 variants that were still in circulation despite Omicron becoming prevalent. Methods: We collected data on 2,267 genotyped PCR-positive swab tests and assessed whether the presence of symptoms, risk of hospitalization, and recovery times were significantly different between Omicron and the earlier variants. Multivariable models adjusted for sex, age class, citizenship, comorbidities, and symptomatology allowed assessing the difference in outcomes between Omicron and the earlier variants according to vaccination status and timing of administration. Results: Compared to the earlier variants in the same period, Omicron was less symptomatic, resulted in fewer hospital admissions for those who were unvaccinated and for those who were already immunized after the booster dose, and was associated with quicker recovery, yet not in subjects with three vaccination doses. Conclusion: Despite being milder, Omicron's higher transmissibility and vaccine resistance should not lead to underrating its damage potential, especially with regard to hospital and health service saturation.
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- 2022
7. Italian pool of asbestos workers cohorts: asbestos related mortality by industrial sector and cumulative exposure
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Magnani C., Silvestri S., Angelini A., Ranucci A., Azzolina D., Cena T., Chellini E., Merler E., Pavone V., Miligi L., Gorini G., Bressan V., Girardi P., Bauleo L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Mattioli S., Baldassarre A., Barone-Adesi F., Musti M., Mirabelli D., Pirastu R., Marinaccio A., Massari S., Ferrante D, Working Group, Ballarin MN, Brentisci C, Cortini B, Curti S, Gangemi M, Gioffrè F, Legittimo P, Mangone L, Marinelli F, Marinilli P, Panato C, Roncaglia F, Storchi C, Stura A, Vicentini M, Verdi S, Nannavecchia AM, Bisceglia L, Magnani C., Silvestri S., Angelini A., Ranucci A., Azzolina D., Cena T., Chellini E., Merler E., Pavone V., Miligi L., Gorini G., Bressan V., Girardi P., Bauleo L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Mattioli S., Baldassarre A., Barone-Adesi F., Musti M., Mirabelli D., Pirastu R., Marinaccio A., Massari S., Ferrante D, Working Group, Ballarin MN, Brentisci C, Cortini B, Curti S, Gangemi M, Gioffrè F, Legittimo P, Mangone L, Marinelli F, Marinilli P, Panato C, Roncaglia F, Storchi C, Stura A, Vicentini M, Verdi S, Nannavecchia AM, and Bisceglia L
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Risk ,Mesothelioma ,Lung Neoplasms ,Pleural Neoplasms ,Socio-culturale ,Asbesto ,Cohort Studies ,Cause of Death ,Occupational Exposure ,Asbestos ,Glassworks ,Rolling stock ,Shipyards ,Humans ,Industry ,Peritoneal Neoplasms ,Retrospective Studies ,Mineral Fibers ,Ovarian Neoplasms ,Construction Materials ,Ambientale ,Italy ,Urinary Bladder Neoplasms ,Asbestosis ,Glasswork ,Female - Abstract
Italy has been a large user of asbestos and asbestos containing materials until the 1992 ban. We present a pooled cohort study on long-term mortality in exposed workers.Pool of 43 Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding, glasswork, harbors, insulation and other industries). SMRs were computed by industrial sector for the 1970-2010 period, for the major causes, using reference rates by age, sex, region and calendar period.The study included 51 801 subjects (5741 women): 55.9% alive, 42.6% died (cause known for 95%) and 1.5% lost to follow-up. Asbestos exposure was estimated at the plant and period levels. Asbestos related mortality was significantly increased. All industrial sectors showed increased mortality from pleural malignancies, and most also from peritoneal and lung cancer and asbestosis, with exposure related trend. Increased mortality was also observed for ovarian cancer and for bladder cancer.The study confirmed the increased risk for cancer of the lung, ovary, pleura and peritoneum but not of the larynx and the digestive tract. A large increase in mortality from asbestosis was observed.
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- 2020
8. Additional file 1 of Environmental asbestos exposure and clustering of malignant mesothelioma in community: a spatial analysis in a population-based case–control study
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Airoldi, C., Magnani, C., Lazzarato, F., Mirabelli, D., Tunesi, S., and Ferrante, D.
- Abstract
Additional file 1: Table S1.1. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories. Logistic models adjusted by age, sex, type of interview (*) and age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**), and age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Table S1.2. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories. Logistic models adjusted by age, sex, type of interview (*); age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**) and age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Table S1.3. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories and median [interquartile range] of distance. Logistic models adjusted by age, sex, type of interview, occupational exposure in a dichotomous way (*) and age, sex, type of interview and domestic exposure in a dichotomous way (**) and age, sex, type of interview and asbestos exposure (occupational, domestic and environmental) as continuous covariate (***) and age, sex, type of interview and asbestos exposure (domestic and environmental) as continuous covariate (****); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Figure S1. Case control study on MM in Casale Monferrato area. Spatial distribution of the residences of cases (triangles) and controls (circles) in a geographic area of approximately 2500 km2 around Casale Monferrato (solid line). Residences are the longest-held among all residences of each individual after excluding 20 years before the date of diagnosis of the index case. The location of the AC plant (red triangle) and the center of the cluster found using the Kulldorf test (green triangle) in the town of Casale Monferrato are also indicated. [R Spatstat]. Table S2. Case control study on MM in Casale Monferrato area. Cuzick Edward test statistics (Tq) and associate p-values based on 999 random labelling simulations for a variety of q values (3, 5, 7, 9, 11, 13, 15). Table S3.1. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of longest-held residence (after exclusion of 10 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories and median [interquartile range] of distance. Logistic models adjusted by age, sex, type of interview (*) and age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**) or age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC). Table S3.2. Case control study on MM in Casale Monferrato area. Risk of MM of the pleura in relation to the distance of shorter residence (after exclusion of 20 years before the date of diagnosis) from the AC plant. Absolute and relative frequencies of distance categories and median [interquartile range] of distance. Logistic models adjusted by age, sex, type of interview (*) and age, sex, type of interview and occupational and domestic asbestos exposure as continuous covariate (**) or age, sex, type of interview and domestic asbestos exposure as continuous covariate (***); odds ratios (OR), 95% confidence intervals (in brackets) and Akaike Information Criterion (AIC).
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- 2021
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9. Evaluation of the anti-COVID-19 vaccination campaign in the Metropolitan Area of Milan (Lombardy Region, Northern Italy)
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Russo, A, Tunesi, S, Consolazio, D, Decarli, A, Bergamaschi, W, Russo, AG, Russo, A, Tunesi, S, Consolazio, D, Decarli, A, Bergamaschi, W, and Russo, AG
- Abstract
OBJECTIVES: to present an evaluation of the campaign for vaccination against COVID-19 in the territory covered by the Agency for Health Protection of the Metropolitan Area of Milan from 01.01.2021 to 30.09.2021. DESIGN: descriptive study of vaccine adherence; predictive study of the factors associated with vaccine adherence, efficacy of vaccination in terms of hospitalization and mortality, and factors that increase the risk of hospital admission following full vaccination. SETTING AND PARTICIPANTS: population-based study with subjects aged >18 years eligible for vaccination (N. 2,981,997). An information system obtained by integrating various administrative healthcare sources made it possible to analyse socioeconomic characteristics, COVID-19 related hospitalizations, and general mortality in subjects eligible for vaccination. MAIN OUTCOME MEASURES: full vaccination (2 doses); COVID-19-related hospitalizations, COVID-19-related hospitalizations occurring more than 15 days after the second dose, general mortality. RESULTS: in the first nine months of the vaccination campaign, 74.7% of the subjects (N. 2,228,915) was fully vaccinated, whereas 15.6% (N. 465,829) did not even receive one dose. Women have a lower probability of getting vaccinated than men; the 50-59 years and 70+ years age groups emerge as the most problematic to reach, while the younger one (<40) is the most adherent. A social gradient emerged, with residents of more disadvantaged areas progressively less incline to get vaccinated than those living in more affluent areas. Adherence is greater in Italian citizenship and is likely to increase with an increase in the number of chronic conditions. Hospitalizations amounted to 1.22% (N. 5,672) in the unvaccinated population compared to 0.05% (N. 1,013) in the vaccinated population; general mortality was 4.51% (N. 15,198) in the unvaccinated population against 0.32% (N. 8.733) in the vaccinated population. Sociodemographic factors and the presence of p
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- 2021
10. Assessing the Impact of Individual Characteristics and Neighborhood Socioeconomic Status During the COVID-19 Pandemic in the Provinces of Milan and Lodi
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Consolazio, D, Murtas, R, Tunesi, S, Gervasi, F, Benassi, D, Russo, A, Consolazio, David, Murtas, Rossella, Tunesi, Sara, Gervasi, Federico, Benassi, David, Russo, Antonio Giampiero, Consolazio, D, Murtas, R, Tunesi, S, Gervasi, F, Benassi, D, Russo, A, Consolazio, David, Murtas, Rossella, Tunesi, Sara, Gervasi, Federico, Benassi, David, and Russo, Antonio Giampiero
- Abstract
Social inequalities in health are known to be influenced by the socioeconomic status of the territory in which people live. In the context of the ongoing coronavirus disease 2019 (COVID-19) pandemic, this study is aimed at assessing the role of 5 area-level indicators in shaping the risk of contagion in the provinces of Milan and Lodi (Lombardy, Italy), namely: educational disadvantage, unemployment, housing crowding, mobility, and population density. The study area includes the municipalities at the origin of the first Italian epidemic outbreak. Data on COVID-19 patients from the Integrated Datawarehouse for COVID Analysis in Milan were used and matched with aggregate-level data from the National Institute of Statistics Italy (Istat). Multilevel logistic regression models were used to estimate the association between the census block-level predictors and COVID-19 infection, independently of age, sex, country of birth, and preexisting health conditions. All the variables were significantly associated with the outcome, with different effects before and after the lockdown and according to the province of residence. This suggests a pattern of socioeconomic inequalities in the outbreak, which should be taken into account in the eventuality of future epidemics to contain their spread and its related disparities.
