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1. Adolescence-onset atypical hemolytic uremic syndrome: is it different from infant-onset?

Author

Celegen, Kubra, Gulhan, Bora, Fidan, Kibriya, Yuksel, Selcuk, Yilmaz, Neslihan, Yılmaz, Aysun Caltik, Demircioğlu Kılıç, Beltinge, Gokce, Ibrahim, Kavaz Tufan, Aslı, Kalyoncu, Mukaddes, Nalcacıoglu, Hulya, Ozlu, Sare Gulfem, Kurt Sukur, Eda Didem, Canpolat, Nur, K. Bayazit, Aysun, Çomak, Elif, Tabel, Yılmaz, Tulpar, Sebahat, Celakil, Mehtap, Bek, Kenan, Zeybek, Cengiz, Duzova, Ali, Özçakar, Zeynep Birsin, Topaloglu, Rezan, Soylemezoglu, Oguz, and Ozaltin, Fatih

Published
2024
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2. Correction to: Adolescence‑onset atypical hemolytic uremic syndrome: is it different from infant‑onset?

Author

Celegen, Kubra, Gulhan, Bora, Fidan, Kibriya, Yuksel, Selcuk, Yilmaz, Neslihan, Yılmaz, Aysun Caltik, Demircioğlu Kılıç, Beltinge, Gokce, Ibrahim, Kavaz Tufan, Aslı, Kalyoncu, Mukaddes, Nalcacıoglu, Hulya, Ozlu, Sare Gulfem, Kurt Sukur, Eda Didem, Canpolat, Nur, K. Bayazit, Aysun, Çomak, Elif, Tabel, Yılmaz, Tulpar, Sebahat, Celakil, Mehtap, Bek, Kenan, Zeybek, Cengiz, Duzova, Ali, Özçakar, Zeynep Birsin, Topaloglu, Rezan, Soylemezoglu, Oguz, and Ozaltin, Fatih

Published
2024
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3. Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study

Author

Aksu, Bagdagul, Afonso, Alberto Caldas, Akil, Ipek, Alpay, Harika, Atmis, Bahriye, Aydog, Ozlem, Bayazıt, Aysun Karabay, Bayram, Meral Torun, Bilge, Ilmay, Bulut, Ipek Kaplan, Buyukkaragoz, Bahar, Comak, Elif, Demir, Belde Kasap, Dincel, Nida, Donmez, Osman, Durmus, Mehmet Akif, Dursun, Hasan, Dusunsel, Ruhan, Duzova, Ali, Ertan, Pelin, Gedikbasi, Asuman, Goknar, Nilufer, Guven, Sercin, Hacihamdioglu, Duygu, Jankauskiene, Augustina, Kalyoncu, Mukaddes, Kavukcu, Salih, Kenan, Bahriye Uzun, Kucuk, Nuran, Kural, Bahar, Litwin, Mieczysław, Montini, Giovanni, Morello, William, Obrycki, Lukasz, Omer, Beyhan, Oner, Huseyin Adil, Ozdemir, Ebru Misirli, Ozkayin, Nese, Paripovic, Dusan, Pehlivanoglu, Cemile, Saygili, Seha, Schaefer, Franz, Schaefer, Susanne, Sonmez, Ferah, Tabel, Yilmaz, Tas, Nesrin, Tasdemir, Mehmet, Teixeira, Ana, Tekcan, Demet, Topaloglu, Rezan, Tulpar, Sebahat, Turkkan, Ozde Nisa, Uysal, Berfin, Uysalol, Metin, Vitkevic, Renata, Yavuz, Sevgi, Yel, Sibel, Yildirim, Tarik, Yildirim, Zeynep Yuruk, Yildiz, Nurdan, Yuksel, Selcuk, Yurtseven, Eray, and Yilmaz, Alev

Published
2024
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4. Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study

Author

Yilmaz, Alev, Afonso, Alberto Caldas, Akil, Ipek, Aksu, Bagdagul, Alpay, Harika, Atmis, Bahriye, Aydog, Ozlem, Bayazıt, Aysun Karabay, Bayram, Meral Torun, Bilge, Ilmay, Bulut, Ipek Kaplan, Buyukkaragoz, Bahar, Comak, Elif, Demir, Belde Kasap, Dincel, Nida, Donmez, Osman, Durmus, Mehmet Akif, Dursun, Hasan, Dusunsel, Ruhan, Duzova, Ali, Ertan, Pelin, Gedikbasi, Asuman, Goknar, Nilufer, Guven, Sercin, Hacihamdioglu, Duygu, Jankauskiene, Augustina, Kalyoncu, Mukaddes, Kavukcu, Salih, Kenan, Bahriye Uzun, Kucuk, Nuran, Kural, Bahar, Litwin, Mieczysław, Montini, Giovanni, Morello, William, Nayir, Ahmet, Obrycki, Lukasz, Omer, Beyhan, Ozdemir, Ebru Misirli, Ozkayin, Nese, Paripovic, Dusan, Pehlivanoglu, Cemile, Saygili, Seha, Schaefer, Susanne, Sonmez, Ferah, Tabel, Yilmaz, Tas, Nesrin, Tasdemir, Mehmet, Teixeira, Ana, Tekcan, Demet, Tulpar, Sebahat, Turkkan, Ozde Nisa, Uysal, Berfin, Uysalol, Metin, Vaiciuniene, Daiva, Yavuz, Sevgi, Yel, Sibel, Yildirim, Tarik, Yildirim, Zeynep Yuruk, Yildiz, Nurdan, Yuksel, Selcuk, Yurtseven, Eray, Schaefer, Franz, and Topaloglu, Rezan

Published
2023
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5. PROGRESS STUDY : Progression of chronic kidney disease in children and heat shock proteins

Author

Yildirim, Zeynep Nagehan Yuruk, Akgul, Sebahat Usta, Alpay, Harika, Aksu, Bagdagul, Oguz, Fatma Savran, Kiyak, Aysel, Akinci, Nurver, Yavuz, Sevgi, Ozcelik, Gul, Gedikbasi, Asuman, Gokce, Ibrahim, Ozkayin, Nese, Yildiz, Nurdan, Pehlivanoglu, Cemile, Goknar, Nilufer, Saygili, Seha, Tulpar, Sebahat, Kucuk, Nuran, Bilge, Ilmay, Tasdemir, Mehmet, Agbas, Ayse, Dirican, Ahmet, Emre, Sevinc, Nayir, Ahmet, and Yilmaz, Alev

