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1. Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia

Author

Stefano Zucchini, Stefano Tumini, Andrea Enzo Scaramuzza, Riccardo Bonfanti, Maurizio Delvecchio, Roberto Franceschi, Dario Iafusco, Lorenzo Lenzi, Enza Mozzillo, Stefano Passanisi, Claudia Piona, Ivana Rabbone, Novella Rapini, Andrea Rigamonti, Carlo Ripoli, Giuseppina Salzano, Silvia Savastio, Riccardo Schiaffini, Angela Zanfardino, Valentino Cherubini, Diabetes Study Group of the Italian Society for Pediatric Endocrinology Diabetes, Albino Claudia Accursia, Aloe Monica, Anzelotti Maria Teresa, Arnaldi Claudia, Barbetti Fabrizio, Bassi Marta, Berioli Maria Giulia, Bernardini Luca, Bertelli Enrica, Biagioni Martina, Bobbio Adriana, Bombaci Bruno, Bonfanti Riccardo, Bonura Clara, Bracciolini Giulia Patrizia, Bruzzese Mariella, Bruzzi Patrizia, Buono Pietro, Buscarino Piera, Cadario Francesco, Calcaterra Valeria, Calzi Elena, Cappa Marco, Cardani Roberta, Cardella Francesca, Cardinale Giuliana Marcella, Casertano Alberto, Castorani Valeria, Cauvin Vittoria, Cenciarelli Valentina, Ceruti Franco, Cherubini Valentino, Chiarelli Francesco, Chiari Giovanni, Cianfarani Stefano, Cicchetti Mario, Cipriano Paola, Cirillo Dante, Citriniti Felice, Coccioli Maria Susanna, Confetto Santino, Contreas Giovanna, Coro Anna, Correddu Antonella, Corsini Elisa, Crino’ Antonino, d’Annunzio Giuseppe, De Berardinis Fiorella, De Donno Valeria, De Filippo Gianpaolo, De Marco Rosaria, De Sanctis Luisa, Del Duca Elisabetta, Delvecchio Maurizio, Deodati Annalisa, Di Bonito Procolo, Di Candia Francesca, Faleschini Elena, Fattorusso Valentina, Favia Anna, Federico Giovanni, Felappi Barbara, Ferrari Mara, Ferrito Lucia, Fichera Graziella, Fontana Franco, Fornari Elena, Franceschi Roberto, Franco Francesca, Franzese Adriana, Frongia Anna Paola, Frontino Giulio, Gaiero Alberto, Galassi Sabrina Maria, Gallo Francesco, Gargantini Luigi, Giani Elisa, Gortan Anna Jolanda, Graziani Vanna, Grosso Caterina, Gualtieri Antonella, Guasti Monica, Guerraggio Lucia Paola, Guzzetti Chiara, Iafusco Dario, Iannicelli Gennaro, Iezzi Maria Laura, Ignaccolo Maria Giovanna, Innaurato Stefania, Inzaghi Elena, Iovane Brunella, Iughetti Lorenzo, Kaufmann Peter, La Loggia Alfonso, Lambertini Anna Giulia, Lapolla Rosa, Lasagni Anna, Lazzaro Nicola, Lazzeroni Pietro, Lenzi Lorenzo, Lera Riccardo, Levantini Gabriella, Lezzi Marilea, Lia Rosanna, Liguori Alice, Lo Presti Donatella, Lombardo Fortunato, Lonero Antonella, Longhi Silvia, Lorubbio Antonella, Lucchesi Sonia, Maccioni Rosella, Macedoni Maddalena, Macellaro Patrizia Cristiana, Madeo Simona Filomena, Maffeis Claudio, Mainetti Benedetta, Maltoni Giulio, Mameli Chiara, Mammì Francesco, Manca Bitti Maria Luisa, Mancioppi Valentina, Manco Melania, Marigliano Marco, Marino Monica, Marsciani Alberto, Matteoli Maria Cristina, Mazzali Elena, Minute Marta, Minuto Nicola, Monti Sara, Morandi Anita,, Morganti Gianfranco, Morotti Elisa, Mozzillo Enza, Musolino Gianluca, Olivieri Francesca, Ortolani Federica, Pampanini Valentina, Pardi Daniela, Pascarella Filomena, Pasquino Bruno, Passanisi Stefano, Patera Ippolita Patrizia, Pedini Annalisa, Pennati Maria Cristina, Peruzzi Sonia, Peverelli Paola, Pezzino Giulia, Piccini Barbara, Piccinno Elvira Eugenia Rosaria, Piona Claudia, Piredda Gavina, Piscopo Alessia, Pistone Carmelo, Pozzi Erica, Prandi Elena, Predieri Barbara, Prudente Sabrina, Pulcina Anna, Rabbone Ivana, Randazzo Emioli, Rapini Novella, Reinstadler Petra, Riboni Sara, Ricciardi Maria Rossella, Rigamonti Andrea, Ripoli Carlo, Rossi Virginia, Rossi Paolo, Rutigliano Irene, Sabbion Alberto, Salvatoni Alessandro, Salvo Caterina, Salzano Giuseppina, Sanseviero Mariateresa, Savastio Silvia, Savini Rosanna, Scanu Mariapiera, Scaramuzza Andrea Enzo, Schiaffini Riccardo, Schiavone Maurizio, Schieven Eleonardo, Scipione Mirella, Secco Andrea, Silvestri Francesca, Siri Giulia, Sogno Valin Paola, Sordelli Silvia, Spiri Daniele, Stagi Stefano, Stamati Filomena Andreina, Suprani Tosca, Talarico Valentina, Tiberi Valentina, Timpanaro Tiziana Antonia Lucia, Tinti Davide, Tirendi Antonina, Tomaselli Letizia Grazia, Toni Sonia, Torelli Cataldo, Tornese Gianluca, Trada Michela,, Trettene Adolfo Andrea, Tumini Stefano, Tumminelli Marilena, Valerio Giuliana, Vandelli Sara, Ventrici Claudia, Zampolli Maria, Zanatta Manuela, Zanfardino Angela, Zecchino Clara, Zonca Silvia, and Zucchini Stefano

Subjects
adolescents, automated insulin delivery, children, hypoglycemia, glucagon, oral glucose, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

There has been continuous progress in diabetes management over the last few decades, not least due to the widespread dissemination of continuous glucose monitoring (CGM) and automated insulin delivery systems. These technological advances have radically changed the daily lives of people living with diabetes, improving the quality of life of both children and their families. Despite this, hypoglycemia remains the primary side-effect of insulin therapy. Based on a systematic review of the available scientific evidence, this paper aims to provide evidence-based recommendations for recognizing, risk stratifying, treating, and managing patients with hypoglycemia. The objective of these recommendations is to unify the behavior of pediatric diabetologists with respect to the timely recognition and prevention of hypoglycemic episodes and the correct treatment of hypoglycemia, especially in patients using CGM or advanced hybrid closed-loop systems. All authors have long experience in the specialty and are members of the Italian Society of Pediatric Endocrinology and Diabetology. The goal of treating hypoglycemia is to raise blood glucose above 70 mg/dL (3.9 mmol/L) and to prevent further decreases. Oral glucose at a dose of 0.3 g/kg (0.1 g/kg for children using “smart pumps” or hybrid closed loop systems in automated mode) is the preferred treatment for the conscious individual with blood glucose

