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1. Pityriasis Rosea-like Drug Eruption Due to Isotretinoin

Author

Cahit Yavuz, Büşra Taşkın, Fatma Tuncez Akyurek, and Gülcan Saylam Kurtipek

Subjects
Medicine (General), R5-920
Abstract

Drug-induced skin eruptions are frequently encountered in daily practice. The diagnosis of such conditions is mostly made by dermatologists. There are such situations like common disorders with rash and also specific dermatoses were seen. We want to report two patient with pityriasis rosea like eruption caused by systemic isotretinoin treatment used for acne vulgaris.

Published
2024
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3. Association of BMI, lipid-lowering medication, and age with prevalence of type 2 diabetes in adults with heterozygous familial hypercholesterolaemia: a worldwide cross-sectional study

Author

Elshorbagy, Amany, Lyons, Alexander R.M., Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Dharmayat, Kanika I., Brandts, Julia, Catapano, Alberico L., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Raal, Frederick J., Santos, Raul D., Soran, Handrean, Watts, Gerald F., Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid F., Alkhnifsawi, Mutaz, Almahmeed, Wael, Alonso, Rodrigo, Al-Rasadi, Khalid, Al-Sarraf, Ahmad, Ashavaid, Tester F., Banach, Maciej, Binder, Christoph J., Bourbon, Mafalda, Brunham, Liam R., Chlebus, Krzysztof, Corral, Pablo, Cruz, Diogo, Davletov, Kairat, Descamps, Olivier S., Ezhov, Marat, Gaita, Dan, Groselj, Urh, Harada-Shiba, Mariko, Holven, Kirsten B., Kayikcioglu, Meral, Khovidhunkit, Weerapan, Lalic, Katarina, Latkovskis, Gustavs, Laufs, Ulrich, Liberopoulos, Evangelos, Lima-Martinez, Marcos M., Lin, Jie, Maher, Vincent, Marais, A. David, März, Winfried, Mirrakhimov, Erkin, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Nordestgaard, Børge G., Panayiotou, Andrie G., Paragh, György, Petrulioniene, Zaneta, Pojskic, Belma, Postadzhiyan, Arman, Reda, Ashraf, Reiner, Željko, Reyes, Ximena, Sadiq, Fouzia, Sadoh, Wilson E., Schunkert, Heribert, Shek, Aleksandr B., Stroes, Erik, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey V., Tilney, Myra, Tomlinson, Brian, Truong, Thanh-Huong, Tselepis, Alexandros D., Tybjærg-Hansen, Anne, Vázquez, Alejandra C., Viigimaa, Margus, Vohnout, Branislav, Wang, Luya, Yamashita, Shizuya, Arca, Marcello, Averna, Maurizio, Schreier, Laura, Pang, Jing, Ebenbichler, Christoph, Dieplinger, Hans, Innerhofer, Reinhold, Winhofer-Stöckl, Yvonne, Greber-Platzer, Susanne, Krychtiuk, Konstantin, Speidl, Walter, Toplak, Hermann, Widhalm, Kurt, Stulnig, Thomas, Huber, Kurt, Höllerl, Florian, Rega-Kaun, Gersina, Kleemann, Lucas, Mäser, Martin, Scholl-Bürgi, Sabine, Säly, Christoph, Mayer, Florian J., Sperone, Alexandra, Tanghe, Chloé, Gérard, Anne-Catherine, Pojskic, Lamija, Sisic, Ibrahim, Durak Nalbantic, Azra, Ejubovic, Malik, Jannes, Cinthia E., Pereira, Alexandre C., Krieger, Jose E., Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Baass, Alexis, Bergeron, Jean, Bernard, Sophie, Brisson, Diane, Cermakova, Lubomira, Couture, Patrick, Francis, Gordon A., Gaudet, Daniel, Hegele, Robert A., Khoury, Etienne, Mancini, G.B. John, McCrindle, Brian W., Paquette, Martine, Ruel, Isabelle, Iatan, Iulia, Cuevas, Ada, Wang, Xumin, Meng, Kang, Song, Xiantao, Yong, Qiang, Jiang, Tao, Liu, Ziyou, Duan, Yanyu, Hong, Jing, Ye, Pucong, Chen, Yan, Qi, Jianguang, Liu, Zesen, Li, Yuntao, Zhang, Chaoyi, Peng, Jie, Yang, Ya, Yu, Wei, Wang, Qian, Yuan, Hui, Cheng, Shitong, Jiang, Long, Chong, Mei, Jiao, Jian, Wu, Yue, Wen, Wenhui, Xu, Liyuan, Zhang, Ruiying, Qu, Yichen, He, Jianxun, Fan, Xuesong, Wang, Zhenjia, Chow, Elaine, Pećin, Ivan, Perica, Dražen, Symeonides, Phivos, Vrablik, Michal, Ceska, Richard, Soska, Vladimir, Tichy, Lukas, Adamkova, Vera, Franekova, Jana, Cifkova, Renata, Kraml, Pavel, Vonaskova, Katerina, Cepova, Jana, Dusejovska, Magdalena, Pavlickova, Lenka, Blaha, Vladimir, Rosolova, Hana, Nussbaumerova, Barbora, Cibulka, Roman, Vaverkova, Helena, Cibickova, Lubica, Krejsova, Zdenka, Rehouskova, Katerina, Malina, Pavel, Budikova, Milena, Palanova, Vaclava, Solcova, Lucie, Lubasova, Alena, Podzimkova, Helena, Bujdak, Juraj, Vesely, Jiri, Jordanova, Marta, Salek, Tomas, Urbanek, Robin, Zemek, Stanislav, Lacko, Jan, Halamkova, Hana, Machacova, Sona, Mala, Sarka, Cubova, Eva, Valoskova, Katerina, Burda, Lukas, Benn, Marianne, Bendary, Ahmed, Daoud, Ihab, Emil, Sameh, Elbahry, Atef, Rafla, Samir, Sanad, Osama, Kazamel, Ghada, Ashraf, Dr Mohamed, Sobhy, Mohamed, El-Hadidy, Amro, Shafy, Mohamed Abdoul, Kamal, Saif, Bendary, Mohamed, Talviste, Grete, Christmann, Jutta, Dressel, Alexander, Fath, Felix, Ferraro, Chiara, Frenzke, Lydia, Gopon, Alica, Klein, Isabel, Pienkowska, Dominika, Sietmann, Tobias, Sonntag, Antonia, Adjan, Omar, Bahrmann, Philipp, Baessler, Andrea, Barkowski, Rasmus, Beckerdjian, Raffi, Berr, Christina, Birkenfeld, Andreas, Böll, Gereon, Carstensen, Avisha, Demuth, Ilya, Finkernagel, Holger, Gouni-Berthold, Ioanna, Hahmann, Harry, Hamerle, Michael, Halder, Julian, Heide, Maria, Julius, Ulrich, Kassner, Ursula, Katzmann, Julius L, Kirschbaum, Anja, Klose, Gerald, Könemann, Stephanie, König, Christel, König, Wolfgang, Krämer, Bernhard, Kuprat, Gerrit, Koschker, Ann-Cathrin, Kilic, Özlem, Lindenmeier, Gerd, Van de Loo, Iris, Lorenz, Babette, Lorenz, Elke, Löhr, Birgit, McChord, Johanna, Maslarska, Mariya, Methe, Heiko, Merkel, Martin, Moussaoui, Zineb, Müller-Kozarez, Irina, Olivier, Christoph B, Ong, Peter, Otte, Britta, Parhofer, Klaus, Partsch, Carl-Joachim, Paulus, Michael, Pehlivanli, Sinan, Pflederer, Tobias, Pusl, Thomas, Richter, Veronika, Rosner, Stefanie, Sanin, Veronika, Schäfer, Sebastian, Schäfer, Christoph, Schatz, Ulrike, Schirmer, Stephan, Schmidt, Christine, Seeger, Wolfgang, Sisovic, Snezna, Spens, Antje, Jablonski, Ksenija Stach, Stadelmann, Alexander, Steinhagen-Thiessen, Elisabeth, Stürzebecher, Paulina, Tafelmeier, Maria, Tillack, Dörthe, Tselmin, Sergey, Tünnemann-Tarr, Adrienn, Vogt, Anja, Beckerath, Jens von, Wilke, Andreas, Wolf, Ulrich, Zemmrich, Claudia, Rizos, Christos V., Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Athyros, Vasileios, Skalidis, Emmanouil, Kolovou, Genovefa, Kolovou, Vana, Garoufi, Anastasia, Bilianou, Eleni, Koutagiar, Iosif, Kiouri, Estela, Antza, Christina, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Koutsogianni, Amalia-Despoina, Petkou, Ermioni, Milionis, Haralambos, Koulouri, Anastasia, Prodromiadou, Elisavet, Karányi, Zsolt, Harangi, Mariann, Bajnok, László, Audikovszky, Mária, Márk, László, Benczúr, Béla, Reiber, István, Nagy, Gergely, Nagy, András, Reddy, Lakshmi Lavanya, Shah, Swarup A. V, Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Altaey, Mays, Al-Jumaily, Khalid, Rasul, Dilshad, Abdalsahib, Ali Fawzi, Jabbar, Amer Abdl, Al-ageedi, Mohanad, Dhamin, Mohammed, AlFil, Sarmad, Khadhim, Foad, Miahy, Sabah, Agar, Ruth, Catapano, Alberico Luigi, Calandra, Sebastiano, Tarugi, Patrizia, Casula, Manuela, Galimberti, Federica, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Piro, Salvatore, Suppressa, Patrizia, Meregalli, Giancarla, Borghi, Claudio, Muntoni, Sandro, Calabrò, Paolo, Cipollone, Francesco, Purrello, Francesco, Pujia, Arturo, Passaro, Angelina, Marcucci, Rossella, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, Josè Pablo, Parati, Gianfranco, Carubbi, Francesca, Iughetti, Lorenzo, Fortunato, Giuliana, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Cefalù, Angelo Baldassare, Biasucci, Giacomo, Zambon, Sabina, Pirro, Matteo, Sbrana, Francesco, Trenti, Chiara, D'Erasmo, Laura, Federici, Massimo, Ben, Maria Del, Bartuli, Andrea, Giaccari, Andrea, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Lia, Salvatore, Benso, Andrea, Biolo, Gianni, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Rinaldi, Elisabetta, Zenti, Maria Grazia, Matsuki, Kota, Hori, Mika, Ogura, Masatsune, Masuda, Daisaku, Kobayashi, Takuya, Nagahama, Kumiko, Al-Jarallah, Mohammed, Radovic, Mirjana, Lunegova, Olga, Bektasheva, Erkayim, Abilova, Saamay, Erglis, Andrejs, Gilis, Dainus, Nesterovics, Georgijs, Saripo, Vita, Meiere, Ruta, Skudrina, Gunda, Terauda, Elizabete, Jambart, Selim, Ayoub, Carine, Ghaleb, Youmna, Aliosaitiene, Urte, Kutkiene, Sandra, Abdul Kadir, Siti Hamimah Sheikh, Kasim, Noor Alicezah Mohd, Nor, Noor Shafina Mohd, Abdul Hamid, Hasidah, Abdul Razak, Suraya, Al-Khateeb, Alyaa, Abd Muid, Suhaila, Abdul Rahman, Thuhairah, Kasim, Sazzli Shahlan, Radzi, Ahmad Bakhtiar Md, Ibrahim, Khairul Shafiq, Rosli, Marshima Mohd, Razali, Rafezah, Chua, Yung An, Razman, Aimi Zafira, Nazli, Sukma Azureen, Aziz, Nazirul, Rosman, Azhari, Abdul Murad, NorAzian, Jalaludin, Mohd Amin, Abdul Latif, Ahmad Zubaidi, Azzopardi, C., Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A. Galan, Villa, Neftali E Antonio, Vazquez, Arsenio Vargas, Elias-Lopez, Daniel, Retana, Gustavo Gonzalez, Rodriguez, Betsabel, Macías, Jose J. Ceballos, Zazueta, Alejandro Romero, Alvarado, Rocio Martinez, Portano, Julieta D. Morales, Lopez, Humberto Alvares, Sauque-Reyna, Leobardo, Herrera, Laura G. Gomez, Mendia, Luis E. Simental, Aguilar, Humberto Garcia, Cooremans, Elizabeth Ramirez, Aparicio, Berenice Peña, Zubieta, Victoria Mendoza, Gonzalez, Perla A. Carrillo, Ferreira-Hermosillo, Aldo, Portilla, Nacu Caracas, Dominguez, Guadalupe Jimenez, Garcia, Alinna Y. Ruiz, Cazares, Hector E. Arriaga, Gonzalez, Jesus R., Valencia, Carla V. Mendez, Padilla, Francisco G., Prado, Ramon Madriz, Ibarra, Manuel O. De los Rios, Villicaña, Ruy D. Arjona, Rivera, Karina J. Acevedo, Carrera, Ricardo Allende, Alvarez, Jose A., Martinez, Jose C. Amezcua, Bustillo, Manuel de los Reyes Barrera, Vargas, Gonzalo Carazo, Chacon, Roberto Contreras, Andrade, Mario H. Figueroa, Ortega, Ashanty Flores, Alcala, Hector Garcia, de Leon, Laura E. Garcia, Guzman, Berenice Garcia, Garcia, Jose J. Garduño, Cuellar, Juan C. Garnica, Cruz, Jose R. Gomez, Garcia, Anell Hernandez, Almada, Jesus R. Holguin, Herrera, Ursulo Juarez, Sobrevilla, Fabiola Lugo, Rodriguez, Eduardo Marquez, Sibaja, Cristina Martinez, Rodriguez, Alma B. Medrano, Oyervides, Jose C. Morales, Vazquez, Daniel I. Perez, Rodriguez, Eduardo A. Reyes, Osorio, Ma. Ludivina Robles, Saucedo, Juan Rosas, Tamayo, Margarita Torres, Talavera, Luis A. Valdez, Arroyo, Luis E. Vera, Carrillo, Eloy A. Zepeda, Stroes, Erik S, Defesche, J, Zuurbier, L, Reeskamp, L, Ibrahim, S, Roeters van Lennep, Jeanine, Wiegman, Albert, Isara, Alphonsus, Obaseki, Darlington E., Al-Waili, Khalid, Al-Zadjali, Fahad, Al-Zakwani, Ibrahim, Al-Kindi, Mohammed, Al-Mukhaini, Suad, Al-Barwani, Hamida, Rana, Asim, Shah, Lahore Saeed Ullah, Al-Nouri, Fahad, Starostecka, Ewa, Konopka, Agnieszka, Bielecka-Dabrowa, Agata, Lewek, Joanna, Sosnowska, Bozena, Gąsior, Mariusz, Dyrbuś, Krzysztof, Jóźwiak, Jacek, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Chmara, Magdalena, Wasąg, Bartosz, Stróżyk, Aneta, Michalska-Grzonkowska, Aleksandra, Medeiros, Ana Margarida, Alves, Ana Catarina, Silva, Francisco, Lobarinhas, Goreti, Palma, Isabel, de Moura, Jose Pereira, Rico, Miguel Toscano, Rato, Quitéria, Pais, Patrícia, Correia, Susana, Moldovan, Oana, Virtuoso, Maria João, Araujo, Francisco, Salgado, Jose Miguel, Colaço, Ines, Dumitrescu, Andreea, Lengher, Calin, Mosteoru, Svetlana, Meshkov, Alexey, Ershova, Alexandra, Rozhkova, Tatiana, Korneva, Victoria, Yu, Kuznetsova T., Zafiraki, Vitaliy, Voevoda, Mikhail, Gurevich, Victor, Duplyakov, Dmitry, Ragino, Yulia, Chubykina, Uliana, Shaposhnik, Igor, Alkaf, Fahmi, Khudari, Alia, Rwaili, Nawal, Al-Allaf, Faisal, Alghamdi, Mohammad, Batais, Mohammed A, Almigbal, Turky H, Kinsara, Abdulhalim, AlQudaimi, Ashraf Hammouda Ahmed, Awan, Zuhier, Elamin, Omer A, Altaradi, Hani, Popovic, Ljiljana, Singh, Sandra, Rasulic, Iva, Petakov, Ana, Lalic, Nebojsa M., Lam, Carolyn, Le, Tan Ju, Siang, Eric Lim Tien, Dissanayake, Sanjaya, I-Shing, Justin Tang, Shyong, Tai E, Jin, Terrance Chua Siang, Ting, Sharon Pek Li, Ming, Jeremy Hoe Kian, Drum, Chester Lee, Nastar, Fathima Ashna, Jia, Loh Wann, Ya, Natalie Koh Si, Jie, Marvin Chua Wei, Dalan, Rinkoo, Wei, Yong Quek, sian, Tiong Yee, Keong, Yeo Khung, Rong, Siau Kai, Jin, Darren Seah Ee, Ming, Ian Koh Jan, Chang, Tan Hong, Peng, Fabian Yap Kok, Vasanwala, Rashida Farhad, Raslova, Katarina, Balinth, Karin, Buganova, Ingrid, Fabryova, Lubomira, Kadurova, Michaela, Klabnik, Alexander, Kozárová, Miriam, Sirotiakova, Jana, Battelino, Tadej, Cevc, Matija, Debeljak, Marusa, Torkar, Ana Drole, Fras, Zlatko, Jug, Borut, Cugalj, Barbara Kern, Kovac, Jernej, Mlinaric, Matej, Sikonja, Jaka, Pilcher, Gillian Joan, Blom, D J, Wolmarans, K H, Brice, B C, Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose Luis, de Isla, Leopoldo Pérez, Fuentes, Francisco, Badimon, Lina, Martin, François, Miserez, Eleonore B., Shipton, Janine L., Ganokroj, Poranee, Chattranukulchai, Pairoj, Jiamjarasrungsi, Wiroj, Thongtang, Nuntakorn, Krittayaphong, Rungroj, Vathesatogkit, Prin, Sriphrapradang, Chutintorn, Phimphilai, Mattabhorn, Leelawattana, Rattana, Anthanont, Pimjai, Suraamornkul, Swangjit, Deerochanawong, Chaicharn, Senthong, Vichai, Torpongpun, Artit, Suteerayongprasert, Panuwat, Pengpong, Nawarat, Sathavarodom, Nattapol, Sunanta, Usanee, Porntharukchareon, Thachanun, Kiatpanabhikul, Phatharaporn, Kaewkrasaesin, Chatchon, Kongkit, Jaruwan, Umphonsathien, Mongkontida, Akbulut, Mehmet, Alici, Gökhan, Bayram, Fahri, Can, Levent Hürkan, Celik, Ahmet, Ceyhan, Ceyhun, Coskun, Fatma Yilmaz, Demir, Mesut, Demircan, Sabri, Dogan, Volkan, Durakoglugil, Emre, Dural, İbrahim Etem, Gedikli, Omer, Hacioglu, Aysa, Ildizli, Muge, Kilic, Salih, Kirilmaz, Bahadir, Kutlu, Merih, Oguz, Aytekin, Ozdogan, Oner, Onrat, Ersel, Ozer, Savas, Sabuncu, Tevfik, Sahin, Tayfun, Sivri, Fatih, Sonmez, Alper, Temizhan, Ahmet, Topcu, Selim, Tokgozoglu, Lale, Tuncez, Abdullah, Vural, Mirac, Yenercag, Mustafa, Yesilbursa, Dilek, Yigit, Zerrin, Yildirim, Aytul Belgi, Yildirir, Aylin, Yilmaz, Mehmet Birhan, Atallah, Bassam, Traina, Mahmoud, Sabbour, Hani, Abdul Hay, Dana, Luqman, Neama, Elfatih, Abubaker, Abdulrasheed, Arshad, Manla, Yosef, Kwok, See, DellOca, Nicolas, Alieva, Rano B., Fozilov, Khurshid G., Hoshimov, Shavkat U., Nizamov, Ulugbek I., Kan, Liliya E., Kim, Andrey R., Abdullaeva, Guzal J., Abdullaev, Alisher A., Do, Doan Loi, Nguyen, Mai Ngoc Thi, Kim, Ngoc Thanh, Le, Thanh Tung, Le, Hong An, and Ray, Kausik K.

