12 results on '"Tudor Cristea-Platon"'
Search Results
2. Case fatality rates for COVID-19 are higher than case fatality rates for motor vehicle accidents for individuals over 40 years of age
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Emily Lindemer, Colin Pawlowski, Tudor Cristea-Platon, Patrick Lenehan, Michiel J.M. Niesen, Arjun Puranik, and Venky Soundararajan
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medicine.medical_specialty ,Heart disease ,business.industry ,Public health ,Mortality rate ,Disease ,medicine.disease ,Vaccination ,Case fatality rate ,Pandemic ,medicine ,business ,Cause of death ,Demography - Abstract
The death toll of the COVID-19 pandemic has been unprecedented, due to both the high number of SARS-CoV-2 infections and the seriousness of the disease resulting from these infections. Here, we present mortality rates and case fatality rates for COVID-19 over the past year compared with other historic leading causes of death in the United States. Among the risk categories considered, COVID-19 is the third leading cause of death for individuals 40 years old and over, with an overall annual mortality rate of 325 deaths per 100K individuals, behind only cancer (385 deaths per 100K individuals) and heart disease (412 deaths per 100K individuals). In addition, for individuals 40 years old and over, the case fatality rate for COVID-19 is greater than the case fatality rate for motor vehicle accidents. In particular, for the age group 40-49, the relative case fatality rate of COVID-19 is 1.5 fold (95% CI: [1.3, 1.7]) that of a motor vehicle accident, demonstrating that SARS-CoV-2 infection may be significantly more dangerous than a car crash for this age group. For older adults, COVID-19 is even more dangerous, and the relative case fatality rate of COVID-19 is 29.4 fold (95% CI: [23.2, 35.7]) that of a motor vehicle accident for individuals over 80 years old. On the other hand, motor vehicle accidents have a 4.5 fold (95% CI: [3.9, 5.1]) greater relative case fatality rate compared to COVID-19 for the age group of 20-29 years. These results highlight the severity of the COVID-19 pandemic especially for adults above 40 years of age and underscore the need for large-scale preventative measures to mitigate risks for these populations. Given that FDA-authorized COVID-19 vaccines have now been validated by multiple studies for their outstanding real-world effectiveness and safety, vaccination of all individuals who are over 40 years of age is one of the most pressing public health priorities of our time.
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- 2021
3. Hair loss in females and thromboembolism in males are significantly enriched in post-acute sequelae of COVID (PASC) relative to recent medical history
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Elliot Akama-Garren, Praveen Anand, Tudor Cristea-Platon, Patrick Lenehan, Emily Lindemer, Sairam Bade, Saran Liukasemsarn, John C. O’Horo, Ryan T. Hurt, Amy W. Williams, Gregory J. Gores, Andrew D. Badley, Samir Awasthi, and Venky Soundararajan
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Pediatrics ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Disease ,medicine.disease ,Obesity ,Age groups ,Pandemic ,medicine ,Anxiety ,medicine.symptom ,business ,Depression (differential diagnoses) - Abstract
After one year of the COVID-19 pandemic, over 130 million individuals worldwide have been infected with the novel coronavirus, yet the post-acute sequelae of COVID-19 (PASC), also referred to as the ‘long COVID’ syndrome, remains mostly uncharacterized. We leveraged machine-augmented curation of the physician notes from electronic health records (EHRs) across the multi-state Mayo Clinic health system to retrospectively contrast the occurrence of symptoms and diseases in COVID-19 patients in the post-COVID period relative to the pre-COVID period (n=6,413). Through comparison of the frequency of 10,039 signs and symptoms before and after diagnosis, we identified an increase in hypertensive chronic kidney disease (OR 47.3, 95% CI 23.9-93.6, p=3.50×10−9), thromboembolism (OR 3.84, 95% CI 3.22-4.57, p=1.18×10−4), and hair loss (OR 2.44, 95% CI 2.15-2.76, p=8.46×10−3) in COVID-19 patients three to six months after diagnosis. The sequelae associated with long COVID were notably different among male vs female patients and patients above vs under 55 years old, with the hair loss enrichment found primarily in females and the thromboembolism enrichment in males. These findings compel targeted investigations into what may be persistent dermatologic, cardiovascular, and coagulopathic phenotypes following SARS-CoV-2 infection.