Published
2024
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2. Future acceptance of automated insulin delivery systems in youths with type 1 diabetes: validation of the Italian artificial pancreas-acceptance measure

Author

Franceschi, Roberto, Pertile, Riccardo, Marigliano, Marco, Mozzillo, Enza, Maffeis, Claudio, Zaffani, Silvana, Dusini, Carlotta, Antonelli, Annalisa, Candia, Francesca Di, Maltoni, Giulio, Cantarelli, Erika, Minuto, Nicola, Bassi, Marta, Rabbone, Ivana, Savastio, Silvia, Passanisi, Stefano, Lombardo, Fortunato, Cherubini, Valentino, Saltarelli, Maria Alessandra, and Tumini, Stefano

Published
2024
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3. Factors influencing the acceptability of automated insulin delivery systems in youths with type 1 diabetes and their parents

Author

Franceschi, Roberto, Pertile, Riccardo, Marigliano, Marco, Mozzillo, Enza, Maffeis, Claudio, Zaffani, Silvana, Dusini, Carlotta, Antonelli, Annalisa, Maltoni, Giulio, Candia, Francesca Di, Cantarelli, Erika, Minuto, Nicola, Bassi, Marta, Rabbone, Ivana, Savastio, Silvia, Passanisi, Stefano, Lombardo, Fortunato, Cherubini, Valentino, Saltarelli, Maria Alessandra, and Tumini, Stefano

Published
2025
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4. Insulin Therapy

Author

Rabbone, Ivana, Savastio, Silvia, Zanetta, Sara, Saltarelli, Maria Alessandra, Tumini, Stefano, Rabbone, Ivana, editor, and Iafusco, Dario, editor

Published
2023
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5. Prevalence of hypospadias in Italy according to severity, gestational age and birthweight: an epidemiological study

Author

Magnani Cinzia, Gragnani Giuseppe S, Giuffrè Mario, Gerola Orietta, Di Stefano Maria C, De Santis Luisa, Danieli Roberto, Cocchi Guido, Celandroni Amerigo, Pardi Daniela, Bertelloni Silvano, Scaramuzzo Rosa T, Ghirri Paolo, Meossi Cristiano, Merusi Ilaria, Sabatino Giuseppe, Tumini Stefano, Corsello Giovanni, and Boldrini Antonio

Subjects
Pediatrics, RJ1-570
Abstract

Abstract Background Hypospadias is a congenital displacement of the urethral meatus in male newborns, being either an isolated defect at birth or a sign of sexual development disorders. The aim of this study was to assess the prevalence rate of hypospadias in different Districts of Italy, in order to make a comparison with other countries all over the world. Methods We reviewed all the newborns file records (years 2001–2004) in 15 Italian Hospitals. Results We found an overall hypospadias prevalence rate of 3.066 ± 0.99 per 1000 live births (82.48% mild hypospadias, 17.52% moderate-severe). In newborns Small for Gestational Age (birthweight < 10th percentile) of any gestational age the prevalence rate of hypospadias was 6.25 per 1000 live births. Performing multivariate logistic regression analysis for different degrees of hypospadias according to severity, being born SGA remained the only risk factor for moderate-severe hypospadias (p = 0.00898) but not for mild forms (p > 0.1). Conclusion In our sample the prevalence of hypospadias results as high as reported in previous European and American studies (3–4 per 1000 live births). Pathogenesis of isolated hypospadias is multifactorial (genetic, endocrine and environmental factors): however, the prevalence rate of hypospadias is higher in infants born small for gestational age than in newborns with normal birth weight.

Published
2009
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6. A Very Early Diagnosis of Complete Androgen Insensitivity Syndrome Due to a Novel Variant in the AR Gene: A Neonatal Case Study.

Author

Ferrante, Rossella, Tumini, Stefano, Saltarelli, Maria Alessandra, Di Rado, Sara, Scorrano, Vincenzo, Tommolini, Maria Lucia, Zucchelli, Mirco, Lauriola, Federico, Lisi, Gabriele, Lauriti, Giuseppe, Marino, Nino, Stuppia, Liborio, Rossi, Claudia, and Bucci, Ines

Subjects
ANDROGEN-insensitivity syndrome, SEX differentiation disorders, ANDROGEN receptors, GENETIC variation, MISSENSE mutation
Abstract

Androgen insensitivity syndrome (AIS) is one of the most common Disorders of Sexual Differentiation (DSDs). AIS is characterized by an X-linked recessive inheritance pattern associated with variants in the androgen receptor (AR) gene that affects the masculinization process in individuals with XY karyotype. Here, we report a neonatal case of a very early diagnosis of complete AIS due to a novel variant in the AR gene. In the present case, after the clinical evaluation, the infant has undergone the following tests: biochemical analyses, including newborn screening workflow, karyotype analysis, and Next-Generation Sequencing (NGS) panel of 50 genes involved in DSDs. The NGS analysis identified a missense variant, c.2108C>A, in the AR gene. According to a cytogenetic analysis, the patient presented a 46, XY karyotype, thus the resulting hemizygote for the AR gene variant. The variant is not currently described in the literature nor in the ClinVar database. However, according to computational models, the variant could have a pathogenetic effect. This clinical case reveals a novel variant of the AR gene with a possible pathogenetic effect associated with AIS and highlights the importance of a multidisciplinary approach for the timely diagnosis and appropriate follow-up of the patient. [ABSTRACT FROM AUTHOR]

Published
2024
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7. The Impact of Atmospheric Temperature Variations on Glycaemic Patterns in Children and Young Adults with Type 1 Diabetes.

Author

Chiacchiaretta, Piero, Tumini, Stefano, Mascitelli, Alessandra, Sacrini, Lorenza, Saltarelli, Maria Alessandra, Carabotta, Maura, Osmelli, Jacopo, Di Carlo, Piero, and Aruffo, Eleonora

Subjects
CONTINUOUS glucose monitoring, ATMOSPHERIC temperature, TYPE 1 diabetes, HEAT waves (Meteorology), TEMPERATURE control
Abstract