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- 2021
11. Data Collection and Priority List Definition for Hazardous Waste Sites Remediation
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Milani, A., Perghem, F., Tunesi, S., Eijsackers, Herman J. P., editor, and Hamers, Timo, editor
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- 1993
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12. Factors Affecting Asbestosis Mortality Among Asbestos-Cement Workers in Italy
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Girardi P., Merler E., Ferrante D., Silvestri S., Chellini E., Angelini A., Luberto F., Fedeli U., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Miligi L., Perticaroli P., Pettinari A., Cuccaro F., Nannavecchia A. M., Bisceglia L., Marinaccio A., Pavone V. L. M., Magnani C., Working Group, Ancona L., Baldassarre A., Brentisci C., Cortini B., Curti S., Gangemi M., Gorini G., Legittimo P., Marinelli F., Marinilli P., Bressan V., Mattioli S., Ranucci A., Romeo E., Scarnato C., Storchi C., Stura A., Verdi S., Girardi P., Merler E., Ferrante D., Silvestri S., Chellini E., Angelini A., Luberto F., Fedeli U., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Miligi L., Perticaroli P., Pettinari A., Cuccaro F., Nannavecchia A.M., Bisceglia L., Marinaccio A., Pavone V.L.M., Magnani C., Working Group, Ancona L., Baldassarre A., Brentisci C., Cortini B., Curti S., Gangemi M., Gorini G., Legittimo P., Marinelli F., Marinilli P., Bressan V., Mattioli S., Ranucci A., Romeo E., Scarnato C., Storchi C., Stura A., and Verdi S.
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Male ,Asbestos, Serpentine ,Asbestosis ,Cumulative Exposure ,Asbesto ,cohort mortality study ,medicine.disease_cause ,Asbestos ,Settore MED/01 - Statistica Medica ,NO ,03 medical and health sciences ,asbestos exposure ,0302 clinical medicine ,Occupational Exposure ,Chrysotile ,Medicine ,Humans ,030212 general & internal medicine ,Asbestos-related diseases ,Asbestos-related disease ,business.industry ,Asbestos exposure ,Cohort mortality study ,Retrospective assessment ,asbestos-related diseases ,asbestosis ,retrospective assessment ,Public Health, Environmental and Occupational Health ,Asbestosi ,Middle Aged ,medicine.disease ,030210 environmental & occupational health ,Asbestos cement ,Cohort effect ,Italy ,Cohort ,Female ,business ,Settore SECS-S/01 - Statistica ,Demography ,Human - Abstract
Objectives This study was performed with the aim of investigating the temporal patterns and determinants associated with mortality from asbestosis among 21 cohorts of Asbestos-Cement (AC) workers who were heavily exposed to asbestos fibres. Methods Mortality for asbestosis was analysed for a cohort of 13 076 Italian AC workers (18.1% women). Individual cumulative asbestos exposure index was calculated by factory and period of work weighting by the different composition of asbestos used (crocidolite, amosite, and chrysotile). Two different approaches to analysis, based on Standardized Mortality Ratios (SMRs) and Age-Period-Cohort (APC) models were applied. Results Among the considered AC facilities, asbestos exposure was extremely high until the end of the 1970s and, due to the long latency, a peak of asbestosis mortality was observed after the 1990s. Mortality for asbestosis reached extremely high SMR values [SMR: males 508, 95% confidence interval (CI): 446–563; females 1027, 95% CI: 771–1336]. SMR increased steeply with the increasing values of cumulative asbestos exposure and with Time Since the First Exposure. APC analysis reported a clear age effect with a mortality peak at 75–80 years; the mortality for asbestosis increased in the last three quintiles of the cumulative exposure; calendar period did not have a significant temporal component while the cohort effect disappeared if we included in the model the cumulative exposure to asbestos. Conclusions Among heaviest exposed workers, mortality risk for asbestosis began to increase before 50 years of age. Mortality for asbestosis was mainly determined by cumulative exposure to asbestos.
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- 2019
13. Cumulative asbestos exposure and mortality from asbestos related diseases in a pooled analysis of 21 asbestos cement cohorts in Italy
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Luberto F., Ferrante D., Silvestri S., Angelini A., Cuccaro F., Nannavecchia A. M., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Chellini E., Miligi L., Perticaroli P., Pettinari A., Bressan V., Merler E., Girardi P., Bisceglia L., Marinaccio A., Massari S., Magnani C., Working group, Curti S., Mattioli S., Luberto F., Ferrante D., Silvestri S., Angelini A., Cuccaro F., Nannavecchia A.M., Oddone E., Vicentini M., Barone-Adesi F., Cena T., Mirabelli D., Mangone L., Roncaglia F., Sala O., Menegozzo S., Pirastu R., Azzolina D., Tunesi S., Chellini E., Miligi L., Perticaroli P., Pettinari A., Bressan V., Merler E., Girardi P., Bisceglia L., Marinaccio A., Massari S., Magnani C., Working group, Curti S., and Mattioli S.
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Male ,Mesothelioma ,Asbestos, Asbestos-cement, Dose response relationship, Mesothelioma, Lung cancer, Ovarian Cancer, Epidemiology ,Time Factors ,Epidemiology ,Health, Toxicology and Mutagenesis ,Asbestosis ,Physiology ,Cumulative Exposure ,medicine.disease_cause ,Cohort Studies ,Neoplasms ,Chrysotile ,Asbestos-related diseases ,0303 health sciences ,lcsh:Public aspects of medicine ,Middle Aged ,Asbestos-cement ,Asbestos cement ,Ovarian Cancer ,Italy ,Dose response relationship ,lcsh:Industrial medicine. Industrial hygiene ,Female ,Lung cancer ,Settore SECS-S/01 - Statistica ,Adult ,Asbesto ,Asbestos ,Settore MED/01 - Statistica Medica ,NO ,03 medical and health sciences ,lcsh:RC963-969 ,Young Adult ,Sex Factors ,Occupational Exposure ,medicine ,Humans ,business.industry ,Research ,Public Health, Environmental and Occupational Health ,030311 toxicology ,lcsh:RA1-1270 ,medicine.disease ,business - Abstract
Background Despite the available information on cancer risk, asbestos is used in large areas in the world, mostly in the production of asbestos cement. Moreover, questions are raised regarding the shape of the dose response relation, the relation with time since exposure and the association with neoplasms in various organs. We conducted a study on the relationship between cumulative asbestos exposure and mortality from asbestos related diseases in a large Italian pool of 21 cohorts of asbestos-cement workers with protracted exposure to both chrysotile and amphibole asbestos. Methods The cohort included 13,076 workers, 81.9% men and 18.1% women, working in 21 Italian asbestos-cement factories, with over 40 years of observation. Exposure was estimated by plant and period, and weighted for the type of asbestos used. Data were analysed with consideration of cause of death, cumulative exposure and time since first exposure (TSFE), and by gender. SMRs were computed using reference rates by region, gender and calendar time. Poisson regression models including cubic splines were used to analyse the effect of cumulative exposure to asbestos and TSFE on mortality for asbestos-related diseases. 95% Confidence Intervals (CI) were computed according to the Poisson distribution. Results Mortality was significantly increased for ‘All Causes’ and ‘All Malignant Neoplasm (MN)’, in both genders. Considering asbestos related diseases (ARDs), statistically significant excesses were observed for MN of peritoneum (SMR: men 14.19; women 15.14), pleura (SMR: 22.35 and 48.10), lung (SMR: 1.67 and 1.67), ovary (in the highest exposure class SMR 2.45), and asbestosis (SMR: 507 and 1023). Mortality for ARDs, in particular pleural and peritoneal malignancies, lung cancer, ovarian cancer and asbestosis increased monotonically with cumulative exposure. Pleural MN mortality increased progressively in the first 40 years of TSFE, then reached a plateau, while peritoneal MN showed a continuous increase. The trend of lung cancer SMRs also showed a flattening after 40 years of TSFE. Attributable proportions for pleural, peritoneal, and lung MN were respectively 96, 93 and 40%. Conclusions Mortality for ARDs was associated with cumulative exposure to asbestos. Risk of death from pleural MN did not increase indefinitely with TSFE but eventually reached a plateau, consistently with reports from other recent studies. Electronic supplementary material The online version of this article (10.1186/s12940-019-0510-6) contains supplementary material, which is available to authorized users.
