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13 results on '"Tubergen, Astrid M."'

2. One-year effectiveness of long-term exercise therapy in people with axial spondyloarthritis and severe functional limitations

Author

van Wissen, Maria A T, primary, van den Ende, Cornelia H M, additional, Gademan, Maaike G J, additional, Teuwen, Max M H, additional, Peter, Wilfred F, additional, Mahler, Elien A M, additional, van Schaardenburg, Dirkjan, additional, van Gaalen, Floris A, additional, Spoorenberg, Anneke, additional, van den Hout, Wilbert B, additional, van Tubergen, Astrid M, additional, Vliet Vlieland, Theodora P M, additional, and van Weely, Salima F E, additional

Published
2024
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3. Functional limitations of people with rheumatoid arthritis or axial spondyloarthritis and severe functional disability: a cross-sectional descriptive study

Author

Teuwen, Max M. H., primary, van Weely, Salima F. E., additional, Vliet Vlieland, Thea P. M., additional, Douw, Thom, additional, van Schaardenburg, Dirkjan, additional, den Broeder, Alfons A., additional, van Tubergen, Astrid M., additional, van Wissen, Maria A. T., additional, van den Ende, Cornelia H. M., additional, and Gademan, Maaike G. J., additional

Published
2023
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4. Progression From Subclinical Inflammation to Overt Spondyloarthritis (SpA) in First-Degree Relatives of SpA Patients in Association With HLA-B27: the Pre-SpA cohort

Author

de Jong, Henriëtte M Y, de Winter, Janneke J H, van der Horst-Bruinsma, Irene E, van Schaardenburg, Dirk-Jan, van Gaalen, Floris A, van Tubergen, Astrid M, Weel, Angelique E A M, Landewé, Robert B M, Baeten, Dominique L P, van de Sande, Marleen G H, Interne Geneeskunde, MUMC+: MA Reumatologie (9), and RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation

Subjects
musculoskeletal diseases
Abstract

OBJECTIVES: As first-degree relatives (FDRs) of HLA-B27-positive axial spondyloarthritis (axSpA) patients have an increased risk of developing axSpA, the objectives were 1) to evaluate presence of highly specific imaging features as well as clinical signs of SpA at baseline and after one year of follow-up, and 2) describe the evolution towards clinical disease within one year of follow-up in a cohort of seemingly healthy FDRs of HLA-B27 positive axSpA patients. METHODS: The Pre-SpA cohort is a 5-year prospective inception cohort of seemingly healthy FDRs of HLA-B27 positive axSpA patients. Clinical and imaging features were collected and recorded. RESULTS: At baseline 19% of the FDRs reported inflammatory back pain. Thirty-two percent reported current arthralgia, 3% arthritis (ever), 5% enthesitis (ever) and 1% dactylitis (ever). Three percent had an extra-articular manifestation. CRP was elevated in 16%, ESR in 7%. On MRI-SIJ, 10% had a SPARCC score ≥2, 4% ≥5, and 4% deep lesions. One percent fulfilled the mNY criteria for radiographic sacroiliitis. Clinical, MRI and acute phase findings were equally distributed between HLA-B27 positive and negative FDRs. After 1 year of follow-up, clinical parameters did not change on the group level but 6% of the FDRs were clinically diagnosed with axSpA, of whom 86% were HLA-B27 positive. CONCLUSION: Features associated with spondyloarthritis or imaging abnormalities were found in up to 32% of seemingly healthy FDRs, with an equal distribution between HLA-B27 positive and negative FDRs. Progression to clinical axSpA within 1 year of follow-up was mainly observed in HLA-B27 positive FDRs.

