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38 results on '"Tumangelova-Yuzeir, Kalina"'

1. Umbilical Cord Mesenchymal Stem Cell Secretome: A Potential Regulator of B Cells in Systemic Lupus Erythematosus.

Author

Yordanova, Adelina, Ivanova, Mariana, Tumangelova-Yuzeir, Kalina, Angelov, Alexander, Kyurkchiev, Stanimir, Belemezova, Kalina, Kurteva, Ekaterina, Kyurkchiev, Dobroslav, and Ivanova-Todorova, Ekaterina

Abstract

Autoimmune diseases represent a severe personal and healthcare problem that seeks novel therapeutic solutions. Mesenchymal stem cells (MSCs) are multipotent cells with interesting cell biology and promising therapeutic potential. The immunoregulatory effects of secretory factors produced by umbilical cord mesenchymal stem cells (UC-MSCs) were assessed on B lymphocytes from 17 patients with systemic lupus erythematosus (SLE), as defined by the 2019 European Alliance of Associations for Rheumatology (EULAR)/American College of Rheumatology (ACR) classification criteria for SLE, and 10 healthy volunteers (HVs). Peripheral blood mononuclear cells (PBMCs) from patients and HVs were cultured in a UC-MSC-conditioned medium (UC-MSCcm) and a control medium. Flow cytometry was used to detect the surface expression of CD80, CD86, BR3, CD40, PD-1, and HLA-DR on CD19+ B cells and assess the percentage of B cells in early and late apoptosis. An enzyme-linked immunosorbent assay (ELISA) quantified the production of BAFF, IDO, and PGE2 in PBMCs and UC-MSCs. Under UC-MSCcm influence, the percentage and mean fluorescence intensity (MFI) of CD19+BR3+ cells were reduced in both SLE patients and HVs. Regarding the effects of the MSC secretome on B cells in lupus patients, we observed a decrease in CD40 MFI and a reduced percentage of CD19+PD-1+ and CD19+HLA-DR+ cells. In contrast, in the B cells of healthy participants, we found an increased percentage of CD19+CD80+ cells and decreased CD80 MFI, along with a decrease in CD40 MFI and the percentage of CD19+PD-1+ cells. The UC-MSCcm had a minimal effect on B-cell apoptosis. The incubation of patients' PBMCs with the UC-MSCcm increased PGE2 levels compared to the control medium. This study provides new insights into the impact of the MSC secretome on the key molecules involved in B-cell activation and antigen presentation and survival, potentially guiding the development of future SLE treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Phenotypes Determined by Cluster Analysis in Moderate to Severe Bronchial Asthma

Author

Youroukova Vania M., Dimitrova Denitsa G., Valerieva Anna D., Lesichkova Spaska S., Velikova Tsvetelina V., Ivanova-Todorova Ekaterina I., and Tumangelova-Yuzeir Kalina D.

Subjects
asthma, phenotypes, cluster analysis, Medicine
Abstract

Background: Bronchial asthma is a heterogeneous disease that includes various subtypes. They may share similar clinical characteristics, but probably have different pathological mechanisms.

Published
2017
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7. Alteration of Mesenchymal Stem Cells Isolated from Glioblastoma Multiforme under the Influence of Photodynamic Treatment

Author

Tumangelova-Yuzeir, Kalina, primary, Minkin, Krassimir, additional, Angelov, Ivan, additional, Ivanova-Todorova, Ekaterina, additional, Kurteva, Ekaterina, additional, Vasilev, Georgi, additional, Arabadjiev, Jeliazko, additional, Karazapryanov, Petar, additional, Gabrovski, Kaloyan, additional, Zaharieva, Lidia, additional, Genova, Tsanislava, additional, and Kyurkchiev, Dobroslav, additional

Published
2023
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27. Dynamics of Some Routine Immunological Parameters During Anti - TNF Therapy in Patients with Crohn’s Disease

Author

Velikova, Tsvetelina Veselinova, primary, Spassova, Zoya Angelova, additional, Milatchkov, Lyuben Mitkov, additional, Panova, Dobriana Georgieva, additional, Ivanova - Todorova, Ekaterina Ivanova, additional, Tumangelova - Yuzeir, Kalina Dinkova, additional, Kurteva, Ekaterina Krasimirova, additional, Kyurkchiev, Dobroslav Stanimirov, additional, Deredjan, Siragan Arshavir, additional, Nikolov, Rosen Kirilov, additional, Altankova, Iskra Petrova, additional, and Vladimirova, Lyudmila Mateva, additional

Published
2018
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28. Serological Update on Celiac Disease Diagnostics in Adults