Published
2021

6. Kidney disease profile and encountered problems during follow-up in Syrian refugee children: a multicenter retrospective study

Author

Balat, Ayse, Kilic, Beltinge Demircioglu, Aksu, Bagdagul, Kara, Mehtap Akbalik, Buyukcelik, Mithat, Agbas, Ayse, Eroglu, Fehime Kara, Gungor, Tulin, Alaygut, Demet, Yildiz, Nurdan, Bastug, Funda, Atmis, Bahriye, Melek, Engin, Elmaci, Midhat, Tulpar, Sebahat, Pehlivanoglu, Cemile, Doven, Serra Surmeli, Comak, Elif, Tabel, Yilmaz, Gemici, Atilla, Uysal, Berfin, Ozzorlar, Gamze Seval, Kuçuk, Nuran, Delibas, Ali, Ozcelik, Gul, Goknar, Nilufer, Dursun, Ismail, Ertan, Pelin, Ozunan, Ipek Akil, and Sonmez, Ferah

Published
2022
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7. PROGRESS STUDY: Progression of chronic kidney disease in children and heat shock proteins

Author

Yuruk Yildirim, Zeynep Nagehan, Usta Akgul, Sebahat, Alpay, Harika, Aksu, Bagdagul, Savran Oguz, Fatma, Kiyak, Aysel, Akinci, Nurver, Yavuz, Sevgi, Ozcelik, Gul, Gedikbasi, Asuman, Gokce, Ibrahim, Ozkayin, Nese, Yildiz, Nurdan, Pehlivanoglu, Cemile, Goknar, Nilufer, Saygili, Seha, Tulpar, Sebahat, Kucuk, Nuran, Bilge, Ilmay, Tasdemir, Mehmet, Agbas, Ayse, Dirican, Ahmet, Emre, Sevinc, Nayir, Ahmet, and Yilmaz, Alev

Published
2021
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8. The relationship between urine heat shock protein 70 and congenital anomalies of the kidney and urinary tract: UTILISE study

Author

Aksu, Bagdagul, primary, Afonso, Alberto Caldas, additional, Akil, Ipek, additional, Alpay, Harika, additional, Atmis, Bahriye, additional, Aydog, Ozlem, additional, Bakkaloglu, Sevcan, additional, Bayazıt, Aysun Karabay, additional, Bayram, Meral Torun, additional, Bilge, Ilmay, additional, Bulut, Ipek Kaplan, additional, Cetinkaya, Ayse Pinar Goksu, additional, Comak, Elif, additional, Demir, Belde Kasap, additional, Dincel, Nida, additional, Donmez, Osman, additional, Durmus, Mehmet Akif, additional, Dursun, Hasan, additional, Dusunsel, Ruhan, additional, Duzova, Ali, additional, Ertan, Pelin, additional, Gedikbasi, Asuman, additional, Goknar, Nilufer, additional, Guven, Sercin, additional, Hacihamdioglu, Duygu, additional, Jankauskiene, Augustina, additional, Kalyoncu, Mukaddes, additional, Kavukcu, Salih, additional, Kenan, Bahriye Uzun, additional, Kucuk, Nuran, additional, Kural, Bahar, additional, Litwin, Mieczysław, additional, Montini, Giovanni, additional, Morello, William, additional, Obrycki, Lukasz, additional, Omer, Beyhan, additional, Misirli Ozdemir, Ebru, additional, Ozkayin, Nese, additional, Paripovic, Dusan, additional, Pehlivanoglu, Cemile, additional, Saygili, Seha, additional, Schaefer, Franz, additional, Schaefer, Susanne, additional, Sonmez, Ferah, additional, Tabel, Yilmaz, additional, Tas, Nesrin, additional, Tasdemir, Mehmet, additional, Teixeira, Ana, additional, Tekcan, Demet, additional, Topaloglu, Rezan, additional, Tulpar, Sebahat, additional, Turkkan, Ozde Nisa, additional, Uysal, Berfin, additional, Uysalol, Metin, additional, Vitkevic, Renata, additional, Yavuz, Sevgi, additional, Yel, Sibel, additional, Yildirim, Tarik, additional, Yildirim, Zeynep Yuruk, additional, Yildiz, Nurdan, additional, Yuksel, Selcuk, additional, Yurtseven, Eray, additional, and Yilmaz, Alev, additional

Published
2024
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9. Urine soluble TLR4 levels may contribute to predict urinary tract infection in children: the UTILISE Study

Author

Aksu, Bagdagul, primary, Afonso, Alberto Caldas, additional, Akil, Ipek, additional, Alpay, Harika, additional, Atmis, Bahriye, additional, Aydog, Ozlem, additional, Bayazıt, Aysun Karabay, additional, Bayram, Meral Torun, additional, Bilge, Ilmay, additional, Bulut, Ipek Kaplan, additional, Buyukkaragoz, Bahar, additional, Comak, Elif, additional, Demir, Belde Kasap, additional, Dincel, Nida, additional, Donmez, Osman, additional, Durmus, Mehmet Akif, additional, Dursun, Hasan, additional, Dusunsel, Ruhan, additional, Duzova, Ali, additional, Ertan, Pelin, additional, Gedikbasi, Asuman, additional, Goknar, Nilufer, additional, Guven, Sercin, additional, Hacihamdioglu, Duygu, additional, Jankauskiene, Augustina, additional, Kalyoncu, Mukaddes, additional, Kavukcu, Salih, additional, Kenan, Bahriye Uzun, additional, Kucuk, Nuran, additional, Kural, Bahar, additional, Litwin, Mieczysław, additional, Montini, Giovanni, additional, Morello, William, additional, Obrycki, Lukasz, additional, Omer, Beyhan, additional, Oner, Huseyin Adil, additional, Ozdemir, Ebru Misirli, additional, Ozkayin, Nese, additional, Paripovic, Dusan, additional, Pehlivanoglu, Cemile, additional, Saygili, Seha, additional, Schaefer, Franz, additional, Schaefer, Susanne, additional, Sonmez, Ferah, additional, Tabel, Yilmaz, additional, Tas, Nesrin, additional, Tasdemir, Mehmet, additional, Teixeira, Ana, additional, Tekcan, Demet, additional, Topaloglu, Rezan, additional, Tulpar, Sebahat, additional, Turkkan, Ozde Nisa, additional, Uysal, Berfin, additional, Uysalol, Metin, additional, Vitkevic, Renata, additional, Yavuz, Sevgi, additional, Yel, Sibel, additional, Yildirim, Tarik, additional, Yildirim, Zeynep Yuruk, additional, Yildiz, Nurdan, additional, Yuksel, Selcuk, additional, Yurtseven, Eray, additional, and Yilmaz, Alev, additional