Seasonal variations in glycaemic patterns in children and young adults affected by type 1 diabetes are currently poorly studied. However, the spread of Flash Glucose Monitoring (FGM) and continuous glucose monitoring (CGM) systems and of dedicated platforms for the synchronization and conservation of CGM reports allows an efficient approach to the comprehension of these phenomena. Moreover, the impact that environmental parameters may have on glycaemic control takes on clinical relevance, implying a need to properly educate patients and their families. In this context, it can be investigated how blood glucose patterns in diabetic patients may have a link to outdoor temperatures. Therefore, in this study, the relationship between outdoor temperatures and glucose levels in diabetic patients, aged between 4 and 21 years old, has been analysed. For a one-year period (Autumn 2022–Summer 2023), seasonal variations in their CGM metrics (i.e., time in range (TIR), Time Above Range (TAR), Time Below Range (TBR), and coefficient of variation (CV)) were analysed with respect to atmospheric temperature. The results highlight a negative correlation between glucose in diabetic patients and temperature patterns (R value computed considering data for the entire year; Ry = −0.49), behaviour which is strongly confirmed by the analysis focused on the July 2023 heatwave (R = −0.67), which shows that during heatwave events, the anticorrelation is accentuated. The diurnal analysis shows how glucose levels fluctuate throughout the day, potentially correlating with atmospheric diurnal temperature changes in addition to the standard trend. Data captured during the July 2023 heatwave (17–21 July 2023) highlight pronounced deviations from the long-term average, signalling the rapid effects of extreme temperatures on glucose regulation. Our findings underscore the need to integrate meteorological parameters into diabetes management and clinical trial designs. These results suggest that structured diabetes self-management education of patients and their families should include adequate warnings about the effects of atmospheric temperature variations on the risk of hypoglycaemia and about the negative effects of excessive therapeutic inertia in the adjustment of insulin doses. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Recommendations for recognizing, risk stratifying, treating, and managing children and adolescents with hypoglycemia.

Author

Zucchini, Stefano, Tumini, Stefano, Scaramuzza, Andrea Enzo, Bonfanti, Riccardo, Delvecchio, Maurizio, Franceschi, Roberto, Iafusco, Dario, Lenzi, Lorenzo, Mozzillo, Enza, Passanisi, Stefano, Piona, Claudia, Rabbone, Ivana, Rapini, Novella, Rigamonti, Andrea, Ripoli, Carlo, Salzano, Giuseppina, Savastio, Silvia, Schiaffini, Riccardo, Zanfardino, Angela, and Cherubini, Valentino

Subjects
HYPOGLYCEMIA, CONTINUOUS glucose monitoring, CLOSED loop systems, BLOOD sugar, PEOPLE with diabetes, HONEY, FRUIT juices, HYPERGLYCEMIA, SUCROSE
Abstract

There has been continuous progress in diabetes management over the last few decades, not least due to the widespread dissemination of continuous glucose monitoring (CGM) and automated insulin delivery systems. These technological advances have radically changed the daily lives of people living with diabetes, improving the quality of life of both children and their families. Despite this, hypoglycemia remains the primary side-effect of insulin therapy. Based on a systematic review of the available scientific evidence, this paper aims to provide evidence-based recommendations for recognizing, risk stratifying, treating, and managing patients with hypoglycemia. The objective of these recommendations is to unify the behavior of pediatric diabetologists with respect to the timely recognition and prevention of hypoglycemic episodes and the correct treatment of hypoglycemia, especially in patients using CGM or advanced hybrid closedloop systems. All authors have long experience in the specialty and are members of the Italian Society of Pediatric Endocrinology and Diabetology. The goal of treating hypoglycemia is to raise blood glucose above 70 mg/dL (3.9 mmol/L) and to prevent further decreases. Oral glucose at a dose of 0.3 g/kg (0.1 g/kg for children using "smart pumps" or hybrid closed loop systems in automated mode) is the preferred treatment for the conscious individual with blood glucose <70 mg/dL (3.9 mmol/L), although any form of carbohydrate (e.g., sucrose, which consists of glucose and fructose, or honey, sugary soft drinks, or fruit juice) containing glucose may be used. Using automatic insulin delivery systems, the oral glucose dose can be decreased to 0.1 g/kg. Practical flow charts are included to aid clinical decision-making. Although representing the official position of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED), these guidelines are applicable to the global audience and are especially pertinent in the era of CGM and other advanced technologies. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Author

Aisenberg, Javier, Akkurt, Ilker, Abdul-Latif, Hussein, Al-Abdullah, Anees, Barak, Lubomir, Van Den Bergh, Joop, Bertrand, Anne-Marie, Bizzarri, Carla, Bonfanti, Riccardo, Bruel, Henri, Burrows, Anthony, Cadario, Francesco, Cameron, Fergus J., Carson, Dennis, Cartigny, Maryse, Cauvin, Vittoria, Cave, Helene, Chakera, Ali, Chetan, Ravi, Chiari, Giovanni, Couch, Bob, Coutant, Régis, Cummings, Elizabeth, Dankovcikova, Adriana, Davis, Liz, Deiss, Dorothee, Delvecchio, Maurizio, Faleschini, Elena, Fauret, Anne-Laure, Finn, Roisin, Ford, Tamsin, Franco, Elisa De, Gallen, Bastian De, Gasperíková, Daniela, Guntamukkala, Padma, Hakeem, Vaseem, Hasegawa, Shinji, Hathout, Eba H., Heffernan, Emmeline, Hill, David, Ho, Josephine, Hoarau, Marie, Holl, Reinhard, Hoddinott, Rebecca, Houghton, Jane, Howard, Neville, Hughes, Natalie, Hunter, Ian, Høgåsen, Anne Kirsti, Kuulasmaa, Helena, Ioacara, Sorin, Iotova, Violeta, Irgens, Henrik, Jaap, Alan, Jones, Kenneth, Kapellen, Thomas, Kaufman, Ellen, Klinge, Andreas, Klupa, Tomasz, Krishnaswamy, Ramaiyer, Lafferty, Tony, LeGault, Laurent, Lambert, Paul, Malecki, Maciej T, Malievsky, Olag, Mathew, Revi, Mathews, Frances, McVie, Robert, Menzel, Ulrike, Metz, Chantale, Meulen, John Van Der, Modgil, Gita, Mul, Dick, Muther, Silvia, Nuboer, Roos, O'Connell, Susan M., O'Riordan, Stephen, Palko, Miroslav, Patel, Kashyap Amratlal, Pesavento, Roberta, Piccinno, Elvira, Pillai, Janani Kumaraguru, Pruhova, Stephanka, Punthakee, Zubin, Rabbone, Ivana, Raile, Klemens, Rincon, Marielisa, Rose, Danette, Sanchez, Janine, Sandereson, Susan, Saxena, Vinay, Schebek, Martin, Schmidt, Dorothee, Shehadeh, Naim, Shiels, Julian P.H., Silva, Jose M. C. L, Stanik, Juraj, Tinklin, Tracy, Tjora, Erling, Tumini, Stefano, Tuomi, Tiinamaija, Uehara, Akiko, Velde, Robert Van der, Vermeulen, Guido, Visser, Uma, Voorhoeve, Paul, Walker, Jan, Weill, Jaques, Weisner, Tobias, Werner, Andrea, Williams, Toni, Woodhead, Helen, øddegård, Rønnaug, Bowman, Pamela, Sulen, Åsta, Barbetti, Fabrizio, Beltrand, Jacques, Svalastoga, Pernille, Codner, Ethel, Tessmann, Ellen H, Juliusson, Petur B, Skrivarhaug, Torild, Pearson, Ewan R, Flanagan, Sarah E, Babiker, Tarig, Thomas, Nicholas J, Shepherd, Maggie H, Ellard, Sian, Klimes, Iwar, Szopa, Magdalena, Polak, Michel, Iafusco, Dario, Hattersley, Andrew T, and Njølstad, Pål R

Published
2018
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14. Can HbA1c combined with fasting plasma glucose help to assess priority for GCK-MODY vs HNF1A-MODY genetic testing?

