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Your search keyword '"Tun, Jortan O."' showing total 10 results
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10 results on '"Tun, Jortan O."'

2. Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus

Author

Neves, Jorge L. B., primary, Urcino, Cristoval, additional, Chase, Kevin, additional, Dowell, Cheryl, additional, Hone, Arik J., additional, Morgenstern, David, additional, Chua, Victor M., additional, Ramiro, Iris Bea L., additional, Imperial, Julita S., additional, Leavitt, Lee S., additional, Phan, Jasmine, additional, Fisher, Fernando A., additional, Watkins, Maren, additional, Raghuraman, Shrinivasan, additional, Tun, Jortan O., additional, Ueberheide, Beatrix M., additional, McIntosh, J. Michael, additional, Vasconcelos, Vitor, additional, Olivera, Baldomero M., additional, and Gajewiak, Joanna, additional

Published
2024
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4. Nicotinic Acetylcholine Receptor Partial Antagonist Polyamides from Tunicates and Their Predatory Sea Slugs

Author

Paguigan, Noemi D., primary, Tun, Jortan O., additional, Leavitt, Lee S., additional, Lin, Zhenjian, additional, Chase, Kevin, additional, Dowell, Cheryl, additional, Deering-Rice, Cassandra E., additional, Lim, Albebson L., additional, Karthikeyan, Manju, additional, Hughen, Ronald W., additional, Zhang, Jie, additional, Peterson, Randall T., additional, Reilly, Christopher A., additional, Light, Alan R., additional, Raghuraman, Shrinivasan, additional, McIntosh, J. Michael, additional, Olivera, Baldomero M., additional, and Schmidt, Eric W., additional

Published
2021
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7. Mindapyrroles A–C, Pyoluteorin Analogues from a Shipworm-Associated Bacterium

Author

Lacerna, Noel M., primary, Miller, Bailey W., additional, Lim, Albebson L., additional, Tun, Jortan O., additional, Robes, Jose Miguel D., additional, Cleofas, Mark Jeremiah B., additional, Lin, Zhenjian, additional, Salvador-Reyes, Lilibeth A., additional, Haygood, Margo G., additional, Schmidt, Eric W., additional, and Concepcion, Gisela P., additional

Published
2019
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10. <italic>Callyspongia samarensis</italic> (Porifera) extracts exhibit anticancer activity and induce bleaching in <italic>Porites cylindrica</italic> (Scleractinia).

Author

Azcuna, Miguel, Tun, Jortan O., Yap, Helen T., and Concepcion, Gisela P.

Subjects
*CHEMICAL ecology, *ALLELOPATHIC agents, *CHROMATOGRAPHIC analysis, *ANTINEOPLASTIC agents, *CHEMICAL synthesis, *METHANOL
Abstract

Marine sponges can produce allelopathic compounds with specific roles in the competition for benthic space. Here we demonstrate that extracts from Callyspongia samarensis (Phylum Porifera) accelerate bleaching in Porites cylindrica (Phylum Cnidaria, Order Scleractinia) and exhibit in vitro anticancer activity. A column chromatography fraction and HPLC fraction, purified from the crude methanol extract of C. samarensis, were incorporated into agar gel cubes at natural concentrations and tested on P. cylindrica corals in a laboratory assay. Statistical analysis of percent bleached area and maximum quantum yield showed that a significant difference existed between P. cylindrica nubbins that were exposed to C. samarensis extracts versus the control group. This suggests that C. samarensis contains allelopathic compounds that can cause bleaching in P. cylindrica, possibly leading to tissue necrosis and death. Furthermore, the aforementioned HPLC fraction exhibited significant growth inhibition of the HCT-116 (human colon cancer) cell line. Understanding the strategies by which sponges exert dominance over other organisms is important because it provides information about the ecological roles of sponge allelopathy and can result in the discovery of compounds with biomedical potential. [ABSTRACT FROM AUTHOR]

Published
2018
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