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- 2019
14. Role of asbestos clearance in explaining long-term risk of pleural and peritoneal cancer: a pooled analysis of cohort studies
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Barone-Adesi F., Ferrante D., Chellini E., Merler E., Pavone V., Silvestri S., Miligi L., Gorini G., Bressan V., Girardi P., Ancona L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Curti S., Baldassarre A., Cena T., Angelini A., Marinaccio A., Mirabelli D., Musti M., Pirastu R., Ranucci A., Magnani C., Working Group, Mattioli S., Barone-Adesi F., Ferrante D., Chellini E., Merler E., Pavone V., Silvestri S., Miligi L., Gorini G., Bressan V., Girardi P., Ancona L., Romeo E., Luberto F., Sala O., Scarnato C., Menegozzo S., Oddone E., Tunesi S., Perticaroli P., Pettinari A., Cuccaro F., Curti S., Baldassarre A., Cena T., Angelini A., Marinaccio A., Mirabelli D., Musti M., Pirastu R., Ranucci A., Magnani C., Working Group, and Mattioli S.
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Oncology ,Adult ,Male ,medicine.medical_specialty ,Time Factors ,Time Factor ,Adolescent ,Pleural Neoplasms ,asbestos ,epidemiology ,mesothelioma ,Asbesto ,medicine.disease_cause ,Asbestos ,Settore MED/01 - Statistica Medica ,NO ,03 medical and health sciences ,Peritoneal Neoplasm ,Young Adult ,0302 clinical medicine ,Internal medicine ,Occupational Exposure ,Epidemiology ,medicine ,Humans ,Pleural Neoplasm ,Mesothelioma ,Young adult ,Peritoneal Neoplasms ,business.industry ,Public Health, Environmental and Occupational Health ,Cancer ,asbestos, epidemiology, mesothelioma, Adolescent, Adult, Italy ,Middle Aged ,Models, Theoretical ,medicine.disease ,030210 environmental & occupational health ,Occupational Disease ,Occupational Diseases ,asbestos, epidemiology, mesothelioma ,Italy ,030220 oncology & carcinogenesis ,Female ,business ,Human ,Cohort study - Abstract
ObjectivesModels based on the multistage theory of cancer predict that rates of malignant mesothelioma continuously increase with time since first exposure (TSFE) to asbestos, even after the end of external exposure. However, recent epidemiological studies suggest that mesothelioma rates level off many years after first exposure to asbestos. A gradual clearance of asbestos from the lungs has been suggested as a possible explanation for this phenomenon. We analysed long-term trends of pleural and peritoneal cancer mortality in subjects exposed to asbestos to evaluate whether such trends were consistent with the clearance hypothesis.MethodsWe used data from a pool of 43 Italian asbestos cohorts (51 801 subjects). The role of asbestos clearance was explored using the traditional mesothelioma multistage model, generalised to include a term representing elimination of fibres over time.ResultsRates of pleural cancer increased until 40 years of TSFE, but remained stable thereafter. On the other hand, we observed a monotonic increase of peritoneal cancer with TSFE. The model taking into account asbestos clearance fitted the data better than the traditional one for pleural (p=0.004) but not for peritoneal (p=0.09) cancer.ConclusionsRates of pleural cancer do not increase indefinitely after the exposure to asbestos, but eventually reach a plateau. This trend is well described by a model accounting for a gradual elimination of the asbestos fibres. These results are relevant for the prediction of future rates of mesothelioma and in asbestos litigations.
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- 2019
15. Assessment of the Overall Mortality during the COVID-19 Outbreak in the Provinces of Milan and Lodi (Lombardy Region, Northern Italy)
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Sandrini, M, Andreano, A, Murtas, R, Tunesi, S, Riussi, A, Guido, D, Teresa Greco, M, Elena Gattoni, M, Gervasi, F, Consolazio, D, Andreoni, L, Decarli, A, Giampiero Russo, A, Monica Sandrini, Anita Andreano, Rossella Murtas, Sara Tunesi, Antonio Riussi, Davide Guido, Maria Teresa Greco, Maria Elena Gattoni, Federico Gervasi, David Consolazio, Laura Andreoni, Adriano Decarli, Antonio Giampiero Russo, Sandrini, M, Andreano, A, Murtas, R, Tunesi, S, Riussi, A, Guido, D, Teresa Greco, M, Elena Gattoni, M, Gervasi, F, Consolazio, D, Andreoni, L, Decarli, A, Giampiero Russo, A, Monica Sandrini, Anita Andreano, Rossella Murtas, Sara Tunesi, Antonio Riussi, Davide Guido, Maria Teresa Greco, Maria Elena Gattoni, Federico Gervasi, David Consolazio, Laura Andreoni, Adriano Decarli, and Antonio Giampiero Russo
- Abstract
Objectives: to describe the overall mortality increase in the provinces of Milan and Lodi – area covered by the Agency for Health Protection of Milan – during the COVID-19 epidemic in the first four months of 2020, compare it with the same time period in the years 2016-2019, and evaluate to what extent the mortality can be directly attributed to the outbreak. Design: cohort study. Setting and participants: using a new information system developed during the pandemic, we gathered data on the number of daily deaths in the population residing in the provinces of Milan and Lodi by Local Health Unit (ASST) and age groups. To describe the case fatality of COVID-19, we performed a record linkage with a database specially constructed during the epidemic to identify deaths that occurred in confirmed cases. Main outcome measures: mortality and excess mortality were analysed by comparing the number of observed deaths in the first 4 months of 2020 with the average deaths of the years 2016-2019 in the same calendar period and with expected deaths, estimated using a Poisson model. Furthermore, a measure of relative risk was calculated as observed/ expected ratio with a 95% confidence interval. Results: the increase in mortality for all causes occurring in the study population in the first 4 months of 2020 was 48.8%, 30.8% for ages between 60 and 69, 43.9% for ages between 70 and 79, and 56.7% for subjects above 80 years of age. Focusing on the epidemic period, from 1 March to 30 April, the excess is quantifiable as more than 2-fold and mainly concerns the population over 60 years of age. The excess mortality was observed in all local health units (ASSTs). The highest increments were in the province of Lodi and the North-East of Milan (ASST Nord). In the ASSTs of Lodi and Melegnano-Martesana the mortality excess was detectable from March 15th, while for the other ASSTs the increase began in the first week of April. Conclusions: evaluation of overall mortality in the provinces of M
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- 2020
16. Association between autoimmune diseases and COVID-19 as assessed in both a test-negative case-control and population case-control design
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Murtas, R, Andreano, A, Gervasi, F, Guido, D, Consolazio, D, Tunesi, S, Andreoni, L, Greco, M, Gattoni, M, Sandrini, M, Riussi, A, Russo, A, Murtas, Rossella, Andreano, Anita, Gervasi, Federico, Guido, Davide, Consolazio, David, Tunesi, Sara, Andreoni, Laura, Greco, Maria Teresa, Gattoni, Maria Elena, Sandrini, Monica, Riussi, Antonio, Russo, Antonio Giampiero, Murtas, R, Andreano, A, Gervasi, F, Guido, D, Consolazio, D, Tunesi, S, Andreoni, L, Greco, M, Gattoni, M, Sandrini, M, Riussi, A, Russo, A, Murtas, Rossella, Andreano, Anita, Gervasi, Federico, Guido, Davide, Consolazio, David, Tunesi, Sara, Andreoni, Laura, Greco, Maria Teresa, Gattoni, Maria Elena, Sandrini, Monica, Riussi, Antonio, and Russo, Antonio Giampiero
- Abstract
Background COVID-19 epidemic has paralleled with the so called infodemic, where countless pieces of information have been disseminated on putative risk factors for COVID-19. Among those, emerged the notion that people suffering from autoimmune diseases (AIDs) have a higher risk of SARS-CoV-2 infection. Methods The cohort included all COVID-19 cases residents in the Agency for Health Protection (AHP) of Milan that, from the beginning of the outbreak, developed a web-based platform that traced positive and negative cases as well as related contacts. AIDs subjects were defined ad having one the following autoimmune disease: rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjogren disease, ankylosing spondylitis, myasthenia gravis, Hashimoto's disease, acquired autoimmune hemolytic anemia, and psoriatic arthritis. To investigate whether AID subjects are at increased risk of SARS-CoV-2 infection, and whether they have worse prognosis than AIDs-free subjects once infected, we performed a combined analysis of a test-negative design case-control study, a case-control with test-positive as cases, and one with test-negative as cases (CC-NEG). Results During the outbreak, the Milan AHP endured, up to April 27th 2020, 20,364 test-positive and 34,697 test-negative subjects. We found no association between AIDs and being positive to COVID-19, but a statistically significant association between AIDs and being negative to COVID-19 in the CC-NEG. If, as likely, test-negative subjects underwent testing because of respiratory infection symptoms, these results imply that autoimmune diseases may be a risk factor for respiratory infections in general (including COVID-19), but they are not a specific risk factor for COVID-19. Furthermore, when infected by SARS-CoV-2, AIDs subjects did not have a worse prognosis compared to non-AIDs subjects. Results highlighted a potential unbalance in the testing campaign, which may be correlated to the characteristics of the teste
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- 2020
17. Descrizione dell’andamento dell’epidemia di COVID-19 nell’ATS di Milano [Describing the epidemic trends of COVID-19 in the area covered by Agency for Health Protection of the Metropolitan Area of Milan]
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Tunesi, S, Murtas, R, Riussi, A, Sandrini, M, Andreano, A, Teresa Greco, M, Elena Gattoni, M, Guido, D, Gervasi, F, Consolazio, D, Andreoni, L, Decarli, A, Bergamaschi, W, Giampiero Russo, A, Sara Tunesi, Rossella Murtas, Antonio Riussi, Monica Sandrini, Anita Andreano, Maria Teresa Greco, Maria Elena Gattoni, Davide Guido, Federico Gervasi, David Consolazio, Laura Andreoni, Adriano Decarli, Walter Bergamaschi, Antonio Giampiero Russo, Tunesi, S, Murtas, R, Riussi, A, Sandrini, M, Andreano, A, Teresa Greco, M, Elena Gattoni, M, Guido, D, Gervasi, F, Consolazio, D, Andreoni, L, Decarli, A, Bergamaschi, W, Giampiero Russo, A, Sara Tunesi, Rossella Murtas, Antonio Riussi, Monica Sandrini, Anita Andreano, Maria Teresa Greco, Maria Elena Gattoni, Davide Guido, Federico Gervasi, David Consolazio, Laura Andreoni, Adriano Decarli, Walter Bergamaschi, and Antonio Giampiero Russo
- Abstract
OBJECTIVES: to describe the epidemic trends of COVID-19 over time and by area in the territory covered by Milan's Agency for Health Protection (ATS-MI) from February to May 2020. DESIGN: descriptive study of COVID-19 cases. SETTING AND PARTICIPANTS: a new information system was developed to record COVID-19 cases with positive nasopharyngeal swab. Patients resident in the area covered by ATS-MI with symptom onset between February and May 2020 were selected. Different epidemic periods were considered based on the timeline of the various regional and national containment measures. MAIN OUTCOME MEASURES: case fatality ratios, incidence rates, and reproduction number by epidemic period and sub-area of ATS-MI. RESULTS: a total of 27,017 swab-positive COVID-19 cases were included. Mean age was 65 years and males were 45%. Incidence in the ATS-MI area was 776 per 100,000 population. The number of deaths was 4,660, the crude case fatality ratio was 17.3%, higher in males (21.2%) than in females (14.0%). The estimated reproduction number registered its peak (3.0) in the early stages of the epidemic and subsequently decreased. Territorial differences were observed in the epidemic spread, with a higher incidence in the Lodi area. CONCLUSIONS: estimated incidence and case fatality ratios were higher than national estimates for Italy. Each ATS-MI area had different epidemic spread patterns.