Author

Delvecchio, Maurizio, Salzano, Giuseppina, Bonura, Clara, Cauvin, Vittoria, Cherubini, Valentino, d’Annunzio, Giuseppe, Franzese, Adriana, Giglio, Sabrina, Grasso, Valeria, Graziani, Vanna, Iafusco, Dario, Iughetti, Lorenzo, Lera, Riccardo, Maffeis, Claudio, Maltoni, Giulio, Mantovani, Vilma, Menzaghi, Claudia, Patera, Patrizia I., Rabbone, Ivana, Reindstadler, Petra, Scelfo, Sabrina, Tinto, Nadia, Toni, Sonia, Tumini, Stefano, Lombardo, Fortunato, Nicolucci, Antonio, Barbetti, Fabrizio, and The Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetes (ISPED)

Published
2018
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19. Recommendations for self-monitoring in pediatric diabetes: a consensus statement by the ISPED

Author

Scaramuzza, Andrea, Cherubini, Valentino, Tumini, Stefano, Bonfanti, Riccardo, Buono, Pietro, Cardella, Francesca, d’Annunzio, Giuseppe, Frongia, Anna Paola, Lombardo, Fortunato, Monciotti, Anna Carla Maria, Rabbone, Ivana, Schiaffini, Riccardo, Toni, Sonia, Zucchini, Stefano, Frontino, Giulio, Iafusco, Dario, and Diabetes Study Group of the Italian Society for Pediatric Endocrinology and Diabetology

Published
2014
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20. Management of childhood-onset craniopharyngioma in Italy: A multicenter seven year follow-up study of 145 patients

Author

Zucchini, Stefano, Di Iorgi, Natascia, Pozzobon, Gabriella, Pedicelli, Stefania, Parpagnoli, Maria, Driul, Daniela, Matarazzo, Patrizia, Baronio, Federico, Crocco, Marco, Giudica, Giovanna, Partenope, Cristina, Nardini, Beatrice, Ubertini, Graziamaria, Menardi, Rachele, Guzzetti, Chiara, Iughetti, Lorenzo, Aversa, Tommaso, Di Mase, Raffaella, Cassio, Alessandra, Cianfarani, Stefano, Maghnie, Mohamad, Tuli, Gerdi, Loche, Sandro, Bruzzi, Patrizia, Wasniewska, Malgorzata, Salerno, Mariacarolina, Rutigliano, Irene, Iezzi, Maria Laura, Cherubini, Valentino, Grandone, Anna, Faienza, Mariafelicia, Tumini, Stefano, Baldoli, Cristina, Consales, Alessandro, Genitori, Lorenzo, Marras, Carlo Efisio, MIlanaccio, Claudia, Mortini, Pietro, Vindigni, Marco, Zenga, Francesco, Zucchelli, Mino, Zucchini, Stefano, Di Iorgi, Natascia, Pozzobon, Gabriella, Pedicelli, Stefania, Parpagnoli, Maria, Driul, Daniela, Matarazzo, Patrizia, Baronio, Federico, Crocco, Marco, Giudica, Giovanna, Partenope, Cristina, Nardini, Beatrice, Ubertini, Graziamaria, Menardi, Rachele, Guzzetti, Chiara, Iughetti, Lorenzo, Aversa, Tommaso, Di Mase, Raffaella, Cassio, Alessandra, Cianfarani, Stefano, Maghnie, Mohamad, Tuli, Gerdi, Loche, Sandro, Bruzzi, Patrizia, Wasniewska, Malgorzata, Salerno, Mariacarolina, Rutigliano, Irene, Iezzi, Maria Laura, Cherubini, Valentino, Grandone, Anna, Faienza, Mariafelicia, Tumini, Stefano, Baldoli, Cristina, Consales, Alessandro, Genitori, Lorenzo, Marras, Carlo Efisio, Milanaccio, Claudia, Mortini, Pietro, Vindigni, Marco, Zenga, Francesco, and Zucchelli, Mino

Subjects
Craniopharyngioma, children, hypothalamic obesity, intracranial tumor, Craniopharyngioma, GH therapy, children, hypothalamic obesity, intracranial tumor, pituitary deficiency, pituitary deficiency, GH therapy
Abstract

Context: Nationwide data on children diagnosed with craniopharyngioma (CP) are not available in Italy. Objective: Identify patients' characteristics, type of surgical approach, complications and recurrences, number of pituitary deficits and number of patients starting GH treatment. Methods: Retrospective multicenter collection of 145 patients aged 0-18 years underwenting surgery for CP between 2000-2018, followed-up in 17 Italian centers of Pediatric Endocrinology. Results: Age at diagnosis was 8.4±4.1 years. Duration of symptoms was 10.8±12.5 months and headache was most frequent (54%), followed by impaired growth (48%) and visual disturbances (44%). Most lesions were suprasellar (85%) and histology was adamantinomatous in all cases but two. Surgical approach was transcranic (TC) in 67.5% of cases and transphenoidal (TS) in 31.%. TC approach was prevalent in all age groups. Post-surgery complications occurred in 53% of cases with water-electrolyte disturbances most frequent. Radiotherapy was used in 39% of cases. All patients but one presented at least one hormone pituitary deficiency, with TSH deficit as most frequent (98.3%), followed by ACTH (96.8%), AVP (91.1%) and GH (77.4%). BMI significantly increased over time. A hypothalamic disturbance was present in 55% of cases. GH therapy was started during follow-up in 112 patients at a mean age of 10.6 years and 54 developed a recurrence or regrowth of the residual lesion. Conclusions: CP is often diagnosed late also in Italy with TC more frequent than TS surgical approach. Post-surgery complications were not rare and hypopituitarism developed almost in all cases. BMI shows a tendency to increase overtime.

Published
2021

21. Fear of hypoglycemia in children with type 1 diabetes and their parents: Validation of the Italian version of the Hypoglycemia Fear Survey for Children and for Parents

Author

Tumini, Stefano, primary, Fioretti, Elisabetta, additional, Rossi, Ilaria, additional, Cipriano, Paola, additional, Franchini, Simone, additional, Guidone, Paola Irma, additional, Petrosino, Marianna Immacolata, additional, Saggino, Aristide, additional, Tommasi, Marco, additional, Picconi, Laura, additional, and Gonder‐Frederick, Linda, additional

Published
2021
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24. Decreasing prevalence of retinopathy in childhood‐onset type 1 diabetes over the last decade: A comparison of two cohorts diagnosed 10 years apart

Author

Salardi, Silvana, primary, Porta, Massimo, additional, Maltoni, Giulio, additional, Bassi, Marta, additional, Minuto, Nicola, additional, D'Annunzio, Giuseppe, additional, Baltatescu, Tamara, additional, Ariaudo, Maria, additional, Zucchini, Stefano, additional, Levantini, Gabriella, additional, Tumini, Stefano, additional, Franceschi, Roberto, additional, Cauvin, Vittoria, additional, Toni, Sonia, additional, Nitto, Elena, additional, Salvatoni, Alessandro, additional, and Schiaffini, Riccardo, additional