Published
2024
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4. Investigation of deaths related to methyl alcohol intoxication in İzmir: A 5-year retrospective study

Author

Ferhat Turgut Tuncez, Gulci̇n Tasci, Ismai̇l Ozgur Can, and Mehmet Tokdemir

Subjects
methanol intoxication, autopsy, alcohol poisoning, Medicine
Abstract

Methyl alcohol consumption results in serious poisoning symptoms and even causes death, so it is not used in legal alcoholic beverages. We aimed to examine deaths due to methyl alcohol intoxication in our region through forensic autopsies performed in İzmir-Turkey to compare these data with international studies. A total of 13,701 autopsies performed between 2016-2021 were scanned retrospectively. 214 cases in which the exact cause of death was methanol intoxication were included in the study. All the cases were analyzed in terms of age, gender, date of death, place of death, length of hospitalization, methanol levels detected in blood and the vitreous humor, ethanol presence in blood, and pathological findings. The ratio of autopsies of the exact cause of death of methanol poisoning to total autopsies is 1.56%. Of these cases, 94.9% were male and 5.1% were female. The age range was 25–80 years, with a mean age of 53.4. According to the age distributions, the highest rate was 39.3% in the sixth decade. The highest number of cases was 129 (60.3%) in 2020. In the analysis of blood methanol levels, the concentration was found to be in the range of 0-642 mg/dl and the mean was 178 mg/dl. During the COVID-19 pandemic, there has been a significant increase in methanol poisoning cases associated with the economic and social problems experienced in Turkey. Our study showed that methanol poisoning deaths are especially common in men aged 50-60 years so this group is at higher risk of methanol poisoning. [Med-Science 2023; 12(4.000): 1324-30]

Published
2023
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7. A novel mutation in the proteoglycan 4 gene causing CACP syndrome: two sisters report

Author

İlknur Bağrul, Serdar Ceylaner, Yasemin Tasci Yildiz, Serife Tuncez, Elif Arslanoglu Aydin, Esra Bağlan, Semanur Ozdel, and Mehmet Bülbül

Subjects
Arthropathy, Camptodactyly, Coxa vara, PRG4 mutation, Pediatrics, RJ1-570, Diseases of the musculoskeletal system, RC925-935
Abstract

Abstract Background Camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome, caused by biallelic pathogenic mutations in the proteoglycan 4 (PRG4) gene, is characterized by early-onset camptodactyly, noninflammatory arthropathy, coxa vara deformity, and rarely, pericardial effusion. This syndrome can mimic juvenile idiopathic arthritis. CACP syndrome is caused by mutations in the proteoglycan 4 (PRG4) gene. To date, only 36 pathogenic mutations have been reported in this gene, but none have been reported from Azerbaijan. Case presentation Herein, we report two siblings presented with chronic polyarthritis, had a prior diagnosis of juvenile idiopathic arthritis, but was subsequently diagnosed as CACP syndrome with novel mutation in the PRG4 gene. Conclusion Our report expands the knowledge of PRG4 mutations, which will aid in CACP patient counseling.