Published
2023
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10. COVID-19 in pediatric nephrology centers in Turkey

Author

Taşdemir, Mehmet (ORCID 0000-0002-5579-6339 & YÖK ID 175867); Bilge, İlmay (ORCID 0000-0002-4852-989X & YÖK ID 198907), Leventoglu, Emre; Ozdemir Atikel, Yesim; Nalcacioglu, Hulya; Dursun, Ismail; Dursun, Hasan; Yuruk Yildirim, Zeynep; Yildiz, Nurdan; Kaya Aksoy, Gulsah; Celakil, Mehtap; Demircioglu Kilic, Beltinge; Zirhli Selcuk, Sena; Canpolat, Nur; Kargin Cakici, Evrim; Ozlu, Sare Gulfem; Tulpar, Sebahat; Yuksel, Selcuk; Atmis, Bahriye; Surmeli Doven, Serra; Taner, Sevgin; Ertan, Pelin; Kavaz, Asli; Torun Bayram, Meral; Kalyoncu, Mukaddes; Gulleroglu, Kaan; Kabasakal, Caner; Kasap Demir, Belde; Cicek, Rumeysa Yasemin; Donmez, Osman; Kara, Aslihan; Yavascan, Onder; Ozcelik, Gul; Gezgin Yildirim, Deniz; Guler, Muhammet Akif; Sonmez, Ferah; Poyrazoglu, Hakan; Akman, Sema; Topaloglu, Rezan; Alpay, Harika; Bakkaloglu, Sevcan A., School of Medicine, Taşdemir, Mehmet (ORCID 0000-0002-5579-6339 & YÖK ID 175867); Bilge, İlmay (ORCID 0000-0002-4852-989X & YÖK ID 198907), Leventoglu, Emre; Ozdemir Atikel, Yesim; Nalcacioglu, Hulya; Dursun, Ismail; Dursun, Hasan; Yuruk Yildirim, Zeynep; Yildiz, Nurdan; Kaya Aksoy, Gulsah; Celakil, Mehtap; Demircioglu Kilic, Beltinge; Zirhli Selcuk, Sena; Canpolat, Nur; Kargin Cakici, Evrim; Ozlu, Sare Gulfem; Tulpar, Sebahat; Yuksel, Selcuk; Atmis, Bahriye; Surmeli Doven, Serra; Taner, Sevgin; Ertan, Pelin; Kavaz, Asli; Torun Bayram, Meral; Kalyoncu, Mukaddes; Gulleroglu, Kaan; Kabasakal, Caner; Kasap Demir, Belde; Cicek, Rumeysa Yasemin; Donmez, Osman; Kara, Aslihan; Yavascan, Onder; Ozcelik, Gul; Gezgin Yildirim, Deniz; Guler, Muhammet Akif; Sonmez, Ferah; Poyrazoglu, Hakan; Akman, Sema; Topaloglu, Rezan; Alpay, Harika; Bakkaloglu, Sevcan A., and School of Medicine

Abstract

Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10-15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period. Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients' susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage., NA

Published
2023

11. CLINICAL COURSE OF ADOLESCENT ONSET ATYPICAL HEMOLYTIC UREMIC SYNDROME: A STUDY OF TURKISH AHUS REGISTRY

Author

KARABAY BAYAZIT, AYSUN, Ozlu, Sare Gulfem, Celegen, Kubra, Zeybek, Cengiz, Soylemezoglu, Oguz, Nalcacioglu, Hulya, ÖZALTIN, FATİH, KILIÇ, BELTİNGE DEMİRCİOĞLU, Canpolat, Nur, BEK, KENAN, Celakil, Mehtap, Tulpar, Sebahat, TABEL, YILMAZ, Yilmaz, Aysun Caltik, Sukur, Eda Didem Kurt, ÖZÇAKAR, ZEYNEP BİRSİN, DÜZOVA, ALİ, TOPALOĞLU, REZAN, GÖKCE, İBRAHİM, KOYUN, MUSTAFA, KAVAZ TUFAN, ASLI, Yilmaz, Neslihan, KALYONCU, MUKADDES, YÜKSEL, SELÇUK, FİDAN, HATİCE KİBRİYA, and GÜLHAN, BORA

Published
2022

12. Urinary HSP70 improves diagnostic accuracy for urinary tract infection in children: UTILISE study

Author

Yilmaz, Alev, primary, Afonso, Alberto Caldas, additional, Akil, Ipek, additional, Aksu, Bagdagul, additional, Alpay, Harika, additional, Atmis, Bahriye, additional, Aydog, Ozlem, additional, Bayazıt, Aysun Karabay, additional, Bayram, Meral Torun, additional, Bilge, Ilmay, additional, Bulut, Ipek Kaplan, additional, Buyukkaragoz, Bahar, additional, Comak, Elif, additional, Demir, Belde Kasap, additional, Dincel, Nida, additional, Donmez, Osman, additional, Durmus, Mehmet Akif, additional, Dursun, Hasan, additional, Dusunsel, Ruhan, additional, Duzova, Ali, additional, Ertan, Pelin, additional, Gedikbasi, Asuman, additional, Goknar, Nilufer, additional, Guven, Sercin, additional, Hacihamdioglu, Duygu, additional, Jankauskiene, Augustina, additional, Kalyoncu, Mukaddes, additional, Kavukcu, Salih, additional, Kenan, Bahriye Uzun, additional, Kucuk, Nuran, additional, Kural, Bahar, additional, Litwin, Mieczysław, additional, Montini, Giovanni, additional, Morello, William, additional, Nayir, Ahmet, additional, Obrycki, Lukasz, additional, Omer, Beyhan, additional, Ozdemir, Ebru Misirli, additional, Ozkayin, Nese, additional, Paripovic, Dusan, additional, Pehlivanoglu, Cemile, additional, Saygili, Seha, additional, Schaefer, Susanne, additional, Sonmez, Ferah, additional, Tabel, Yilmaz, additional, Tas, Nesrin, additional, Tasdemir, Mehmet, additional, Teixeira, Ana, additional, Tekcan, Demet, additional, Tulpar, Sebahat, additional, Turkkan, Ozde Nisa, additional, Uysal, Berfin, additional, Uysalol, Metin, additional, Vaiciuniene, Daiva, additional, Yavuz, Sevgi, additional, Yel, Sibel, additional, Yildirim, Tarik, additional, Yildirim, Zeynep Yuruk, additional, Yildiz, Nurdan, additional, Yuksel, Selcuk, additional, Yurtseven, Eray, additional, Schaefer, Franz, additional, and Topaloglu, Rezan, additional