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- 2021
4. Comparison of COVID-19 with Other Leading Causes of Death in the United States
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Emily Lindemer, Tudor Cristea-Platon, Arjun Puranik, Patrick Lenehan, Michiel J.M. Niesen, Soundararajan, and Colin Pawlowski
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education.field_of_study ,business.industry ,Mortality rate ,Population ,Drug overdose ,medicine.disease ,Homicide ,Relative risk ,Pandemic ,Case fatality rate ,medicine ,education ,business ,Demography ,Cause of death - Abstract
Importance: Over the past year, the COVID-19 pandemic has resulted in the deaths of more than 550,000 individuals in the United States. It is important for us to understand the risks of COVID-19 in relation to other leading causes of death in order to inform public policy decisions and individual behaviors to help mitigate the highest risks. Objective: Contrast COVID-19 with historic leading causes of death. Design: We present mortality rates and case fatality rates for COVID-19 from March 2020 to March 2021 compared with other historic leading causes of death in the United States. For each risk category and 10-year age groups (0-9, 10-19, …, 70-79, ≥ 80), we report the overall mortality and case fatality rates along with the relative risks compared to COVID-19 as a baseline. There were 16 other leading causes of death considered in this analysis, including: cancer, various subtypes of cancer (brain / nervous system, breast, lung / bronchus, pancreatic, prostate, leukemia, lymphoma), cerebrovascular disease, drug overdoses, firearm homicide, heart diseases, influenza, motor vehicle accidents (overall and without restraint), and suicide. Setting: This is a population-based study. Participants: N/A. Exposures: N/A. Main Outcomes and Measures: Overall mortality (number of deaths / population) and case fatality rates (number of deaths / number of cases). Results: COVID-19 is the third leading cause of death for individuals over 40 years old, with an annual mortality rate of 325 deaths/100K, behind only cancer (385 deaths/100K) and heart disease (412 deaths/100K). In addition, for individuals over 40 years old, the case fatality rate for COVID-19 is greater than the case fatality rate for motor vehicle accidents. For the age group 40-49 years old, the relative case fatality rate for COVID-19 is 1.5 fold (95% CI: [1.3,1.7]) that of motor vehicle accidents, and this relative risk increases to 29.4 fold (95% CI: [23.2, 35.7]) for individuals over 80 years old. Conclusions and Relevance: These results highlight the severity of the COVID-19 pandemic especially for adults over 40 years old and underscore the need for large-scale preventative measures to mitigate risks for these populations. Funding Statement: This work was supported by Nference, Inc. Declaration of Interests: None reported.
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- 2021
5. Real-World Effectiveness of Ad26.COV2.S Adenoviral Vector Vaccine for COVID-19
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Juan Corchado-Garcia, David Puyraimond-Zemmour, Travis Hughes, Tudor Cristea-Platon, Patrick Lenehan, Colin Pawlowski, Sairam Bade, John C. O'Horo, Gregory J. Gores, Amy W. Williams, Andrew D. Badley, John Halamka, Abhinash Virk, Melanie D. Swift, Tyler Wagner, and Venky Soundararajan
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Vaccination ,medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Cohort ,Emergency medicine ,Authorization ,Medicine ,Mass vaccination ,business ,Health outcomes ,Viral vector - Abstract
In light of the massive and rapid vaccination campaign against COVID-19, continuous real-world effectiveness and safety assessment of the FDA-authorized vaccines is critical to amplify transparency, build public trust, and ultimately improve overall health outcomes. In this study, we leveraged large-scale longitudinal curation of electronic health records (EHRs) from the multi-state Mayo Clinic health system (MN, AZ, FL, WN, IA). We compared the infection rate of 2,195 individuals who received a single dose of the Ad26.COV2.S vaccine from Johnson & Johnson (J&J) to the infection rate of 21,950 unvaccinated, propensity-matched individuals between February 27th and April 14th 2021. Of the 1,779 vaccinated individuals with at least two weeks of follow-up, only 3 (0.17%) tested positive for SARS-CoV-2 15 days or more after vaccination compared to 128 of 17,744 (0.72%) unvaccinated individuals (4.34 fold reduction rate). This corresponds to a vaccine effectiveness of 76.7% (95% CI: 30.3-95.3%) in preventing SARS-CoV-2 infection with onset at least two weeks after vaccination. This data is consistent with the clinical trial-reported efficacy of Ad26.COV2.S in preventing moderate to severe COVID-19 with onset at least 14 days after vaccine administration (66.9%; 95% CI: 59.0-73.4%). Due to the recent authorization of the Ad26.COV2.S vaccine, there are not yet enough hospitalizations, ICU admissions, or deaths within this cohort to robustly assess the effect of vaccination on COVID-19 severity, but these outcomes will be continually assessed in near-real-time with our platform. Collectively, this study provides further evidence that a single dose of Ad26.COV2.S is highly effective in preventing SARS-CoV-2 infection and reaffirms the urgent need to continue mass vaccination efforts globally.