Author

V. Velikova, Tsvetelina, primary, A. Spassova, Zoya, additional, D. Tumangelova-Yuzeir, Kalina, additional, K. Krasimirova, Ekaterina, additional, I. Ivanova-Todorova, Ekaterina, additional, S. Kyurkchiev, Dobroslav, additional, and P. Altankova, Iskra, additional

Published
2018
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30. Abstracts from the 3rd International Severe Asthma Forum (ISAF)

Author

Ketelaar, M. E., primary, Van De Kant, K., additional, Dijk, F. N., additional, Klaassen, E. M. M., additional, Grotenboer, N., additional, Nawijn, M. C., additional, Dompeling, E., additional, Koppelman, G. H., additional, Murray, Clare, additional, Foden, Philip, additional, Lowe, Lesley, additional, Durrington, Hannah, additional, Custovic, Adnan, additional, Simpson, Angela, additional, Simpson, Andrew J., additional, Shaw, Dominick E., additional, Sousa, Ana R., additional, Fleming, Louise J., additional, Roberts, Graham, additional, Pandis, Ioannis, additional, Bansal, Aruna T., additional, Corfield, Julie, additional, Wagers, Scott, additional, Djukanovic, Ratko, additional, Chung, Kian Fan, additional, Sterk, Peter J., additional, Vestbo, Jorgen, additional, Fowler, Stephen J., additional, Tebbutt, S. J., additional, Singh, A., additional, Shannon, C. P., additional, Kim, Y. W., additional, Yang, C. X., additional, Gauvreau, G. M., additional, Fitzgerald, J. M., additional, Boulet, L. P., additional, O’Byrne, P. M., additional, Begley, N., additional, Loudon, A., additional, Ray, D. W., additional, Baos, Selene, additional, Cremades, Lucía, additional, Calzada, David, additional, Lahoz, Carlos, additional, Cárdaba, Blanca, additional, Asosingh, Kewal, additional, Lauruschkat, Chris, additional, Queisser, Kimberly, additional, Wanner, Nicholas, additional, Weiss, Kelly, additional, Xu, Weiling, additional, Erzurum, Serpil, additional, Sokolowska, Milena, additional, Chen, Li-Yuan, additional, Liu, Yueqin, additional, Martinez-Anton, Asuncion, additional, Logun, Carolea, additional, Alsaaty, Sara, additional, Cuento, Rosemarie, additional, Cai, Rongman, additional, Sun, Junfeng, additional, Quehenberger, Oswald, additional, Armando, Aaron, additional, Dennis, Edward, additional, Levine, Stewart, additional, Shelhamer, James, additional, Choi, Kilyong, additional, Lazova, Snezhina, additional, Perenovska, Penka, additional, Miteva, Dimitrinka, additional, Priftis, Stamatios, additional, Petrova, Guergana, additional, Yablanski, Vassil, additional, Vlaev, Evgeni, additional, Rafailova, Hristina, additional, Kumae, Takashi, additional, Holmes, L. J., additional, Yorke, J., additional, Ryan, D. M., additional, Chinratanapisit, Sasawan, additional, Matchimmadamrong, Khlongtip, additional, Deerojanawong, Jitladda, additional, Karoonboonyanan, Wissaroot, additional, Sritipsukho, Paskorn, additional, Youroukova, Vania, additional, Dimitrova, Denitsa, additional, Slavova, Yanina, additional, Lesichkova, Spaska, additional, Tzocheva, Iren, additional, Parina, Snezhana, additional, Angelova, Svetla, additional, Korsun, Neli, additional, Craiu, Mihai, additional, Stan, Iustina Violeta, additional, Deliu, Matea, additional, Yavuz, Tolga, additional, Sperrin, Matthew, additional, Sahiner, Umit M., additional, Belgrave, Danielle, additional, Sackesen, Cansin Sackesen, additional, Kalayci, Ömer, additional, Velikov, Petar, additional, Velikova, Tsvetelina, additional, Ivanova-Todorova, Ekaterina, additional, Tumangelova-Yuzeir, Kalina, additional, Kyurkchiev, Dobroslav, additional, Megremis, Spyridon, additional, Constantinides, Bede, additional, Sotiropoulos, Alexandros Georgios, additional, Xepapadaki, Paraskevi, additional, Robertson, David, additional, Papadopoulos, Nikolaos, additional, Wilkinson, Maxim, additional, Portsmouth, Craig, additional, Ray, David, additional, Goodacre, Royston, additional, Valerieva, Anna, additional, Bobolea, Irina, additional, Vera, Daiana Guillén, additional, Gonzalez-Salazar, Gabriel, additional, Moreno, Carlos Melero, additional, Rodriguez, Consuelo Fernandez, additional, De Las Cuevas Moreno, Natividad, additional, Wang, R., additional, Satia, I., additional, Niven, R., additional, Smith, J. A., additional, Southworth, T., additional, Plumb, J., additional, Gupta, V., additional, Pearson, J., additional, Ramis, I., additional, Lehner, M. D., additional, Miralpeix, M., additional, Singh, D., additional, Satia, Imran, additional, Woodhead, Mark, additional, O’Byrne, Paul, additional, Smith, Jaclyn Ann, additional, Forss, Cecilia, additional, Cook, Peter, additional, Brown, Sheila, additional, Svedberg, Freya, additional, Stephenson, Katherine, additional, Bertuzzi, Margherita, additional, Bignell, Elaine, additional, Enerbäck, Malin, additional, Cunoosamy, Danen, additional, Macdonald, Andrew, additional, Liu, Caini, additional, Zhu, Liang, additional, Fukuda, Kiochi, additional, Zhang, Cunjin, additional, Ouyang, Suidong, additional, Chen, Xing, additional, Qin, Luke, additional, Rachakonda, Suguna, additional, Aronica, Mark, additional, Qin, Jun, additional, Li, Xiaoxia, additional, Larose, Marie-Chantal, additional, Archambault, Anne-Sophie, additional, Provost, Véronique, additional, Chakir, Jamila, additional, Laviolette, Michel, additional, Flamand, Nicolas, additional, Logan, Nicola, additional, Ruckerl, Dominik, additional, Allen, Judith E., additional, Sutherland, Tara E., additional, Hamelmann, E., additional, Vogelberg, C., additional, Goldstein, S., additional, Azzi, G. E., additional, Engel, M., additional, Sigmund, R., additional, Szefler, S. J., additional, Mesquita, Raquel, additional, Coentrão, Luis, additional, Veiga, Rui, additional, Paiva, José-Artur, additional, Roncon-Albuquerque, Roberto, additional, Porras, Wendy Vargas, additional, Moreno, Ana González, additional, Iglesias, Jesus Macías, additional, Ramos, Gustavo Córdova, additional, Acevedo, Yesenia Peña, additional, Alonso, Miguel Angel Tejedor, additional, Del Mar Moro Moro, Maria, additional, Krcmova, Irena, additional, Novosad, Jakub, additional, Hanania, Nicola Alexander, additional, Massanari, Marc, additional, Hecker, Heike, additional, Kassel, Eric, additional, Laforce, Craig, additional, Rickard, Kathy, additional, Snelder, Sanne, additional, Braunstahl, Gert-Jan, additional, Jones, T. L., additional, Neville, D., additional, Heiden, E. R., additional, Lanning, E., additional, Brown, T., additional, Rupani, H., additional, Babu, K. S., additional, Chauhan, A. J., additional, Eldegeir, M. Y., additional, Chapman, A. A., additional, Ferwana, M., additional, and Caldron, M., additional