Published
2022
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13. Comparison of infants and children with urolithiasis: a large case series

Author

Agbas, Ayse, Bastug, Funda, Tulpar, Sebahat, Yildirim, Zeynep Nagehan Yuruk, Cicek, Neslihan, Gunay, Neslihan, Demircin, Gülay, Agbas, Ayse, Bastug, Funda, Tulpar, Sebahat, Yildirim, Zeynep Nagehan Yuruk, Cicek, Neslihan, Gunay, Neslihan, and Demircin, Gülay

Abstract

We evaluated the demographic features, etiologic risk factors, treatment strategies, and outcome of the infants and children with urolithiasis (UL). A retrospective multicenter study was conducted including 23 Pediatric Nephrology centers in Turkey. The medical records of 2513 children with UL were reviewed. One thousand, three hundred and four boys and 1209 girls (1.1:1) were reported. The mean age at diagnosis was 39.5 +/- 35 months (0.4-231 months), and 1262 patients (50.2%) were in the first year of life (infants). Most of the cases with infantile UL were diagnosed incidentally. Microlithiasis ( 3 mm) was found in 794 patients (31.6%), and 64.5% of the patients with microlithiasis were infants. Stones were located in the pelvis-calyces in 63.2% (n: 1530) of the cases. The most common stone type was calcium oxalate (64.6%). Hypocitraturia was the most common metabolic risk factor (MRF) in children older than 12 months, but in infancy, hypercalciuria was more common. Fifty-five percent of the patients had received at least one medical treatment, mostly potassium citrate. At the end of a year's follow-up, most of the patients with microlithiasis (85%) showed spontaneous remission. The rate of spontaneous stone resolution in infants was higher than in children. Spontaneous remission rate was higher in cases with MRF ( - ) stones than in MRF ( +) stones. However, remission rate with medical treatment was higher in cases with MRF ( +) stones. This study represents the results of a large series of infants and children with UL and showed that there are several differences such as underlying metabolic and anatomic abnormalities, clinical course, and stone remission rates between infants and children with urinary stone disease.

Published
2022

14. COVID-19 in pediatric nephrology centers in Turkey

Author

Bakkaloglu, Sevcan A., Atikel, Yesim Ozdemir, Leventoglu, Emre, Hulya Nalcacioglu, Dursun, Ismail, Poyrazoglu, Hakan, Dursun, Hasan, Yildirim, Zeynep Yuruk, Yildiz, Nurdan, Aksoy, Gulsah Kaya, Akman, Sema, Tasdemir, Mehmet, Bilge, Ilmay, Celakil, Mehtap, Kilic, Beltinge Demircioglu, Selcuk, Senay Zirhli, Canpolat, Nur, Cakici, Evrim Kargin, Ozlu, Sare Gulfem, Tulpar, Sebahat, Yuksel, Selcuk, Atmis, Bahriye, Doven, Serra Surmeli, Taner, Sevgin, Ertan, Pelin, Kavaz, Asli, Bayram, Meral Torun, Kalyoncu, Mukaddes, Gulleroglu, Kaan, Kabasakal, Caner, Demir, Belde Kasap, Cicek, Rumeysa Yasemin, Donmez, Osman, Kara, Aslihan, Yavascan, Onder, Ozcelik, Gul, Yildirim, Deniz Gezgin, Guler, Muhammet Akif, Sonmez, Ferah, Topaloglu, Rezan, and Alpay, Harika

Subjects
kidney, pediatric nephrology, Turkey, COVID-19, General Medicine, Children
Abstract

Background/aim: There is limited data on COVID-19 disease in children with kidney disease. We aimed to investigate the characteristics and prognosis of COVID-19 in pediatric nephrology patients in Turkey. Materials and methods: This was a national, multicenter, retrospective cohort study based on an online survey evaluating the data between 11th March 2020 and 11th March 2021 as an initial step of a detailed pediatric nephrology COVID-19 registry. Results: Two hundred and three patients (89 girls and 114 boys) were diagnosed with COVID-19. One-third of these patients (36.9%) were between 10–15 years old. Half of the patients were on kidney replacement therapy: kidney transplant (KTx) recipients (n = 56, 27.5%), patients receiving chronic hemodialysis (n = 33, 16.3%) and those on peritoneal dialysis (PD) (n = 18, 8.9%). Fifty-four (26.6%) children were asymptomatic. Eighty-two (40.3%) patients were hospitalized and 23 (28%) needed intensive care unit admission. Fifty-five percent of the patients were not treated, while the remaining was given favipiravir (20.7%), steroid (16.3%), and hydroxychloroquine (11.3%). Acute kidney injury developed in 19.5% of hospitalized patients. Five (2.4%) had MIS-C. Eighty-three percent of the patients were discharged without any apparent sequelae, while 7 (3.4%) died. One hundred and eight health care staff were infected during the study period. Conclusion: COVID-19 was most commonly seen in patients who underwent KTx and received HD. The combined immunosuppressive therapy and frequent exposure to the hospital setting may increase these patients’ susceptibility. Staff infections before vaccination era were alarming, various precautions should be taken for infection control, particularly optimal vaccination coverage. © TÜBİTAK.

Published
2022

15. Kidney disease profile and encountered problems during follow-up in Syrian refugee children: a multicenter retrospective study

Author

Balat, Ayse, primary, Kilic, Beltinge Demircioglu, additional, Aksu, Bagdagul, additional, Kara, Mehtap Akbalik, additional, Buyukcelik, Mithat, additional, Agbas, Ayse, additional, Eroglu, Fehime Kara, additional, Gungor, Tulin, additional, Alaygut, Demet, additional, Yildiz, Nurdan, additional, Bastug, Funda, additional, Atmis, Bahriye, additional, Melek, Engin, additional, Elmaci, Midhat, additional, Tulpar, Sebahat, additional, Pehlivanoglu, Cemile, additional, Doven, Serra Surmeli, additional, Comak, Elif, additional, Tabel, Yilmaz, additional, Gemici, Atilla, additional, Uysal, Berfin, additional, Ozzorlar, Gamze Seval, additional, Kuçuk, Nuran, additional, Delibas, Ali, additional, Ozcelik, Gul, additional, Goknar, Nilufer, additional, Dursun, Ismail, additional, Ertan, Pelin, additional, Ozunan, Ipek Akil, additional, and Sonmez, Ferah, additional