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- 2021
6. A hydrodynamic analog of Friedel oscillations
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Pedro Saenz, Tudor Cristea-Platon, and John W. M. Bush
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Physics ,Friedel oscillations ,Multidisciplinary ,Drop (liquid) ,SciAdv r-articles ,Probability density function ,Electron ,Condensed Matter::Mesoscopic Systems and Quantum Hall Effect ,01 natural sciences ,010305 fluids & plasmas ,Open quantum system ,Classical mechanics ,Condensed Matter::Superconductivity ,0103 physical sciences ,Wave field ,Condensed Matter::Strongly Correlated Electrons ,010306 general physics ,Quantum ,Research Articles ,Research Article - Abstract
We report a new classical analog of electron scattering from an impurity on a metal surface., We present a macroscopic analog of an open quantum system, achieved with a classical pilot-wave system. Friedel oscillations are the angstrom-scale statistical signature of an impurity on a metal surface, concentric circular modulations in the probability density function of the surrounding electron sea. We consider a millimetric drop, propelled by its own wave field along the surface of a vibrating liquid bath, interacting with a submerged circular well. An ensemble of drop trajectories displays a statistical signature in the vicinity of the well that is strikingly similar to Friedel oscillations. The droplet trajectories reveal the dynamical roots of the emergent statistics. Our study elucidates a new mechanism for emergent quantum-like statistics in pilot-wave hydrodynamics and so suggests new directions for the nascent field of hydrodynamic quantum analogs.
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- 2020
7. Analysis of the Effectiveness of the Ad26.COV2.S Adenoviral Vector Vaccine for Preventing COVID-19
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Andrew D. Badley, John Halamka, Sairam Bade, Gregory J. Gores, Travis K. Hughes, David Zemmour, Tudor Cristea-Platon, Tyler Wagner, John C. O’Horo, Venky Soundararajan, Melanie D. Swift, Patrick Lenehan, Colin Pawlowski, Amy W. Williams, Hari Bandi, Juan Corchado-Garcia, and Abinash Virk
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Adult ,Male ,medicine.medical_specialty ,COVID-19 Vaccines ,Time Factors ,Adolescent ,Comparative effectiveness research ,Rate ratio ,Severity of Illness Index ,Young Adult ,Internal medicine ,medicine ,Humans ,Young adult ,Propensity Score ,Pandemics ,Aged ,Retrospective Studies ,Ad26COVS1 ,SARS-CoV-2 ,business.industry ,Incidence ,Incidence (epidemiology) ,Vaccination ,COVID-19 ,Retrospective cohort study ,General Medicine ,Middle Aged ,United States ,COVID-19 Nucleic Acid Testing ,Cohort ,Propensity score matching ,Drug Evaluation ,Female ,business - Abstract
Importance: Continuous assessment of the effectiveness and safety of the US Food and Drug Administration-authorized SARS-CoV-2 vaccines is critical to amplify transparency, build public trust, and ultimately improve overall health outcomes. Objective: To evaluate the effectiveness of the Johnson & Johnson Ad26.COV2.S vaccine for preventing SARS-CoV-2 infection. Design, Setting, and Participants: This comparative effectiveness research study used large-scale longitudinal curation of electronic health records from the multistate Mayo Clinic Health System (Minnesota, Arizona, Florida, Wisconsin, and Iowa) to identify vaccinated and unvaccinated adults between February 27 and July 22, 2021. The unvaccinated cohort was matched on a propensity score derived from age, sex, zip code, race, ethnicity, and previous number of SARS-CoV-2 polymerase chain reaction tests. The final study cohort consisted of 8889 patients in the vaccinated group and 88â¯898 unvaccinated matched patients. Exposure: Single dose of the Ad26.COV2.S vaccine. Main Outcomes and Measures: The incidence rate ratio of SARS-CoV-2 infection in the vaccinated vs unvaccinated control cohorts, measured by SARS-CoV-2 polymerase chain reaction testing. Results: The study was composed of 8889 vaccinated patients (4491 men [50.5%]; mean [SD] age, 52.4 [16.9] years) and 88â¯898 unvaccinated patients (44â¯748 men [50.3%]; mean [SD] age, 51.7 [16.7] years). The incidence rate ratio of SARS-CoV-2 infection in the vaccinated vs unvaccinated control cohorts was 0.26 (95% CI, 0.20-0.34) (60 of 8889 vaccinated patients vs 2236 of 88â¯898 unvaccinated individuals), which corresponds to an effectiveness of 73.6% (95% CI, 65.9%-79.9%) and a 3.73-fold reduction in SARS-CoV-2 infections. Conclusions and Relevance: This study's findings are consistent with the clinical trial-reported efficacy of Ad26.COV2.S and the first retrospective analysis, suggesting that the vaccine is effective at reducing SARS-CoV-2 infection, even with the spread of variants such as Alpha or Delta that were not present in the original studies, and reaffirm the urgent need to continue mass vaccination efforts globally.