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- 2020
18. Conversion d’un service de médecine interne en unité mutualisée dédiée à la gestion de cas non réanimatoires de SARS-CoV-2 au sein d’un GHU: expérience et résultats
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Tunesi, S., primary, Dupont, A., additional, Baker, C., additional, Leblanc, C., additional, Rose, C., additional, Taybaly, M., additional, Amor Chelihi, L., additional, Garçon, M.F., additional, Lhuissier, F., additional, and Bourgarit, A., additional
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- 2020
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19. Tuberculose résistante à l’isoniazide : expérience d’un centre de référence français
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Tunesi, S., primary, Guglielmetti, L., additional, Bachir, M., additional, Le Dû, D., additional, Marigot-Outtandy, D., additional, Robert, J., additional, and Fréchet-Jachym, M., additional
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- 2020
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20. Faire face au COVID-19, mise en place de novo d’une unité mutualisée « COVID-19 non réanimatoire » : organisation et résultats
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Tunesi, S., primary, Dupont, A., additional, Baker, C., additional, Leblanc, C., additional, Rose, C., additional, Taybaly, M., additional, Amor Chelihi, L., additional, Garçon, M., additional, Lhuissier, F., additional, and Bourgarit, A., additional
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- 2020
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21. Prescribing COVID-19 treatments: what we should never forget
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Tunesi, S., primary and Bourgarit, A., additional
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- 2020
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22. Headgroup and chain melting transition in dispersed bilayers of GM3 ganglioside
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Brocca, P., Cantù, L., Del Favero, E., Dubois, M., Motta, S., Tunesi, S., and Zemb, Th.
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- 2005
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23. AMIANTO
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Comba, Pietro, Minoia, C, Carnevale, F, Marsili, Daniela, Ferrante, D., Chellini, E., Merler, E., Pavone, V., Silvestri, S., Miligi, L., Gorini, G., Bressan, V., Girardi, P., Ancona, L., Romeo, E., Luberto, F., Sala, O., Scarnato, C., Menegozzo, S., Oddone, E., Tunesi, S., Perticaroli, P., Pettinari, A., Cuccaro, F., Mattioli, S., Baldassarre, A., Angelini, A., Barone Adesi, F., Cena, T., Legittimo, P., Marinaccio, A., Mirabelli, D., Musti, M., Pirastu, R., and Ranucci, A. e Magnani C.
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- 2019
24. AMIANTO
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Comba, P, Minoia, C, Carnevale, F, Marsili, D, Ferrante, D., Chellini, E., Merler, E., Pavone, V., Silvestri, S., Miligi, L., Gorini, G., Bressan, V., Girardi, P., Ancona, L., Romeo, E., Luberto, F., Sala, O., Scarnato, C., Menegozzo, S., Oddone, E., Tunesi, S., Perticaroli, P., Pettinari, A., Cuccaro, F., Mattioli, S., Baldassarre, A., Angelini, A., Barone Adesi, F., Cena, T., Legittimo, P., Marinaccio, A., Mirabelli, D., Musti, M., Pirastu, R., and Ranucci, A. e Magnani C.
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Settore MED/01 - Statistica Medica - Published
- 2019
25. EPIGENETIC PROFILES IN RELATION TO ASBESTOS EXPOSURE IN MALIGNANT PLEURAL MESOTHELIOMA
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Casalone, Elisabetta, Guarrera, Simonetta, Fiorito, Giovanni, Betti, M., Ferrante, D., Voglino, F., DI GAETANO, Cornelia, Rosa, Fabio, Russo, Alessia, Tunesi, S., Padoan, M., Aspesi, A., Casadio, C., Ardissone, Francesco, Ruffini, E., Betta, P. G., Libener, R., Guaschino, R., Piccolini, E., Mirabelli, D., Magnani, C., Dianzani, Irma, and Matullo, Giuseppe
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- 2013
26. Progetto carte antropometriche neonatali italiane
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Spada, E, Zolin, A, Tunesi, S, Occhi, L, Bertino, Enrico, and Milani
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- 2007
27. 936 Has the new edition of the TNM improved the lymph node staging for renal cell carcinoma?
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Terrone, C., primary, Capitanio, U., additional, Volpe, A., additional, Di Trapani, E., additional, Matloob, R., additional, De Angelis, P., additional, Russo, A., additional, Tunesi, S., additional, Zacchero, M., additional, Fusano, M., additional, Briganti, A., additional, and Bertini, R., additional
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- 2014
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28. Development of Methods for the Control of Vertical Barrier at Hazardous Sites
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Napoleoni, Quintilio, D'Amico, L, D'Aprile, L, and Tunesi, S.
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- 2000
29. 641 poster EXTERNAL BEAM RT AND BRACHYTHERAPY AS ADJUVANT TREATMENTS OF ENDOMETRIAL CANCER: A SINGLE INSTITUTION'S SERIES.
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Gambaro, G., primary, Masini, L., additional, Deantonio, L., additional, Tunesi, S., additional, Pisani, C., additional, Magnani, C., additional, and Krengli, M., additional
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- 2011
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30. 5131 Hypofractionated radiotherapy after conservative surgery for breast cancer: analysis of acute and late toxicity in a mono-institutional series
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Deantonio, L., primary, Gambaro, G., additional, Beldı, D., additional, Negri, E., additional, Tunesi, S., additional, Magnani, C., additional, and Krengli, M., additional
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- 2009
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31. Adhesion molecules expression in noncrescentic acute post-streptococcal glomerulonephritis.
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Rastaldi, M P, primary, Ferrario, F, additional, Yang, L, additional, Tunesi, S, additional, Indaco, A, additional, Zou, H, additional, and D'Amico, G, additional
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- 1996
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32. Influence of chemisorption on the photodecomposition of salicylic acid and related compounds using suspended titania ceramic membranes
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Tunesi, S., primary and Anderson, M., additional
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- 1991
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33. Transforming growth factor-β, endothelin-1, and c-fos expression in necrotizing/crescentic IgA glomerulonephritis.
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Rastaldi, MP, Tunesi, S, Ferrario, F, Indaco, A, Zou, H, Napodano, P, and D'Amico, G
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Background: Among our cases of IgA glomerulonephritis (IgAGN), 10% show necrotizing/extracapillary lesions involving a small percentage of glomeruli and associated with a ceratin degree of inflammation in absence of glomerular and interstitial scarring. In our experience, also in repeat biopsies, these cases of IgAGN have a worse prognosis probably because necrotizing/extracapillary lesions can repeat and accumulate, leading to the progression of damage. As it is well known that transforming growth factor-β (TGF-β) and endothelin-1 (ET-1) are key-factors in the progression of glomerulonephritis, aim of the study was to examine their expression in renal biopsies of primary IgAGN with necrotizing/crescentic lesions in complete absence of interstitial fibrosis. To obtain information about the mitogenic effect of ET-1, the expression of c-fos, whose upregulation by ET-1 has been established in culture, was also studied. [ABSTRACT FROM PUBLISHER]
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- 1998
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34. Transforming growth factor-beta, endothelin-1, and c-fos expression in necrotizing/crescentic IgA glomerulonephritis.