Published
2021
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16. COVID-19 in pediatric patients undergoing chronic dialysis and kidney transplantation

Author

Taşdemir, Mehmet, Canpolat, Nur; Yıldırım, Zeynep Yürük; Yıldız, Nurdan; Göknar, Nilufer; Evrengül, Havva; Gülmez, Ruveyda; Aksu, Bağdagül; Dursun, Hasan; Özçelik, Gül; Yavaşcan, Önder; Çicek, Rumeysa Yasemin; Tulpar, Sebahat; HacIhamdioğlu, Duygu Övünç; Nayır, Ahmet; Alpay, Harika, Taşdemir, Mehmet, and Canpolat, Nur; Yıldırım, Zeynep Yürük; Yıldız, Nurdan; Göknar, Nilufer; Evrengül, Havva; Gülmez, Ruveyda; Aksu, Bağdagül; Dursun, Hasan; Özçelik, Gül; Yavaşcan, Önder; Çicek, Rumeysa Yasemin; Tulpar, Sebahat; HacIhamdioğlu, Duygu Övünç; Nayır, Ahmet; Alpay, Harika

Abstract

The study aims to present the incidence of COVID-19 in pediatric patients undergoing renal replacement therapy (RRT) and to compare the severity and outcomes of the disease between the dialysis and kidney transplant (KTx) groups. This multicenter observational study was conducted between 1 April and 31 December 2020 in Istanbul. Members of the Istanbul branch of the Turkish Pediatric Nephrology Association were asked to report all confirmed cases of COVID-19 who were on RRT, as well as the number of prevalent RRT patients under the age of 20. A total of 46 confirmed cases of COVID-19 were reported from 12 centers, of which 17 were dialysis patients, and 29 were KTx recipients. Thus, the incidence rate of COVID-19 was 9.3% among dialysis patients and 9.2% among KTx recipients over a 9-month period in Istanbul. Twelve KTx recipients and three dialysis patients were asymptomatic (p = 0.12). Most of the symptomatic patients in both the dialysis and KTx groups had a mild respiratory illness. Only two patients, one in each group, experienced a severe disease course, and only one hemodialysis patient had a critical illness that required mechanical ventilation. In the entire cohort, one hemodialysis patient with multiple comorbidities died. Conclusion: while most cases are asymptomatic or have a mild disease course, pediatric patients undergoing dialysis and a kidney transplant are at increased risk for COVID-19. What is known: in adult population, both dialysis patients and kidney transplant recipients are at increased risk for severe illness of COVID-19 and have higher mortality rate. Children with kidney transplantation are not at increased risk for COVID-19 and most have mild disease course. Data on children on dialysis are scarce. What is new: pediatric patients undergoing dialysis and kidney transplantation have an increased risk for COVID-19. Most patients undergoing renal replacement therapy either on dialysis or transplanted develop asymptomatic or mild COVID-19 di

Published
2021

18. Rituximab treatment for difficult-to-treat nephrotic syndrome in children: A multicenter study

Author

Tasdemir, Mehmet, Canpolat, Nur, Yildiz, Nurdan, Ozcelik, Gul, Benzer, Meryem, Seha Kamil Saygili, Ozkayin, Nese, Turkkan, Ozde Nisa, Balat, Ayse, Candan, Cengiz, Celakil, Mehtap Ezel, Yavuz, Sevgi, Akinci, Nurver, Goknar, Nilufer, Akgun, Cihangir, Tulpar, Sebahat, Alpay, Harika, Sever, Lale, Bilge, Ilmay, TaSdemir, Mehmet, Bilge, Ilmay Koc Univ, Sch Med, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, Canpolat, Nur, Saygili, Seha Kamil, Sever, Lale Istanbul Univ, Cerrahpaa Sch Med, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, Yildiz, Nurdan, Alpay, Harika Marmara Univ, Sch Med, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, Ozcelik, Gul, Akinci, Nurver Sisli Hamidiye Etfal Educ & Res Hosp, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, Benzer, Meryem, Tulpar, Sebahat Bakirkoy Dr Sadi Konuk Educ & Res Hosp, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, Ozkayin, Nese Trakya Univ, Sch Med, Div Pediat Nephrol, Dept Pediat, Edirne, Turkey, Turkkan, Ozde Nisa Istanbul Univ, Istanbul Sch Med, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, Balat, Ayse Istanbul Aydin Univ, Sch Med, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, Candan, Cengiz Istanbul Medeniyet Univ, Goztepe Educ & Res Hosp, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, Celakil, Mehtap Ezel Kocaeli Univ, Sch Med, Div Pediat Nephrol, Dept Pediat, Kocaeli, Turkey, Yavuz, Sevgi Kanuni Sultan Suleyman Educ & Res Hosp, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, Goknar, Nilufer Bagcilar Educ & Res Hosp, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey, and Akgun, Cihangir Istanbul Medipol Univ, Sch Med, Div Pediat Nephrol, Dept Pediat, Istanbul, Turkey

Subjects
Multicenter Study, Nephrotic Syndrome, Rituximab Treatment
Abstract

WOS: 000443998400408 …

Published
2018

19. CLINICAL,EPIDEMIOLOGICAL AND PRGNOSTIC FEATURES OF CHILDREN WITH HEMOLYTIC UREMIC SYNDROME:MULTICENTER EXPERIENCE OF TURKEY

Author

GÜVEN, SERÇİN, TORUN BAYRAM, MERAL, SOYLU, ALPER, YAVAŞCAN, ÖNDER, BASTUG, FUNDA, UYSAL, BERFIN, ERDOGAN, HAKAN, ERDOĞAN, NECDET HAKAN, MELEK, ENGİN, ÖZKAYIN, EMİNE NEŞE, TABEL, YILMAZ, DELİBAŞ, ALİ, SÖNMEZ, FERAH, KAVAZ TUFAN, ASLI, KOYUN, MUSTAFA, BAHAT ÖZDOĞAN, ELİF, BAKKALOĞLU EZGÜ, SEVCAN AZİME, BAYRAKCİ, UMUT SELDA, YİĞİT, GALİP, DURSUN, İSMAİL, ÇELAKIL, MEHTAP, AKINCI, NURVER, KÜÇÜK, NURAN, BEK, KENAN, SERDAROĞLU, ERKİN, DÜŞÜNSEL, RUHAN, DÖNMEZ, OSMAN, COSKUN, SEDA, TULPAR, SEBAHAT, CICEK, NESLİHAN, KAPLAN BULUT, İPEK, and ERTAN, PELİN