Published
2023
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8. Geographic income diversification of large European banks: Better or worse?

Author

Gerek, Caner and Tuncez, Ahmet M.

Subjects
WORKING capital, BANKING industry, HYPOTHESIS
Abstract

This study examines the impact of geographic income diversification of large European banks on performance and risk‐taking by using unique data. By dividing the total operating income into three regions as the home country, the rest of Europe and the rest of the world, we find evidence that geographic income diversification reduces bank performance and increases risk‐taking. Particularly, shifting operations from home countries to other European countries or the rest of the world reduces bank performance and enhances risk‐taking unless the bank is highly concentrated in these areas. We also identify contributing channels, including the "follow‐the‐customer" hypothesis, new subsidiaries and board diversity, to explain the adverse effect. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Industry tournament incentives and corporate hedging policies

Author

Lonare, Gunratan, Nart, Ahmet, and Tuncez, Ahmet M.

Subjects
Business -- Research, Incentives (Business) -- Research, Hedging (Finance) -- Research -- Laws, regulations and rules, Labor market -- Research, Chief executive officers -- Management, Risk management -- Research, Government regulation, Company business management, Risk management, Banking, finance and accounting industries, Business
Abstract

This paper examines how a tournament among CEOs to progress within the CEO labor market influences their corporate hedging policies. We employ a textual analysis of 10Ks to generate corporate hedging proxies, finding that the likelihood and intensity of hedging grow as the CEO labor market tournament prizes increase. We also explore the mitigating impact of corporate hedging on the adverse effects of risk-inducing industry tournament incentives (ITIs) on the cost of debt and stock price crash risk, noting that these could be possible reasons behind the relation. Additionally, we observe that the relationship between ITIs and corporate hedging is less pronounced for firms that demonstrate more financial distress and for firms whose CEOs are the founders of the company or are of retirement age. We identify a causal relation between ITIs and corporate hedging using an instrumental variable approach and an exogenous shock sourced from changes in the enforceability of noncompetition agreements across states. KEYWORDS corporate hedging, executive compensation, FX hedging, pay gap, risk management, risk-taking, tournament incentives, 1 | INTRODUCTION The use of financial derivatives as hedging tools has been increasing worldwide, even though active corporate risk management is irrelevant under the perfect market assumption of Modigliani [...]

Published
2022
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11. Guns and Ballots: Ethnic Voting in the Times of Ethnic Conflict

Author

Han Tuncez, Beyzanur

Subjects
Political science
Abstract

This dissertation broadly asks: “What is the effect of ethnic conflict on the political behavior of the Kurds in Turkey?” It contributes to scholarly knowledge in five major fields: ethnic conflict, assimilation, ethnic identity, polarization, and political behavior. To understand the effects of assimilation and heterogeneities within the Kurds, it looks at central Anatolian Kurds. This dissertation advances five main arguments by analyzing novel survey data and three years of field research.It reexamines the literature on ethnic conflict and calls for a more comprehensive definition, as how we currently study ethnic conflict fails to recognize some day-to-day or subtler forms of ethnic conflict, which profoundly impacts the ethnic consciousness of the Kurds. I call this “the political scars of the mind.”Secondly, due to long-lasting assimilation and ethnic conflict, central Anatolian Kurds express their identities in unconventional rich ways. Their path of ethnic mobilization has a breaking point that I call “ethnic awakening,” where they realize their either forgotten or oppressed Kurdishness when they are in environments where they feel safer to reclaim their identity. Third, for central Anatolian Kurds, assimilation and fear of discrimination profoundly affect the willingness of the language transfer between Kurdish parents to their children.Fourth, regardless of their geography, all Kurds bear the feeling of the trauma of being a Kurd in Turkey. However, some Kurds purposefully move away from their ethnic identities as a response to assimilation and ethnic conflict.Fifth, the literature on polarization has exclusively focused on hardened ethnic identities and looked at how the dominant and minority groups polarize due to ethnic conflict. However, this dissertation examines how ethnic conflict leads some Kurds to move away from their Kurdishness and argues that ethnic conflicts also create polarization within a minority group, what I call dual polarization. In advancing this set of claims, this dissertation also proposes new avenues for further research into ethnic identity. Assimilation of ethnic identity can take a nonlinear trajectory, and it profoundly affects the expression of ethnic identities through new and unconventional forms that we need to take into account in the study of political behavior.