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Rastaldi, M P, Tunesi, S, Ferrario, F, Indaco, A, Zou, H, Napodano, P, and D'Amico, G
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Among our cases of IgA glomerulonephritis (IgAGN), 10% show necrotizing/extracapillary lesions involving a small percentage of glomeruli and associated with a certain degree of inflammation in absence of glomerular and interstitial scarring. In our experience, also in repeat biopsies, these cases of IgAGN have a worse prognosis probably because necrotizing/extracapillary lesions can repeat and accumulate, leading to the progression of damage. As it is well known that transforming growth factor-beta (TGF-beta) and endothelin-1 (ET-1) are key-factors in the progression of glomerulonephritis, aim of the study was to examine their expression in renal biopsies of primary IgAGN with necrotizing/crescentic lesions in complete absence of interstitial fibrosis. To obtain information about the mitogenic effect of ET-1, the expression of c-fos, whose upregulation by ET-1 has been established in culture, was also studied.
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- 1998
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35. Clinical management of imported malaria in Italy: Results from a national cross-sectional survey in 2015
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Lepore, L., Vairo, F., D Abramo, A., Grilli, E., Corpolongo, A., Scorzolini, L., Nisii, C., Calleri, G., Castelli, F., Chirianni, A., Ippolito, G., Nicastri, E., Andreoni, M., Angarano, G., Anselmo, M., Ascoli Bartoli, T., Bartoloni, A., Bassi, P., Bevilacqua, N., Bisoffi, Z., Cacopardo, B., Caligaris, S., Calzetti, C., Casolari, S., Cassola, G., Chianura, L., Chiodera, A., Conforto, M., Coppola, N., Luca, A., Feasi, M., Ferrari, C., Filippini, P., Foti, G., Francavilla, E., Fusco, F. M., Tekle, S. G., Giancola, M. L., Giammario, A., Giobbia, M., Giordani, M. T., Gobbi, F., Gori, A., Grossi, P., Iacobello, C., Iannetta, M., Libanore, M., Luzzati, R., Magnani, G., Manfrin, V., Mariano, A., Mastroianni, C., Mazzotta, F., Mecocci, L., Mondardini, V., Montineri, A., Nicolini, L. A., Oliva, A., Palazzolo, C., Pasquale, G., Portelli, V., Puoti, M., Quirino, T., Santantonio, T. A., Sarmati, L., Sciotti, M. P., Scotton, P., Tomasoni, L. R., Toscanini, F., Tunesi, S., Elisa Vanino, Viale, P., Viganò, P., Viscoli, C., Vullo, V., Lepore, L., Vairo, F., D'Abramo, A., Grilli, E., Corpolongo, A., Scorzolini, L., Nisii, C., Calleri, G., Castelli, F., Chirianni, A., Ippolito, G., Nicastri, E., Andreoni, M., Angarano, G., Anselmo, M., Ascoli Bartoli, T., Bartoloni, A., Bassi, P., Bevilacqua, N., Bisoffi, Z., Cacopardo, B., Caligaris, S., Calzetti, C., Casolari, S., Cassola, G., Chianura, L., Chiodera, A., Conforto, M., Coppola, N., De Luca, A., Feasi, M., Ferrari, C., Filippini, P., Foti, G., Francavilla, E., Fusco, F. M., Tekle, S. G., Giancola, M. L., Giammario, A., Giobbia, M., Giordani, M. T., Gobbi, F., Gori, A., Grossi, P., Iacobello, C., Iannetta, M., Libanore, M., Luzzati, R., Magnani, G., Manfrin, V., Mariano, A., Mastroianni, C., Mazzotta, F., Mecocci, L., Mondardini, V., Montineri, A., Nicolini, L. A., Oliva, A., Palazzolo, C., Pasquale, G., Portelli, V., Puoti, M., Quirino, T., Santantonio, T. A., Sarmati, L., Sciotti, M. P., Scotton, P., Tomasoni, L. R., Toscanini, F., Tunesi, S., Vanino, E., Viale, P., Vigano, P., Viscoli, C., and Vullo, V.
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Plasmodium ,Travel ,Clinical Management ,Imported Malaria ,Italian National Survey ,Plasmodium falciparum ,Malaria ,Antimalarials ,Cross-Sectional Studies ,Humans ,Italy ,Retrospective Studies ,Surveys and Questionnaires - Abstract
In Italy, malaria continues to be one of the most common imported parasitoses; therefore, continuous surveillance of epidemiological data and clinical management is needed. In 2016, the National Institute for Infectious Diseases 'Lazzaro Spallanzani' in Rome promoted a retrospective questionnaire-based survey to assess the clinical management of imported malaria cases in Italy in 2015. The questionnaire was sent to 104 Tropical and/or Infectious Diseases Units in the country, and 37 of them filled out and returned the questionnaires. A total of 399 malaria cases were reported in 2015, mostly caused by Plasmodium falciparum and imported from Africa. Malaria chemoprophylaxis was correctly used by a minority of patients. Most patients presented with uncomplicated malaria and were treated orally. In severe cases, intravenous artesunate or quinine alone or in combination were administered, although one third of these severe cases received oral treatment. This retrospective survey reveals a lack of homogeneity in management of malaria-imported cases in Italy. Improvement of malaria chemoprophylaxis, standardization of clinical management of malaria cases and harmonization of oral and intravenous drug availability are needed throughout the country.
36. Role of raltegravir in patients co-infected with HIV and HCV in the era of direct antiviral agents
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Taramasso, L., Cenderello, G., Niccolo Riccardi, Tunesi, S., and Di Biagio, A.
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Raltegravir ,Hepatic safety ,Orthotropic liver transplantation ,DAA ,HIV/HCV co-infection
37. Absence of renal involvement in ANCA-positive patients with ulcerative colitis,ASSENZA DI COINVOLGIMENTO RENALE IN PAZIENTI ANCA-POSITIVI CON RETTOCOLITE IDIOPATICA
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Rosa, M., Monteleone, G., ciro esposito, Sinico, R. A., Tunesi, S., Doldo, P., Pallone, F., and Fuiano, G.
38. Assessing the Impact of Individual Characteristics and Neighborhood Socioeconomic Status During the COVID-19 Pandemic in the Provinces of Milan and Lodi
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David Consolazio, Rossella Murtas, Sara Tunesi, David Benassi, Federico Gervasi, Antonio Russo, Consolazio, D, Murtas, R, Tunesi, S, Gervasi, F, Benassi, D, and Russo, A
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Adult ,Male ,Context (language use) ,Social epidemiology ,Comorbidity ,030204 cardiovascular system & hematology ,Social class ,03 medical and health sciences ,health inequalitie ,0302 clinical medicine ,Age Distribution ,Residence Characteristics ,Pandemic ,Humans ,Social inequality ,030212 general & internal medicine ,Sex Distribution ,Socioeconomic status ,Pandemics ,Aged ,Population Density ,SARS-CoV-2 ,Health Policy ,COVID-19 ,Health Status Disparities ,Census ,Middle Aged ,social epidemiology ,Geography ,Logistic Models ,Italy ,Social Class ,Socioeconomic Factors ,social inequalitie ,Housing ,Residence ,Female ,Demography - Abstract
Social inequalities in health are known to be influenced by the socioeconomic status of the territory in which people live. In the context of the ongoing coronavirus disease 2019 (COVID-19) pandemic, this study is aimed at assessing the role of 5 area-level indicators in shaping the risk of contagion in the provinces of Milan and Lodi (Lombardy, Italy), namely: educational disadvantage, unemployment, housing crowding, mobility, and population density. The study area includes the municipalities at the origin of the first Italian epidemic outbreak. Data on COVID-19 patients from the Integrated Datawarehouse for COVID Analysis in Milan were used and matched with aggregate-level data from the National Institute of Statistics Italy (Istat). Multilevel logistic regression models were used to estimate the association between the census block-level predictors and COVID-19 infection, independently of age, sex, country of birth, and preexisting health conditions. All the variables were significantly associated with the outcome, with different effects before and after the lockdown and according to the province of residence. This suggests a pattern of socioeconomic inequalities in the outbreak, which should be taken into account in the eventuality of future epidemics to contain their spread and its related disparities.