Published
2021
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26. Differences between transient neonatal diabetes mellitus subtypes can guide diagnosis and therapy

Author

Bonfanti, Riccardo, primary, Iafusco, Dario, additional, Rabbone, Ivana, additional, Diedenhofen, Giacomo, additional, Bizzarri, Carla, additional, Patera, Patrizia Ippolita, additional, Reinstadler, Petra, additional, Costantino, Francesco, additional, Calcaterra, Valeria, additional, Iughetti, Lorenzo, additional, Savastio, Silvia, additional, Favia, Anna, additional, Cardella, Francesca, additional, Lo Presti, Donatella, additional, Girtler, Ylenia, additional, Rabbiosi, Sarah, additional, D’Annunzio, Giuseppe, additional, Zanfardino, Angela, additional, Piscopo, Alessia, additional, Casaburo, Francesca, additional, Pintomalli, Letizia, additional, Russo, Lucia, additional, Grasso, Valeria, additional, Minuto, Nicola, additional, Mucciolo, Mafalda, additional, Novelli, Antonio, additional, Marucci, Antonella, additional, Piccini, Barbara, additional, Toni, Sonia, additional, Silvestri, Francesca, additional, Carrera, Paola, additional, Rigamonti, Andrea, additional, Frontino, Giulio, additional, Trada, Michela, additional, Tinti, Davide, additional, Delvecchio, Maurizio, additional, Rapini, Novella, additional, Schiaffini, Riccardo, additional, Mammì, Corrado, additional, Barbetti, Fabrizio, additional, _, _, additional, Aloe, Monica, additional, Amadeo, Simona, additional, Arnaldi, Claudia, additional, Bassi, Marta, additional, Beccaria, Luciano, additional, Benelli, Marzia, additional, Maria Berioloi, Giulia, additional, Bertelli, Enrica, additional, Biagioni, Martina, additional, Bobbio, Adriana, additional, Boccato, Stefano, additional, Bologna, Oriana, additional, Bontempi, Franco, additional, Bonura, Clara, additional, Bracciolini, Giulia, additional, Brufani, Claudia, additional, Bruzzi, Patrizia, additional, Buono, Pietro, additional, Cardani, Roberta, additional, Cardinale, Giuliana, additional, Casertano, Alberto, additional, Cristina Castiglione, Maria, additional, Cauvin, Vittoria, additional, Cherubini, Valentino, additional, Chiarelli, Franco, additional, Chiari, Giovanni, additional, Cianfarani, Stefano, additional, Cirillo, Dante, additional, Citriniti, Felice, additional, Coccioli, Susanna, additional, Cogliardi, Anna, additional, Confetto, Santino, additional, Contreas, Giovanna, additional, Corò, Anna, additional, Corsini, Elisa, additional, Cresta, Nicoletta, additional, De Berardinis, Fiorella, additional, De Donno, Valeria, additional, De Filippo, Giampaolo, additional, De Marco, Rosaria, additional, Deodati, Annalisa, additional, Faleschini, Elena, additional, Fattorusso, Valentina, additional, Favalli, Valeria, additional, Felappi, Barbara, additional, Ferrito, Lucia, additional, Fichera, Graziella, additional, Fontana, Franco, additional, Fornari, Elena, additional, Franceschi, Roberto, additional, Franco, Francesca, additional, Franzese, Adriana, additional, Paola Frongia, Anna, additional, Gaiero, Alberto, additional, Gallo, Francesco, additional, Gargantini, Luigi, additional, Giani, Elisa, additional, Giorgetti, Chiara, additional, Bianchi, Giulia, additional, Graziani, Vanna, additional, Gualtieri, Antonella, additional, Guasti, Monica, additional, Iannicelli, Gennaro, additional, Iannilli, Antonio, additional, Giovanna, Ignaccolo, additional, Ingletto, Dario, additional, Innaurato, Stefania, additional, Inzaghi, Elena, additional, Iovane, Brunella, additional, Kaufmann, Peter, additional, La Loggia, Alfonso, additional, Lapolla, Rosa, additional, Lasagni, Anna, additional, Lazzaro, Nicola, additional, Lenzi, Lorenzo, additional, Lera, Riccardo, additional, Levantini, Gabriella, additional, Lombardo, Fortunato, additional, Lonero, Antonella, additional, Longhi, Silvia, additional, Lucchesi, Sonia, additional, Paola Guerraggio, Lucia, additional, Lucieri, Sergio, additional, Macellaro, Patrizia, additional, Maffeis, Claudio, additional, Mainetti, Bendetta, additional, Maltoni, Giulio, additional, Mameli, Chiara, additional, Mammì, Francesco, additional, Luisa Manca-Bitti, Maria, additional, Manco, Melania, additional, Marino, Monica, additional, Mariano, Matteo, additional, Marigliano, Marco, additional, Marsciani, Alberto, additional, Mastrangelo, Costanzo, additional, Cristina Matteoli, Maria, additional, Mazzali, Elena, additional, Meschi, Franco, additional, MIgliaccio, Antonella, additional, Morandi, Anita, additional, Morganti, Gianfranco, additional, Mozzillo, Enza, additional, Musolino, Gianluca, additional, Nugnes, Rosa, additional, Ortolani, Federica, additional, Pardi, Daniela, additional, Pascarella, Filomena, additional, Passanisi, Stefano, additional, Pedini, Annalisa, additional, Pennati, Cristina, additional, Perrotta, Angelo, additional, Peruzzi, Sonia, additional, Peverelli, Paola, additional, Pezzino, Giulia, additional, Claudia Piona, Anita, additional, Piredda, Gavina, additional, Pistone, Carmelo, additional, Prandi, Elena, additional, Pedieri, Barbara, additional, Di Bonito, Procolo, additional, Pulcina, Anna, additional, Quinci, Maria, additional, Randazzo, Emioli, additional, Ricciardi, Rossella, additional, Ripoli, Carlo, additional, Roppolo, Rosanna, additional, Rutigliano, Irene, additional, Sabbio, Alberto, additional, salardi, Silvana, additional, Salvatoni, Alessandro, additional, Saporiti, Anna, additional, Sardi, Rita, additional, Scanu, Mariapiera, additional, Scaramuzza, Andrea, additional, Eleonardo Schiven, ,, additional, Secco, Andrea, additional, Sessa, Linda, additional, Sogno Valin, Paola, additional, Sordelli, Silvia, additional, Spallino, Luisa, additional, Stagi, Stefano, additional, Stamati, Filomena, additional, Suprani, Tosca, additional, Talarico, Valentina, additional, Timapanaro, Tiziana, additional, Tirendi, Antonella, additional, Tomaselli, Letizia, additional, Tornese, Gianluca, additional, Andrea Trettene, Adolfo, additional, Tumini, Stefano, additional, Valerio, Giuliana, additional, Ventrici, Claudia, additional, Viscardi, Matteo, additional, Zaffani, Silvana, additional, Zampolli, Maria, additional, Zanette, Giorgio, additional, Zecchino, Clara, additional, Antonietta Zedda, Maria, additional, Zonca, Silvia, additional, and Zucchini, Stefano, additional