Published
2017
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34. Treg/Th17 cell balance and phytohaemagglutinin activation of T lymphocytes in peripheral blood of systemic sclerosis patients

Author

Krasimirova, Ekaterina, primary, Velikova, Tsvetelina, additional, Ivanova-Todorova, Ekaterina, additional, Tumangelova-Yuzeir, Kalina, additional, Kalinova, Desislava, additional, Boyadzhieva, Vladimira, additional, Stoilov, Nikolay, additional, Yoneva, Tsvetelina, additional, Rashkov, Rasho, additional, and Kyurkchiev, Dobroslav, additional

Published
2017
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38. Targeting the Progression of Lupus-Like Disease in Humanized Mouse Model by Specific Dietary Components.

Author

Ralchev N, Kechidzhieva L, Boneva B, Tumangelova-Yuzeir K, Kyurkchiev D, Kalinova D, Monov S, Tchorbanov A, and Nikolova-Ganeva K

Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a number of immunological aberrations in the mechanisms of innate and adaptive immune responses. Spontaneous and induced mouse models of the disease have contributed significantly to the advancement in lupus treatments. The involvement of humanized models, engrafted with lupus patients' immune cells, represented the possibility to study the development of SLE. In the current research, we engrafted NSG/Rag2-γc- mice with PBMCs from lupus patients and put the mice on specific diet composed of extra amounts of methyl-containing micronutrients and cofactors which are key participants in the DNA methylation processes. The results showed a decrease in anti-dsDNA IgG antibody and in proteinuria levels, less glomerular proliferation and protected renal structures in all mice put on the supplemented diet compared to humanized mice fed with the control diet. The observed therapeutic effect may be related to possible alterations in the methylation level and to targeted suppression of gene expression in the immune cells, which correlate negatively with the development of the clinical SLE characteristics. These findings point to the significant immunomodulating role of methyl donors in human models of SLE and represent new therapeutic opportunities with clinical potential., (© 2025 Wiley‐VCH GmbH.)

Published
2025
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