Published
2023

12. Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Author

Vallejo-Vaz, Antonio J., Stevens, Christophe A.T., Lyons, Alexander R.M., Dharmayat, Kanika I., Freiberger, Tomas, Hovingh, G. Kees, Mata, Pedro, Raal, Frederick J., Santos, Raul D., Soran, Handrean, Watts, Gerald F., Abifadel, Marianne, Aguilar-Salinas, Carlos A., Alhabib, Khalid F., Alkhnifsawi, Mutaz, Almahmeed, Wael, Alnouri, Fahad, Alonso, Rodrigo, Al-Rasadi, Khalid, Al-Sarraf, Ahmad, Al-Sayed, Nasreen, Araujo, Francisco, Ashavaid, Tester F., Banach, Maciej, Béliard, Sophie, Benn, Marianne, Binder, Christoph J., Bogsrud, Martin P., Bourbon, Mafalda, Chlebus, Krzysztof, Corral, Pablo, Davletov, Kairat, Descamps, Olivier S., Durst, Ronen, Ezhov, Marat, Gaita, Dan, Genest, Jacques, Groselj, Urh, Harada-Shiba, Mariko, Holven, Kirsten B., Kayikcioglu, Meral, Khovidhunkit, Weerapan, Lalic, Katarina, Latkovskis, Gustavs, Laufs, Ulrich, Liberopoulos, Evangelos, Lima-Martinez, Marcos M., Lin, Jie, Maher, Vincent, Marais, A. David, März, Winfried, Mirrakhimov, Erkin, Miserez, André R., Mitchenko, Olena, Nawawi, Hapizah, Nordestgaard, Børge G., Panayiotou, Andrie G., Paragh, György, Petrulioniene, Zaneta, Pojskic, Belma, Postadzhiyan, Arman, Raslova, Katarina, Reda, Ashraf, Reiner, Željko, Sadiq, Fouzia, Sadoh, Wilson Ehidiamen, Schunkert, Heribert, Shek, Aleksandr B., Stoll, Mario, Stroes, Erik, Su, Ta-Chen, Subramaniam, Tavintharan, Susekov, Andrey V., Tilney, Myra, Tomlinson, Brian, Truong, Thanh Huong, Tselepis, Alexandros D., Tybjærg-Hansen, Anne, Vázquez Cárdenas, Alejandra, Viigimaa, Margus, Wang, Luya, Yamashita, Shizuya, Kastelein, John J.P., Bruckert, Eric, Vohnout, Branislav, Schreier, Laura, Pang, Jing, Ebenbichler, Christoph, Dieplinger, Hans, Innerhofer, Reinhold, Winhofer-Stöckl, Yvonne, Greber-Platzer, Susanne, Krychtiuk, Konstantin, Speidl, Walter, Toplak, Hermann, Widhalm, Kurt, Stulnig, Thomas, Huber, Kurt, Höllerl, Florian, Rega-Kaun, Gersina, Kleemann, Lucas, Mäser, Martin, Scholl-Bürgi, Sabine, Säly, Christoph, Mayer, Florian J., Sablon, Gaelle, Tarantino, Eric, Nzeyimana, Charlotte, Pojskic, Lamija, Sisic, Ibrahim, Nalbantic, Azra D., Jannes, Cinthia E., Pereira, Alexandre C., Krieger, Jose E., Petrov, Ivo, Goudev, Assen, Nikolov, Fedya, Tisheva, Snejana, Yotov, Yoto, Tzvetkov, Ivajlo, Baass, Alexis, Bergeron, Jean, Bernard, Sophie, Brisson, Diane, Brunham, Liam R., Cermakova, Lubomira, Couture, Patrick, Francis, Gordon A., Gaudet, Daniel, Hegele, Robert A., Khoury, Etienne, Mancini, G.B. John, McCrindle, Brian W., Paquette, Martine, Ruel, Isabelle, Cuevas, Ada, Asenjo, Sylvia, Wang, Xumin, Meng, Kang, Song, Xiantao, Yong, Qiang, Jiang, Tao, Liu, Ziyou, Duan, Yanyu, Hong, Jing, Ye, Pucong, Chen, Yan, Qi, Jianguang, Liu, Zesen, Li, Yuntao, Zhang, Chaoyi, Peng, Jie, Yang, Ya, Yu, Wei, Wang, Qian, Yuan, Hui, Cheng, Shitong, Jiang, Long, Chong, Mei, Jiao, Jian, Wu, Yue, Wen, Wenhui, Xu, Liyuan, Zhang, Ruiying, Qu, Yichen, He, Jianxun, Fan, Xuesong, Wang, Zhenjia, Chow, Elaine, Pećin, Ivan, Perica, Dražen, Symeonides, Phivos, Vrablik, Michal, Ceska, Richard, Soska, Vladimir, Tichy, Lukas, Adamkova, Vera, Franekova, Jana, Cifkova, Renata, Kraml, Pavel, Vonaskova, Katerina, Cepova, Jana, Dusejovska, Magdalena, Pavlickova, Lenka, Blaha, Vladimir, Rosolova, Hana, Nussbaumerova, Barbora, Cibulka, Roman, Vaverkova, Helena, Cibickova, Lubica, Krejsova, Zdenka, Rehouskova, Katerina, Malina, Pavel, Budikova, Milena, Palanova, Vaclava, Solcova, Lucie, Lubasova, Alena, Podzimkova, Helena, Bujdak, Juraj, Vesely, Jiri, Jordanova, Marta, Salek, Tomas, Urbanek, Robin, Zemek, Stanislav, Lacko, Jan, Halamkova, Hana, Machacova, Sona, Mala, Sarka, Cubova, Eva, Valoskova, Katerina, Burda, Lukas, Bendary, Ahmed, Daoud, Ihab, Emil, Sameh, Elbahry, Atef, Rafla, Samir, Sanad, Osama, Kazamel, Ghada, Ashraf, Mohamed, Sobhy, Mohamed, El-Hadidy, Amro, Shafy, Mohamed A., Kamal, Saif, Bendary, Mohamed, Talviste, Grete, Angoulvant, Denis, Boccara, Franck, Cariou, Bertrand, Carreau, Valérie, Carrie, Alain, Charrieres, Sybil, Cottin, Yves, Di-Fillipo, Mathilde, Ducluzeau, Pierre H., Dulong, Sonia, Durlach, Vincent, Farnier, Michel, Ferrari, Emile, Ferrieres, Dorota, Ferrieres, Jean, Gallo, Antonio, hankard, Regis, Inamo, Jocelyne, Lemale, Julie, Moulin, Philippe, Paillard, François, Peretti, Noel, Perrin, Agnès, Pradignac, Alain, Rabes, Jean P., Rigalleau, Vincent, Sultan, Ariane, Schiele, François, Tounian, Patrick, Valero, René, Verges, Bruno, Yelnik, Cécile, Ziegler, Olivier, Haack, Ira A., Schmidt, Nina, Dressel, Alexander, Klein, Isabel, Christmann, Jutta, Sonntag, Antonia, Stumpp, Christine, Boger, Diana, Biedermann, Dana, Usme, Monica M.N., Beil, F. Ulrich, Klose, Gerald, König, Christel, Gouni-Berthold, Ioanna, Otte, Britta, Böll, Gereon, Kirschbaum, Anja, Merke, Jürgen, Scholl, Johannes, Segiet, Thomas, Gebauer, Marco, Predica, Florentina, Mayer, Manfred, Leistikow, Frank, Füllgraf-Horst, Sabine, Müller, Cornelius, Schüler, Melanie, Wiener, Judith, Hein, Konrad, Baumgartner, Peter, Kopf, Stefan, Busch, Reinhold, Schömig, Michael, Matthias, Stephan, Allendorf-Ostwald, Nicole, Fink, Bruno, Böhm, Dieter, Jäkel, Alexander, Koschker, Ann-Cathrin, Schweizer, Rüdiger, Vogt, Anja, Parhofer, Klaus, König, Wolfgang, Reinhard, Wibke, Bäßler, Andrea, Stadelmann, Alexander, Schrader, Volker, Katzmann, Julius, Tarr, Adrienne, Steinhagen-Thiessen, Elisabeth, Kassner, Ursula, Paulsen, Gerret, Homberger, Jürgen, Zemmrich, Claudia, Seeger, Wolfgang, Biolik, Kathrin, Deiss, Dorothee, Richter, Corinna, Pantchechnikova, Elina, Dorn, Elena, Schatz, Ulrike, Julius, Ulrich, Spens, Antje, Wiesner, Tobias, Scholl, Michael, Rizos, Christos V., Sakkas, Nikolaos, Elisaf, Moses, Skoumas, Ioannis, Tziomalos, Konstantinos, Rallidis, Loukianos, Kotsis, Vasileios, Doumas, Michalis, Athyros, Vasileios, Skalidis, Emmanouil, Kolovou, Genovefa, Garoufi, Anastasia, Bilianou, Eleni, Koutagiar, Iosif, Agapakis, Dimitrios, Kiouri, Estela, Antza, Christina, Katsiki, Niki, Zacharis, Evangelos, Attilakos, Achilleas, Sfikas, George, Koumaras, Charalambos, Anagnostis, Panagiotis, Anastasiou, Georgia, Liamis, George, Koutsogianni, Amalia-Despoina, Karányi, Zsolt, Harangi, Mariann, Bajnok, László, Audikovszky, Mária, Márk, László, Benczúr, Béla, Reiber, István, Nagy, Gergely, Nagy, András, Reddy, Lakshmi L., Shah, Swarup A.V., Ponde, Chandrashekhar K., Dalal, Jamshed J., Sawhney, Jitendra P.S., Verma, Ishwar C., Altaey, Mays, Al-Jumaily, Khalid, Rasul, Dilshad, Abdalsahib, Ali F., Jabbar, Amer A., Al-ageedi, Mohanad, Agar, Ruth, Cohen, Hofit, Ellis, Avishay, Gavishv, Dov, Harats, Dror, Henkin, Yaacov, Knobler, Hila, Leavit, Leah, Leitersdorf, Eran, Rubinstein, Ardon, Schurr, Daniel, Shpitzen, Shoshi, Szalat, Auryan, Casula, Manuela, Zampoleri, Veronica, Gazzotti, Marta, Olmastroni, Elena, Sarzani, Riccardo, Ferri, Claudio, Repetti, Elena, Sabbà, Carlo, Bossi, Antonio Carlo, Borghi, Claudio, Muntoni, Sandro, Cipollone, Francesco, Purrello, Francesco, Pujia, Arturo, Passaro, Angelina, Marcucci, Rossella, Pecchioli, Valerio, Pisciotta, Livia, Mandraffino, Giuseppe, Pellegatta, Fabio, Mombelli, Giuliana, Branchi, Adriana, Fiorenza, Anna Maria, Pederiva, Cristina, Werba, Josè Pablo, Parati, Gianfranco, Carubbi, Francesca, Iughetti, Lorenzo, Iannuzzi, Arcangelo, Iannuzzo, Gabriella, Calabrò, Paolo, Averna, Maurizio, Biasucci, Giacomo, Zambon, Sabina, Roscini, Anna Rita, Trenti, Chiara, Arca, Marcello, Federici, Massimo, Del Ben, Maria, Bartuli, Andrea, Giaccari, Andrea, Pipolo, Antonio, Citroni, Nadia, Guardamagna, Ornella, Bonomo, Katia, Benso, Andrea, Biolo, Gianni, Maroni, Lorenzo, Lupi, Alessandro, Bonanni, Luca, Zenti, Maria Grazia, Matsuki, Kota, Hori, Mika, Ogura, Masatsune, Masuda, Daisaku, Kobayashi, Takuya, Nagahama, Kumiko, Al-Jarallah, Mohammed, Radovic, Mirjana, Lunegova, Olga, Bektasheva, Erkayim, Khodzhiboboev, Elyor, Erglis, Andrejs, Gilis, Dainus, Nesterovics, Georgijs, Saripo, Vita, Meiere, Ruta, Upena-RozeMicena, Arta, Terauda, Elizabete, Jambart, Selim, Khoury, Petra E., Elbitar, Sandy, Ayoub, Carine, Ghaleb, Youmna, Aliosaitiene, Urte, Kutkiene, Sandra, Kasim, Noor A.M., Nor, Noor S.M., Ramli, Anis S., Razak, Suraya A., Al-Khateeb, Alyaa, Kadir, Siti H.S.A., Muid, Suhaila A., Rahman, Thuhairah A., Kasim, Sazzli S., Radzi, Ahmad B.M., Ibrahim, Khairul S., Razali, Salmi, Ismail, Zaliha, Ghani, Rohana A., Hafidz, Muhammad I.A., Chua, Ang L., Rosli, Marshima M., Annamalai, Muthukkaruppan, Teh, Lay K., Razali, Rafezah, Chua, Yung A., Rosman, Azhari, Sanusi, Abdul R., Murad, Nor A.A., Jamal, A. Rahman A., Nazli, Sukma A., Razman, Aimi Z., Rosman, Norhidayah, Rahmat, Radzi, Hamzan, Nur S., Azzopardi, C., Mehta, Roopa, Martagon, Alexandro J., Ramirez, Gabriela A.G., Villa, Neftali E.A., Vazquez, Arsenio V., Elias-Lopez, Daniel, Retana, Gustavo G., Rodriguez, Betsabel, Macías, Jose J.C., Zazueta, Alejandro R., Alvarado, Rocio M., Portano, Julieta D.M., Lopez, Humberto A., Sauque-Reyna, Leobardo, Herrera, Laura G.G., Mendia, Luis E.S., Aguilar, Humberto Garcia, Cooremans, Elizabeth R., Aparicio, Berenice P., Zubieta, Victoria M., Gonzalez, Perla A.C., Ferreira-Hermosillo, Aldo, Portilla, Nacu C., Dominguez, Guadalupe J., Garcia, Alinna Y.R., Cazares, Hector E.A., Gonzalez, Jesus R., Valencia, Carla V.M., Padilla, Francisco G., Prado, Ramon M., De los Rios Ibarra, Manuel O., Villicaña, Ruy D.A., Rivera, Karina J.A., Carrera, Ricardo A., Alvarez, Jose A., Martinez, Jose C.A., de los Reyes Barrera Bustillo, Manuel, Vargas, Gonzalo C., Chacon, Roberto C., Andrade, Mario H.F., Ortega, Ashanty F., Alcala, Hector G., de Leon, Laura E.G., Guzman, Berenice G., Garcia, Jose J.G., Cuellar, Juan C.G., Cruz, Jose R.G., Garcia, Anell Hernandez, Almada, Jesus R.H., Herrera, Ursulo J., Sobrevilla, Fabiola L., Rodriguez, Eduardo M., Sibaja, Cristina M., Rodriguez, Alma B.M., Oyervides, Jose C.M., Vazquez, Daniel I.P., Rodriguez, Eduardo A.R., Osorio, Ma L.R., Saucedo, Juan R., Tamayo, Margarita T., Talavera, Luis A.V., Arroyo, Luis E.V., Carrillo, Eloy A.Z., Isara, Alphonsus, Obaseki, Darlington E., Al-Waili, Khalid, Al-Zadjali, Fahad, Al-Zakwani, Ibrahim, Al-Kindi, Mohammed, Al-Mukhaini, Suad, Al-Barwani, Hamida, Rana, Asim, Shah, Lahore S.U., Starostecka, Ewa, Konopka, Agnieszka, Lewek, Joanna, Bartłomiejczyk, Marcin, Gąsior, Mariusz, Dyrbuś, Krzysztof, Jóźwiak, Jacek, Gruchała, Marcin, Pajkowski, Marcin, Romanowska-Kocejko, Marzena, Żarczyńska-Buchowiecka, Marta, Chmara, Magdalena, Wasąg, Bartosz, Parczewska, Aleksandra, Gilis-Malinowska, Natasza, Borowiec-Wolna, Justyna, Stróżyk, Aneta, Woś, Marlena, Michalska-Grzonkowska, Aleksandra, Medeiros, Ana M., Alves, Ana C., Silva, Francisco, Lobarinhas, Goreti, Palma, Isabel, de Moura, Jose P., Rico, Miguel T., Rato, Quitéria, Pais, Patrícia, Correia, Susana, Moldovan, Oana, Virtuoso, Maria J., Salgado, Jose M., Colaço, Ines, Dumitrescu, Andreea, Lengher, Calin, Mosteoru, Svetlana, Meshkov, Alexey, Ershova, Alexandra, Rozkova, Tatiana, Korneva, Victoria, Yu, Kuznetsova T., Zafiraki, Vitaliy, Voevoda, Mikhail, Gurevich, Victor, Duplyakov, Dmitry, Ragino, Yulia, Safarova, Maya, Shaposhnik, Igor, Alkaf, Fahmi, Khudari, Alia, Rwaili, Nawal, Al-Allaf, Faisal, Alghamdi, Mohammad, Batais, Mohammed A., Almigbal, Turky H., Kinsara, Abdulhalim, AlQudaimi, Ashraf H.A., Awan, Zuhier, Elamin, Omer A., Altaradi, Hani, Rajkovic, Natasa, Popovic, Ljiljana, Singh, Sandra, Stosic, Ljubica, Rasulic, Iva, Lalic, Nebojsa M., Lam, Carolyn, Le, Tan J., Siang, Eric L.T., Dissanayake, Sanjaya, I-Shing, Justin T., Shyong, Tai E., Jin, Terrance C.S., Balinth, Karin, Buganova, Ingrid, Fabryova, Lubomira, Kadurova, Michaela, Klabnik, Alexander, Kozárová, Miriam, Sirotiakova, Jana, Battelino, Tadej, Kovac, Jernej, Mlinaric, Matej, Sustar, Ursa, Podkrajsek, Katarina T., Fras, Zlatko, Jug, Borut, Cevc, Matija, Pilcher, Gillian J., Blom, D.J., Wolmarans, K.H., Brice, B.C., Muñiz-Grijalvo, Ovidio, Díaz-Díaz, Jose L., de Isla, Leopoldo P., Fuentes, Francisco, Badimon, Lina, Martin, François, Lux, Angela, Chang, Nien-Tzu, Ganokroj, Poranee, Akbulut, Mehmet, Alici, Gökhan, Bayram, Fahri, Can, Levent H., Celik, Ahmet, Ceyhan, Ceyhun, Coskun, Fatma Y., Demir, Mesut, Demircan, Sabri, Dogan, Volkan, Durakoglugil, Emre, Dural, Ibrahim E., Gedikli, Omer, Hacioglu, Aysa, Ildizli, Muge, Kilic, Salih, Kirilmaz, Bahadir, Kutlu, Merih, Oguz, Aytekin, Ozdogan, Oner, Onrat, Ersel, Ozer, Savas, Sabuncu, Tevfik, Sahin, Tayfun, Sivri, Fatih, Sonmez, Alper, Temizhan, Ahmet, Topcu, Selim, Tuncez, Abdullah, Vural, Mirac, Yenercag, Mustafa, Yesilbursa, Dilek, Yigit, Zerrin, Yildirim, Aytul B., Yildirir, Aylin, Yilmaz, Mehmet B., Atallah, Bassam, Traina, Mahmoud, Sabbour, Hani, Hay, Dana A., Luqman, Neama, Elfatih, Abubaker, Abdulrasheed, Arshad, Kwok, See, Oca, Nicolas D., Reyes, Ximena, Alieva, Rano B., Kurbanov, Ravshanbek D., Hoshimov, Shavkat U., Nizamov, Ulugbek I., Ziyaeva, Adolat V., Abdullaeva, Guzal J., Do, Doan L., Nguyen, Mai N.T., Kim, Ngoc T., Le, Thanh T., Le, Hong A., Tokgozoglu, Lale, Catapano, Alberico L., and Ray, Kausik K.