Published
2021
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29. Role of the KCNJ Gene Variants in the Clinical Outcome of Type 1 Diabetes

Author

Blasetti, Annalisa, additional, Castorani, Valeria, additional, Comegna, Laura, additional, Franchini, Simone, additional, Prezioso, Giovanni, additional, Provenzano, Martina, additional, Di Giulio, Concetta, additional, Iannucci, Daniela, additional, Matonti, Lorena, additional, Tumini, Stefano, additional, Chiarelli, Francesco, additional, and Stuppia, Liborio, additional

Published
2020
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30. Effectiveness and safety of flexible therapeutic schemes including first- and secondgeneration basal insulins during a pediatric summer diabetes camp

Author

Tumini, Stefano, primary, Comegna, Laura, additional, Fioretti, Elisabetta, additional, Guidone, Paola, additional, Levantini, Gabriella, additional, Panichi, Daniele, additional, Catenaro, Milena, additional, Rossi, Ilaria, additional, Amaro, Flavia, additional, Graziano, Giusi, additional, Rossi, Maria Chiara, additional, and Cipriano, Paola, additional

Published
2020
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31. Insulin/carbohydrates ratio during the first 6‐month therapy with insulin degludec in a paediatric population with type 1 diabetes previously treated with insulin glargine. An observational longitudinal study

Author

Tumini, Stefano, primary, Iacono, Olimpia, additional, Comegna, Laura, additional, Fioretti, Elisabetta, additional, Guidone, Paola, additional, Levantini, Gabriella, additional, Panichi, Daniele, additional, Catenaro, Milena, additional, Rossi, Ilaria, additional, Amaro, Flavia, additional, Graziano, Giusi, additional, Rossi, Maria Chiara, additional, and Cipriano, Paola, additional

Published
2020
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32. Fear of hypoglycemia in children with type 1 diabetes and their parents: Validation of the Italian version of the Hypoglycemia Fear Survey for Children and for Parents.

Author

Tumini, Stefano, Fioretti, Elisabetta, Rossi, Ilaria, Cipriano, Paola, Franchini, Simone, Guidone, Paola Irma, Petrosino, Marianna Immacolata, Saggino, Aristide, Tommasi, Marco, Picconi, Laura, and Gonder‐Frederick, Linda

Subjects
*PARENT attitudes, *GLYCOSYLATED hemoglobin, *PSYCHOLOGY of parents, *CONFIDENCE intervals, *RESEARCH methodology evaluation, *RESEARCH methodology, *TYPE 1 diabetes, *FEAR, *RISK assessment, *PATIENTS' attitudes, *HYPOGLYCEMIA, *FACTOR analysis, *PSYCHOLOGICAL distress, *DISEASE risk factors, *DISEASE complications, *CHILDREN, RESEARCH evaluation
Abstract

Background: Currently, Italian versions of the Hypoglycemia Fear Survey for Children (CHFS) and for Parents (PHFS) quantifying Fear of Hypoglycemia (FoH) in pediatric diabetes are not available. Objective: To validate the Italian version of the CHFS and PHFS. Subjects and methods: One hundred and seventy‐four children with type 1 diabetes aged 6–18 and 178 parents completed the CHFS and PHFS, the PedsQL 3.0 Diabetes module and the KIDSCREEN‐10. Internal consistency was good (α = 0.85 for CHFS, α = 0.88 for PHFS); validity was supported by correlations of CHFS total score (CHFS‐T r = −0.50; p < 0.001, CI = ‐0.62 to −0.35) and Worry subscale (CHFS‐W r = −0.49; p < 0.001, CI = −0.62 to −0.32) with measures of health‐related quality of life (QoL), which were not related to PHFS scores. Factor analyses justified the structure and the separate scoring of Behavior and Worry subscales. Children's age was negatively correlated with CHFS‐T (r = −0.16; p = 0.03, CI = −0.36 to 0.00), CHFS‐W (r = −0.29; p = 0.02, CI = −0.39 to −0.07), PHFS‐T (r = −0.20; p = 0.006, CI = −0.35 to −0.04), PHFS‐B (r = −0.30; p = 0.001, CI = −0.43 to −0.17). Mean (SD) item scores of CHFS‐T (1.47 ± 0.56 vs. 1.27 ± 0.57; p < 0.05) and CHFS‐W (1.20 ± 0.73 vs. 0.96 ± 0.68; p < 0.05) were higher in children with HbA1c ≥7.5%. Higher levels of distress for upsetting hypoglycemia were associated with lower child's QoL scores as perceived by children (Peds‐QL: 72.6 ± 12.8 vs. 80.4 ± 11.9; p < 0.001) and parents (Peds‐QL: 70.6 ± 13.8 vs. 75.8 ± 12.9; p < 0.05). Conclusion: The Italian version of CHFS and PHFS appears to be a valid measure to assess FoH in clinical practice and factor analysis supports separate scoring for the Worry and Behavior subscales. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Serum Steroid Profiling by Liquid Chromatography–Tandem Mass Spectrometry for the Rapid Confirmation and Early Treatment of Congenital Adrenal Hyperplasia: A Neonatal Case Report

Author

Cicalini, Ilaria, primary, Tumini, Stefano, additional, Guidone, Paola Irma, additional, Pieragostino, Damiana, additional, Zucchelli, Mirco, additional, Franchi, Sara, additional, Lisi, Gabriele, additional, Lelli Chiesa, Pierluigi, additional, Stuppia, Liborio, additional, De Laurenzi, Vincenzo, additional, and Rossi, Claudia, additional

Published
2019
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43. High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: A nationwide longitudinal study, 2004-2013