Published
2018

20. AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY DISEASE IN CHILDREN: PRELIMINARY RESULTS OF A TURKISH NATIONAL, MULTICENTER STUDY

Author

Ozdogan, Elif Bahat, Hulya Nalcacioglu, Alpay, Harika, Dursun, Ismail, Bek, Kenan, Demir, Belde Kasap, Tekcan, Demet, Acikgoz, Yonca, Melek, Engin, Yazilitas, Fatma, Bayram, Meral Torun, Yildirim, Zeynep Yuruk, Gokce, Ibrahim, Yilmaz, Dilek, Tulpar, Sebahat, Isik, Gunes, Ertan, Pelin, Agbas, Ayse, Aydog, Ozlem, Mutlubas, Fatma, Bircan, Zelal, Cicek, Neslihan, Bayazit, Aysun Karabay, Soylu, Alper, Soyaltin, Eren, Celakil, Mehtap Ezel, and Yildiz, Nurdan

Published
2018

21. CLINICAL, EPIDEMIOLOGICAL AND PROGNOSTIC FEATURES OF CHILDREN WITH HEMOLYTIC UREMIC SYNDROME: MULTICENTER EXPERIENCE OF TURKEY

Author

Ertan, Pelin, Bulut, Ipek Kaplan, Guven, Sercin, Cicek, Neslihan, Tulpar, Sebahat, Coskun, Seda, Donmez, Osman, Dusunsel, Ruhan, Serdaroglu, Erkin, Bek, Kenan, Kucuk, Nuran, Akinci, Nurver, Celakil, Mehtap Ezel, Dursun, Ismail, Yigit, Galip, Soylu, Alper, Bayram, Meral Torun, Bayrakci, Umut Selda, Bakkaloglu, Sevcan, Ozdogan, Elif Bahat, Koyun, Mustafa, Tufan, Asli Kavaz, Sonmez, Ferah, Delibas, Ali, Tabel, Yilmaz, Ozkayin, Nese, Melek, Engin, hakan erdogan, Uysal, Berlin, Bastug, Funda, and Yavascan, Onder

Published
2018

22. Voiding cystourethrogram: How much should we be selective?

Author

Yel, Sibel, primary, Tulpar, Sebahat, additional, Dusunsel, Ruhan, additional, Poyrazoglu, Hakan Muammer, additional, Dursun, Ismail, additional, Abdulrezzak, Ummuhan, additional, Gunduz, Zubeyde, additional, Yilmaz, Kenan, additional, and Bastug, Funda, additional

Published
2017
Full Text
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23. Nail Fold Capillary Abnormality and Insulin Resistance in Children with Familial Mediterranean Fever: Is There Any Relationship Between Vascular Changes and Insulin Resistance?

Author

Dursun, İsmail, Tulpar, Sebahat, Yel, Sibel, Kartal, Demet, Borlu, Murat, Baştuğ, Funda, Poyrazoğlu, Hakan, Gündüz, Zübeyde, Yüksel, Mehmet E., Köse, Kader, Çalışkan, Abdulah, Cekgeloglu, Ahmet B., and Düşünsel, Ruhan

Subjects
*CAPILLARIES, *INSULIN resistance, *DRUG resistance, *CARDIOVASCULAR diseases, *TYPE 2 diabetes, *DISEASES
Abstract

Objective: Nail fold capillary changes are accepted as early symptoms of several rheumatic disorders such as scleroderma and dermatomyositis. In adults, nail fold capillary abnormality (NCA) has been described in Familial Mediterranean Fever (FMF). However, there is not enough study in children with FMF. The aim of the present study was (1) to investigate whether children with FMF have NCA in both active and/or remission period or not and (2) to assess insulin resistance in children with FMF in both active and/or remission period of the disease compared with the control group. Materials and Methods: Ninety-two patients with FMF, including 25 patients in the active period and 67 patients in the remission period, and 33 apparently healthy children were enrolled in the study. Nail fold capillary examination was performed. Groups were compared for inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, and serum amyloid A (SAA)), insulin resistance (homeostatic model assessment of insulin resistance, HOMA-IR), and NCA. The relationship among the NCA, insulin resistance, and inflammatory markers was evaluated. Results: Overt NCA was found in 20% of patients at the attack period and in 2.9% of patients in remission. HOMA-IR was higher at the attack period than at the attack-free period and control. However, this did not reach statistical significance. Nevertheless, HOMA-IR was positively correlated with SAA. The NCA was significantly positively correlated with increased levels of acute-phase reactants and was significantly negatively correlated with serum high-density lipoprotein levels. Conclusion: There are apparent NCA in children with FMF especially in the active period of the disease. There is insulin resistance that is likely associated with inflammation. The NCA becomes overt in the active period of the disease as insulin resistance. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

32. MEMBRANOUS NEPHROPATHY IN CHILDREN: A RETROSPECTIVE OBSERVATIONAL MULTICENTRE STUDY IN TURKEY

Author

Gokce, Ibrahim, Sak, Mehtap, Bayram, Meral Torun, Aksoy, Ozlem, Melek, Engin, Yildirim, Zeynep Nagehan Yuruk, Tekcan, Demet, Pinarbasi, Ayse Seda, Soyaltin, Eren, Goknar, Nilufer, Serdaroglu, Erkin, Ozcelik, Gul, Hulya Nalcacioglu, Tulpar, Sebahat, Ozkayin, Nese, Ozdogan, Elif Bahat, Ertan, Pelin, Buyan, Necla, Aydog, Ozlem, Bayrakci, Umut Selda, Bayazit, Aysun Karabay, Soylu, Alper, Kavukcu, Salih, Yilmaz, Alev, and Anarat, Ali

33. COVID-19 in pediatric patients undergoing chronic dialysis and kidney transplantation

Author

Harika Alpay, Duygu Övünç Hacıhamdioğlu, Zeynep Yuruk Yildirim, Gul Ozcelik, Bağdagül Aksu, Rumeysa Yasemin Cicek, Hasan Dursun, Önder Yavaşcan, Ahmet Nayir, Nurdan Yildiz, Rüveyda Gülmez, Mehmet Taşdemir, Havva Evrengül, Sebahat Tulpar, Nur Canpolat, Nilüfer Göknar, Acibadem University Dspace, Taşdemir, Mehmet, Canpolat, Nur, Yıldırım, Zeynep Yürük, Yıldız, Nurdan, Göknar, Nilufer, Evrengül, Havva, Gülmez, Ruveyda, Aksu, Bağdagül, Dursun, Hasan, Özçelik, Gül, Yavaşcan, Önder, Çicek, Rumeysa Yasemin, Tulpar, Sebahat, HacIhamdioğlu, Duygu Övünç, Nayır, Ahmet, Alpay, Harika, Koç University Hospital, İstinye Üniversitesi, Hastane, Evrengul, Havva, Yildirim, Zeynep Yuruk, Yildiz, Nurdan, Tasdemir, Mehmet, Goknar, Nilufer, Gulmez, Ruveyda, Aksu, Bagdagul, Ozcelik, Gul, Yavascan, Onder, Cicek, Rumeysa Yasemin, Hacihamdioglu, Duygu Ovunc, and Nayir, Ahmet