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- 2021
39. Association between autoimmune diseases and COVID-19 as assessed in both a test-negative case-control and population case-control design
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Maria Elena Gattoni, Federico Gervasi, Davide Guido, Anita Andreano, David Consolazio, Maria Teresa Greco, Antonio Riussi, Laura Andreoni, Antonio Russo, Sara Tunesi, Rossella Murtas, Monica Sandrini, Murtas, R, Andreano, A, Gervasi, F, Guido, D, Consolazio, D, Tunesi, S, Andreoni, L, Greco, M, Gattoni, M, Sandrini, M, Riussi, A, and Russo, A
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Test-negative design ,medicine.medical_specialty ,Autoimmune diseases ,Immunology ,Population ,Disease ,03 medical and health sciences ,0302 clinical medicine ,Autoimmune Diseases, Test-negative design, COVID-19 ,Rheumatology ,Acquired immunodeficiency syndrome (AIDS) ,Internal medicine ,Autoimmune disease ,Medicine ,030212 general & internal medicine ,Risk factor ,education ,Original Research ,030203 arthritis & rheumatology ,Ankylosing spondylitis ,education.field_of_study ,business.industry ,Respiratory infection ,medicine.disease ,Cohort ,business ,Covid-19 - Abstract
Background COVID-19 epidemic has paralleled with the so called infodemic, where countless pieces of information have been disseminated on putative risk factors for COVID-19. Among those, emerged the notion that people suffering from autoimmune diseases (AIDs) have a higher risk of SARS-CoV-2 infection. Methods The cohort included all COVID-19 cases residents in the Agency for Health Protection (AHP) of Milan that, from the beginning of the outbreak, developed a web-based platform that traced positive and negative cases as well as related contacts. AIDs subjects were defined ad having one the following autoimmune disease: rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjogren disease, ankylosing spondylitis, myasthenia gravis, Hashimoto’s disease, acquired autoimmune hemolytic anemia, and psoriatic arthritis. To investigate whether AID subjects are at increased risk of SARS-CoV-2 infection, and whether they have worse prognosis than AIDs-free subjects once infected, we performed a combined analysis of a test-negative design case–control study, a case–control with test-positive as cases, and one with test-negative as cases (CC-NEG). Results During the outbreak, the Milan AHP endured, up to April 27th 2020, 20,364 test-positive and 34,697 test-negative subjects. We found no association between AIDs and being positive to COVID-19, but a statistically significant association between AIDs and being negative to COVID-19 in the CC-NEG. If, as likely, test-negative subjects underwent testing because of respiratory infection symptoms, these results imply that autoimmune diseases may be a risk factor for respiratory infections in general (including COVID-19), but they are not a specific risk factor for COVID-19. Furthermore, when infected by SARS-CoV-2, AIDs subjects did not have a worse prognosis compared to non-AIDs subjects. Results highlighted a potential unbalance in the testing campaign, which may be correlated to the characteristics of the tested person, leading specific frail population to be particularly tested. Conclusions Lack of availability of sound scientific knowledge inevitably lead unreliable news to spread over the population, preventing people to disentangle them form reliable information. Even if additional studies are needed to replicate and strengthen our results, these findings represent initial evidence to derive recommendations based on actual data for subjects with autoimmune diseases.
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- 2020
40. Assessment of the Overall Mortality during the COVID-19 Outbreak in the Provinces of Milan and Lodi (Lombardy Region, Northern Italy)
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Monica, Sandrini, Anita, Andreano, Rossella, Murtas, Sara, Tunesi, Antonio, Riussi, Davide, Guido, Maria Teresa, Greco, Maria Elena, Gattoni, Federico, Gervasi, David, Consolazio, Laura, Adreoni, Adriano, Decarli, Antonio Giampiero, Russo, Sandrini, M, Andreano, A, Murtas, R, Tunesi, S, Riussi, A, Guido, D, Teresa Greco, M, Elena Gattoni, M, Gervasi, F, Consolazio, D, Andreoni, L, Decarli, A, and Giampiero Russo, A
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Adult ,Aged, 80 and over ,Male ,Risk ,SARS-CoV-2 ,COVID-19, mortality, excess mortality ,COVID-19 ,Middle Aged ,Italy ,Cause of Death ,Quarantine ,Humans ,Female ,Poisson Distribution ,Registries ,Geography, Medical ,Mortality ,Pandemics ,Aged - Abstract
Objectives: to describe the overall mortality increase in the provinces of Milan and Lodi – area covered by the Agency for Health Protection of Milan – during the COVID-19 epidemic in the first four months of 2020, compare it with the same time period in the years 2016-2019, and evaluate to what extent the mortality can be directly attributed to the outbreak. Design: cohort study. Setting and participants: using a new information system developed during the pandemic, we gathered data on the number of daily deaths in the population residing in the provinces of Milan and Lodi by Local Health Unit (ASST) and age groups. To describe the case fatality of COVID-19, we performed a record linkage with a database specially constructed during the epidemic to identify deaths that occurred in confirmed cases. Main outcome measures: mortality and excess mortality were analysed by comparing the number of observed deaths in the first 4 months of 2020 with the average deaths of the years 2016-2019 in the same calendar period and with expected deaths, estimated using a Poisson model. Furthermore, a measure of relative risk was calculated as observed/ expected ratio with a 95% confidence interval. Results: the increase in mortality for all causes occurring in the study population in the first 4 months of 2020 was 48.8%, 30.8% for ages between 60 and 69, 43.9% for ages between 70 and 79, and 56.7% for subjects above 80 years of age. Focusing on the epidemic period, from 1 March to 30 April, the excess is quantifiable as more than 2-fold and mainly concerns the population over 60 years of age. The excess mortality was observed in all local health units (ASSTs). The highest increments were in the province of Lodi and the North-East of Milan (ASST Nord). In the ASSTs of Lodi and Melegnano-Martesana the mortality excess was detectable from March 15th, while for the other ASSTs the increase began in the first week of April. Conclusions: evaluation of overall mortality in the provinces of Milan and Lodi during the first wave of the Covid-19 epidemic showed a significant excess compared to the first 4 months of the years 2016-2019, mainly in the population over 60 years of age. However, this excess cannot be completely attributed directly to COVID-19 itself. This phenomenon was more intense in the Lodi ASST, with daily deaths up to 5 times higher than expected.
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- 2020
41. Descrizione dell’andamento dell’epidemia di COVID-19 nell’ATS di Milano [Describing the epidemic trends of COVID-19 in the area covered by Agency for Health Protection of the Metropolitan Area of Milan]
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Sara Tunesi, Rossella Murtas, Antonio Riussi, Monica Sandrini, Anita Andreano, Maria Teresa Greco, Maria Elena Gattoni, Davide Guido, Federico Gervasi, David Consolazio, Laura Andreoni, Adriano Decarli, Walter Bergamaschi, Antonio Giampiero Russo, Tunesi, S, Murtas, R, Riussi, A, Sandrini, M, Andreano, A, Teresa Greco, M, Elena Gattoni, M, Guido, D, Gervasi, F, Consolazio, D, Andreoni, L, Decarli, A, Bergamaschi, W, and Giampiero Russo, A
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COVID-19, case fatality ratio, incidence, comorbidities, information system - Abstract
OBJECTIVES: to describe the epidemic trends of COVID-19 over time and by area in the territory covered by Milan's Agency for Health Protection (ATS-MI) from February to May 2020. DESIGN: descriptive study of COVID-19 cases. SETTING AND PARTICIPANTS: a new information system was developed to record COVID-19 cases with positive nasopharyngeal swab. Patients resident in the area covered by ATS-MI with symptom onset between February and May 2020 were selected. Different epidemic periods were considered based on the timeline of the various regional and national containment measures. MAIN OUTCOME MEASURES: case fatality ratios, incidence rates, and reproduction number by epidemic period and sub-area of ATS-MI. RESULTS: a total of 27,017 swab-positive COVID-19 cases were included. Mean age was 65 years and males were 45%. Incidence in the ATS-MI area was 776 per 100,000 population. The number of deaths was 4,660, the crude case fatality ratio was 17.3%, higher in males (21.2%) than in females (14.0%). The estimated reproduction number registered its peak (3.0) in the early stages of the epidemic and subsequently decreased. Territorial differences were observed in the epidemic spread, with a higher incidence in the Lodi area. CONCLUSIONS: estimated incidence and case fatality ratios were higher than national estimates for Italy. Each ATS-MI area had different epidemic spread patterns.
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- 2020
42. Asbestos exposure and asbestosis mortality in Italian cement-asbestos cohorts: Dose-response relationship and the role of competing death causes.
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Girardi P, Rigoni S, Ferrante D, Silvestri S, Angelini A, Cuccaro F, Oddone E, Vicentini M, Barone-Adesi F, Tunesi S, Migliore E, Roncaglia F, Sala O, Pirastu R, Chellini E, Miligi L, Perticaroli P, Bressan V, Merler E, Azzolina D, Marinaccio A, Massari S, and Magnani C
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- Humans, Italy epidemiology, Male, Middle Aged, Female, Aged, Cohort Studies, Pleural Neoplasms mortality, Proportional Hazards Models, Peritoneal Neoplasms mortality, Occupational Diseases mortality, Adult, Dose-Response Relationship, Drug, Asbestosis mortality, Occupational Exposure adverse effects, Occupational Exposure analysis, Asbestos, Construction Materials adverse effects, Cause of Death, Lung Neoplasms mortality
- Abstract
Objectives: In Italy, asbestos was used intensively until its ban in 1992, which was extended for asbestos cement factories until 1994. The aim of this study was to evaluate the dose-response between asbestos exposure and asbestosis mortality across a pool of Italian occupational cohorts, taking into account the presence of competing risks., Methods: Cohorts were followed for vital status and the cause of death was ascertained by a linkage with mortality registers. Cause-specific (CS) Cox-regression models were used to evaluate the dose-exposure relationship between asbestosis mortality and the time-dependent cumulative exposure index (CEI) to asbestos. Fine and Gray regression models were computed to assess the effect of competing risks of death., Results: The cohort included 12,963 asbestos cement workers. During the follow-up period (1960-2012), of a total of 6961 deaths, we observed 416 deaths attributed to asbestosis, 879 to lung cancer, 400 to primary pleural cancer, 135 to peritoneal cancer, and 1825 to diseases of the circulatory system. The CS model showed a strong association between CEI and asbestosis mortality. Dose-response models estimated an increasing trend in mortality even below a CEI of 25 ff/mL-years. Lung cancer and circulatory diseases were the main competing causes of death., Conclusions: Asbestos exposure among Italian asbestos-cement workers has led to a very high number of deaths from asbestosis and asbestos-related diseases. The increasing risk trend associated with excess deaths, even at low exposure levels, suggests that the proposed limit values would not have been adequate to prevent disability and mortality from asbestosis., (© 2024 Wiley Periodicals LLC.)