Author

Cherubini, Valentino, Skrami, Edlira, Ferrito, Lucia, Zucchini, Stefano, Scaramuzza, Andrea, Bonfanti, Riccardo, Buono, Pietro, Cardella, Francesca, Cauvin, Vittoria, Chiari, Giovanni, D'Annunzio, Giuseppe, Frongia, Anna Paola, Iafusco, Dario, Patera, Ippolita Patrizia, Toni, Sonia, Tumini, Stefano, Rabbone, Ivana, Lombardo, Fortunato, Carle, Flavia, Gesuita, Rosaria, Lera, Riccardo, De Luna, Livia, Gualtieri, Antonella, Zecchino, Clara, Piccinno, Elvira, Reinstadler, Petra, Prandi, Elena, Gallo, Francesco, Morganti, Gianfranco, Ripoli, Carlo, La Loggia, Alfonso, Scanu, Piera, Cardinale, Giuliana, Tomaselli, Letizia Grazia, Citriniti, Felice, Lazzaro, Nicola, De Donno, Valeria, Mainetti, Benedetta, Coccioli, Maria Susanna, Maccioni, Rosella, Marongiu, Ugo, Bruzzese, Mariella, Iannilli, Antonio, Pardi, Daniela, Confetto, Santino, Zanfardino, Angela, Iughetti, Lorenzo, Franzese, Adriana, Cadario, Francesco, Milia, Anna Franca, Piredda, Gavina, Soro, Miriam, Correddu, Antonella, Galderisi, Alfonso, De Berardinis, Fiorella, Federico, Giovanni, Zanette, Giorgio, Suprani, Tosca, Pedini, Annalisa, Bitti, Maria Luisa Manca, Delvecchio, Maurizio, Trada, Michela, Meloni, Gianfranco, Gaiero, Alberto, Bulciolu, Pasquale, Guerraggio, Lucia, Faleschini, Elena, Zanatta, Manuela, Salvatoni, Alessandro, Maffeis, Claudio, Arnaldi, Claudia, Cherubini, Valentino, Skrami, Edlira, Ferrito, Lucia, Zucchini, Stefano, Scaramuzza, Andrea, Bonfanti, Riccardo, Buono, Pietro, Cardella, Francesca, Cauvin, Vittoria, Chiari, Giovanni, D'Annunzio, Giuseppe, Frongia, Anna Paola, Iafusco, Dario, Patera, Ippolita Patrizia, Toni, Sonia, Tumini, Stefano, Rabbone, Ivana, Lombardo, Fortunato, Carle, Flavia, Gesuita, Rosaria, Lera, Riccardo, De Luna, Livia, Gualtieri, Antonella, Zecchino, Clara, Piccinno, Elvira, Reinstadler, Petra, Prandi, Elena, Gallo, Francesco, Morganti, Gianfranco, Ripoli, Carlo, La Loggia, Alfonso, Scanu, Piera, Cardinale, Giuliana, Tomaselli, Letizia Grazia, Citriniti, Felice, Lazzaro, Nicola, De Donno, Valeria, Mainetti, Benedetta, Coccioli, Maria Susanna, Maccioni, Rosella, Marongiu, Ugo, Bruzzese, Mariella, Iannilli, Antonio, Pardi, Daniela, Confetto, Santino, Zanfardino, Angela, Iughetti, Lorenzo, Franzese, Adriana, Cadario, Francesco, Milia, Anna Franca, Piredda, Gavina, Soro, Miriam, Correddu, Antonella, Galderisi, Alfonso, De Berardinis, Fiorella, Federico, Giovanni, Zanette, Giorgio, Suprani, Tosca, Pedini, Annalisa, Bitti, Maria Luisa Manca, Delvecchio, Maurizio, Trada, Michela, Meloni, Gianfranco, Gaiero, Alberto, Bulciolu, Pasquale, Guerraggio, Lucia, Faleschini, Elena, Zanatta, Manuela, Salvatoni, Alessandro, Maffeis, Claudio, Arnaldi, Claudia, Cherubini, V., Skrami, E., Ferrito, L., Zucchini, S., Scaramuzza, A., Bonfanti, R., Buono, P., Cardella, F., Cauvin, V., Chiari, G., D'Annunzio, G., Frongia, A. P., Iafusco, D., Patera, I. P., Toni, S., Tumini, S., Rabbone, I., Lombardo, F., Carle, F., Gesuita, R., Lera, R., De Luna, L., Gualtieri, A., Zecchino, C., Piccinno, E., Reinstadler, P., Prandi, E., Gallo, F., Morganti, G., Ripoli, C., La Loggia, A., Scanu, P., Cardinale, G., Tomaselli, L. G., Citriniti, F., Lazzaro, N., De Donno, V., Mainetti, B., Coccioli, M. S., Maccioni, R., Marongiu, U., Bruzzese, M., Iannilli, A., Pardi, D., Confetto, S., Zanfardino, A., Iughetti, L., Franzese, A., Cadario, F., Milia, A. F., Piredda, G., Soro, M., Correddu, A., Galderisi, A., De Berardinis, F., Federico, G., Zanette, G., Suprani, T., Pedini, A., Bitti, M. L. M., Delvecchio, M., Trada, M., Meloni, G., Gaiero, A., Bulciolu, P., Guerraggio, L., Faleschini, E., Zanatta, M., Salvatoni, A., Maffeis, C., and Arnaldi, C.

Subjects
Male, Longitudinal study, Pediatrics, medicine.medical_specialty, endocrine system diseases, Diabetic ketoacidosis, Adolescent, Population, 030209 endocrinology & metabolism, Longitudinal Studie, Logistic regression, Article, Diabetic Ketoacidosis, Diabetic Ketoacidosi, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Diabetes mellitus, Humans, Medicine, Age Factor, Longitudinal Studies, Family history, education, Diabetes, Ketoacidosis, Type 1 diabetes, education.field_of_study, Multidisciplinary, business.industry, Age Factors, nutritional and metabolic diseases, medicine.disease, Ketoacidosis, Diabetes Mellitus, Type 1, Italy, Female, business, Human
Abstract

This longitudinal population-based study analyses the frequency of diabetic ketoacidosis (DKA) at type 1 diabetes diagnosis in Italian children under 15 years of age, during 2004–2013. DKA was defined as absent (pH ≥ 7.30), mild/moderate (7.1 ≤ pH

Published
2016

44. Yq Microdeletion in a Patient with VACTERL Association and Shawl Scrotum with Bifid Scrotum: A Real Pathogenetic Association or a Coincidence?

Author

Tumini, Stefano, primary, Alfonsi, Melissa, additional, Carinci, Silvia, additional, Morizio, Elisena, additional, Antonucci, Ivana, additional, Gatta, Valentina, additional, Lisi, Gabriele, additional, Lelli Chiesa, Pierluigi, additional, Calabrese, Giuseppe, additional, Stuppia, Liborio, additional, and Palka, Chiara, additional

Published
2019
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45. Optimal predictive low glucose management settings during physical exercise in adolescents with type 1 diabetes

Author

Cherubini, Valentino, primary, Gesuita, Rosaria, additional, Skrami, Edlira, additional, Rabbone, Ivana, additional, Bonfanti, Riccardo, additional, Arnaldi, Claudia, additional, D'Annunzio, Giuseppe, additional, Frongia, Annapaola, additional, Lombardo, Fortunato, additional, Piccinno, Elvira, additional, Schiaffini, Riccardo, additional, Toni, Sonia, additional, Tumini, Stefano, additional, Tinti, Davide, additional, Cipriano, Paola, additional, Minuto, Nicola, additional, Lenzi, Lorenzo, additional, Ferrito, Lucia, additional, Ventrici, Claudia, additional, Ortolani, Federica, additional, Cohen, Ohad, additional, and Scaramuzza, Andrea, additional

Published
2018
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46. Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study