Subjects
Adult, medicine.medical_specialty, medicine.medical_treatment, HEMODIALYSIS-PATIENTS, Outcomes, Asymptomatic, Pediatrics, DISEASE, RRT, Kidney transplantation, Renal Dialysis, Internal medicine, medicine, Humans, Hemodialysis-Patients, Disease, Renal replacement therapy, Mortality, Child, Children, Dialysis, Mechanical ventilation, Pediatric, OUTCOMES, SARS-CoV-2, business.industry, MORTALITY, Incidence (epidemiology), COVID-19, medicine.disease, RECIPIENTS, Nephrology, Pediatrics, Perinatology and Child Health, Cohort, Kidney Failure, Chronic, Original Article, Recipients, Hemodialysis, medicine.symptom, business, Renal Replacement Therapy
Abstract

The study aims to present the incidence of COVID-19 in pediatric patients undergoing renal replacement therapy (RRT) and to compare the severity and outcomes of the disease between the dialysis and kidney transplant (KTx) groups. This multicenter observational study was conducted between 1 April and 31 December 2020 in Istanbul. Members of the Istanbul branch of the Turkish Pediatric Nephrology Association were asked to report all confirmed cases of COVID-19 who were on RRT, as well as the number of prevalent RRT patients under the age of 20. A total of 46 confirmed cases of COVID-19 were reported from 12 centers, of which 17 were dialysis patients, and 29 were KTx recipients. Thus, the incidence rate of COVID-19 was 9.3% among dialysis patients and 9.2% among KTx recipients over a 9-month period in Istanbul. Twelve KTx recipients and three dialysis patients were asymptomatic (p = 0.12). Most of the symptomatic patients in both the dialysis and KTx groups had a mild respiratory illness. Only two patients, one in each group, experienced a severe disease course, and only one hemodialysis patient had a critical illness that required mechanical ventilation. In the entire cohort, one hemodialysis patient with multiple comorbidities died. Conclusion: while most cases are asymptomatic or have a mild disease course, pediatric patients undergoing dialysis and a kidney transplant are at increased risk for COVID-19. What is known: in adult population, both dialysis patients and kidney transplant recipients are at increased risk for severe illness of COVID-19 and have higher mortality rate. Children with kidney transplantation are not at increased risk for COVID-19 and most have mild disease course. Data on children on dialysis are scarce. What is new: pediatric patients undergoing dialysis and kidney transplantation have an increased risk for COVID-19. Most patients undergoing renal replacement therapy either on dialysis or transplanted develop asymptomatic or mild COVID-19 disease with a favorable outcome., NA

Published
2022

34. Rituximab treatment for difficult-to-treat nephrotic syndrome in children: a multicenter, retrospective study

Author

Özde Nisa Türkkan, Cihangir Akgun, Cengiz Candan, Fatma Sever, Sebahat Tulpar, Meryem Benzer, Seha Saygili, Gul Ozcelik, Harika Alpay, Nur Canpolat, Ayse Balat, Ilmay Bilge, Emine Neşe Özkayin, Mehmet Taşdemir, Nurdan Yildiz, Mehtap Ezel Çelakil, Nurver Akinci, Sevgi Yavuz, Nilüfer Göknar, Taşdemir, Mehmet, Bilge, İlmay (ORCID 0000-0002-4852-989X & YÖK ID 198907), Canpolat, N., Yıldız, N., Özçelik, G., Benzer, M., Saygılı, S.K, Özkayin, E.N., Türkkan, Ö.N., Balat, A., Candan, C., Çelakıl, M., Yavuz, S., Akıncı, N., Göknar, N., Akgün, C., Tülpar, S., Alpay, H., Sever, F.L., Koç University Hospital, School of Medicine, TasdemIr, Mehmet, Canpolat, Nur, Yildiz, Nurdan, OzcelIk, Gul, Benzer, Meryem, Saygili, Seha Kamil, Ozkayin, Emine Nese, Turkkan, Ozde Nisa, Balat, Ayse, Candan, Cengiz, Celakil, Mehtap, Yavuz, Sevgi, Akinci, Nurver, Goknar, Nilufer, Akgun, Cihangir, Tulpar, Sebahat, Alpay, Harika, Sever, Fatma Lale, and BIlge, Ilmay

Subjects
Male, Frequently Relapsing Nephrotic Syndrome, Pediatrics, medicine.medical_specialty, Nephrotic Syndrome, Childhood-Onset, Adolescent, Remission, Follow-Up, Relapse rate, immunosuppressive agents, Article, remission, Recurrence, steroid-resistant nephrotic syndrome, Humans, Medicine, Initial treatment, Child, steroid-dependent nephrotic syndrome, Retrospective Studies, Steroid-Dependent Nephrotic Syndrome, Frequently relapsing nephrotic syndrome, business.industry, Complete remission, General and internal medicine, Infant, Retrospective cohort study, General Medicine, CHILDHOOD-ONSET, medicine.disease, Steroid-resistant nephrotic syndrome, Regimen, Treatment Outcome, Child, Preschool, Cyclosporine, Immunosuppressive agents, Steroid-dependent nephrotic syndrome, CYCLOSPORINE, Female, Steroids, Rituximab, FOLLOW-UP, business, Steroid-Resistant Nephrotic Syndrome, Nephrotic syndrome, Immunosuppressive Agents, medicine.drug
Abstract