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- 2024
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43. Antimicrobial susceptibility of Mycobacterium abscessus and treatment of pulmonary and extra-pulmonary infections.
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Tunesi S, Zelazny A, Awad Z, Mougari F, Buyck JM, and Cambau E
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- Humans, Drug Resistance, Bacterial, Respiratory Tract Infections drug therapy, Respiratory Tract Infections microbiology, Mycobacterium abscessus drug effects, Mycobacterium Infections, Nontuberculous drug therapy, Mycobacterium Infections, Nontuberculous microbiology, Microbial Sensitivity Tests, Anti-Bacterial Agents therapeutic use, Anti-Bacterial Agents pharmacology, Anti-Bacterial Agents pharmacokinetics
- Abstract
Background: Mycobacterium abscessus (MAB) is the mycobacterial species least susceptible to antimicrobials. Infections are difficult to treat, and cure rates are below 50% even after a combination of 4-5 drugs for many months., Objectives: To examine antimicrobial susceptibilities and treatment recommendations in light of what is known about mechanisms of resistance and pharmacodynamics/pharmacokinetics (PK/PD) interactions., Sources: Original papers on the topics of 'antimicrobials', 'susceptibility', 'treatment', and 'outcome' from 2019 onwards, in the context of the evidence brought by the guidelines published in 2020 for pulmonary infections., Content: MAB is susceptible in vitro to only a few antimicrobials. Breakpoints were set by the Clinical and Laboratory Standards Institute and are revised by the European Committee on Antimicrobial Susceptibility Testing for epidemiological cut-off values. Innate resistance is due to multiple resistance mechanisms involving efflux pumps, inactivating enzymes, and low drug-target affinity. In addition, MAB may display acquired resistance to macrolides and amikacin through mutations in drug binding sites. Treatment outcomes are better for macrolide-based combinations and MAB subspecies massiliense. New compounds in the family of cyclines, oxazolidinones, and penem-β-lactamase inhibitor combinations (described in another paper), as well as bedaquiline, a new antituberculous agent, are promising, but their efficacy remains to be proven. PK/PD studies, which are critical for establishing optimal dosing regimens, were mainly done for monotherapy and healthy individuals., Implications: Medical evidence is poor, and randomized clinical trials or standardized cohorts are needed to compare outcomes of patients with similar underlying disease, clinical characteristics, and identified MAB subspecies/sequevar. Microbiological diagnosis and susceptibility testing need to be harmonized to enable the comparison of agents and the testing of new compounds. Testing antimicrobial combinations requires new methods, especially for PK/PD parameters. Molecular testing may help in assessing MAB resistance prior to treatment. New antimicrobials need to be systematically tested against MAB to find an effective antimicrobial regimen., (Copyright © 2023 European Society of Clinical Microbiology and Infectious Diseases. All rights reserved.)
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- 2024
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44. Are autopsies on minors a taboo?: The experience of Milan in a 19-year retrospective study.
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Tambuzzi S, Crudele G, Maggioni L, Collini F, Tunesi S, Decarli A, Russo AG, and Cattaneo C
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- Child, Male, Adolescent, Female, Humans, Infant, Newborn, Infant, Retrospective Studies, Asphyxia, Taboo, Cause of Death, Autopsy, Homicide, Suicide, Wounds, Gunshot, Wounds, Nonpenetrating
- Abstract
Forensic autopsy is an important tool for the proper management of non-natural deaths in minors. However, it seems that autopsy in minors is a practice which may not be performed routinely. In this framework, we conducted a study analyzing autopsies of minors (under 18 years of age in Italy) performed at the Institute of Forensic Medicine in Milan in the period 2001-2019. For the period 2015-2019, we extrapolated all deaths due to non-natural causes in minors to investigate how many and which of these deaths were not subjected to forensic autopsy. Of the total, 344 minors (235 males and 109 females) underwent autopsies, with an overall downward trend of about 80% since 2004. Most autopsies occurred between the ages of 0 and 1 year, and the fewest between the ages of 5 and 9 years. The place of death was home in most cases, and accidental death was most common, followed by natural death, suicide, and homicide, with prevalence varying by age group. Blunt force trauma predominated among accidental death in all age groups, followed by asphyxia. Similar findings were observed for suicides, although there was a more differentiated pattern for suicides between the ages of 15 and 17 years. Among homicides, blunt force trauma, asphyxia, and gunshot wounds were fairly evenly distributed across all age groups. Between 2015 and 2019, a total of 86 minors died of a non-natural cause, and a forensic autopsy was performed in only 33 cases (38%). Our data shows that fewer and fewer autopsies are being performed over the last years, which indicates a dangerous lack of forensic investigation of children and adolescent deaths, with enormous implications for prevention of child abuse., (© 2023. The Author(s).)
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- 2024
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45. Estimated number of deaths attributable to NO2, PM10, and PM2.5 pollution in the Municipality of Milan in 2019.
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Tunesi S, Bergamaschi W, and Russo AG
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- Humans, Environmental Exposure adverse effects, Environmental Exposure analysis, Italy epidemiology, Nitrogen Dioxide toxicity, Particulate Matter analysis, Particulate Matter toxicity, Air Pollutants toxicity, Air Pollutants analysis, Air Pollution adverse effects, Air Pollution analysis, Environmental Pollutants toxicity, Lung Neoplasms epidemiology
- Abstract
Background: there is growing evidence that exposure to environmental pollutants affects health, including mortality, chronic diseases, and acute diseases. The World Health Organisation has recently revised downwards the safety thresholds for exposure to environmental pollutants. The City of Milan (CoM) has particularly high levels of pollution; this is due both to the presence of various emission sources and to climatic and orographic conditions., Objectives: to describe the health effects of exposure to pollutants, measured by deaths due to environmental exposure to NO2, PM10, and PM2.5 in 2019., Design: observational study. Using a pollutant concentration estimation model, annual mean values of NO2, PM10, and PM2.5 were estimated for the CoM in 2019. The number of deaths attributable to each exposure was estimated using risk functions available in the literature; the values recommended by the new World Health Organisation guidelines were used as counterfactual exposure limits., Setting and Participants: the population assisted by the Agency for Health Protection of Milan and resident in the CoM on 01.01.2019, aged 30 years or older. The place of residence was georeferenced and the population was followed up until 31.12.2019. Deaths and their causes were obtained from the Causes of Death Registry., Main Outcome Measures: deaths attributable to exposure from non-accidental causes, cardiovascular diseases, respiratory diseases, and lung cancer were estimated., Results: in 2019, the estimated annual average level of NO2 was 36.6 µg/m3, that of PM10 was 24.9 µg/m3, and that of PM2.5 was 22.4 µg/m3, with levels varying across the city area. Concerning exposure to NO2, in 2019 10% of deaths for natural causes were estimated to be attributable to annual mean levels of NO2 above 10 µg/m3. As regard PM2.5, 13% of deaths for natural causes and 18% of deaths from lung cancer were attributable to an annual mean level above 5 µg/m3. The impact of exposure to particulate matter on mortality does not seem to be the same in all the areas of the CoM., Conclusions: the health impact of exposure to airborne particulate matter in the CoM population is high. It is important that citizens, policy-makers, and stakeholders address this issue, because of its impact on both health and healthcare costs.
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- 2024
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46. Trends in mortality from non-natural causes in children and adolescents (0-19 years) in Europe from 2000 to 2018.
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Tunesi S, Tambuzzi S, Decarli A, Cattaneo C, and Russo AG
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- Child, Adolescent, Humans, Europe epidemiology, Poland, United Kingdom, Italy, Accidents, Traffic, Mortality
- Abstract
Background: Non-natural mortality in children and adolescents is a global public health problem that varies widely from country to country. Data on child and adolescent maltreatment are not readily available, and mortality due to violent causes is also underestimated., Methods: Injury-related mortality rates (overall and by specific causes) from 2000 to 2018 in selected European countries were analysed to observe mortality patterns in children and adolescents using data from the Eurostat database. Age-standardized mortality rates per 100,000 person-years were calculated for each country. Joinpoint regression analysis with a significance level of 0.05 and 95% confidence intervals was performed for mortality trends., Results: Children and adolescent mortality from non-natural causes decreased significantly in Europe from 10.48 around 2005 to 5.91 around 2015. The Eastern countries (Romania, Bulgaria, Poland, Slovakia, Czech Republic) had higher rates; while Spain, Denmark, Italy, and the United Kingdom had the lowest. Rates for European Country declined by 5.10% per year over the entire period. Larger downward trends were observed in Ireland, Spain and Portugal; smaller downward trends were observed for Eastern countries (Bulgaria, Czech Republic, Poland, Slovakia) and Finland. Among specific causes of death, the largest decreases were observed for accidental causes (-5.9%) and traffic accidents (-6.8%)., Conclusions: Mortality among children and adolescents due to non-natural causes has decreased significantly over the past two decades. Accidental events and transport accidents recorded the greatest decline in mortality rates, although there are still some European countries where the number of deaths among children and adolescents from non-natural causes is high. Social, cultural, and health-related reasons may explain the observed differences between countries., (© 2023. The Author(s).)
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- 2023
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47. Rate advancement measurement for lung cancer and pleural mesothelioma in asbestos-exposed workers.