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- 2021
8. Statistical projection effects in a hydrodynamic pilot-wave system
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Tudor Cristea-Platon, Pedro Saenz, and John W. M. Bush
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Physics ,Pilot wave ,Field (physics) ,General Physics and Astronomy ,Electron ,01 natural sciences ,Projection (linear algebra) ,010305 fluids & plasmas ,Quantum realm ,Quantum mirage ,Classical mechanics ,Excited state ,0103 physical sciences ,010306 general physics ,Quantum - Abstract
Millimetric liquid droplets can walk across the surface of a vibrating fluid bath, self-propelled through a resonant interaction with their own guiding or ‘pilot’ wave fields. These walking droplets, or ‘walkers’, exhibit several features previously thought to be peculiar to the microscopic, quantum realm. In particular, walkers confined to circular corrals manifest a wave-like statistical behaviour reminiscent of that of electrons in quantum corrals. Here we demonstrate that localized topological inhomogeneities in an elliptical corral may lead to resonant projection effects in the walker’s statistics similar to those reported in quantum corrals. Specifically, we show that a submerged circular well may drive the walker to excite specific eigenmodes in the bath that result in drastic changes in the particle’s statistical behaviour. The well tends to attract the walker, leading to a local peak in the walker’s position histogram. By placing the well at one of the foci, a mode with maxima near the foci is preferentially excited, leading to a projection effect in the walker’s position histogram towards the empty focus, an effect strongly reminiscent of the quantum mirage. Finally, we demonstrate that the mean pilot-wave field has the same form as the histogram describing the walker’s statistics. Droplets moving on the surface of a vibrating fluid bath mimic the behaviour of electrons in quantum corrals. Introducing submerged features in the bath can even drive the droplets to excite modes that induce effects reminiscent of quantum mirages.
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- 2017
9. Sources of Long‐Range Anthropogenic Noise in Southern California and Implications for Tectonic Tremor Detection
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Susan E. Hough, Gregor Hillers, Tudor Cristea-Platon, Jean-Paul Ampuero, Asaf Inbal, Duncan Carr Agnew, Géoazur, Publications, Seismological Laboratory [Berkeley], Tel Aviv University [Tel Aviv], Massachusetts Institute of Technology (MIT), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Institue of Seismology [Helsinki], Department of Geosciences and Geography [Helsinki], Falculty of Science [Helsinki], University of Helsinki-University of Helsinki-Falculty of Science [Helsinki], University of Helsinki-University of Helsinki, Scripps Institution of Oceanography (SIO), University of California [San Diego] (UC San Diego), University of California-University of California, US Geological Survey [Pasadena], United States Geological Survey [Reston] (USGS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Department of Geosciences and Geography, and Institute of Seismology
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1171 Geosciences ,010504 meteorology & atmospheric sciences ,Range (biology) ,education ,[SDU.STU]Sciences of the Universe [physics]/Earth Sciences ,ZONE ,010502 geochemistry & geophysics ,ANZA ,01 natural sciences ,NON-VOLCANIC TREMOR ,INTERFEROMETRY ,Noise ,Tectonics ,Geophysics ,Oceanography ,SEISMIC EVENTS ,Geochemistry and Petrology ,[SDU.STU] Sciences of the Universe [physics]/Earth Sciences ,ARRAY ,EARTHQUAKE ,FIELD ,SAN-JACINTO FAULT ,SEDIMENTS ,Geology ,0105 earth and related environmental sciences - Abstract
International audience; We study anthropogenic noise sources seen on seismic recordings along the central section of the San Jacinto fault near Anza, southern California. The strongest signals are caused by freight trains passing through the Coachella Valley north of Anza. Train‐induced transients are observed at distances of up to 50 km from the railway, with durations of up to 20 min, and spectra that are peaked between 3 and 5 Hz. Additionally, truck traffic through the Coachella Valley generates a sustained hum with a similar spectral signature as the train transients but with lower amplitude. We also find that wind turbine activity in northern Baja California introduces a seasonal modulation of 1– to 5‐Hz energy across the Anza network. We show that the observed train‐generated transients can be used to constrain shallow attenuation structure at Anza. Using the results from this study as well as available borehole data, we further evaluate the performance of approaches that have been used to detect nonvolcanic tremor at Anza. We conclude that signals previously identified as spontaneous tremor (Hutchison and Ghosh, 2017) were probably generated by other nontectonic sources such as trains.