Published
2022

5. Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort

Author

de Jong, Henriëtte M. Y., primary, de Winter, Janneke J. H., additional, van der Horst‐Bruinsma, Irene E., additional, van Schaardenburg, Dirk‐Jan, additional, van Gaalen, Floris A., additional, van Tubergen, Astrid M., additional, Weel, Angelique E. A. M., additional, Landewé, Robert B. M., additional, Baeten, Dominique L. P., additional, and van de Sande, Marleen G. H., additional

Published
2022
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6. Progression from subclinical inflammation to overt SpA in first degree relatives of SpA patients is associated with HLA-B27: the Pre-SpA cohort

Author

de Jong, Henriëtte M Y, de Winter, Janneke J H, van der Horst-Bruinsma, Irene E, van Schaardenburg, Dirk-Jan, van Gaalen, Floris A, van Tubergen, Astrid M, Weel, Angelique E A M, Landewé, Robert B M, Baeten, Dominique L P, van de Sande, Marleen G H, Clinical Immunology and Rheumatology, and AII - Inflammatory diseases

Subjects
musculoskeletal diseases
Abstract

OBJECTIVES: As first-degree relatives (FDRs) of HLA-B27-positive axial spondyloarthritis (axSpA) patients have an increased risk of developing axSpA, the objectives were 1) to evaluate presence of highly specific imaging features as well as clinical signs of SpA at baseline and after one year of follow-up, and 2) describe the evolution towards clinical disease within one year of follow-up in a cohort of seemingly healthy FDRs of HLA-B27 positive axSpA patients. METHODS: The Pre-SpA cohort is a 5-year prospective inception cohort of seemingly healthy FDRs of HLA-B27 positive axSpA patients. Clinical and imaging features were collected and recorded. RESULTS: At baseline 19% of the FDRs reported inflammatory back pain. Thirty-two percent reported current arthralgia, 3% arthritis (ever), 5% enthesitis (ever) and 1% dactylitis (ever). Three percent had an extra-articular manifestation. CRP was elevated in 16%, ESR in 7%. On MRI-SIJ, 10% had a SPARCC score ≥2, 4% ≥5, and 4% deep lesions. One percent fulfilled the mNY criteria for radiographic sacroiliitis. Clinical, MRI and acute phase findings were equally distributed between HLA-B27 positive and negative FDRs. After 1 year of follow-up, clinical parameters did not change on the group level but 6% of the FDRs were clinically diagnosed with axSpA, of whom 86% were HLA-B27 positive. CONCLUSION: Features associated with spondyloarthritis or imaging abnormalities were found in up to 32% of seemingly healthy FDRs, with an equal distribution between HLA-B27 positive and negative FDRs. Progression to clinical axSpA within 1 year of follow-up was mainly observed in HLA-B27 positive FDRs.

Published
2021

7. Effectiveness and cost‐effectiveness of longstanding exercise therapy versus usual care in patients with axial spondyloarthritis or rheumatoid arthritis and severe limitations: The protocols of two parallel randomized controlled trials

Author

Wissen, Maria. A. T., primary, Teuwen, Max. M. H., additional, Ende, Cornelia. H. M., additional, Vlieland, Thea. P. M., additional, Broeder, Alfons. A., additional, Hout, Wilbert. B., additional, Peter, Wilfred. F., additional, Schaardenburg, Dirkjan., additional, Tubergen, Astrid. M., additional, Gademan, Maaike. G. J., additional, and Weely, Salima. F. E., additional

Published
2021
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8. Gastrointestinal Adverse Drug Reaction Profile of Etanercept: Real-world Data From Patients and Healthcare Professionals

Author

van Lint, Jette A., primary, Jessurun, Naomi T., additional, Tas, Sander W., additional, van den Bemt, Bart J.F., additional, Nurmohamed, Michael T., additional, van Doorn, Martijn B.A., additional, Spuls, Phyllis I., additional, van Tubergen, Astrid M., additional, ten Klooster, Peter M., additional, van Puijenbroek, Eugene P., additional, Hoentjen, Frank, additional, and Vonkeman, Harald E., additional

Published
2021
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9. Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort

Author

Jong, Henriëtte M. Y., Winter, Janneke J. H., Horst‐Bruinsma, Irene E., Schaardenburg, Dirk‐Jan, Gaalen, Floris A., Tubergen, Astrid M., Weel, Angelique E. A. M., Landewé, Robert B. M., Baeten, Dominique L. P., and Sande, Marleen G. H.