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Azzolina D, Consonni D, Ferrante D, Mirabelli D, Silvestri S, Luberto F, Angelini A, Cuccaro F, Nannavecchia AM, Oddone E, Vicentini M, Barone-Adesi F, Cena T, Mangone L, Roncaglia F, Sala O, Menegozzo S, Pirastu R, Tunesi S, Chellini E, Miligi L, Perticaroli P, Pettinari A, Bressan V, Merler E, Girardi P, Bisceglia L, Marinaccio A, Massari S, and Magnani C
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- Humans, Cohort Studies, Italy epidemiology, Mortality trends, Risk Assessment, Male, Female, Construction Industry, Adult, Middle Aged, Aged, Asbestos toxicity, Lung Neoplasms epidemiology, Lung Neoplasms mortality, Mesothelioma epidemiology, Mesothelioma mortality, Occupational Diseases epidemiology, Occupational Diseases mortality, Occupational Exposure adverse effects, Pleural Neoplasms epidemiology, Pleural Neoplasms mortality
- Abstract
Introduction: Exposure to asbestos increases the risk of lung cancer and mesothelioma. Few studies quantified the premature occurrence of these diseases in asbestos-exposed workers. Focus on premature disease onset (rate advancement or acceleration) can be useful in risk communication and for the evaluation of exposure impact. We estimated rate advancement for total mortality, lung cancer and pleural mesothelioma deaths, by classes of cumulative asbestos exposure in a pooled cohort of asbestos cement (AC) workers in Italy., Method: The cohort study included 12 578 workers from 21 cohorts, with 6626 deaths in total, 858 deaths from lung cancer and 394 from pleural malignant neoplasm (MN). Rate advancement was estimated by fitting a competitive mortality Weibull model to the hazard of death over time since first exposure (TSFE)., Result: Acceleration time (AT) was estimated at different TSFE values. The highest level of cumulative exposure compared with the lowest, for pleural MN AT was 16.9 (95% CI 14.9 to 19.2) and 33.8 (95% CI 29.8 to 38.4) years at TSFE of 20 and 40 years, respectively. For lung cancer, it was 13.3 (95% CI 12.0 to 14.7) and 26.6 (95% CI 23.9 to 29.4) years, respectively. As for total mortality, AT was 3.35 (95% CI 2.98 to 3.71) years at 20 years TSFE, and 6.70 (95% CI 5.95 to 7.41) at 40 years TSFE., Conclusion: The current study observed marked rate advancement after asbestos exposure for lung cancer and pleural mesothelioma, as well as for total mortality., Competing Interests: Competing interests: The authors declare that they have no competing interests. The following authors or working group components reported that they served as expert witness in court trials on asbestos related diseases: AA, AB, CM, DM, EM, EO, FB-A, LBi, LMa, LMi, MM, SMe, SS, VP., (© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.)
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- 2023
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48. [Reduction of adverse outcome due to COVID-19 infection in a high-risk population: evaluation of an informative intervention through active call by General Practitioners].
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Russo AG, Faccini M, Riusso A, Lamberti A, Tunesi S, Senatore S, Murtas R, Fagandini F, Decarli A, and Bergamaschi W
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- Humans, Italy epidemiology, Pandemics prevention & control, COVID-19 epidemiology, COVID-19 prevention & control, General Practitioners, Influenza, Human
- Abstract
Background: currently, individuals at risk of adverse outcomes for COVID-19 can access to vaccination and pharmacological interventions. But, during the first epidemic wave, there were no treatments or therapeutic strategies available to reduce adverse outcomes in patients at risk., Objectives: to assess the impact of an intervention at 15-month follow-up developed by the Agency for Health Protection of the Metropolitan Area of Milan (ATS Milan) based on telephone triage and consultation by the General Practitioners (GPs) for patient with high-risk for adverse outcomes., Design: intervention on population., Setting and Participants: a total of 127,292 patients in the ATS aged ≥70 years and with comorbidities associated with an increased risk of dying from COVID-19 infection were identified. Using a specific information system, patients were assigned to their GPs for telephone triage and consultation. GPs inform them about the risks of the disease, non-pharmacological prevention measures, and precautions in contacts with family members and other persons. No specific clinical intervention was carried out, only an information/training intervention was performed., Main Outcome Measures: by the end of May 2020, 48.613 patients had been contacted and 78.679 had not been contacted. Hazard Ratios (HRs) of infection hospitalisation and death at 3 and 15 months were estimated using Cox regression models adjusted by confounder., Results: no differences in gender, age class distribution, prevalence of specific diseases, and Charlson Index were found between the two groups (treated such as called patients and not called). Called patients had a higher propensity for influenza and antipneumococcal vaccination and have more comorbidities and greater access to pharmacological therapies. Non-called patients have a greater risk for COVID-19 infection: HR was 3.88 (95%CI 3.48-4.33) at 3 months and 1.28 (95%CI 1.23-1.33) at 15 months; for COVID-19 hospitalization HR was 2.66 (95%CI 2.39-2,95) at 3 months and 1.31 (95%CI 1.25-1.37) at 15 months; for overall mortality HR was 2,52 (95%CI 2.35-2:72) at 3 months and 1.23 (95%CI 1.19-1.27) at 15 months., Conclusions: the results of this study show a reduction in hospitalization and deaths and support, in case of pandemic events, the implementation of new care strategies based on adapted stratification systems in order to protect the population's health. This study presents some limits: it is not randomized; a selection bias is present (called patients were those most in contact with the GPs); the intervention is indication-based (on march 2020, the actual benefit of protection and distancing for high-risk groups was unclear), and the adjustment is not able to fully control for confounding. However, this study points out the importance to develop information systems and improve methods to best protect the health of the population in setting of territorial epidemiology.
- Published
- 2023
- Full Text
- View/download PDF
49. Preventive Therapy for Contacts of Drug-Resistant Tuberculosis.
- Author
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Kherabi Y, Tunesi S, Kay A, and Guglielmetti L
- Abstract
Preventing the progression of a drug-resistant tuberculosis (DR-TB) infection to disease is an important pillar of the DR-TB elimination strategy. International guidelines have recently proposed fluoroquinolones for tuberculosis preventive therapy (TPT) in DR-TB contacts, although the available evidence is low quality. The pooled data from small observational studies suggest that a fluoroquinolone-based TPT is safe, effective and cost-effective as a preventive treatment in DR-TB contacts. Three clinical trials are currently ongoing to generate higher quality evidence on the efficacy of levofloxacin and delamanid as a DR-TB preventive therapy. Additional evidence is also needed, regarding TPT treatment in fluoroquinolone-resistant-TB contacts, patient and health care worker perceptions on DR-TB preventive therapy for contacts, and the service delivery models to increase DR-TPT access. This state-of-the-art review presents the current literature on TPT for contacts of DR-TB cases, focusing on the available evidence and international guidelines.
- Published
- 2022
- Full Text
- View/download PDF
50. First SARS-CoV-2 vaccine booster and influenza vaccination: risk assessment of COVID-19 hospitalisation and death.
- Author
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Russo AG, Faccini M, Decarli A, Cattaneo S, Tunesi S, Murtas R, Fagandini F, and Bergamaschi W
- Subjects
- Humans, COVID-19 Vaccines, SARS-CoV-2, Prospective Studies, Italy epidemiology, Vaccination, Hospitalization, Risk Assessment, COVID-19 epidemiology, COVID-19 prevention & control, Influenza Vaccines, Influenza, Human epidemiology, Influenza, Human prevention & control
- Abstract
Background: the influenza and SARS-CoV-2 viruses share a common respiratory symptomatology and transmission mode. COVID-19 and influenza R0 overlapped in the first epidemic wave. In autumn 2021-winter 2022, the influenza epidemic had a delayed onset compared to pre-COVID-19 years and lower incidence rates than in the pre-pandemic period. The SARS-CoV-2 and influenza vaccination campaign overlapped in 2021-2022., Objectives: to evaluate in the SARS-CoV-2 vaccinated cohort the effect of different timing of influenza vaccination on hospitalisations for COVID-19 and overall mortality., Design: prospective cohort study., Setting and Participants: subjects aged 65 years or older who were administered the first booster dose of SARS-COV-2 vaccine between 01.10.2021 and 01.03.2022. Based on the date of influenza vaccination, subjects were divided into the following 4 different mutually exclusive groups: 1. two vaccinations in the same vaccination session; 2. influenza vaccination following SARS-CoV-2 vaccination; 3. influenza vaccination preceding SARS-CoV-2 vaccination; 4. no influenza vaccination. Using Cox regression models, hazard ratio (HR) and corresponding 95% confidence intervals (95% CI) of hospitalisation and death were estimated for the influenza-vaccinated subjects compared to influenza-unvaccinated subjects., Main Outcome Measures: ordinary hospital admissions for COVID-19 and general mortality., Results: the cohort included 618,964 subjects: 16.3% received two vaccinations in the same vaccination session, 8.5% received the influenza vaccination after SARS-CoV-2 vaccination, 33.9% received it before and 41.1% did not receive an influenza vaccination. Those vaccinated against both SARS-CoV-2 and influenza had a combined HR of 0.73 (0.62-0.86) of hospitalisation for COVID-19 and 0.55 (0.49-0.62) of overall mortality compared to those vaccinated against SARS-CoV-2 only., Conclusions: influenza vaccination combined with SARS-CoV-2 vaccination increases the protective effect against hospitalisations and overall mortality compared to SARS-CoV-2 vaccination alone. Both organisational and communication actions aimed to promote and encourage vaccination are required.
- Published
- 2022
- Full Text
- View/download PDF
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