Published
2021
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14. Beta-thalassemia mutation types and the relationship with the demographic factors in Sanliurfa, Turkey

Author

Ebru Tuncez, Özlem Öz, Burcu Akıncı, and Fatma Demir

Subjects
beta-thalassemia major, beta-thalassemia intermedia, mutation, consanguineous marriage, beta-talasemi majör, beta-talasemi intermedia, mutasyon, akraba evliliği, Public aspects of medicine, RA1-1270
Abstract

Introduction: Beta-thalassemia is an autosomal recessive disease that occurs as a result of a disorder in the (β-globin chains synthesis), and the gold standard method for diagnosis is genetic mutation analysis. It is important to know the distribution of mutations according to regions and races. The aim of this study is to document the mutations in the beta-globin gene of beta-thalassemia major and intermedia patients who were followed and treated in Sanliurfa province, and to examine the relationships between these mutations by defining them according to gender, nationality, consanguineous marriage, history of disease in siblings and blood type.Methods: The files of 272 patients diagnosed with beta-thalassemia major and intermedia followed up in the Pediatric Hematology-Oncology outpatient clinic of Sanliurfa Training and Research Hospital between August 2016 and August 2017 were retrospectively reviewed and mutation analyzes were documented. Coding exons and exon-intron junction regions of beta globin-HBB gene were amplified by PCR method and then DNA sequencing was performed. Gender, nationality, consanguineous marriage, sibling history and blood type information were recorded.Results: Out of 272 patients, 94.1% were thalassemia major and the others were thalassemia intermedia. Approximately one third of the patients (30.1%) were foreign nationals. A total of 27 different mutations in the beta-globin gene were detected. The most common mutation is IVS-I-110 c.93-21 (G gt; A) (23.1%), which is followed by IVS-I-1 c.92 + 1 (G gt; A) (15.8%) and Codon 39 c.118 (C gt; T) (11.5%). One hundred and forty-two individuals (52.2%) had no sibling history, while 103 (37.9%) had one sibling and 27 (9.9%) had two siblings with thalassemia disorder. First-degree, second degree and third degree consanguineous marriages were present in 42.6% (n = 116), 8.1% (n = 22), 11% (n = 30) of parents, respectively.Conclusions: Beta-thalassemia disease is a common hematological condition in Sanliurfa. Approximately one-third of the patients who apply are foreign nationals. Correct identification of beta-globin gene mutations will guide genetic counseling and preventing prenatal disease. This data can contribute to the national thalassemia prevention program in Turkey.

Published
2021
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15. Evaluation of forensic autopsies performed on fatal traffic accidents in Izmir

Author

Ferhat Turgut Tuncez, Umut Erdar Bilgin, Erkan Saruhan, Hatice Sezin Yilmazer, and Mehmet Tokdemir

Subjects
traffic accidents, forensic medicine, autopsy, Medicine
Abstract

The frequency of fatal traffic accidents in our country is still one of the important social problems. Identifying the problems is the first step of the solution phase. Therefore, in our study; demographic data about deaths due to traffic accidents, the types of injuries that caused death, and effects of alcohol and/or narcotic substances on the accident were evaluated. In Izmir province, in a three-year period between January 2015 and January 2018, the cases that were in The Council of Forensic Medicine Izmir Group Presidency UYAP (National Judiciary Informatics System) system archive, sent by the prosecutor for autopsy due to a traffic accident were analyzed and evaluated retrospectively. And autopsies of the cases were performed in The Council of Forensic Medicine Izmir Group Presidency Morgue Specialization Department. Information about the cases such as age, gender, event date (season/day), event time (hours), whether there is an in-vehicle/non-vehicle traffic accident, whether the case is a driver/passenger, crime scene (location), whether the case has an alcohol/narcotic substance effect, whether there is a history of hospital treatment, and the exact cause of death were included in the study. The data obtained were analyzed with the SPSS 18.0 statistical program. The number of deaths due to traffic accidents at Izmir Forensic Medicine Institute between 2015 and 2018 was 1044, and the majority of them were male (81.7%, n=853) and the average age was 44.7±20.9. Traffic accidents in our study occur more frequently on intercity roads (52.9% n=552), most frequently between 19:00-00:00 (25.6%) and in summer (June-July-August: 31.4%). It was observed that more than half of the cases (55.6%) died at the scene (no hospitalization) and alcohol was detected in toxicological examination in 20.9%. In our study, it was determined that deaths mostly occurred as a result of head injuries. The demographic data of the study are generally compatible with the literature. Increasing traffic controls especially in summer, making traffic fines more effective, psychotechnical evaluation for drivers who repeatedly violate traffic rules, presenting visual educational messages to all age groups with appropriate communication tools (media, advertising, school, internet, etc.) are our solution suggestions to reduce the number of deaths due to traffic accidents. [Med-Science 2021; 10(2.000): 346-9]

Published
2021
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16. Women severely injured as a result of domestic violence: Case report

Author

Ferhat Turgut Tuncez, Gulcin Tasci, Dogu Baris Kiliccioglu, Zeynep Saglik Kucuk, and Mehmet Tokdemir

Subjects
domestic violence, violence against women, forensic medicine, Medicine
Abstract

Domestic violence; is a multidimensional legal, social and medical problem that concerns almost every step of the society, that has not been overcome currently in our country and in many countries of the world. The most common form of domestic violence is spousal violence against women. It is a condition in which the woman is exposed physically, sexually, emotionally or economically; causing injury, death or psychological trauma. In this study, 3 women who were admitted to the Emergency Service of Izmir Kâtip Celebi University Hospital in 2019 on the grounds that they were beaten and injured; and who were in danger of life as a result of the violence they were exposed to, were examined in terms of forensic medicine and these 3 cases were presented as an example. 2 of the cases were foreign nationals and were subjected to long-term physical violence and sexual abuse by the same man, up to the level of torture. The first of these women is 24 years old, she was examined for sexual abuse in our hospital and findings of sodomy were detected. She was also referred to another hospital with a burn center due to severe burns on her body. The second of the spouses is 32 years old and when she came to our hospital due to physical violence, it was found that she had multiple rib fractures, vertebra fractures, extensive ecchymoses and burn wounds on her body. Our third case, a 33-year-old female, was injured by her husband with a firearm at the time of divorce, and applied to the emergency room, and it was observed that she had a wide defect wound, fracture of the tibia and bone exposure below the left knee. Afterwards, her left leg was amputated below the knee in our hospital. In our cases, it is striking in terms of the fact that, violence against women creates a life-threatening danger even if it does not result in death, and shows how major and permanent damage it can cause in the rest of the life of the victim of violence. [Med-Science 2021; 10(2.000): 614-8]

Published
2021
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17. Assessment of arterial stiffness and epicardial adipose tissue thickness in predicting the subclinical atherosclerosis in patients with ankylosing spondylitis

Author

Kenan Demir, Ahmet Avcı, Serpil Ergulu Esmen, Abdullah Tuncez, Muhammed Ulvi Yalcın, Ahmet Yılmaz, Sema Yılmaz, and Bülent Behlül Altunkeser

Subjects
ankylosing spondylitis, subclinical atherosclerosis, epicardial adipose tissue, pulse wave velocity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Objective Atherosclerosis is a chronic, progressive, inflammatory disease. Recognition of subclinical atherosclerotic vascular changes before clinical manifestation in an asymptomatic population is important for risk stratification and optimal management, which finally leads to the prevention of cardiovascular disease. We aimed to determine the risk of premature subclinical atherosclerosis by evaluating epicardial adipose tissue thickness (EATT) and arterial stiffness parameters in patients with ankylosing spondylitis (AS). Methods We performed a prospective study of 60 consecutive patients meeting modified New York criteria for AS compared to 60 controls matched for age and sex. Patients with traditional cardiovascular risk factors were excluded. Arterial stiffness parameters and EATT (examined via echocardiography) values of all patients and control groups were measured. Results There was no difference between basal characteristic and echocardiographic parameters in patients with AS and in the control group. EATT and pulse wave velocity (PWV) were higher in the AS patients compared to the control group. EATT was 5.74 ± 1.22 mm and 4.91 ± 1.21 mm (p