Abstract

As first‐degree relatives (FDRs) of HLA–B27–positive patients with axial spondyloarthritis (SpA) have an increased risk of developing axial SpA, the objectives were 1) to evaluate the presence of highly specific imaging features as well as clinical signs of SpA at baseline and after 1 year of follow‐up, and 2) to describe the evolution toward clinical disease within 1 year of follow‐up in a cohort of seemingly healthy FDRs of HLA–B27–positive axial SpA patients. The Pre‐SpA cohort is a 5‐year prospective inception cohort of seemingly healthy FDRs of HLA–B27–positive axial SpA patients. Clinical and imaging features were collected and recorded. At baseline, 19% of the FDRs reported inflammatory back pain, 32% current arthralgia, 3% arthritis (ever), 5% enthesitis (ever), and 1% dactylitis (ever), and 3% had an extraarticular manifestation. C‐reactive protein level was elevated in 16%, and erythrocyte sedimentation rate was elevated in 7%. On magnetic resonance imaging (MRI) views of sacroiliac joints, 10% had a Spondyloarthritis Research Consortium of Canada score of ≥2, 4% had a score of ≥5, and 4% had deep lesions. In total, 1% fulfilled the modified New York criteria for radiographic sacroiliitis. Clinical, MRI, and acute phase findings were equally distributed between HLA–B27–positive and –negative FDRs. After 1 year of follow‐up, clinical parameters did not change on the group level, but 6% of the FDRs were clinically diagnosed with axial SpA, of whom 86% were HLA–B27–positive. Features associated with SpA or imaging abnormalities were found in up to 32% of seemingly healthy FDRs, with an equal distribution between HLA–B27–positive and –negative FDRs. Progression to clinical axial SpA within 1 year of follow‐up was mainly observed in HLA–B27–positive FDRs.

Published
2022
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12. Effectiveness and cost‐effectiveness of longstanding exercise therapy versus usual care in patients with axial spondyloarthritis or rheumatoid arthritis and severe limitations: The protocols of two parallel randomized controlled trials.

Author

van Wissen, Maria. A. T., Teuwen, Max. M. H., van den Ende, Cornelia. H. M., Vliet Vlieland, Thea. P. M., den Broeder, Alfons. A., van den Hout, Wilbert. B., Peter, Wilfred. F., van Schaardenburg, Dirkjan., van Tubergen, Astrid. M., Gademan, Maaike. G. J., and van Weely, Salima. F. E.

Subjects
PHYSICAL therapy, HEALTH status indicators, TREATMENT effectiveness, RANDOMIZED controlled trials, FUNCTIONAL assessment, RHEUMATOID arthritis, COST effectiveness, EXERCISE therapy
Abstract

Objectives: Research on effectiveness and cost‐effectiveness of longstanding exercise therapy in patients with axial SpondyloArthritis (axSpA) or Rheumatoid Arthritis (RA) is scarce, and mainly concerned patients with a relatively favorable health status. We aim to evaluate the effectiveness and cost‐effectiveness of longstanding exercise therapy compared to usual care in the subgroup of patients with axSpA or RA and severe limitations in functioning. Methods: In two separate, parallel randomized controlled trials the effectiveness and cost‐effectiveness of longstanding, active exercise therapy (52 weeks) compared with usual care (1:1) will be evaluated. The longstanding, active exercise therapy will focus on improving individual limitations in daily activities and participation and will be given by a trained physical therapist in the vicinity of the participant. For each diagnosis, 215 patients with severe limitations in activities and participation will be included. Assessments are performed at baseline, 12, 26, and 52 weeks. The primary outcome measure of effectiveness is the individual level of functioning (activities and participation), as measured with the Patient‐Specific Complaints instrument at 52 weeks. For cost‐effectiveness analyses, the EuroQol (EQ‐5D‐5L) and questionnaires on healthcare use and productivity will be administered. The economic evaluation will be a cost‐utility analysis from a societal perspective. After 52 weeks, the patients in the usual care group are offered longstanding, active exercise therapy as well. Follow‐up assessments are done at 104, 156, and 208 weeks. Conclusion: The results of these studies will provide insights in the effectiveness and cost‐effectiveness of longstanding exercise therapy in the subgroup of axSpA and RA patients with severe functional limitations. [ABSTRACT FROM AUTHOR]

Published
2022
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13. An automatic testing environment for SOPHO-S

Author

Brink, v.d., Jan, Timmermans, P.M.A., van der Stok, Peter, van Tubergen, Astrid M., and Stan Ackermans Instituut, Centrum voor Technologisch Ontwerpen

Published
1993

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