Author

Bowman, Pamela, primary, Sulen, Åsta, additional, Barbetti, Fabrizio, additional, Beltrand, Jacques, additional, Svalastoga, Pernille, additional, Codner, Ethel, additional, Tessmann, Ellen H, additional, Juliusson, Petur B, additional, Skrivarhaug, Torild, additional, Pearson, Ewan R, additional, Flanagan, Sarah E, additional, Babiker, Tarig, additional, Thomas, Nicholas J, additional, Shepherd, Maggie H, additional, Ellard, Sian, additional, Klimes, Iwar, additional, Szopa, Magdalena, additional, Polak, Michel, additional, Iafusco, Dario, additional, Hattersley, Andrew T, additional, Njølstad, Pål R, additional, Aisenberg, Javier, additional, Akkurt, Ilker, additional, Abdul-Latif, Hussein, additional, Al-Abdullah, Anees, additional, Barak, Lubomir, additional, Van Den Bergh, Joop, additional, Bertrand, Anne-Marie, additional, Bizzarri, Carla, additional, Bonfanti, Riccardo, additional, Bruel, Henri, additional, Burrows, Anthony, additional, Cadario, Francesco, additional, Cameron, Fergus J., additional, Carson, Dennis, additional, Cartigny, Maryse, additional, Cauvin, Vittoria, additional, Cave, Helene, additional, Chakera, Ali, additional, Chetan, Ravi, additional, Chiari, Giovanni, additional, Couch, Bob, additional, Coutant, Régis, additional, Cummings, Elizabeth, additional, Dankovcikova, Adriana, additional, Davis, Liz, additional, Deiss, Dorothee, additional, Delvecchio, Maurizio, additional, Faleschini, Elena, additional, Fauret, Anne-Laure, additional, Finn, Roisin, additional, Ford, Tamsin, additional, Franco, Elisa De, additional, Gallen, Bastian De, additional, Gasperíková, Daniela, additional, Guntamukkala, Padma, additional, Hakeem, Vaseem, additional, Hasegawa, Shinji, additional, Hathout, Eba H., additional, Heffernan, Emmeline, additional, Hill, David, additional, Ho, Josephine, additional, Hoarau, Marie, additional, Holl, Reinhard, additional, Hoddinott, Rebecca, additional, Houghton, Jane, additional, Howard, Neville, additional, Hughes, Natalie, additional, Hunter, Ian, additional, Høgåsen, Anne Kirsti, additional, Kuulasmaa, Helena, additional, Ioacara, Sorin, additional, Iotova, Violeta, additional, Irgens, Henrik, additional, Jaap, Alan, additional, Jones, Kenneth, additional, Kapellen, Thomas, additional, Kaufman, Ellen, additional, Klinge, Andreas, additional, Klupa, Tomasz, additional, Krishnaswamy, Ramaiyer, additional, Lafferty, Tony, additional, LeGault, Laurent, additional, Lambert, Paul, additional, Malecki, Maciej T, additional, Malievsky, Olag, additional, Mathew, Revi, additional, Mathews, Frances, additional, McVie, Robert, additional, Menzel, Ulrike, additional, Metz, Chantale, additional, Meulen, John Van Der, additional, Modgil, Gita, additional, Mul, Dick, additional, Muther, Silvia, additional, Nuboer, Roos, additional, O'Connell, Susan M., additional, O'Riordan, Stephen, additional, Palko, Miroslav, additional, Patel, Kashyap Amratlal, additional, Pesavento, Roberta, additional, Piccinno, Elvira, additional, Pillai, Janani Kumaraguru, additional, Pruhova, Stephanka, additional, Punthakee, Zubin, additional, Rabbone, Ivana, additional, Raile, Klemens, additional, Rincon, Marielisa, additional, Rose, Danette, additional, Sanchez, Janine, additional, Sandereson, Susan, additional, Saxena, Vinay, additional, Schebek, Martin, additional, Schmidt, Dorothee, additional, Shehadeh, Naim, additional, Shiels, Julian P.H., additional, Silva, Jose M. C. L, additional, Stanik, Juraj, additional, Tinklin, Tracy, additional, Tjora, Erling, additional, Tumini, Stefano, additional, Tuomi, Tiinamaija, additional, Uehara, Akiko, additional, Velde, Robert Van der, additional, Vermeulen, Guido, additional, Visser, Uma, additional, Voorhoeve, Paul, additional, Walker, Jan, additional, Weill, Jaques, additional, Weisner, Tobias, additional, Werner, Andrea, additional, Williams, Toni, additional, Woodhead, Helen, additional, and øddegård, Rønnaug, additional

Published
2018
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49. Optimal predictive low glucose management settings during physical exercise in adolescents with type 1 diabetes.

Author

Cherubini, Valentino, Gesuita, Rosaria, Skrami, Edlira, Rabbone, Ivana, Bonfanti, Riccardo, Arnaldi, Claudia, D'Annunzio, Giuseppe, Frongia, Annapaola, Lombardo, Fortunato, Piccinno, Elvira, Schiaffini, Riccardo, Toni, Sonia, Tumini, Stefano, Tinti, Davide, Cipriano, Paola, Minuto, Nicola, Lenzi, Lorenzo, Ferrito, Lucia, Ventrici, Claudia, and Ortolani, Federica

Subjects
HYPERGLYCEMIA treatment, HYPOGLYCEMIA treatment, TREATMENT of diabetes, TYPE 1 diabetes, ALGORITHMS, EXERCISE, GLYCOSYLATED hemoglobin, TIME, MANN Whitney U Test
Abstract

Objectives: To assess the optimal setting of the predictive low glucose management (PLGM) algorithm for preventing exercise‐induced hypoglycemia in adolescents with type 1 diabetes. Methods: Thirty‐four adolescents, 15 to 20 years, wearing PLGM system, were followed during 3 days exercise during a diabetes camp. PLGM threshold was set at 70 mg/dL between 8 am and 10 pm and 90 mg/dL during 10 pm and 8 am Adolescents were divided into group A and B, with PLGM threshold at 90 and 70 mg/dL, respectively, during exercise. Time spent in hypoglycemia and AUC for time slots 8 am to 1 pm, 1 to 4 pm, 4 to 11 pm, 11 pm to 3 am, 3 to 8 am, in 3 days were compared between groups by Wilcoxon rank sum test. Results: We analyzed 31 patients (median age 15.0 years, 58.1% males, median diabetes duration 7.0 years, hemoglobin A1c [HbA1c] 7.1%). No significant difference has been observed in time spent in hypoglycemia between groups using threshold 70 or 90. Time spent in target was similar in both groups, as well as time spent in hypo or hyperglycemia. The trends of blood glucose over the 3 days in the 2 groups over‐lapped without significant differences. Conclusions: A PLGM threshold of 90 mg/dL during the night was associated with reduced time in hypoglycemia in adolescents doing frequent physical exercise, while maintaining 65.1% time in range during the day. However, a threshold of 70 mg/dL seems to be safe in the duration of the physical exercise. PLGM system in adolescents with type 1 diabetes was effective to prevent hypoglycemia during and after exercise, irrespective of the PLGM thresholds used. [ABSTRACT FROM AUTHOR]

Published
2019
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50. Aetiological Diagnosis of Diabetes in Italian Diabetic Children and Adolescents

Author

Delvecchio, Maurizio, Salzano, Giuseppina, Mozzillo, Enza, Frontino, Giulio, Patera, Patrizia, Toni, Sonia, Rabbone, Ivana, Cherubini, Valentino, Tumini, Stefano, D’Annunzio, Giuseppe, Iughetti, Lorenzo, Maltoni, Giulio, Cauvin, Vittoria, Marigliano, Marco, and Barbetti, Fabrizio

Subjects
diabetes, MODY, diabetes, MODY
Published
2015

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