Published
2021
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18. Relationship between behcets disease and oxidant and antioxidant markers

Author

Fikret Akyurek and Fatma Tuncez Akyurek

Subjects
behcets disease, tas, tos, hdl, ldl, Medicine
Abstract

Behcets disease is known as a chronic and inflammatory vasculitis with multiple system and organ involvement. In this study, we aimed to evaluate the relationship between BD and oxidative stress by evaluating the total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in healthy control group and patients with Behcets disease (BD). Materials and Methods: Study groups were composed of BD patients (n = 57) and healthy controls (n = 54). Serum total TAS, TOS, (OSI) and serum lipid levels were measured by photometric method. All measurements were made on Beckman Coulter AU5800 Series (Japan). OSI was determined by the TOS / TAS ratio. Serum TAS levels in BD were lower than the healthy controls (p = 0.039). Serum levels of TOS, OSI and lipids did not differ significantly in BD patients compared to healthy controls. Also, the sensitivity of TAS for BD was high (0.825). Low TAS levels can play an important role in the etiopathology of BD. Increasing serum TAS levels may be beneficial for the clinical process. More studies are needed in this regard. [Med-Science 2020; 9(3.000): 625-8]

Published
2020
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19. Evaluation of Zinc and Copper Levels in Superficial Fungal Infections

Author

Fatma Tuncez Akyurek and Fikret Akyürek

Subjects
copper, dermatophytosis, superficial fungal infections, trace elements, zinc, bakır, çinko, dermatofitozis, eser element, yüzeyel mantar enfeksiyonları, Medicine
Abstract

Objective: Superficial fungal infections are one of the common skin diseases. Zinc and copper are essential elements for humans, and concentrations of these trace elements may vary in various inflammatory conditions. Our aim in this study is to measure serum zinc and copper levels in patients with superficial fungal infection and to evaluate its relationship with clinical types of the disease. Materials and Methods: This study included 81 patients diagnosed with superficial fungal infection (tinea capitis, faciei, pedis, unguim, corporis, and versicolor) who applied to the Department of Skin and Venereal Diseases, Faculty of Medicine, Selcuk University. Serum zinc and copper levels were measured in all patients. Results: The mean age of the patients was 36.68 ± 17.12, and 54 (66.6%) of patients were male and 27 (33.3%) were female. There were tinea versicolor in 32 (39.5%) of the patients and other dermatophytosis infections (tinea capitis, faciei, pedis, unguium and corporis) in 49 (60.5%) of the patients. The mean serum zinc levels of the patients were determined close to the lower limit of the normal reference range with 11.41 ± 2.07 µmol / L, but zinc and copper levels were within the normal reference range (normal reference values of zinc and copper; 11-19.5 µmol / L, 80-155 µg / dL, respectively). There was no statistically significant difference in zinc and copper levels between patients with tinea versicolor and patients with other dermatophyte infections (p = 0.348, p = 0.173, respectively). In addition, there was a negative correlation between serum zinc levels and age, serum copper levels showed a statistically significant negative relationship with male sex and smoking (r = -0.359, p = 0.001; r = -0.343, p = 0.002, r = -0.283 , p = 0.033, respectively). Discussion: In our study, the majority of patients with superficial fungal infections were men. It was determined that the frequency of dermatophyte infections increased as the mean age of the patients increased. Although serum zinc and copper levels measured in patients were within the normal reference range, especially zinc levels were close to the lower limit of reference values. In addition, it was observed that various factors such as age, gender and smoking affect zinc and copper levels. As a result of these data, we think that irregularities in serum zinc and copper levels may predispose to the development of fungal infections.

Published
2020
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21. Turkey Urticaria Diagnosis and Treatment Guide based; Distribution of Chronic Urticaria Patients Treated in Our Clinic According to Step Therapy

Author

Fatma Tuncez Akyurek, Gözde Ulutaş Demirbaş, Gülcan Saylam Kurtipek, Nihal Sari, Emre Zekey, Mehmet Akyürek, and Neriman Akdam

Subjects
cyclosporine, omelizumab, treatment, urticaria, siklosporin, tedavi, ürtiker, Medicine
Abstract

Aim: Chronic urticaria is a condition that requires long-term treatment. In recent years, many countries have created their own guides to evaluate urticaria diagnosis and treatment approaches in an algorithm. In this study, we aimed to evaluate the distribution of patients with chronic urticaria treated in our clinic according to the treatment algorithm the "Turkey Urticaria Diagnosis and Treatment Guide" Material and Method: The files of the patients who applied to the Department of Dermatology and Venereal Diseases at Selcuk University and were followed up and treated with the diagnosis of chronic urticaria were investigated. Results: A total of 102 chronic urticaria patients without angioedema were included in the study. According to this guide, 17.6% of patients responded with standard dose antihistamine therapy, while the antihistamine dose given in 15.7% of patients was increased. The antihistamine treatment of 5.7% of patients was replaced by a different group of antihistamines at the same dose as the previous one. 52% of patients responded to omalizumab 300 mg / subcutaneous treatment every 28 days. However, 7.8% of the patients received omalizumab treatment every 14 days or cyclosporine treatment was required to be added to omalizumab treatment. Response to other treatments other than standard treatments was received in 1% of patients. Conclusion: We believe that our study will facilitate predicting the treatment responses of patients in clinical practice by shedding light on the distribution of chronic urticaria patients according to the treatment algorithm.

Published
2021
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22. The evaluation of depression and anxiety levels of mothers of patients with periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome and familial Mediterranean fever.

Author

Arslanoglu Aydin, Elif, Baglan, Esra, Bagrul, İlknur, Kocamaz, Nesibe Gokce, Tuncez, Serife, Bulbul, Mehmet, and Ozdel, Semanur

Subjects
PHARYNGITIS, FAMILIAL Mediterranean fever, ANXIETY, BECK Anxiety Inventory, MOTHERS, LYMPHADENITIS
Abstract

Periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome and familial Mediterranean fever (FMF) are autoinflammatory disorders typically characterized by recurrent fever attacks. These recurrent fever attacks can lead to depression and anxiety in mothers of these patients. This study aimed to compare the depression and anxiety levels in mothers of PFAPA and FMF patients. This study is a cross-sectional observational study. 48 mothers of children with FMF and 70 mothers of children with PFAPA participated in the study. Mothers in these two groups were compared in terms of anxiety and depression by using the validated Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Depression and anxiety scores of mothers were found to be similar in FMF and PFAPA groups. Moderate or high level of anxiety was seen in 32% of mothers of patients with PFAPA and 27% of mothers of patients with FMF. 23% of mothers of patients with PFAPA were evaluated as having moderate or severe depression, and 18% of mothers of patients with FMF were evaluated as having moderate depression. There was no statistically significant difference between the duration, frequency of attacks, recurrent hospitalizations, sociodemographic characteristics, and inventory scores. Depression and anxiety scores of mothers with children diagnosed with FMF and PFAPA are similar. These two diseases affect families psychosocially at similar levels. It is important to provide psychosocial support to families. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Is there really association between lichen planus and hepatitis C ?

Author

Fatma Tuncez Akyurek and Gulcan Saylam Kurtipek

Subjects
lichen planus, hcv, association, Medicine
Abstract

Lichen planus (LP) is a T-cell mediated dermatosis with unknown etiology that is affecting the skin, oral mucosa, nail and hair follicle. Although the cause is not known, there are many articles in the literature that show the association between LP and hepatitis-C, especially oral LP. However, this association may vary according to geographical regions. We aimed to determine whether such an epidemiological relationship exists in a group of patients with lichen planus who applied to our clinic. The records of 145 patients who were admitted to our clinic between March 2014 and 2018 and diagnosed clinically and histopathologically as LP were retrospectively reviewed and none of them had anti-HCV positivity. Discussion: The prevalence of chronic hepatitis C in oral LP patients has been reported to vary between geographical regions. Based on the literature and books, hepatitis-C screenings were performed in patients who were followed up with LP clinically and histopathologically in our clinic for a long time. We did not find any association between HCV and LP in our study. This could be attributed to a lower prevalence of HCV in our country or other triggering factors contributing in our cases. [Med-Science 2019; 8(4.000): 913-5]

Published
2019
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26. Jüvenil İdiopatik Artritli Hastalarda Leflunomid Tedavisinin Değerlendirilmesi: Tek Merkez Deneyimi

Author

Elif ARSLANOĞLU AYDIN, Semanur ÖZDEL, Ilknur BAGRUL, Nesibe Gokce KOCAMAZ, Esra BAĞLAN, Serife TUNCEZ, and Mehmet BULBUL

Subjects
General Earth and Planetary Sciences
Abstract

Amaç: Juvenil idiyopatik artrit (JİA), çocukluk çağının en sık görülen kronik romatizmal hastalığıdır. Metotreksat (MTX), leflunomid (LFN) gibi hastalık modifiye edici antiromatizmal ilaçlar (DMARD) JİA'da birinci basamak tedavilerdir. MTX en sık reçete edilen ilaçtır ve çalışmalar ağırlıklı olarak MTX etkinliğini ve güvenliğini ele almaktadır. Ancak LFN ile ilgili veriler sınırlıdır. Bu çalışmada, JİA hastalarında LFN tedavisi ile ilgili kliniğimizin deneyimlerini sunmayı amaçladık. Gereç ve Yöntem: Bu retrospektif çalışmaya hastanemiz çocuk romatoloji polikliniğinde düzenli olarak takip edilen ve LFN tedavisi verilmiş JİA hastaları dahil edildi. Hasta demografik bilgileri, klinik ve laboratuvar özellikleri ile ilgili veriler tıbbi dosyalardan elde edildi. Bulgular: Çalışmaya ortanca (çeyrekler arası aralık) hastalık başlangıç yaşı 7,3 (3,1-12,0) yıl olan 18 hasta (15 kadın ve 3 erkek) dahil edildi. 8 hastada oligoartiküler JİA, 7 hastada poliartiküler JİA, 2 hastada sistemik JİA ve 1 hastada entezitle ilişkili artrit (ERA) vardı. Tüm hastalara başlangıç tedavisi olarak MTX verildi (ERA tanısı konan bir hasta sulfasalazin ile tedavi edildi hariç). Gastrointestinal sistem (GİS) intoleransı nedeniyle başlangıçta MTX alan tüm hastalarda MTX kesildi ve LFN tedavisi başlandı. Daha önce MTX alırken GİS intoleransı gelişen hastalık aktivitesi düşük olan yedi hastadan altısına LFN tedavisi verildi. Bu hastalarda LFN ile tam remisyon sağlandı. MTX ile remisyonda izlenen dört hastada hastalık aktivasyonu görüldü. Daha önce MTX intoleransı olan bu hastalara LFN tedavisi verildi. Dört hastanın üçünde LFN ile remisyon sağlandı. MTX ile remisyon sağlanamayan orta ve yüksek hastalık aktivitesine sahip altı hastaya biyolojik tedavi başlandı. Yeterli yanıt alınamayan bu hastalarda MTX kesilerek LFN tedavisi başlandı. LFN ve biyolojik ajan kombinasyonu ile sadece bir hastada inaktif hastalık elde edildi. ERA tanılı bir hastada sulfasalazin tedavisine yetersiz yanıt alması üzerine LFN tedavisine geçildi ve LFN ile tam remisyon elde edildi. Sonuçlar: LFN tedavisi, diğer DMARD'larla düşük hastalık aktivitesi ve/veya remisyonu olan ve ilaç kesildikten sonra nüks olan hastalarda faydalı olabilir.