Background/aim: this study aimed to evaluate the efficacy of rituximab in children with difficult-to-treat nephrotic syndrome, considering the type of disease (steroid-sensitive or -resistant) and the dosing regimen. Materials and methods: this multicenter retrospective study enrolled children with difficult-to-treat nephrotic syndrome on rituximab treatment from 13 centers. The patients were classified based on low (single dose of 375 mg/m(2)) or high (2-4 doses of 375 mg/m(2)) initial dose of rituximab and the steroid response. Clinical outcomes were compared. Results: data from 42 children [20 steroid-sensitive (frequent relapsing / steroid-dependent) and 22 steroid-resistant nephrotic syndrome, aged 1.9-17.3 years] were analyzed. Eleven patients with steroid-sensitive nephrotic syndrome (55%) had a relapse following initial rituximab therapy, with the mean time to first relapse of 8.4 +/- 5.2 months. Complete remission was achieved in 41% and 36% of steroid-resistant patients, with the median remission time of 3.65 months. At Year 2, eight patients in steroid-sensitive group (40%) and four in steroid-resistant group (18%) were drug-free. Total cumulative doses of rituximab were higher in steroid-resistant group (p = 001). Relapse rates and time to first relapse in steroid-sensitive group or remission rates in steroid-resistant group did not differ between the low and high initial dose groups. Conclusion: the current study reveals that rituximab therapy may provide a lower relapse rate and prolonged relapse-free survival in the steroid-sensitive group, increased remission rates in the steroid-resistant group, and a significant number of drug-free patients in both groups. The optimal regimen for initial treatment and maintenance needs to be determined., NA

Published
2021

35. A nationwide retrospective study in Turkish children with nephrocalcinosis

Author

Pelin Ertan, Burcu Yazicioğlu, Hulya Nalcacioglu, Yeşim Özdemir Atikel, Neşe Bıyıklı, Alev Yilmaz, Duygu Övünç Hacıhamdioğlu, Sebahat Tulpar, Ayşe Ağbaş, Bahriye Atmis, Elif Çomak, Nimet Öner, Neslihan Cicek, Sibel Yel, Nuran Kucuk, Funda Bastug, Ibrahim Gökce, Ahmet Midhat Elmaci, Berfin Uysal, Binnaz Celik, Atilla Gemici, Neslihan Günay, Harika Alpay, Sema Akman, Ismail Dursun, Bağdagül Aksu, Fatma Sever, Serra Sürmeli Döven, Zeynep Nagehan Yürük Yildirim, Emine Özlem Çam Delebe, Ali Delibaş, Esra Karabağ Yilmaz, OMÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nalcacıoğlu, Hülya, Doven, Serra Surmeli, Tulpar, Sebahat, Bastug, Funda, Yildirim, Zeynep Nagehan Yuruk, Yilmaz, Esra Karabag, Cicek, Neslihan, Kucuk, Nuran, Comak, Elif, Yazicioglu, Burcu, Nalcacioglu, Hulya, Delibas, Ali, Uysal, Berfin, Agbas, Ayse, Gemici, Atilla, Gunay, Neslihan, Ertan, Pelin, Biyikli, Nese, Hacihamdioglu, Duygu Ovunc, Elmaci, Ahmet Midhat, Atikel, Yesim Ozdemir, Delebe, Emine Ozlem Cam, Sever, Fatma Lale, Gokce, Ibrahim, Oner, Nimet, Akman, Sema, Aksu, Bagdagul, Atmis, Bahriye, Yel, Sibel, Yilmaz, Alev, Celik, Binnaz, Dursun, Ismail, and Alpay, Harika

Subjects
Male, Pediatrics, medicine.medical_specialty, Turkey, bartter syndrome, Renal tubular acidosis, Primary hyperoxaluria, Distal renal tubular acidosis, nephrocalcinosis, medicine, Humans, Hypercalciuria, Medical history, Child, Retrospective Studies, hypercalciuria, business.industry, Retrospective cohort study, Acidosis, Renal Tubular, General Medicine, medicine.disease, Bartter syndrome, Child, Preschool, Hyperoxaluria, Primary, Etiology, Female, Nephrocalcinosis, renal tubular acidosis, business
Abstract

Tam Metin / Full Text Q4 PMID: 34174796 WOS:000724833600003 SCI-Expanded Nephrocalcinosis (NC) is defined as calcium deposition in the kidney parenchyma and tubules. This study aims to determine the etiology, risk factors, and follow-up results of patients with NC in Turkey. Materials and methods: Patients diagnosed with NC in the pediatric nephrology Department Units of 19 centers from all geographical regions of Turkey over a 10-year period (2010–2019) were included in the study. The medical records from the centers were reviewed and demographic data, admission complaints, medical history, systemic and genetic disorders, risk factors for NC, treatment details, and presence of NC after one-year follow-up, were recorded retrospectively. Results: The study sample included 195 patients (88 females, 107 males). The mean age at diagnosis was 39.44 ± 47.25 (0.5–208) months; 82/190 patients (43.2%) were diagnosed incidentally; 46/195 patients (23.6%) had an underlying disease; idiopathic hypercalciuria was detected in 75/195 (38.4%) patients. The most common systemic diseases were distal renal tubular acidosis in 11/46 patients (23.9%), primary hyperoxaluria in 9/46 patients (19.6%) and Bartter syndrome in 7/46 patients (15.3%). After one year of follow-up, NC resolved in 56/159 patients (35.2%) and they all did not have an underlying systemic disease. Conclusion: The most common presentation of NC was incidental. Distal renal tubular acidosis and primary hyperoxaluria were the main systemic diseases leading to NC, while hypercalciuria was the most common metabolic risk factor. Nephrocalcinosis was found to remain in most of the patients at a one-year follow-up. It may resolve particularly in patients with no underlying systemic disease. Keywords: Bartter syndrome, hypercalciuria, nephrocalcinosis, renal tubular acidosis

Published
2021

36. Amyloidosis in a Child With Hyperimmunoglobulinemia D Syndrome.

Author

Yel, Sibel, Gunduz, Zubeyde, Bastug, Funda, Dusunsel, Ruhan, Dursun, Ismail, Poyrazoglu, Hakan, Tulpar, Sebahat, Deniz, Kemal, and Demirkaya, Erkan

Subjects
*AMYLOIDOSIS, *FEVER, *LYMPHOPROLIFERATIVE disorders, *PROTEIN metabolism disorders, *NEPHROTIC syndrome, *KIDNEY failure
Abstract

Hereditary periodic fever syndromes are a group of genetic diseases clinically characterized by recurrent febrile attacks. Patients are at variable risks for the development of systemic reactive (AA) amyloidosis, leading to the nephrotic syndrome and kidney failure. We present the first report of the occurrence of renal AA amyloidosis causing severe nephrotic syndrome in a Turkish child affected with hyperimmunoglobulinemia D syndrome. [ABSTRACT FROM AUTHOR]

Published
2013

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