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Objectives: To evaluate anatomic and functional results after switching from intravitreal bevacizumab or ranibizumab treatment to aflibercept for wet (neovascular) age-related macular degeneration. Materials and Methods: This retrospective study included 22 eyes of 22 patients resistant to treatment with at least 6 injections of bevacizumab or ranibizumab. The first three injections had been applied monthly, the others pro re nata (PRN). Outcome measures were follow-up period, injection number, best corrected visual acuity (BCVA), central retinal thickness (CRT) and pigment epithelial detachment (PED) height. Dosing regimen of aflibercept was determined PRN. The patients were examined monthly. In all visits, BCVA and optical coherence tomography results were assessed together and injections were applied according to these findings. Patients with at least three months of follow-up were included in the study. Results: Twenty-two eyes of 22 patients treated with bevacizumab or ranibizumab were switched to aflibercept therapy. Seven patients had serous PED and 4 patients had fibrovascular PED. The mean follow-up periods for these groups were 20.59±6.76 months and 8.68±3.79 months, respectively. The mean injection numbers were 10.5±3.61 vs 4.54±1.56. Statistically significant reductions were noted in CRT (533.86±164.06 µm vs 412.04±143.86 µm, p0.05) for serous PEDs and 251.25±43.85 µm to 225.75±73.09 µm (p>0.05) for fibrovascular PEDs. Conclusion: Switching to aflibercept resulted in significant improvement in CRT, but not in BCVA or PED heights.

Chorioretinal folds are parallel grooves or striae involving the inner choroid, Bruch membrane, the retinal pigment...

The purpose of this study is to evaluate the capabilities of ultrasound biomicroscopy (UBM) as a diagnostic method for surgical planning of secondary intraocular lens (IOL) implantation in aphakia and intraocular lens dislocation. In this retrospective study, 19 eyes of 19 patients with aphakia and IOL dislocation that was not possible to evaluate by biomicroscopy because of the causes like corneal edema, opacity, anterior chamber reaction, ectopic pupil or poor pupil dilatation following cataract surgery were included. Ultrasound biomicroscopy was performed preoperatively to determine the capsule integrity, degree of ciliary sulcus support and iridocapsular adhesions. Seven patients with aphakia and 12 patients with posterior chamber IOL following cataract surgery were studied. Ultrasound biomicroscopy revealed that 4 of 7 eyes with aphakia had adequate capsule integrity (two eyes also had iridocapsular adhesions) and ciliary sulcus support, and 3 eyes had inadequate capsular remnant. Sulcus-supported posterior chamber IOLs were implanted in 4 eyes, and scleral-fixated posterior chamber IOLs were implanted in 3 eyes. Ultrasound biomicroscopy showed that 4 of 12 eyes with IOL dislocation had adequate capsule remnant, and there was no adequate capsular remnant and ciliary sulcus support in 8 eyes. IOL reposition or IOL exchange were performed in 4 eyes and IOL exchange and scleral-fixated posterior chamber IOLs implantation or scleral fixation of dislocated IOLs were performed in 8 eyes. In conclusion, ultrasound biomicroscopy helps the surgeon to select the appropriate surgical protocol by determining the capsule integrity, implant bed and iridocapsular adhesions preoperatively. It is also useful to choose the IOL model and its fixation type. [Med-Science 2015; 4(4.000): 2849-56]

Purpose To evaluate the efficacy of adjunctive mitomycin C (MMC) in transcanalicular multidiode laser dacryocystorhinostomy (TCL-DCR) in different age groups. Methods Ninety-six eyes of 96 patients who underwent TCL-DCR for the treatment of nasolacrimal duct obstruction were included in this retrospective, comparative study. Patients were divided into 4 groups based on age and intraoperative use of MMC: group 1, TCL-DCR without MMC in the 20- to 44-year age group; group 2, TCL-DCR with MMC in the 20- to 44-year age group; group 3, TCL-DCR without MMC in the 45- to 76-year age group; group 4, TCL-DCR with MMC in the 45- to 76-year age group. The postoperative evaluation consisted of calculating and comparing the success rates between groups. Results Success rates at the final visit were 50% for group 1, 66.66% for group 2, 79.16% for group 3, and 84.61% for group 4. The differences between group 1 and group 4, and group 1 and group 3, were significant (p = 0.01 and p = 0.038, respectively). Logistic regression showed that age group had significant effect on success rate (p = 0.013). However, use of MMC had no significant effect on success rate (p = 0.23). Conclusions The success rates of the TCL-DCR with MMC application were found to be higher than those of TCL-DCR without MMC in different age groups. However, the differences did not reach statistical significance. In addition, our study demonstrated that age may be a significant factor influencing the surgical outcome of TCL-DCR.

Aim. To compare the surgical outcomes of surgery with and without bicanalicular silicon tube intubation for the treatment of patients who have primary uncomplicated nasolacrimal duct obstruction.Methods. This retrospective study is comprised of 113 patients with uncomplicated primary nasolacrimal duct obstruction. There were 2 groups in the study: Group 1 (n=58) patients underwent transcanalicular diode laser dacryocystorhinostomy surgery with bicanalicular silicon tube intubation and Group 2 (n=55) patients underwent transcanalicular diode laser dacryocystorhinostomy surgery without bicanalicular silicon tube intubation. The follow-up period was18.42±2.8months for Group 1 and18.8±2.1months for Group 2.Results. Success was defined by irrigation of the lacrimal system without regurgitation and by the absence of epiphora. Success rates were 84.4% for Group 1 and 63.6% for Group 2 (P=0.011). Statistically a significant difference was found between the two groups.Conclusion. The results of the study showed that transcanalicular diode laser dacryocystorhinostomy surgery with bicanalicular silicon tube intubation was more successful than the other method of surgery. Consequently, the application of silicone tube intubation in transcanalicular diode laser dacryocystorhinostomy surgery is recommended.