Published
2023

27. What have we learned from Turkish familial hypercholesterolemia registries (A-HIT1 and A-HIT2)?

Author

Kayikcioglu, Meral, Tokgozoglu, Lale, Dogan, Volkan, Ceyhan, Ceyhun, Tuncez, Abdullah, Kutlu, Merih, Onrat, Ersel, Alici, Gokhan, Akbulut, Mehmet, Celik, Ahmet, Yesilbursa, Dilek, Sahin, Tayfun, Sonmez, Alper, Ozdogan, Oner, Temizhan, Ahmet, Kilic, Salih, Bayram, Fahri, Sabuncu, Tevfik, Coskun, Fatma Yilmaz, Ildizli, Muge, Durakoglugil, Emre, Kirilmaz, Bahadir, Yilmaz, Mehmet Birhan, Yigit, Zerrin, Yildirim, Aytul Belgi, Gedikli, Omer, Topcu, Selim, Oğuz, Aytekin, Demir, Mesut, Yenerçağ, Mustafa, Yıldırır, Aylin, Demircan, Sabri, Yilmaz, Mehmet, Kaynar, Leyla Gul, Aktan, Melih, Durmus, Rana Berru, Gokce, Cumali, Ozcebe, Osman İlhami, Akyol, Tulay Karaagac, Okutan, Harika, Sag, Saim, Gul, Ozen Oz, Salcioglu, Zafer, Altunkeser, Bülent Behlul, Kuku, Irfan, Yasar, Hurriyet Yilmaz, Kurtoglu, Erdal, Kose, Melis Demir, Demircioglu, Sinan, Pekkolay, Zafer, Ilhan, Osman, and Can, Levent H.

Published
2018
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29. Is heart-type fatty acid binding protein (H-FABP) a valid marker of arterial stiffness in patients with systemic sclerosis?

Author

Ercüment Öztürk, Sema Yılmaz, Abdullah Tuncez, Nazif Aygül, Ali Ünlü, and Hüsamettin Vatansev

Abstract

Background/Aim: Both micro- and macro-vascular involvement has been researched in systemic sclerosis (SSc) for many years. In this study, the relationship of arterial stiffness with heart-type fatty acid binding protein (h-FABP), which is well-accepted as a cardiac marker, was investigated for the first time. Methods: In this case-control study, 40 patients diagnosed with SSc between the ages of 18 and 65 were included. Thirty healthy individuals of similar age and gender were included as the control group. Patients were excluded from the study if they had cardiovascular risk factors, active infections, and/or malignancies. Along with detecting biochemical markers in the blood, results from methods, such as 24-h blood pressure Holter recordings, pulse-wave velocities (PWV), and echocardiograms (ECHO) were obtained from patients. Results: The homocysteine mean level was higher in the patient group than in the control group (P < 0.001). H-FABP and asymmetric dimethylarginine (ADMA) means were similar between the two groups (P = 0.286 and P = 0.340, respectively). Vascular parameters, including mean arterial pressure (MAP), augmentation index normalized to the 75 /min heart rate (AIx @ 75), and PWV were also similar between the two groups (P = 0.498, P = 0.382 and P = 0.180, respectively). Conclusion: It can be concluded that no ongoing myocardial damage occurs based on normotensive Holter findings, normal h-FABP levels, and ECHO findings in our patients. It is suggested that vasodilatory treatments, such as pentoxifylline and calcium channel blockers, which the patients receive for SSc treatment due to Raynaud Syndrome, may protect them from hypertension and therefore offer protection from myocardial damage.

Published
2022

30. The Effect of Frequency of Sexual Intercourse on Symptoms in Women with Fibromyalgia.

Author

Karpuz, Savas, Yilmaz, Ramazan, Akdere, Emine, Aksanyar, Behiye, Tuncez, Ismail Hakki, and Yilmaz, Halim

Subjects
SEXUAL intercourse, FIBROMYALGIA, BECK Depression Inventory, VISUAL analog scale, QUESTIONNAIRES
Abstract

Objectives: Fibromyalgia is known to affect sexual function, but the effect of frequency of sexual intercourse on fibromyalgia symptom severity is unclear. This study investigated how frequently women with fibromyalgia engaged in sexual activity affected how severe the disease was. Methods: The depression status of the participants was evaluated with the Beck Depression Inventory (BDI) and the mean monthly frequency of sexual intercourse in the last 3 months was noted. Pain levels of fibromyalgia patients were evaluated with Visual Analog Scale (VAS), pain prevalence Widespread Pain Index (WPI), symptom level Symptom Severity Scale (SSS), and fibromyalgia exposure status with Fibromyalgia Impact Questionnaire (FIQ). Results: A hundred women with fibromyalgia with a mean age of 37.11±6.2 years and 100 healthy female controls with a mean age of 36.53 ± 5.85 years participated in the study. Female patients with fibromyalgia had higher BDI and VAS scores and lower frequency of sexual intercourse (p<0.001). While no significant relationship was observed between the frequency of sexual intercourse and VAS, FIQ, SSS and WPI scores, it was found that BDI was lower in those with an average monthly frequency of 8 or more sexual intercourses (p=0.02). Conclusion: This study revealed that the frequency of sexual intercourse is low in female patients with FM and that depression is less common in women with FM who have a higher frequency of sexual intercourse. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Investigation of deaths related to methyl alcohol intoxication in İzmir: A 5-year retrospective study.

Author

Tuncez, Ferhat Turgut, Tasci, Gulci̇n, Can, Ismai̇l Ozgur, and Tokdemir, Mehmet

Subjects
METHANOL, CAUSES of death, COVID-19 pandemic, SOCIAL problems
Abstract

Methyl alcohol consumption results in serious poisoning symptoms and even causes death, so it is not used in legal alcoholic beverages. We aimed to examine deaths due to methyl alcohol intoxication in our region through forensic autopsies performed in İzmir-Türkiye to compare these data with international studies. A total of 13,701 autopsies performed between 2016-2021 were scanned retrospectively. 214 cases in which the exact cause of death was methanol intoxication were included in the study. All the cases were analyzed in terms of age, gender, date of death, place of death, length of hospitalization, methanol levels detected in blood and the vitreous humor, ethanol presence in blood, and pathological findings. The ratio of autopsies of the exact cause of death of methanol poisoning to total autopsies is 1.56%. Of these cases, 94.9% were male and 5.1% were female. The age range was 25–80 years, with a mean age of 53.4. According to the age distributions, the highest rate was 39.3% in the sixth decade. The highest number of cases was 129 (60.3%) in 2020. In the analysis of blood methanol levels, the concentration was found to be in the range of 0-642 mg/dl and the mean was 178 mg/dl. During the COVID-19 pandemic, there has been a significant increase in methanol poisoning cases associated with the economic and social problems experienced in Türkiye. Our study showed that methanol poisoning deaths are especially common in men aged 50-60 years so this group is at higher risk of methanol poisoning [ABSTRACT FROM AUTHOR]

Published
2023
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33. Convergent Double Coronary Sinus Potentials During Atrial Tachycardia

Author

MEROVCI, IDRIZ, primary, YAKUT, IDRIS, additional, GULCU, OKTAY, additional, TUNCEZ, ABDULLAH, additional, KARA, MERYEM, additional, CETIN, ELIF, additional, KORKMAZ, AHMET, additional, OZEKE, OZCAN, additional, CAY, SERKAN, additional, OZCAN, FIRAT, additional, ARAS, DURSUN, additional, and TOPALOGLU, SERKAN, additional

Published
2023
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35. Transition from two wide to a narrow QRS complex tachycardia: What is the mechanism of tachycardia and transition?

Author

Abdullah Tuncez, Idriz Merovci, Tolga H. Efe, Meryem Kara, Bulent Deveci, Elif H. O. Cetin, Ahmet Korkmaz, Ozcan Ozeke, Serkan Cay, Firat Ozcan, Dursun Aras, and Serkan Topaloglu

Subjects
Electrocardiography, Tachycardia, Physiology (medical), Atrioventricular Nodal Reentrant Tachycardia, Wide QRS, Humans, Tachycardia, Atrioventricular Nodal Reentry, Narrow QRS, Cardiology and Cardiovascular Medicine
Abstract

A 21 years old man presented with regular palpitations anddocumented both narrow and wide QRS complex tachycardia (NCTand WCT, respectively). At electrophysiological study, the retrogradeconduction was decremental and concentric with the earliestactivation site at the His bundle (HB) region. Para‐Hisian pacingindicated retrograde conduction over the fast pathway of theatrioventricular (AV) node. After the AH interval jump, two WCTswith both right bundle branch block (RBBB) and left BBB (LBBB)BBB morphologies that spontaneously transform to an NCT wereobserved (Figure1). What are the possible mechanism of tachycar-dias and transition?

Published
2022

36. Protracted febrile myalgia as a first and challenging manifestation of familial Mediterranean fever.

Author

Aydin, Elif Arslanoglu, Baglan, Esra, Bagrul, Ilknur, Tuncez, Serife, Ozdel, Semanur, and Bulbul, Mehmet

Subjects
FAMILIAL Mediterranean fever, MYALGIA
Abstract

Objectives: Familial Mediterranean fever (FMF) is an auto-inflammatory disease that causes recurrent episodes of fever, abdominal pain, chest pain, and arthritis. Although FMF is well known, protracted febrile myalgia syndrome (PFMS) is a clinical condition that is rare and difficult to diagnose than other symptoms of FMF. PFMS causes fever, myalgia, and acute phase reactant elevation that lasts 2-4 weeks if corticosteroid treatment is not given. In some cases, fever may not be seen. The purpose of this report is to share our experience with PFMS patients in our clinic. Methods: This is an observational, retrospective, single-centre study. We evaluated patients who had been diagnosed with PFMS at our paediatric rheumatology clinic. Results: Protracted febrile myalgia syndrome was observed in 14 patients. Nine of the patients were female. The median age at the time of diagnosis of PFMS was 10 years. Only three patients had previously been diagnosed with FMF. Most of our patients were patients who had no previous complaint of FMF. PFMS attack was seen as the first clinical manifestation of FMF in 11 patients. Two patients who did not respond to steroid treatment improved with anakinra treatment. Conclusions: PFMS is a rare condition of FMF disease. It may be the first clinical manifestation of FMF disease. Fever may not be seen in all patients. Clinicians should be aware of this situation. [ABSTRACT FROM AUTHOR]

Published
2023
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37. Retrospective Assessment of Forensic Facts Under 18 Years of Age in İzmir.