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- 2018
10. Walking droplets in a circular corral: Quantisation and chaos
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Tudor Cristea-Platon, Pedro Saenz, and John W. M. Bush
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Physics ,Angular momentum ,Applied Mathematics ,General Physics and Astronomy ,Statistical and Nonlinear Physics ,Electron ,Radius ,Simple harmonic motion ,01 natural sciences ,010305 fluids & plasmas ,Quantum realm ,Acceleration ,Classical mechanics ,0103 physical sciences ,Two-phase flow ,010306 general physics ,Quantum ,Mathematical Physics - Abstract
A millimetric liquid droplet may walk across the surface of a vibrating liquid bath through a resonant interaction with its self-generated wavefield. Such walking droplets, or “walkers,” have attracted considerable recent interest because they exhibit certain features previously believed to be exclusive to the microscopic, quantum realm. In particular, the intricate motion of a walker confined to a closed geometry is known to give rise to a coherent wave-like statistical behavior similar to that of electrons confined to quantum corrals. Here, we examine experimentally the dynamics of a walker inside a circular corral. We first illustrate the emergence of a variety of stable dynamical states for relatively low vibrational accelerations, which lead to a double quantisation in angular momentum and orbital radius. We then characterise the system’s transition to chaos for increasing vibrational acceleration and illustrate the resulting breakdown of the double quantisation. Finally, we discuss the similarities and differences between the dynamics and statistics of a walker inside a circular corral and that of a walker subject to a simple harmonic potential.A millimetric liquid droplet may walk across the surface of a vibrating liquid bath through a resonant interaction with its self-generated wavefield. Such walking droplets, or “walkers,” have attracted considerable recent interest because they exhibit certain features previously believed to be exclusive to the microscopic, quantum realm. In particular, the intricate motion of a walker confined to a closed geometry is known to give rise to a coherent wave-like statistical behavior similar to that of electrons confined to quantum corrals. Here, we examine experimentally the dynamics of a walker inside a circular corral. We first illustrate the emergence of a variety of stable dynamical states for relatively low vibrational accelerations, which lead to a double quantisation in angular momentum and orbital radius. We then characterise the system’s transition to chaos for increasing vibrational acceleration and illustrate the resulting breakdown of the double quantisation. Finally, we discuss the similarities ...
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- 2018
11. Spin lattices of walking droplets
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Alexis Goujon, John W. M. Bush, Jörn Dunkel, Pedro Saenz, Tudor Cristea-Platon, Giuseppe Pucci, Massachusetts Institute of Technology. Department of Mathematics, Massachusetts Institute of Technology. Department of Physics, Saenz Hervias, Pedro Javier, Pucci, Giuseppe, Goujon, Alexis Marie Fr, Cristea-Platon, Tudor, Dunkel, Jorn, and Bush, John W. M.
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Fluid Flow and Transfer Processes ,Physics ,Work (thermodynamics) ,Classical mechanics ,Modeling and Simulation ,0103 physical sciences ,Computational Mechanics ,Fluid motion ,010306 general physics ,01 natural sciences ,010305 fluids & plasmas ,Spin-½ - Abstract
This paper is associated with a video winner of a 2017 APS/DFD Gallery of Fluid Motion Award for work presented at the DFD Gallery of Fluid Motion. The original video is available from the Gallery of Fluid Motion, https://doi.org/10.1103/APS.DFD.2017.GFM.V0018, National Science Foundation (U.S.) (Grant No. CMMI-1333242), National Science Foundation (U.S.) (Grant No. DMS-1614043), National Science Foundation (U.S.) (Grant No. CMMI-1727565)
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- 2018
12. Video: Spin lattices of walking droplets
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Tudor Cristea-Platon, John W. M. Bush, Pucci Giuseppe, Jörn Dunkel, Pedro Saenz, and Alexis Goujon
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Physics ,Optics ,Condensed matter physics ,business.industry ,business ,Spin-½ - Published
- 2017
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