Author

Tuncez, Ferhat Turgut, Yegen, Ece Ergun, Oz, Derya Gulmez, and Kiliccioglu, Dogu Baris

Subjects
PREVENTION of child abuse, PEDIATRICS, RETROSPECTIVE studies, MANN Whitney U Test, CRIME victims, DESCRIPTIVE statistics, FORENSIC medicine, DATA analysis software, CHILDREN
Abstract

Aim: The aim of this study was to examine the cases under the age of 18 who applied to the forensic medicine outpatient clinic of our hospital in İzmir. Material and Methods: Among the 6,492 reports prepared for the patients who applied to İzmir Katip Çelebi University, Atatürk Training and Research Hospital Forensic Medicine Polyclinic between January 2019 and January 2022, 471 final reports prepared for forensic cases under the age of 18; age, gender, type of incident, area of injury, according to TCK 86 law clause; It was examined retrospectively with parameters such as whether it is life-threatening or not, and whether it can be eliminated with a simple medical intervention or not. Results: In our study, 471 reports were examined; The most common age was 18, the mean age was 14, the number of girl cases was 203 (43.1%), the number of male cases was 268 (56.9%), the most common type of event was the assault, while traffic accidents were the second most frequent, the most frequently injured body area in cases under 18 years old was the extremities in 154 (32.7%), followed by head injuries in 101 (21.4%) cases, and life-threatening injuries in 19 (4%) cases. It was found that it was seen most frequently in July and least in April. Conclusion: The data determined in our study were in parallel with similar studies in the literature, while the most common cause of death in autopsy series was determined as traffic accident, it was seen that the most common cause of injury in outpatients who applied to our polyclinic was assault. [ABSTRACT FROM AUTHOR]

Published
2023
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41. On Long-Run Stock Returns After Corporate Events

Author

Seppo Pynnönen, Ahmet M. Tuncez, and James W. Kolari

Subjects
ta112, Financial economics, business.industry, Equity (finance), Standardized test, Monetary economics, Abnormal return, Mergers and acquisitions, Dividend, business, Empirical evidence, ta512, Initial public offering, Finance, Stock (geology), Calendar time
Abstract

This paper revisits the controversial question of whether long-run abnormal returns are associated with major corporate events. Our analyses investigate initial public offerings (IPOs), seasoned equity offerings (SEOs), mergers and acquisitions (M&As), and dividend initiations. In an attempt to resolve ambiguous empirical evidence with respect to these events, we conduct a variety of tests for abnormal long-run performance, including buy-and-hold returns (BHARs), different calendar time approaches, and a recent standardized test. Empirical tests for these different methods consistently detect significant long-run abnormal returns for all four corporate events. We conclude that long-run abnormal returns exist with respect to these major corporate actions.

Published
2022

44. A Case of Combined Oxidative Phosphorylation Deficiency 35 Associated with a Novel Missense Variant of the TRIT1 Gene

Author

Serap Teber, Ömer Bektaş, Miraç Yıldırım, Nurşah Yeniay Süt, Yavuz Sayar, Ümmühan Öncül, and Ebru Tuncez

Subjects
Genetics, Missense mutation, Oxidative phosphorylation, Biology, Gene, Molecular biology, Genetics (clinical)
Abstract

Combined oxidative phosphorylation deficiency 35 (COXPD35) is a rare autosomal recessive disorder associated with homozygous or compound heterozygous mutations in the tRNA isopentenyltransferase (TRIT1) gene in chromosome 1p34.2. To date, only 10 types of allelic variants in the TRIT1 gene have been previously reported in 9 patients with COXPD35. Herein, we describe a case with a novel homozygous missense variant in TRIT1. A 6-year, 6-month-old boy presented with global developmental delay, microcephaly, intractable seizures, and failure to thrive. The other main clinical manifestations were intellectual disability, spastic tetraparesis, truncal hypotonia, malnutrition, polyuria and polydipsia, ketotic hypoglycemia, dysmorphic facial features, strabismus, bicuspid aortic valve, and nephrolithiasis. The detailed biochemical, radiological, and metabolic evaluations were unremarkable. Chromosomal analysis confirmed a normal male 46,XY karyotype and the array comparative genomic hybridization analysis revealed no abnormalities. We identified a novel homozygous missense variant of c.246G>C (p.Met82Ile) in the TRIT1 gene, and the variant was confirmed by Sanger sequencing. The present case is the first report describing strabismus, ketotic hypoglycemia, nephrolithiasis, and bicuspid aortic valve in TRIT1-related COXPD35. This study expands the genotype-phenotype spectrum of TRIT1-related COXPD35.

Published
2021

46. Dynamic changes in atrial activation sequence during supraventricular tachycardia

Author

Gulcu, Oktay, primary, Merovci, Idriz, additional, Tuncez, Abdullah, additional, Kara, Meryem, additional, Ozcan Cetin, Elif Hande, additional, Can, Irem Dilara, additional, Kaplan, Elmas, additional, Korkmaz, Ahmet, additional, Ozeke, Ozcan, additional, Cay, Serkan, additional, Ozcan, Firat, additional, Aras, Dursun, additional, and Topaloglu, Serkan, additional

Published
2022
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47. Beta-thalassemia mutation types and the relationship with the demographic factors in Sanliurfa, Turkey

Author

Burcu Akinci, Fatma Demir, Ebru Tuncez, and Özlem Öz

Subjects
Genetics, Mutation (genetic algorithm), medicine, Beta thalassemia, Biology, medicine.disease
Abstract

Introduction: Beta-thalassemia is an autosomal recessive disease that occurs as a result of a disorder in the (β-globin chains synthesis), and the gold standard method for diagnosis is genetic mutation analysis. It is important to know the distribution of mutations according to regions and races. The aim of this study is to document the mutations in the beta-globin gene of beta-thalassemia major and intermedia patients who were followed and treated in Sanliurfa province, and to examine the relationships between these mutations by defining them according to gender, nationality, consanguineous marriage, history of disease in siblings and blood type.Methods: The files of 272 patients diagnosed with beta-thalassemia major and intermedia followed up in the Pediatric Hematology-Oncology outpatient clinic of Sanliurfa Training and Research Hospital between August 2016 and August 2017 were retrospectively reviewed and mutation analyzes were documented. Coding exons and exon-intron junction regions of beta globin-HBB gene were amplified by PCR method and then DNA sequencing was performed. Gender, nationality, consanguineous marriage, sibling history and blood type information were recorded.Results: Out of 272 patients, 94.1% were thalassemia major and the others were thalassemia intermedia. Approximately one third of the patients (30.1%) were foreign nationals. A total of 27 different mutations in the beta-globin gene were detected. The most common mutation is IVS-I-110 c.93-21 (G> A) (23.1%), which is followed by IVS-I-1 c.92 + 1 (G> A) (15.8%) and Codon 39 c.118 (C> T) (11.5%). One hundred and forty-two individuals (52.2%) had no sibling history, while 103 (37.9%) had one sibling and 27 (9.9%) had two siblings with thalassemia disorder. First-degree, second degree and third degree consanguineous marriages were present in 42.6% (n = 116), 8.1% (n = 22), 11% (n = 30) of parents, respectively.Conclusions: Beta-thalassemia disease is a common hematological condition in Sanliurfa. Approximately one-third of the patients who apply are foreign nationals. Correct identification of beta-globin gene mutations will guide genetic counseling and preventing prenatal disease. This data can contribute to the national thalassemia prevention program in Turkey.

Published
2021

48. Further evidence on long-run abnormal returns after corporate events

Author

Ahmet M. Tuncez, Seppo Pynnönen, and James W. Kolari

Subjects
Economics and Econometrics, 050208 finance, genetic structures, 05 social sciences, Share repurchase, Corporate action, Abnormal return, 0502 economics and business, Mergers and acquisitions, Test statistic, Econometrics, Economics, Dividend, 050207 economics, Initial public offering, Finance, Stock (geology)
Abstract

This paper investigates abnormal standardized returns (ASRs) after major corporate events. Dutta, Knif, Kolari, and Pynnonen (2018) have shown that the ASR t-test has superior size and power compared to traditional test statistics. Based on this new test statistic compared to traditional test methods, we re-examine long-run abnormal returns after mergers and acquisitions, initial public offerings, seasoned equity offerings, dividend initiations, stock repurchases, stock splits, and reverse stock splits. While some recent studies report disappearing long-run event effects over time, our ASR tests in different subperiods from 1980 to 2015 detect significant long-run abnormal returns after these corporate actions. Graphical analyses of ASRs further support our statistical test results. We conclude that long-run abnormal returns persist after major corporate events.

Published
2021

49. Comparison of clinical and laboratory features and treatment responses in patients with clinically amyopathic juvenile dermatomyositis and classical juvenile dermatomyositis.

Author

Gezgin Yıldırım, Deniz, Baglan, Esra, Güngörer, Vildan, Yıldız, Cisem, Tuncez, Serife, Bülbül, Mehmet, Acar, Banu, and Bakkaloğlu, Sevcan A.

Subjects
DERMATOMYOSITIS, PATHOLOGICAL laboratories, CALCINOSIS, MUSCLE weakness, LYMPHOCYTE count, SKIN ulcers, DELAYED diagnosis
Abstract

Aim: The aim of this study was to compare the clinical and laboratory features, treatment choices and responses, and outcomes between patients with clinically amyopathic juvenile dermatomyositis (CAJDM) and classical juvenile dermatomyositis (JDM). Methods: We retrospectively reviewed the medical records of patients with CAJDM and JDM, and compared the 2 groups' clinical and laboratory data, treatment agents and responses, and outcomes. Results: There were 38 JDM and 12 CAJDM patients, with female dominance. There was a higher delay time in diagnosis for CAJDM (P = 0.000). Compared to other clinical symptoms of JDM, muscle weakness and myalgia were more prominent in JDM than in CAJDM (P = 0.000). The absolute lymphocyte count was lower (P = 0.034) in patients with JDM than in those with CAJDM. Anti‐p155/140 (TIF‐1) antibody positivity was significantly more common in the CAJDM group (P = 0.000), while anti‐NXP2 antibody was more common in the JDM group (P = 0.046). In terms of treatment, pulse corticosteroid usage was more common in patients with JDM than in those with CAJDM (P = 0.000). Conclusion: Close clinical follow‐ups with effective treatments are important to prevent complications, such as calcinosis and skin ulcers, that may develop in patients with poorly controlled CAJDM. Anti‐p155/140 antibodies may be a useful indicator for detecting amyopathic forms of dermatomyositis in children. [ABSTRACT FROM AUTHOR]

Published
2023
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